LOCUS       NM_030961              10910 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 56 (TRIM56), mRNA.
ACCESSION   NM_030961
VERSION     NM_030961.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10910)
  AUTHORS   Guan,A., Dai,Z., Jiang,C., Sun,J., Yang,B., Xie,B. and Chen,Q.
  TITLE     PGRMC1 promotes NSCLC stemness phenotypes by disrupting
            TRIM56-mediated ubiquitination of AHR
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167440 (2024)
   PUBMED   39059592
  REMARK    GeneRIF: PGRMC1 promotes NSCLC stemness phenotypes by disrupting
            TRIM56-mediated ubiquitination of AHR.
REFERENCE   2  (bases 1 to 10910)
  AUTHORS   Wang,Y., Dong,Y., Luan,T., Chen,Y., Lin,L., Li,S., Feng,D., Wei,J.,
            Fei,Y., Wang,G., Pan,J., Wang,Y., Zhong,Z. and Zhao,W.
  TITLE     TRIM56 restricts Coxsackievirus B infection by mediating the
            ubiquitination of viral RNA-dependent RNA polymerase 3D
  JOURNAL   PLoS Pathog 20 (9), e1012594 (2024)
   PUBMED   39348396
  REMARK    GeneRIF: TRIM56 restricts Coxsackievirus B infection by mediating
            the ubiquitination of viral RNA-dependent RNA polymerase 3D.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10910)
  AUTHORS   Liu,B.M., Li,N.L., Wang,R., Li,X., Li,Z.A., Marion,T.N. and Li,K.
  TITLE     Key roles for phosphorylation and the Coiled-coil domain in
            TRIM56-mediated positive regulation of TLR3-TRIF-dependent innate
            immunity
  JOURNAL   J Biol Chem 300 (5), 107249 (2024)
   PUBMED   38556084
  REMARK    GeneRIF: Key roles for phosphorylation and the Coiled-coil domain
            in TRIM56-mediated positive regulation of TLR3-TRIF-dependent
            innate immunity.
REFERENCE   4  (bases 1 to 10910)
  AUTHORS   Wang,B., Wang,Z., Li,Y., Shang,Z., Liu,Z., Fan,H., Zhan,R. and
            Xin,T.
  TITLE     TRIM56: a promising prognostic immune biomarker for glioma revealed
            by pan-cancer and single-cell analysis
  JOURNAL   Front Immunol 15, 1327898 (2024)
   PUBMED   38348047
  REMARK    GeneRIF: TRIM56: a promising prognostic immune biomarker for glioma
            revealed by pan-cancer and single-cell analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10910)
  AUTHORS   Fu,L., Zhou,X., Jiao,Q. and Chen,X.
  TITLE     The Functions of TRIM56 in Antiviral Innate Immunity and
            Tumorigenesis
  JOURNAL   Int J Mol Sci 24 (5), 5046 (2023)
   PUBMED   36902478
  REMARK    GeneRIF: The Functions of TRIM56 in Antiviral Innate Immunity and
            Tumorigenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10910)
  AUTHORS   Shen,Y., Li,N.L., Wang,J., Liu,B., Lester,S. and Li,K.
  TITLE     TRIM56 is an essential component of the TLR3 antiviral signaling
            pathway
  JOURNAL   J Biol Chem 287 (43), 36404-36413 (2012)
   PUBMED   22948160
  REMARK    GeneRIF: TRIM56 is an essential component of the TLR3 antiviral
            signaling pathway and reveal a novel role for TRIM56 in innate
            antiviral immunity.
REFERENCE   7  (bases 1 to 10910)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 10910)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 10910)
  AUTHORS   Wang,J., Liu,B., Wang,N., Lee,Y.M., Liu,C. and Li,K.
  TITLE     TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase
            that restricts pestivirus infection
  JOURNAL   J Virol 85 (8), 3733-3745 (2011)
   PUBMED   21289118
  REMARK    GeneRIF: These data demonstrate that TRIM56 is a novel antiviral
            host factor that restricts pestivirus infection.
REFERENCE   10 (bases 1 to 10910)
  AUTHORS   Tsuchida,T., Zou,J., Saitoh,T., Kumar,H., Abe,T., Matsuura,Y.,
            Kawai,T. and Akira,S.
  TITLE     The ubiquitin ligase TRIM56 regulates innate immune responses to
            intracellular double-stranded DNA
  JOURNAL   Immunity 33 (5), 765-776 (2010)
   PUBMED   21074459
  REMARK    GeneRIF: TRIM56 is an interferon-inducible E3 ubiquitin ligase that
            modulates STING to confer double-stranded DNA-mediated innate
            immune responses.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005847.2, BC048194.1 and AC105446.4.
            
            On Nov 24, 2018 this sequence version replaced NM_030961.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048194.1, SRR1660803.9512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306085.11/ ENSP00000305161.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BC005847.2         43-66
            25-1166             BC048194.1         1-1142
            1167-10910          AC105446.4         125462-135205
FEATURES             Location/Qualifiers
     source          1..10910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..10910
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /note="tripartite motif containing 56"
                     /db_xref="GeneID:81844"
                     /db_xref="HGNC:HGNC:19028"
                     /db_xref="MIM:616996"
     exon            1..91
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /inference="alignment:Splign:2.1.0"
     exon            92..254
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /inference="alignment:Splign:2.1.0"
     exon            255..10910
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2523
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 56; RING finger
                     protein 109; RING-type E3 ubiquitin transferase TRIM56"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM56"
                     /protein_id="NP_112223.1"
                     /db_xref="CCDS:CCDS43625.1"
                     /db_xref="GeneID:81844"
                     /db_xref="HGNC:HGNC:19028"
                     /db_xref="MIM:616996"
                     /translation="MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDC
                     LAQLADGGRVRCPECRETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACA
                     LCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEE
                     ARERQAAQCPQHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEG
                     LLAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQ
                     LRAHVEAAEEAARERLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQ
                     LQGCPWAPGPAPCLLPQLELHPGLLDKNCHLLRLSFEEQQPQKDGGKDGAGTQGGEES
                     QSRREDEPKTERQGGVQPQAGDGAQTPKEEKAQTTREEGAQTLEEDRAQTPHEDGGPQ
                     PHRGGRPNKKKKFKGRLKSISREPSPALGPNLDGSGLLPRPIFYCSFPTRMPGDKRSP
                     RITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQSAVAFSA
                     SARLYLINPNGEVQWRRALSLSQASHAVAALPSGDRVAVSVAGHVEVYNMEGSLATRF
                     IPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGEYKGPGLHGCQPG
                     SVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTTMVDGRYLVVSL
                     SNGTIHIFRVRSPDS"
     regulatory      10818..10823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /note="hexamer: AATAAA"
     polyA_site      10843
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /note="major polyA site"
     regulatory      10885..10890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
                     /note="hexamer: AATAAA"
     polyA_site      10910
                     /gene="TRIM56"
                     /gene_synonym="RNF109"
ORIGIN      
        1 agttttgttt cttttccagg cacccagcaa cggcggcctc caggcctcag gccccctcac
       61 catcctagag gtcaagatca gctctggcta gttctcacag gtctgaccca acaagtagca
      121 ctgacatttt tacgtttgct ggatgtacac acggaagtgg aggaggagga ggagaaggag
      181 gagggcagct ccttagctca agagcaagtg gcccaaggcc tcagaagact agaaggaagt
      241 tcctggccat tcagcatggt ttcccacggg tcctcgccct ccctcctgga ggccctgagc
      301 agcgacttcc tggcctgtaa aatctgcctg gagcagctgc gggcacccaa gacactgccc
      361 tgcctgcata cctactgcca agactgcctg gcacagctgg cggatggcgg ccgcgtccgc
      421 tgccccgagt gccgcgagac agtgcctgtg ccgcccgagg gtgtggcctc cttcaagacc
      481 aacttcttcg tcaatgggct gctggacctg gtgaaggccc gggcctgtgg agacctgcgt
      541 gccgggaagc cagcctgtgc cctgtgtccc ctggtgggtg gcaccagcac cggggggccg
      601 gccacggccc ggtgcctgga ctgtgccgat gacttgtgcc aggcctgtgc cgacgggcac
      661 cgctgcaccc gccagaccca cacccaccgc gtggtggacc tggtgggcta cagggccggg
      721 tggtatgatg aggaggcccg ggagcgccaa gcggcccagt gtccccagca ccccggggag
      781 gcactgcgct tcctgtgcca gccctgctca cagttgctgt gcagagagtg ccgcctagac
      841 ccccacctgg accacccctg cctgcctctg gctgaagctg tgcgtgcccg gaggccgggc
      901 ctggagggac tgctggccgg tgtggacaat aacctggtgg agctggaggc agcgcggagg
      961 gtggagaagg aggcgctagc ccggctgcgg gagcaggcgg cccgggtggg gactcaggtg
     1021 gaggaggcgg ctgagggcgt cctccgggcc ctgctggccc agaagcagga ggtgctgggg
     1081 cagctacgag cccacgtgga ggctgccgaa gaagctgctc gggagaggct ggcggagctt
     1141 gagggccggg agcaggtggc cagggccgca gccgccttcg cccgccgggt actcagcctg
     1201 gggcgagagg ccgagatcct ctccctggaa ggggcgatcg cacagcggct caggcagctg
     1261 cagggctgcc cctgggcacc aggcccggcc ccctgcctgc tcccacagct ggagctccat
     1321 cctgggctcc tggacaagaa ctgccacctt cttcggctgt cctttgagga gcagcagccc
     1381 cagaaggatg gtgggaaaga cggagctggt acccagggag gtgaggagag ccagagccgg
     1441 agggaggatg agccgaagac tgagagacag ggtggagtcc agccccaggc tggagatgga
     1501 gcccagaccc caaaagagga aaaagcccag acaacccgag aagagggagc ccagaccttg
     1561 gaggaggaca gggcccagac accccacgag gatggaggac cccagcccca caggggtggc
     1621 agacccaaca agaagaaaaa gttcaaaggc aggctcaagt caatttcccg ggagcccagc
     1681 ccagccctgg ggccgaatct ggacggctct ggcctcctcc ccagacccat cttttactgc
     1741 agtttcccca cgcggatgcc tggagacaag cggtcccccc ggatcaccgg gctctgtccc
     1801 ttcggtcccc gggagatcct ggtggcggat gagcagaacc gggcactgaa acgcttctcc
     1861 ctcaacggcg actacaaggg caccgtgccg gtccctgagg gctgctcccc ttgcagcgtg
     1921 gccgccctgc agagcgcggt ggccttctcc gctagcgcac ggctctatct catcaacccc
     1981 aacggcgaag tgcagtggcg cagggccctg agcctctccc aggccagcca cgcggtggcg
     2041 gcactgccta gcggggaccg cgtggctgtc agcgtggcgg gccacgtgga ggtgtacaat
     2101 atggaaggca gcctggccac ccggttcatt cctggaggca aggccagccg gggcctgcgg
     2161 gcgctggtgt ttctgaccac cagcccccag gggcatttcg tggggtcgga ctggcagcag
     2221 aatagtgtgg taatctgtga tgggctgggc caggtggttg gggagtacaa ggggccaggc
     2281 ctgcatggct gccagccggg ctccgtgtct gtggataaga agggctacat ctttctgacc
     2341 cttcgagaag tcaacaaggt ggtgatcctg gacccgaagg ggtccctcct tggagacttc
     2401 ctgacagcct accacggcct ggaaaagccc cgggttacca ccatggtgga tggcaggtac
     2461 ctggtcgtgt ccctcagtaa cgggaccatc cacatctttc gggtccgttc tccggacagt
     2521 taaaggggct aggactaggg tgagagggag tggggaggga gagggcagga aggaggcaga
     2581 gctgtccgtg ggaggtggag gccgaggaca ttttcctgaa gggcaggggt tggcaacttt
     2641 tcaacatgga gtgccaaact gctaacccgt cttctagtgt gtgagaatag ggaccaaggt
     2701 ggtggcgtga ccttaactct cagaagcaga ggaggcaggt gggtggaggg ggatgctggg
     2761 agttcacctg cctcttgctt tttgtgggtg gctgctgcca ccaccgccgc tgctatatag
     2821 tttaggtttc tgaggtttgt gagcctgtcc tgctttgcat tcttcaaaac cattcctgat
     2881 agagtagccg agggagagtc ttggggccaa gaagggccca gggtgggtca ggcgtgtgca
     2941 ctgtggaaca gagctgagac cccggccccc cttggactgg cacagggtcc tacagagtca
     3001 gaggaggcct gagatttcga atgggcagtg aatggcctct tctgccagcc acaggcagga
     3061 tgctccttga tcacggcatc ccccggcggt agtacagggt gagcttgcag gagggtctgc
     3121 aagtgcagac agcagctggg gccaaagagg tgttaggttc aaaggctgcg aagagaatag
     3181 gctactggaa aaccaaaccc aacagaattc acgtccaaaa atccacattc tccatcgctt
     3241 ctcagccttt tggctaagat taagtattaa aaaaaaacca ggctctgcca ggcgcagtgg
     3301 ctcatgccta taatcccggc actttgggag tctgtggcag gaggattgct tgaggccagg
     3361 agtttgagac cagcctgggc aacatagcga gaccccatct ctacaaaaga ttaaaaatta
     3421 gctgcgtgta gtagcatatg cctttcaacg tagctactca ggaggctgag gtgggaggat
     3481 cccttgagcc gaggagtttg agtctgcagt gagctatgat cgcaccactg cattccagac
     3541 cccatctcga aaaaaaaaaa aaaaaaaaaa aacagaaaca acagaaaaag caggttatcc
     3601 atcacttctc agctaagatc aagtgttaaa ataaataaat aaataaataa ataaataaat
     3661 aaataaatac caagttatga gtgtcagagc aggggagccc tccacgcagc cacggagcca
     3721 gtctgaggga agaggtacat aggatagaaa aatctctagg ctccaacgct tctgcttcgg
     3781 tgtctttcca tttcccaggg tctatgtgtt gccttctctt cattttccag caaaattcct
     3841 tttgagatat gttggccttc actcggctga actagggggt gaaggaaggt tgtcctctgt
     3901 gggccactat tgctggggaa acagctaaac cctgcaggcc aagtggaact tggaggtgcc
     3961 aagaaaacct agaaggtgca atggggctgc gacggataga ggtgtcaaac cagaagggag
     4021 gaacccgtcg gaggtgggct gtgaccaccg gaccttttca taagtggtgg cagtggtaga
     4081 attgaggggg caagtaggct tggagaatgt ttttagccag gggctgttga gagatggcag
     4141 aagggggtct taatgtgggg actgtggaca gtggggcatt cgtgggaacc agagggattt
     4201 tggacaagtc cagatggaat gtgcagggca taggtagagg gaaaagaaaa tccctttctg
     4261 ggaaaaccat ttcttgttta ttgaaacaat gcaggacatc atcaaagtcc gggtggacac
     4321 attccattat ctacaaatta caaaggtagg cacagcaaag aataatgaag attataagaa
     4381 aaccaagcgc caggcacggt gactcaagcc tgtaatccca gcactctggg aggctggggt
     4441 gggtggatca ctcaaggtca ggagttcgag accagcctgg ccaacatgga gaaaccccat
     4501 ctctactaaa aatacaaaaa ttagctaggc gtgggagcgg gcgtctgtaa tcccagctac
     4561 ttgggaggct gaggcaggag aatcatttga acccaggagg tggaagttgc agtgagctca
     4621 gatcgcacca ttgcactcca gcctgggtaa caagaatgaa actccatctc aaaaaaaaag
     4681 aaaaagaaaa gaaagaaaac caaggtccct ctccctctcc ctctccccac ggtctccctc
     4741 tgcctctctt tccatggtca cggtctccct ctgatgccga gccgaagctg gactgtactg
     4801 ctgccatctc ggctcactgc aacctccctg cctgattctc ctgcctcagc ctgccgagtg
     4861 cctgcgattg caggcgcgcg ccgccacgcc tgactggttt tcgtattttt ttggtggaga
     4921 cggggtttca ctgtgttggc cgggctggtc tccagctcct aaccgcgagt gatccgccag
     4981 cctcggcctc cggaggtgcc gggattgcag acggagtctc gttcactcgg tgctcaatgt
     5041 tgcccaggct ggagtgcagt gtcgtgatct cggctagcta caacctccac ctcccagccg
     5101 cccgccttgg cctcccaaag tgccgagatt acagcctctg cccggccgcc accccctctg
     5161 ggaagtgcgg agtgtctctg cctggccgcc cattgtctgg gatgtgagga gcccctctgc
     5221 ccggctgccc agtctgggaa gtgaggagcg cctcttcctg gccgccatcc catctaggaa
     5281 gtgaggagtg tctctgcccg gctgcccatc atctgagatg tggggagcac ctcagccccg
     5341 ccgccccgtc tgggatgtga ggagcgcctc tgcccggccg cgacccagtc tgggaggtga
     5401 ggagcgtctc tgcccagccg ccccgtctga gaagtgagga gcccctccgc ctggcagccg
     5461 ccccgtctga gaagtgagga gcccctccgc ccggcagccg ccccgtccgg gagggaggtg
     5521 gggggtcagc cccctcccgg ccagccgcgc cgtccgggag ggaggtgggg ggtcagcccc
     5581 cgcccggcca gccgcgcctt ccgggaggga ggtgggggat cagtccccgc ccggccagcc
     5641 gccccgcccg ggagcgaggt ggggggcgcc tccgcccggc cgctgtcccg tccgggaggt
     5701 ggggggtcgc ctctgcccgg ccgccccgtc tgggaggtga ggagcccctc tgcccggcca
     5761 ccaccccgtc tgggaggtgt acccaacagc tcattgagaa cgggccatga tgacgatggc
     5821 ggttttgtgg aatagaaaag ggggaaaggt ggggaaaaga tagagaaatc agattgttgc
     5881 cgtgtctgtg tagaaagaag tagacatggg agacttcatt ttgttctgta ctaagaaaaa
     5941 ttcttctgcc ttgggatgct gttaatctaa gaccttaccc ccaaccccgt gctctctgaa
     6001 atatgtgctg tgtccactca gggttaaatg gattaagggc ggtgcaagat gtgctttgtt
     6061 aaacagatgc ttgaaggcag catgctcctt aagagtcatc accactccct aatctcaagt
     6121 acccagggac acaaacactg cggaaggccg cagggtcgtc tgcctaggaa aaccagagac
     6181 ctttgttcac ttgtttatct gctgaccttc cctccactat tgtcctatga ccctgccaaa
     6241 tccccctctg cgagaaacac ccaagaatga tcaataaaaa attaaaaaaa aaaaaaaaaa
     6301 aagaaaacca agaagatggg aaaaccatgc agaattgatt tgacgaggaa agccttggtc
     6361 tctaatacat gcaatgacta gaacagtatt tggtcaaaga accacataag ctctgtaccc
     6421 tggaggaaat gtatgcaggc aaggactagt aaaataaaaa ataataataa ttaaaaaaaa
     6481 aaaaaagaaa ggctggacgc ggtggctcac acctgtaatc ccagcacttt gggaggctga
     6541 ggtgggtgga tcacctgagg tcaggagttt gagaccagcc tggccactac ggtgaaaccc
     6601 catctctact aaaaatacaa aaattacccg ggtgtggtgg cgcatgcctg taatcccagc
     6661 tactggggag tctgaggcag gagactcgct tgaacctggg aggcagaggg tgcagcgagc
     6721 cgagttcacc ccattgcact ccagcctggg tgtcacagtg agactctgtc tcaaaaaaat
     6781 aataaataaa taattaaatc cacttgcagt ggtcaaaaat aaatgttaaa taaatgggtg
     6841 agaaatcttg cggagaaata gactcctggc actataaaaa tgatcctgga gaataatttg
     6901 gctagacttt gcaagaatga caaaaatgat tataagaatc agttgtctca ctttggggaa
     6961 tacattctgg gaaaataatg taagagaaaa aatatttgca tacagacatt tgaggctgct
     7021 ctgtatatta caggcaagaa ctggaaactg ttcggctgca gggtgacagc taactagatt
     7081 gtggtttatt aggggaatga gcctttcttt gtgtatgaca actatgaaaa ctattgagaa
     7141 gaaatagtta cgtgatacag tcataatcct caaaaacgga gaatcaggaa ttatgatcaa
     7201 atagtgatag taacaaggaa aacatctgtc taaataatta ctgagtagaa ataggttcgg
     7261 aatttgtaaa tagtcattaa tttgggagat tggggttttt tttgttttgt tttttgtttg
     7321 tttttcatta ttttgtgcta ttattcatac gtgtacattt ctacttcagt ttttattatc
     7381 cattacataa catacatgct tgattatttg cttcaaggaa atacaccttt ataagtaata
     7441 ctcaataact actgggtttg agaatgaagg tgtcagaacg aatgagattg tcctatgaaa
     7501 gaagaggcag gagccaggga ggaggatccc acccggccgg ggctcagcca ggaggcaggg
     7561 ccattggggc agggtggcag tccaaggaac cgctctggga aggtttgcaa aggtcggggt
     7621 cccccctgcc aggtgatcga attatcgtgg agtgtctgga aggcggggga agttttgttg
     7681 agttcaccaa ataactcaga ccaactggaa accaagtgga gtttctacag gaccaactag
     7741 aatagggatc agctacatgg gggcgggggg aggggggcag ggaacggtgt ctgtcttcat
     7801 tgcagctctg tctgcagagc cagcactgtg atacctcata gtaggtgctc agtgaatgtc
     7861 tgtgaagtga attactatct agacaaggat gagactggta tgactctcca aagctttccc
     7921 acctccaaaa cctcggcttg tggggaatct ccagtagggg gcactgtgga cacggttcgc
     7981 atctgcctcc caaggctggg ctccgcgtca aaaaaaaaaa aaaaaaatga gactgagcca
     8041 ggtgcagtgg tcactcctgt tatctcagca ctttgcgtgg ccaaggcggg aggatgtctt
     8101 gaggccagga gttcaagact aggctgggca acatagcaag accccatctc tacaaaaaaa
     8161 tttttaaatt agccagaggt ggtggcatgc acccgtagtc ccagctgctc gggaggctga
     8221 ggcagaagat tgctcgagcc caggagttca aggctgcagt gagctctgat tgtgccactg
     8281 cactccagcc tgagtgacag agcaaaacct ggtttcctaa gggggggata aaagagggag
     8341 agatgagatc ggggtgtccc gcttctgtgc atgtggaggg ggtaactggg aaccgtgtac
     8401 tgtaggggat cgcacacctt ggggtggaaa cagcagctct ccggagttgc atgggagcca
     8461 tgggcagtgg tcctggctgg tgaaatgatt ctagccacgt ggcccaccca gggggcaaaa
     8521 caatagaaac cttcagaaat gaaacgtcac ctggctgcaa gaagatagtc ccacaggcgc
     8581 cctagagatg gggatgccaa gtggcttctc gggaagctgt aagaatccac agggcattgt
     8641 aagatggagg gaaatattaa gttttcttcg taaagaggtg aggggggcga gagcagcaaa
     8701 ggacactgga aaatgagaag catggatggg aagtgttgca ttgagcataa tttggaggta
     8761 aaatctccaa caccgtaact gagtggcctg gggacctgat agaaagccct gctcaggact
     8821 aaggcagagt tcccagttat atcgcagata caaagagacc aggaacacgc ttgtaatcac
     8881 agcacttagg gaggctgagg cgggtggatg acctgaggtc aggagttcga gaccagccta
     8941 gccaacatgg tgaaaccccc atctctacta aaaatacaaa aattagccag gcgtggtggc
     9001 acatgcctgt aatcccagct actcaggagg ctgaggtggg agaatcgctt gagcccggga
     9061 ggcaggggtt gcagcgagct gagatcgtac cactgcactc cagcctgggc aacagagtga
     9121 gaccctgtct caaaaagaaa aaaaaaaaag agagaaatca ggaacatcat gaaagataca
     9181 gcaaaatgtt ttaccccagc ccactgcacc acacctggga ttgtgacaat taacttgata
     9241 aattgttcct tttcctgttc ggaactgact aggttgtgcg tggatggacc agtgaaaaga
     9301 aaatcctgtt tgggtaggga agagggaagt agaaaacctc tttcgtattc ttggtgtcaa
     9361 gaaatgggaa gagaatgagg gagcagagac ctgggttgag tgttggctct gcactaaaca
     9421 gctgtgtgat cttggtctag tgccttaacc tctctgagcc tcagtttgta catcagtaac
     9481 attgggataa tgacatccac atgcccactt cacagagctg ctgtgaggac tggatgagaa
     9541 atgtagagaa gtatttcgga caccataaag ctcaaataca aggtgttggt taggaaaagt
     9601 ttcaactgac ttgtacccac ctgatacccc tccatcagca taagcgtgta tgaggatgtt
     9661 aggtacatgt gttgtgagtg aaagctctgg aacacccgag tagagctttc tgcaaatcag
     9721 cttctccttc agaggagacc attttgtttt gctttccagc agttacttga agaagcctta
     9781 tctgaagtca caacagtgac ttcaggaata gaagggacca atggccagct tgctgaaatg
     9841 taatgccatt cttaaaagcc agctaagaat cagaccgtat tagttaagga cccataagag
     9901 tagacattta gaaaaagtga aaaatggcaa gagtggccca atcttttgag agtttagaga
     9961 aaatatcatt tggaaaggga gtagctctcc ttctatttta gccttattat tacggtatct
    10021 ataaagcaat gccatattct aaatctgcag aaataaaatt ctaaggggcg aaagtccaag
    10081 gcagaagtca aaagttttgc aaggaaaccg atgaggttgc tgacctgagc tgggcagggt
    10141 tgaacaggcg agtgccaaga tcaaggtctc tgattgtctc tccttgaaag gtaagcagag
    10201 aactagggct atcccataaa ttaagtggga gattggaaag gggtgcggac ttctgtattg
    10261 gggagaaggt cttggatgaa ctggggcaga gaactgccag agagagtacc taggaatacg
    10321 ttgttagcag gagaaagacc aagttcagat gcagacttgg gaaagtaggt aacttgacca
    10381 aaggtagcaa aattagacta cccaactgga ttgtgaatgc agtttatgaa atggatcagg
    10441 acaggagcaa aaatagattt tctagaaact gcagactcct gtgattggag cagtatacaa
    10501 agtacagcaa catcagacta gatctcacct gaggtgctgg gtgagaaatc ttagggacca
    10561 gatggaagag ggcctgtgta taaagacatt aggaaggagg tttgggaggg cagcctgact
    10621 tgtctccaga gaaagttaga actggttgac ttagcaacca agggacactg ggtcaaagac
    10681 gaggaatcag gacgtcggtg cctagtgact gagcgccagc ccagcccatt tctctacatt
    10741 gccatgggct aaacccagtg tgctgtaaac tcttcagttc ctttggttat ggattttgta
    10801 tcttttctgt gtttcttaat aaagttcttt tgaaaaatgg gaacctttct cagatgggaa
    10861 ttttgtatct ttcctctgtt tcttaataaa gttcttttga aaaattggaa
//
