LOCUS       NM_184085               2679 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 55 (TRIM55), transcript
            variant 1, mRNA.
ACCESSION   NM_184085
VERSION     NM_184085.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Hammami,N.E.H., Merindol,N., Plourde,M.B., Maisonnet,T., Lebel,S.
            and Berthoux,L.
  TITLE     SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55
  JOURNAL   Biochem Cell Biol 102 (1), 73-84 (2024)
   PUBMED   37703582
  REMARK    GeneRIF: SUMO-3 promotes the ubiquitin-dependent turnover of
            TRIM55.
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Lin,L., Yu,H., Li,L., Yang,W., Chen,X., Gong,Y., Lei,Q., Li,Z.,
            Zhou,Z., Dai,L., Zhang,H. and Hu,H.
  TITLE     TRIM55 promotes noncanonical NF-kappaB signaling and B
            cell-mediated immune responses by coordinating p100 ubiquitination
            and processing
  JOURNAL   Sci Signal 16 (806), eabn5410 (2023)
   PUBMED   37816088
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Lin,M., Fang,Z., Lin,X., Zhou,W., Wang,Y., Han,S., Ye,M. and Zhu,F.
  TITLE     TRIM55 inhibits colorectal cancer development via enhancing protein
            degradation of c-Myc
  JOURNAL   Cancer Med 12 (12), 13511-13521 (2023)
   PUBMED   37212463
  REMARK    GeneRIF: TRIM55 inhibits colorectal cancer development via
            enhancing protein degradation of c-Myc.
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Heliste,J., Chheda,H., Paatero,I., Salminen,T.A., Akimov,Y.,
            Paavola,J., Elenius,K. and Aittokallio,T.
  TITLE     Genetic and functional implications of an exonic TRIM55 variant in
            heart failure
  JOURNAL   J Mol Cell Cardiol 138, 222-233 (2020)
   PUBMED   31866377
  REMARK    GeneRIF: Genetic and functional implications of an exonic TRIM55
            variant in heart failure.
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   7  (bases 1 to 2679)
  AUTHORS   Lange,S., Xiang,F., Yakovenko,A., Vihola,A., Hackman,P.,
            Rostkova,E., Kristensen,J., Brandmeier,B., Franzen,G., Hedberg,B.,
            Gunnarsson,L.G., Hughes,S.M., Marchand,S., Sejersen,T., Richard,I.,
            Edstrom,L., Ehler,E., Udd,B. and Gautel,M.
  TITLE     The kinase domain of titin controls muscle gene expression and
            protein turnover
  JOURNAL   Science 308 (5728), 1599-1603 (2005)
   PUBMED   15802564
REFERENCE   8  (bases 1 to 2679)
  AUTHORS   Pizon,V., Iakovenko,A., Van Der Ven,P.F., Kelly,R., Fatu,C.,
            Furst,D.O., Karsenti,E. and Gautel,M.
  TITLE     Transient association of titin and myosin with microtubules in
            nascent myofibrils directed by the MURF2 RING-finger protein
  JOURNAL   J Cell Sci 115 (Pt 23), 4469-4482 (2002)
   PUBMED   12414993
REFERENCE   9  (bases 1 to 2679)
  AUTHORS   McElhinny,A.S., Kakinuma,K., Sorimachi,H., Labeit,S. and
            Gregorio,C.C.
  TITLE     Muscle-specific RING finger-1 interacts with titin to regulate
            sarcomeric M-line and thick filament structure and may have nuclear
            functions via its interaction with glucocorticoid modulatory
            element binding protein-1
  JOURNAL   J Cell Biol 157 (1), 125-136 (2002)
   PUBMED   11927605
REFERENCE   10 (bases 1 to 2679)
  AUTHORS   Centner,T., Yano,J., Kimura,E., McElhinny,A.S., Pelin,K.,
            Witt,C.C., Bang,M.L., Trombitas,K., Granzier,H., Gregorio,C.C.,
            Sorimachi,H. and Labeit,S.
  TITLE     Identification of muscle specific ring finger proteins as potential
            regulators of the titin kinase domain
  JOURNAL   J Mol Biol 306 (4), 717-726 (2001)
   PUBMED   11243782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK091310.1 and AJ291712.1.
            
            On Nov 23, 2018 this sequence version replaced NM_184085.1.
            
            Summary: The protein encoded by this gene contains a RING zinc
            finger, a motif known to be involved in protein-protein
            interactions. This protein associates transiently with
            microtubules, myosin, and titin during muscle sarcomere assembly.
            It may act as a transient adaptor and plays a regulatory role in
            the assembly of sarcomeres. Four alternatively spliced transcript
            variants encoding distinct isoforms have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.23076.1,
                                           SRR1660803.259629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315962.9/ ENSP00000323913.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1376              AK091310.1         237-1612
            1377-2210           AJ291712.1         1369-2202
            2211-2679           AK091310.1         2159-2627
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..2679
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /note="tripartite motif containing 55"
                     /db_xref="GeneID:84675"
                     /db_xref="HGNC:HGNC:14215"
                     /db_xref="MIM:606469"
     exon            1..308
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1787
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 29; muscle specific ring finger 2;
                     tripartite motif-containing protein 55; muscle-specific
                     RING finger protein 2"
                     /codon_start=1
                     /product="tripartite motif-containing protein 55 isoform
                     1"
                     /protein_id="NP_908973.1"
                     /db_xref="CCDS:CCDS6184.1"
                     /db_xref="GeneID:84675"
                     /db_xref="HGNC:HGNC:14215"
                     /db_xref="MIM:606469"
                     /translation="MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQH
                     NLCRKCASDIFQASNPYLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVE
                     NIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAP
                     LTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYL
                     YGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAV
                     FLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEE
                     EEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALP
                     VSSPEPPPALPPAADAPVTQGEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQT
                     RKATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQ
                     IGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE"
     exon            309..481
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            482..647
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            648..743
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            744..977
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1000
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1125
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1376
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1664
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2679
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /note="hexamer: AATAAA"
     polyA_site      2022
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /note="major polyA site"
     regulatory      2660..2665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
                     /note="hexamer: AATAAA"
     polyA_site      2679
                     /gene="TRIM55"
                     /gene_synonym="MURF-2; muRF2; RNF29"
ORIGIN      
        1 agggcctgaa acaatgtcct ccaccgagag aaacgtaaag gacacttgat cacacaatcc
       61 ctggaataat atccaggaaa cacttgctgg agccactcgc agcacccttc cctggcagca
      121 cacttgggga cagcgaggag atgagcgcat ctctgaatta caaatctttt tccaaagagc
      181 agcagaccat ggataactta gagaagcaac tcatctgtcc catctgctta gagatgttca
      241 cgaaacctgt ggtgattctc ccttgtcagc acaacctgtg taggaaatgt gccagtgata
      301 ttttccaggc ctctaacccg tatttgccca caagaggagg taccaccatg gcatcagggg
      361 gccgattccg ctgcccatcc tgtagacatg aagtggtttt ggatagacat ggggtatatg
      421 gacttcagag gaacctgctg gtggaaaata tcattgacat ctacaagcag gagtccacca
      481 ggccagaaaa gaaatccgac cagcccatgt gcgaggaaca tgaagaggag cgcatcaaca
      541 tctactgtct gaactgcgaa gtacccacct gctctctgtg caaggtgttt ggtgcacaca
      601 aagactgcca ggtggctccc ctcactcatg tgttccagag acagaagtct gagctcagtg
      661 atggcatcgc catcctcgtg ggcagcaacg atcgagtcca gggagtgatc agccagctgg
      721 aagacacctg caaaactatc gaggaatgtt gcagaaaaca gaaacaagag ctttgtgaga
      781 agtttgatta cctgtatggc attttggagg agaggaagaa tgaaatgacc caagtcatta
      841 cccgaaccca agaggagaaa ctggaacatg tccgtgctct gatcaaaaag tattctgatc
      901 atttggagaa cgtctcaaag ttggttgagt caggaattca gtttatggat gagccagaaa
      961 tggcagtgtt tctgcagaat gccaaaaccc tgctaaaaaa aatctcggaa gcatcaaagg
     1021 catttcagat ggagaaaata gaacatggct atgagaacat gaaccacttc acagtcaacc
     1081 tcaatagaga agaaaagata atacgtgaaa ttgactttta cagagaagat gaagatgaag
     1141 aagaagaaga aggcggagaa ggagaaaaag aaggagaagg agaagtggga ggagaagcag
     1201 tagaagtgga agaggtagaa aatgttcaaa cagagtttcc aggagaagat gaaaacccag
     1261 aaaaagcttc agagctctct caggtggagc tgcaggctgc ccctggggca cttccagttt
     1321 cctctccaga gccacctcca gccctgccac ctgctgcgga tgcccctgtg acacaggggg
     1381 aggttgtacc cactggctct gagcagacca cagagtctga aactccagtc cctgcagcag
     1441 cagaaactgc ggatcccttg ttttacccta gttggtataa aggccaaacc cggaaagcca
     1501 ccaccaaccc accttgcacc ccagggagcg aaggtctggg gcaaataggg cctccaggtt
     1561 ctgaggattc gaatgtacgg aaggcagaag tggcagcagc cgcagcgagt gagagggcag
     1621 ctgtgagtgg taaggaaact agtgcacctg cagctacttc tcagattgga tttgaggctc
     1681 ctcccctcca gggacaggct gcagctccag cgagtggcag tggagctgat tctgagccag
     1741 ctcgccatat cttctccttt tcctggttga actccctaaa tgaatgatat tcattccaac
     1801 tgctgcccct ctgtctgcct ggctgagatg catgtgggca gcaggaagcc caagtgaaat
     1861 taatattatg cagatgatga aagggacctc tgaacaggat ttctgcaaaa atagccccaa
     1921 actgcaattc catatgactt atctaacatc ttggggggaa agaatatttt gagaaaatag
     1981 ttgcagaaag cactggaaat aataaacttg atcttataca aatcttctat tgtgtggaaa
     2041 atgttgtgaa gggtgtgtag gtgtggtaca tgtgtatgtc actaacaagt ggcaaatggt
     2101 gaaaaaagtg gtcactatgc ttttgtctct cataggcact gactttttgt tattatatta
     2161 tggtagcttt catttccttt actctttaac agtgcaggtg gtcagtgaaa atcagtgtca
     2221 actcagaagt gactgattta tcaatacatg gacaaaaagt aaatcattga ccaaagctat
     2281 gaaatgtttc acaaagtttt cctcttttgc ataacagatg tcactggatg tacattcaga
     2341 aatgttcttt gaatttggtg acactttcat ggtccagaaa gctgaaggcc tgggcatctc
     2401 ttgtgacatt tttctaatat tagttttaga ttttcacgta ttaggcactt tagttgaatc
     2461 ttccagcaaa agctgtctac tttctctttt attcactgtg gcaccaatct ggtaaattgt
     2521 agaacaattg catgtgttta aatatatata caaacatatc acacattaaa tatatatata
     2581 tttaaatcat gctttgttaa tatttgtccc accataatgc ctccttcaga acataagtgt
     2641 aactttatat gaactcttaa ataaatgatg tttttaaaa
//
