LOCUS       NM_001346048            2856 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 52 (TRIM52), transcript
            variant 2, mRNA.
ACCESSION   NM_001346048 XM_005266000
VERSION     NM_001346048.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Ma,T., Wu,C.B., Shen,Q.X., Wang,Q. and Zhou,Q.
  TITLE     TRIM52 knockdown inhibits proliferation, inflammatory responses and
            oxidative stress in IL-1beta-induced synovial fibroblasts to
            alleviate temporomandibular joint osteoarthritis
  JOURNAL   J Cell Mol Med 28 (8), e18244 (2024)
   PUBMED   38520211
  REMARK    GeneRIF: TRIM52 knockdown inhibits proliferation, inflammatory
            responses and oxidative stress in IL-1beta-induced synovial
            fibroblasts to alleviate temporomandibular joint osteoarthritis.
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Zhao,F., Li,S., Liu,J., Wang,J. and Yang,B.
  TITLE     Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate
            diffuse large B cell lymphoma progression via increasing TRIM52
            expression
  JOURNAL   Hum Cell 35 (4), 1234-1247 (2022)
   PUBMED   35676608
  REMARK    GeneRIF: Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to
            facilitate diffuse large B cell lymphoma progression via increasing
            TRIM52 expression.
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Sun,J., Liu,P., Mao,J., Han,W., Jiang,X. and Gu,Y.
  TITLE     TRIM52 positively mediates NF-kappaB to promote the growth of human
            benign prostatic hyperplasia cells through affecting TRAF2
            ubiquitination
  JOURNAL   Life Sci 259, 118380 (2020)
   PUBMED   32898524
  REMARK    GeneRIF: TRIM52 positively mediates NF-kappaB to promote the growth
            of human benign prostatic hyperplasia cells through affecting TRAF2
            ubiquitination.
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Mu,X., Li,H., Zhou,L. and Xu,W.
  TITLE     TRIM52 regulates the proliferation and invasiveness of lung cancer
            cells via the Wnt/beta-catenin pathway
  JOURNAL   Oncol Rep 41 (6), 3325-3334 (2019)
   PUBMED   31002351
  REMARK    GeneRIF: Based on these data, it was speculated that TRIM52 is
            critical for lung cancer progression and that downregulation of
            TRIM52 could inhibit cell proliferation by blocking cell cycle
            progression.
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Hacker,K., Benke,S., Agerer,B., Scinicariello,S., Budroni,V. and
            Versteeg,G.A.
  TITLE     A repetitive acidic region contributes to the extremely rapid
            degradation of the cell-context essential protein TRIM52
  JOURNAL   Sci Rep 9 (1), 7901 (2019)
   PUBMED   31133683
  REMARK    GeneRIF: A repetitive acidic region contributes to the extremely
            rapid degradation of the cell-context essential protein TRIM52.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Zhang,Y., Wu,S.S., Chen,X.H., Tang,Z.H., Yu,Y.S. and Zang,G.Q.
  TITLE     Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation
            in Hepatitis B Virus-Associated Hepatocellular Carcinoma
  JOURNAL   Med Sci Monit 23, 5202-5210 (2017)
   PUBMED   29089476
  REMARK    GeneRIF: TRIM52 can promote cell proliferation and HBx may regulate
            TRIM52 expression via the NF-kappaB signaling pathway in Hepatitis
            B Virus-Associated Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Fan,W., Liu,T., Li,X., Zhou,Y., Wu,M., Cui,X., Chen,H. and Qian,P.
  TITLE     TRIM52: A nuclear TRIM protein that positively regulates the
            nuclear factor-kappa B signaling pathway
  JOURNAL   Mol Immunol 82, 114-122 (2017)
   PUBMED   28073078
  REMARK    GeneRIF: these data suggested that TRIM52 was a positive regulator
            of the NF-kappaB pathway.
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Fan,W., Wu,M., Qian,S., Zhou,Y., Chen,H., Li,X. and Qian,P.
  TITLE     TRIM52 inhibits Japanese Encephalitis Virus replication by
            degrading the viral NS2A
  JOURNAL   Sci Rep 6, 33698 (2016)
   PUBMED   27667714
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2856)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   10 (bases 1 to 2856)
  AUTHORS   Malfavon-Borja,R., Sawyer,S.L., Wu,L.I., Emerman,M. and Malik,H.S.
  TITLE     An evolutionary screen highlights canonical and noncanonical
            candidate antiviral genes within the primate TRIM gene family
  JOURNAL   Genome Biol Evol 5 (11), 2141-2154 (2013)
   PUBMED   24158625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008443.10 and KF510262.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001346048.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.2286.1,
                                           SRR1803616.115587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688015.1/ ENSP00000508553.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1143              AC008443.10        80541-81683         c
            1144-2210           AC008443.10        76333-77399         c
            2211-2580           KF510262.1         1-370
            2581-2856           AC008443.10        75686-75961         c
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2856
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /note="tripartite motif containing 52"
                     /db_xref="GeneID:84851"
                     /db_xref="HGNC:HGNC:19024"
                     /db_xref="MIM:619265"
     exon            1..1143
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1194
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif-containing protein 52; RING finger
                     protein 102; E3 ubiquitin-protein ligase TRIM52"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM52 isoform 2"
                     /protein_id="NP_001332977.1"
                     /db_xref="CCDS:CCDS93844.1"
                     /db_xref="GeneID:84851"
                     /db_xref="HGNC:HGNC:19024"
                     /db_xref="MIM:619265"
                     /translation="MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCV
                     TQLWSKEDEEDQNEEEDEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDD
                     ELWLGDSGITNWDNVDYMWDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDED
                     EDEELYPDIHPPPSLPLPGQFTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRG
                     NRSNDQGMCFKHQEALKLFCEVDKEAICVVCRESRSHKQHSVLPLEEVVQEYQKIGST
                     SSVELSESVGQ"
     exon            1144..2856
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /note="hexamer: AATAAA"
     polyA_site      2856
                     /gene="TRIM52"
                     /gene_synonym="RNF102"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcctcgg gcagggtagc cagcggctgc atctgaggcg gacgccgcag tgtagggcac
       61 accctgaggg tagcgagaga cgtgacagga ccgagcagct gggggctgca gcctgctctg
      121 tccccaccga tcccagagag aggctgtgag tctggatctg ggcgttcgca ccctgagaga
      181 gggggtcaaa gctcccctgc ggccccgagg aagaagagca aggttgagga cagcctcggg
      241 tcaccagagt agtttggagg caggcctgca ggcgcgtccc cgctcctcag ctccaagctg
      301 acgtatctac acctgccggc gggcattaag atggctggtt atgccactac tcccagcccc
      361 atgcagaccc ttcaggagga agcggtgtgt gccatctgct tggattactt caaggacccc
      421 gtgtccatca gctgtgggca caacttctgc cgagggtgtg tgacccagct gtggagtaag
      481 gaggacgagg aggaccagaa cgaggaggaa gatgaatggg aggaggagga ggacgaggaa
      541 gcggtggggg ccatggatgg atgggacggc tccattcgag aggtgttgta tcgggggaat
      601 gctgacgaag agttgttcca agaccaagat gacgatgaac tctggctcgg tgacagtggt
      661 ataactaatt gggacaacgt agactatatg tgggacgagg aggaagaaga agaagaggaa
      721 gatcaggact attacctagg aggcttgaga cctgacctga gaattgatgt ctaccgagaa
      781 gaagaaatac tggaagcata cgatgaggac gaagatgaag agctgtatcc tgacatccac
      841 ccgcctcctt ccttgcccct tccagggcag ttcacctgcc cccagtgccg aaagagcttt
      901 acacgtcgca gctttcgtcc caacttgcag ctggccaaca tggtccagat aattcgccag
      961 atgtgcccca ctccttatcg gggaaaccgg agtaatgatc agggcatgtg ctttaaacac
     1021 caggaagccc tgaaactctt ctgtgaggtg gacaaagagg ccatctgtgt ggtgtgccga
     1081 gaatccagga gccacaaaca gcacagcgtg ctgcctttgg aggaggtggt gcaggagtac
     1141 cagaagatag ggtcaacttc ttcagttgag ttatctgaaa gtgttgggca gtgacaccat
     1201 gccaaacact gttaaattca tgccattaaa aacagtggag tgttctgcaa agcccgattc
     1261 tctgcagctt taagactgga cagtattgaa atattcacag gaatcttcca agccgtgaaa
     1321 gcttaatatt aaacagccct tttaattgca aaggagaaaa aaatggagac acttgtgaaa
     1381 ccttgcattc tgagtgctgc cacaaataaa ttaaggaatt ccagaatttc ttcatctact
     1441 tctgcagtct taactctgaa ttaatgactg tatatatcaa acttcagatc ttaaaaaaca
     1501 tcagctcgca agaggctgag gcaggagaat gacatgaacc tgggaggcgg agcttgcagt
     1561 aagccgagac tgagccactg cactccagcc tgggcaatag agcaagactc catctcaaaa
     1621 aaaaaaaaaa atcggctcat cttttattgc tgttggttga gatgaatcta ctgatgaaga
     1681 aaactgtact ttgcttacat tcagaataag gctttcaaaa ctgtgggtgt gctgttttcg
     1741 tgagccttct acttgaccac caaagacagt atttttgcag ctgtatcaaa tgaaccgagt
     1801 tggaggaaat tgtataggag tatatcttaa tggcactaca gcaaactgtg ttaaatttgg
     1861 gtttttggca aagattgaag aaaactggta ttcaagatgt actgcagctg tcaccaccaa
     1921 gcatgaactt tcactgatta cccataacct actggaaatc ttcagccttg ctgtcagcat
     1981 agaccactgt gagaaacagt acattccatt ccagtttgcc ctgctttttg aagatctaaa
     2041 tgccattcca tgttttctgt tacatattga agtttcttgg ttgccaaaga aaaacggatt
     2101 ctgctgaact tgtggacaga acaaccccaa ggttggaaga acaatgaaaa ataatctata
     2161 cttgaacatt tcaaaagtta aaattttcaa cagagtttta acacactgaa gcttaaaata
     2221 cattgacact gaaatgtcaa tgggcaaaca ccaatttcgc cgttcattat gaaatacatc
     2281 aaacaaaact tgccaaaaat acaaccataa aaatatagca aatgtatgta tgagcaaact
     2341 aatgctaaaa atgtctaatt ttcttggcta gtctttcaag gaccagattc atgagtgtta
     2401 tttgaaggga aaaagtgaaa tacttggaat tattttgagt gatgtgctcc tgagcttgtt
     2461 cttaaaatct accagtggta gcttttggaa agaatgtgtt tcataccgat gtgcaggcct
     2521 cactggaaga gcttcaagag gagtttgtga aactcaaagt ctaatggttt tgattagaaa
     2581 cttccaggca aatactccag agaaacttgg gtgtaaaatg actaaacaga tgaaaaggct
     2641 ttatccacta ttccatttgc tccttacacc ttaaaaagct tttttatttt ttaatgtttt
     2701 gatatatcta gctttgggga gaaagcagtg caagagtgtt attaaaagca gcttgtgttt
     2761 tcttgcacct ttcacaccac ccaggaaaga aaagttcagg cttaacagtg acatggctat
     2821 cacatcatct gaataaattt tttccttcta aaatta
//
