LOCUS       NM_033034               3364 bp    mRNA    linear   PRI 23-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 5 (TRIM5), transcript
            variant alpha, mRNA.
ACCESSION   NM_033034
VERSION     NM_033034.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Saha,B., Olsvik,H., Williams,G.L., Oh,S., Evjen,G., Sjottem,E. and
            Mandell,M.A.
  TITLE     TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery
  JOURNAL   Cell Rep 43 (6), 114294 (2024)
   PUBMED   38814780
  REMARK    GeneRIF: TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy
            machinery.
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Spada,S.J., Grigg,M.E., Bouamr,F., Best,S.M. and Zhang,P.
  TITLE     TRIM5alpha: A Protean Architect of Viral Recognition and Innate
            Immunity
  JOURNAL   Viruses 16 (7), 997 (2024)
   PUBMED   39066160
  REMARK    GeneRIF: TRIM5alpha: A Protean Architect of Viral Recognition and
            Innate Immunity.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Bratosiewicz-Wasik,J., Miklasinska-Majdanik,M. and Wasik,T.J.
  TITLE     The effect of TRIM5 variants on the susceptibility to HIV-1
            infection and disease progression in the Polish population
  JOURNAL   Ann Hum Genet 88 (2), 154-170 (2024)
   PUBMED   37942942
  REMARK    GeneRIF: The effect of TRIM5 variants on the susceptibility to
            HIV-1 infection and disease progression in the Polish population.
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Zhao,Y., Lu,Y., Richardson,S., Sreekumar,M., Albarnaz,J.D. and
            Smith,G.L.
  TITLE     TRIM5alpha restricts poxviruses and is antagonized by CypA and the
            viral protein C6
  JOURNAL   Nature 620 (7975), 873-880 (2023)
   PUBMED   37558876
  REMARK    GeneRIF: TRIM5alpha restricts poxviruses and is antagonized by CypA
            and the viral protein C6.
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Lagisquet,J., Conrad,M., Wittmann,S., Volkmann,B., Weissinger,H.,
            Sticht,H. and Gramberg,T.
  TITLE     A frequent SNP in TRIM5alpha strongly enhances the innate immune
            response against LINE-1 elements
  JOURNAL   Front Immunol 14, 1168589 (2023)
   PUBMED   37180175
  REMARK    GeneRIF: A frequent SNP in TRIM5alpha strongly enhances the innate
            immune response against LINE-1 elements.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Keckesova,Z., Ylinen,L.M. and Towers,G.J.
  TITLE     The human and African green monkey TRIM5alpha genes encode Ref1 and
            Lv1 retroviral restriction factor activities
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10780-10785 (2004)
   PUBMED   15249687
  REMARK    GeneRIF: Data show that the human and African green monkey (AGM)
            TRIM5alpha genes encode Ref1 and Lv1 antiretroviral activities,
            respectively.
REFERENCE   7  (bases 1 to 3364)
  AUTHORS   Hatziioannou,T., Perez-Caballero,D., Yang,A., Cowan,S. and
            Bieniasz,P.D.
  TITLE     Retrovirus resistance factors Ref1 and Lv1 are species-specific
            variants of TRIM5alpha
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10774-10779 (2004)
   PUBMED   15249685
  REMARK    GeneRIF: Data show that lentivirus susceptibility factor 1 and Ref1
            are species-specific variants of tripartite interaction motif
            5alpha (TRIM5alpha), a cytoplasmic body component that can block
            infection by widely divergent retroviruses.
REFERENCE   8  (bases 1 to 3364)
  AUTHORS   Stremlau,M., Owens,C.M., Perron,M.J., Kiessling,M., Autissier,P.
            and Sodroski,J.
  TITLE     The cytoplasmic body component TRIM5alpha restricts HIV-1 infection
            in Old World monkeys
  JOURNAL   Nature 427 (6977), 848-853 (2004)
   PUBMED   14985764
  REMARK    GeneRIF: HIV-1 infection is restricted more efficiently by rhesus
            monkey TRIM5alpha than by human TRIM5alpha
            GeneRIF: Human TRIM5alpha interacts with HIV-1 p2 capsid protein to
            partially block HIV infection.  Rhesus macaque TRIM5alpha
            AAS48505.1 provides stronger block to HIV-1.
REFERENCE   9  (bases 1 to 3364)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
  REMARK    GeneRIF: TRIM5delta colocalized with BTBD1/2 and appeared to serve
            as a scaffold for the assembly of endogenous BTBD1/2 proteins
REFERENCE   10 (bases 1 to 3364)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA475412.1, AK027593.1,
            CN334837.1 and AC015691.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_033034.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein forms homo-oligomers via the
            coilel-coil region and localizes to cytoplasmic bodies. It appears
            to function as a E3 ubiquitin-ligase and ubiqutinates itself to
            regulate its subcellular localization. It may play a role in
            retroviral restriction. Multiple alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (alpha) encodes the longest
            isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027593.1, SRR18074967.201409.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380034.8/ ENSP00000369373.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA475412.1         36-46
            12-493              AK027593.1         1-482
            494-940             CN334837.1         189-635
            941-2800            AK027593.1         930-2789
            2801-3364           AC015691.6         2191-2754
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3364
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="tripartite motif containing 5"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
     exon            1..207
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            208..685
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1750
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /EC_number="2.3.2.27"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; tripartite motif protein TRIM5; ring finger protein
                     88; RING-type E3 ubiquitin transferase TRIM5; tripartite
                     motif-containing protein 5 alpha"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform
                     alpha"
                     /protein_id="NP_149023.2"
                     /db_xref="CCDS:CCDS31393.1"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
                     /translation="MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHK
                     KSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKL
                     LLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELE
                     ADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSE
                     TEMVQQTQSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVF
                     RAPDLKGMLEVFRELTDVRRYWVDVTVAPNNISCAVISEDKRQVSSPKPQIIYGARGT
                     RYQTFVNFNYCTGILGSQSITSGKHYWEVDVSKKTAWILGVCAGFQPDAMCNIEKNEN
                     YQPKYGYWVIGLEEGVKCSAFQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVS
                     FFNITNHGFLIYKFSHCSFSQPVFPYLNPRKCGVPMTLCSPSS"
     exon            686..781
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1012
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1035
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1136
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1163
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..3364
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2934..2939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="hexamer: AACAAA"
     polyA_site      2953
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="major polyA site"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="major polyA site"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="hexamer: AATAAA"
     polyA_site      3331
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /note="major polyA site"
ORIGIN      
        1 aagaatttcc tgcggttcct ctaggaaaat tcctttgtgc agatcaggcc cgtggattgg
       61 tgagtgaatc ctaaccacgt cttccctggc ctgtcttcac tcttctcccc agaatcacca
      121 cttctgcact ggtgtctgaa ggtgtattga gtgattttgt ggagggcaga agtaggaagt
      181 ctttgggaca aaactgtatt taccttggga tctgtgaaca agaggaacct cagcagccag
      241 gacaggcagg agcagtggaa tagctactat ggcttctgga atcctggtta atgtaaagga
      301 ggaggtgacc tgccccatct gcctggaact cctgacacaa cccctgagcc tggactgcgg
      361 ccacagcttc tgccaagcat gcctcactgc aaaccacaag aagtccatgc tagacaaagg
      421 agagagtagc tgccctgtgt gccggatcag ttaccagcct gagaacatac ggcctaatcg
      481 gcatgtagcc aacatagtgg agaagctcag ggaggtcaag ttgagcccag aggggcagaa
      541 agttgatcat tgtgcacgcc atggagagaa acttctactc ttctgtcagg aggacgggaa
      601 ggtcatttgc tggctttgtg agcggtctca ggagcaccgt ggtcaccaca cgttcctcac
      661 agaggaggtt gcccgggagt accaagtgaa gctccaggca gctctggaga tgctgaggca
      721 gaagcagcag gaagctgaag agttagaagc tgacatcaga gaagagaaag cttcctggaa
      781 gactcaaata cagtatgaca aaaccaacgt cttggcagat tttgagcaac tgagagacat
      841 cctggactgg gaggagagca atgagctgca aaacctggag aaggaggagg aagacattct
      901 gaaaagcctt acgaactctg aaactgagat ggtgcagcag acccagtccc tgagagagct
      961 catctcagat ctggagcatc ggctgcaggg gtcagtgatg gagctgcttc agggtgtgga
     1021 tggcgtcata aaaaggacgg agaacgtgac cttgaagaag ccagaaactt ttccaaaaaa
     1081 tcaaaggaga gtgtttcgag ctcctgatct gaaaggaatg ctagaagtgt ttagagagct
     1141 gacagatgtc cgacgctact gggttgatgt gacagtggct ccaaacaaca tttcatgtgc
     1201 tgtcatttct gaagataaga gacaagtgag ctctccgaaa ccacagataa tatatggggc
     1261 acgagggaca agataccaga catttgtgaa tttcaattat tgtactggca tcctgggctc
     1321 tcaaagtatc acatcaggga aacattactg ggaggtagac gtgtccaaga aaactgcttg
     1381 gatcctgggg gtatgtgctg gcttccaacc tgatgcaatg tgtaatattg aaaaaaatga
     1441 aaattatcaa cctaaatacg gctactgggt tatagggtta gaggaaggag ttaaatgtag
     1501 tgctttccag gatagttcct tccatactcc ttctgttcct ttcattgtgc ccctctctgt
     1561 gattatttgt cctgatcgtg ttggagtttt cctagactat gaggcttgca ctgtctcatt
     1621 cttcaatatc acaaaccatg gatttctcat ctataagttt tctcactgtt ctttttctca
     1681 gcctgtattt ccatatttaa atcctagaaa atgtggagtc cccatgactc tgtgctcacc
     1741 aagctcttga accttcttac acactcagcc ccttctgtac agcacctctt gtccaggtgc
     1801 atctcataca cctgaactca tttgcatcat tttaaccatc ttttccttgc tgtctccctt
     1861 ctttctattt gaacgtcctt cactcatcag taaaatgtaa taattgcctt gtgccatatt
     1921 gtccccaata ttttattgac atttgatagc aatttttttc atcattttcc gtactcctaa
     1981 ggaaaactga cctatacctc ataaaatgag accgctattt aggtattact tctgccagat
     2041 atttatcacc caattgcctc tgacactgac taagaagatg aagaaaagct tttcaacagc
     2101 ctttctatat catcgtgtga taattgttca ccaatgaatg agtccttagc cctgtgtcag
     2161 tttaccctcg atgcccttat ttgtgagtta aagagaaaat atcataaatg gtatactctt
     2221 aagtatagag gttttgtatc tagaggatct cagttcaact cctgtctctc catataccag
     2281 cagtgtaact gtgaataaca tacttaaatg gctgtgctta tttccttttc ttttcttttt
     2341 tctttttttt tttttttgag atgaagtttt gctcttgttc cccaggctgg agtgcaatgg
     2401 cacgatctcg gttcactgca acctccacct ctcagattca agcaattctc ctgcctcagc
     2461 ctcccaagta gctgggatta caggtgccca ccaccacccc tggctaaatt tgtattttca
     2521 gtagagacgg ggtttcccca tgttggttag gctcgtctag aacctctgac ctcaggtgat
     2581 ccacccgcct cggcctccca aagtgctggg attacaggcg tgagccacgg cgcccagcct
     2641 gtgcttattt tcttaaaata atttttgtat taaaaacttc acattaaata agtgctaatg
     2701 ttttattgca tagtagggtg actagagtta acaataacct attgcatata ttttgaaata
     2761 gctagaagag aggattttga aagttctcaa cacaaagaaa tgacacatat ttgaggtgat
     2821 ggatatgcta attaccctgg ttcggttatt acgcaatgta tacatgtatc aaaacatcac
     2881 actgtaccac ataaatatgt atatttatta tttgtcaatt aaaagcaaaa taaaacaaaa
     2941 aaccttcatc taatactttg gatcattgtg aaaaaataaa ttcctgaagt ataaagcatc
     3001 tatctaagtg tcttgatcta ataagtactt gttctacaaa ttattgaaaa acataaactc
     3061 tgttaatgtc tcatggaaca ggttgtgcct tcagggaaac taggattgga tttactaaat
     3121 tctcattttt tagatctcag atactactgt caaaatgact tcaattctgc cttctatata
     3181 taatacacac atatatttag gattttattg taattctagt gttgctacat attagtcttt
     3241 atcaaacaaa ctgaattatg tgggaatcag tttattaatt gtaaaaaata attataataa
     3301 aattagctga tgtagttttt taaaagttaa acgagttttt tgaatagctt cactcatttc
     3361 tagc
//
