LOCUS       NM_020358               2163 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 49 (TRIM49), mRNA.
ACCESSION   NM_020358 XM_941871
VERSION     NM_020358.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Guimaraes,D.S. and Gomes,M.D.
  TITLE     Expression, purification, and characterization of the TRIM49
            protein
  JOURNAL   Protein Expr Purif 143, 57-61 (2018)
   PUBMED   29107100
  REMARK    GeneRIF: Expressed and purified human TRIM49 protein, and
            investigated the role of the SPRY and RING domains of human TRIM49
            protein in E3 ubiquitin ligase activity.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Niu,N., Schaid,D.J., Abo,R.P., Kalari,K., Fridley,B.L., Feng,Q.,
            Jenkins,G., Batzler,A., Brisbin,A.G., Cunningham,J.M., Li,L.,
            Sun,Z., Yang,P. and Wang,L.
  TITLE     Genetic association with overall survival of taxane-treated lung
            cancer patients - a genome-wide association study in human
            lymphoblastoid cell lines followed by a clinical association study
  JOURNAL   BMC Cancer 12, 422 (2012)
   PUBMED   23006423
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Han,K., Lou,D.I. and Sawyer,S.L.
  TITLE     Identification of a genomic reservoir for new TRIM genes in primate
            genomes
  JOURNAL   PLoS Genet 7 (12), e1002388 (2011)
   PUBMED   22144910
REFERENCE   9  (bases 1 to 2163)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   10 (bases 1 to 2163)
  AUTHORS   Yoshikawa,T., Seki,N., Azuma,T., Masuho,Y., Muramatsu,M.,
            Miyajima,N. and Saito,T.
  TITLE     Isolation of a cDNA for a novel human RING finger protein gene,
            RNF18, by the virtual transcribed sequence (VTS) approach(1)
  JOURNAL   Biochim Biophys Acta 1493 (3), 349-355 (2000)
   PUBMED   11018261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP004833.2.
            
            On or before Sep 20, 2006 this sequence version replaced
            XM_941871.2, NM_020358.1.
            
            Summary: The protein encoded by this gene contains a RING zinc
            finger, a motif known to be involved in protein-protein
            interactions. This gene has been found to be preferentially
            expressed in testis. Related pseudogenes and gene duplicates have
            also been identified on chromosome 11. [provided by RefSeq, Aug
            2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329758.5/ ENSP00000327604.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AP004833.2         24574-24712         c
            140-325             AP004833.2         23236-23421         c
            326-740             AP004833.2         20196-20610         c
            741-836             AP004833.2         19835-19930         c
            837-1067            AP004833.2         17839-18069         c
            1068-1090           AP004833.2         17103-17125         c
            1091-1188           AP004833.2         15853-15950         c
            1189-2163           AP004833.2         13792-14766         c
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.3"
     gene            1..2163
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /note="tripartite motif containing 49"
                     /db_xref="GeneID:57093"
                     /db_xref="HGNC:HGNC:13431"
                     /db_xref="MIM:606124"
     exon            1..139
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..325
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..740
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1688
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /note="ring finger protein 18; testis-specific RING Finger
                     protein; testis-specific ring-finger protein"
                     /codon_start=1
                     /product="tripartite motif-containing protein 49"
                     /protein_id="NP_065091.1"
                     /db_xref="CCDS:CCDS8287.1"
                     /db_xref="GeneID:57093"
                     /db_xref="HGNC:HGNC:13431"
                     /db_xref="MIM:606124"
                     /translation="MNSGILQVFQGELICPLCMNYFIDPVTIDCGHSFCRPCFYLNWQ
                     DIPFLVQCSECTKSTEQINLKTNIHLKKMASLARKVSLWLFLSSEEQMCGTHRETKKI
                     FCEVDRSLLCLLCSSSQEHRYHRHRPIEWAAEEHREKLLQKMQSLWEKACENHRNLNV
                     ETTRTRCWKDYVNLRLEAIRAEYQKMPAFHHEEEKHNLEMLKKKGKEIFHRLHLSKAK
                     MAHRMEILRGMYEELNEMCHKPDVELLQAFGDILHRSESVLLHMPQPLNPELSAGPIT
                     GLRDRLNQFRVHITLHHEEANNDIFLYEILRSMCIGCDHQDVPYFTATPRSFLAWGVQ
                     TFTSGKYYWEVHVGDSWNWAFGVCNMYRKEKNQNEKIDGKAGLFLLGCVKNDIQCSLF
                     TTSPLMLQYIPKPTSRVGLFLDCEAKTVSFVDVNQSSLIYTIPNCSFSPPLRPIFCCI
                     HF"
     exon            741..836
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1067
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1090
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1188
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..2163
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaatcttcc agttgccccc tattgacttt aaaccaaagc tttgattcat gaccactggg
       61 atccagccag cgggggattt cttttcctga tggactgtac ccaggatctc acatttgctt
      121 aagcagctcc cacaattggg ttcttataaa aggacacgga agagacaagc tcagttttct
      181 ctgaaggaga aggactgcac ttagaactgc attttggcga cctctgaaat tcagtactgc
      241 agtgaatgag cttctgatct tgaggtgaac ttaacaaaat tatttttgga aaaatcgttg
      301 tgggaaccat taaaagaact ccaggaaaca tgaattctgg aatcttacag gtctttcagg
      361 gggaactcat ctgccccctg tgcatgaact acttcataga cccggtcacc atagactgtg
      421 ggcacagctt ttgcaggcct tgtttctacc tcaactggca agacatccca tttcttgtcc
      481 agtgctctga atgcacaaag tcaaccgagc agataaacct caaaaccaac attcatttga
      541 agaagatggc ttctcttgcc agaaaagtca gtctctggct attcctgagc tctgaggagc
      601 aaatgtgtgg cactcacagg gagacaaaga agatattctg tgaagtggac aggagcctgc
      661 tctgtttgct gtgctccagc tctcaggagc accggtatca cagacaccgt cccattgagt
      721 gggctgctga ggaacaccgg gagaagcttt tacagaaaat gcagtctttg tgggaaaaag
      781 cttgtgaaaa tcacagaaac ctgaatgtgg aaaccaccag aaccagatgc tggaaggatt
      841 atgtgaattt aaggctagaa gcaattagag ctgagtatca gaagatgcct gcatttcatc
      901 atgaagaaga aaaacataat ttggagatgc tgaaaaagaa ggggaaagaa atttttcatc
      961 gacttcattt aagtaaagcc aaaatggctc ataggatgga gattttaaga ggaatgtatg
     1021 aggagctgaa cgaaatgtgc cataaaccag atgtggagct acttcaggct tttggagaca
     1081 tattacacag gagtgagtcc gtgctgctgc acatgcccca gcctctgaat ccagagctca
     1141 gtgcagggcc catcactgga ctgagggaca ggctcaacca attccgagtg catattactc
     1201 tgcatcatga agaagccaac aatgatatct ttctgtatga aattttgaga agcatgtgta
     1261 ttggatgtga ccatcaagat gtaccctatt tcactgcaac acctagaagt tttcttgcat
     1321 ggggtgttca gactttcacc tcgggcaaat attactggga ggtccatgta ggggactcct
     1381 ggaattgggc ttttggtgtc tgtaatatgt atcggaaaga gaagaatcag aatgagaaga
     1441 tagatggaaa ggcgggactc tttcttcttg ggtgtgttaa gaatgacatt caatgcagtc
     1501 tctttaccac ctccccactt atgctgcaat atatcccaaa acctaccagc cgagtaggat
     1561 tattcctgga ttgtgaggct aagactgtga gctttgttga tgttaatcaa agctccctaa
     1621 tatacaccat ccctaattgc tctttctcac ctcctctcag gcctatcttt tgctgtattc
     1681 acttctgacc agagacaaat cagaaatgtg ttcacatgct gtgggaaccc ctttatccca
     1741 ggaagtcctc ttccttgtgc cttaacatac aggacaaata ggctctattt tatgtcttga
     1801 attgccttct aatgttatca aaactcattt attgtgttac tattaaatat gctgaaaacg
     1861 ctaaaagtat acgtattggt tctttattaa ataatttttg aaaaatcatt attcatgatc
     1921 atggcataca gtatattctc ttttttttct ttatttatga ctgtcactga gtgaaataat
     1981 agatgacaga catgtctgaa tgaagtaaaa atcaatggaa gacagtcggg atcttttgct
     2041 tcatgcaaaa aacttggagt gaagtctcaa tgataactgg gaaatgtttt tcttcctctt
     2101 tatctaacta tattacactt atccatcagg tttcattgta ttaatctatc ctttgaggta
     2161 ata
//
