LOCUS       NM_024114               1467 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens tripartite motif containing 48 (TRIM48), mRNA.
ACCESSION   NM_024114
VERSION     NM_024114.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T,
            Naguro I, Kano K, Udagawa T, Natsume T, Aoki J, Inada T, Noguchi T,
            Ichijo H and Matsuzawa A.
  TITLE     TRIM48 Promotes ASK1 Activation and Cell Death through
            Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator
            PRMT1
  JOURNAL   Cell Rep 21 (9), 2447-2457 (2017)
   PUBMED   29186683
  REMARK    GeneRIF: TRIM48 Promotes ASK1 Activation and Cell Death through
            Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator
            PRMT1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005597.2 and BC001862.2.
            
            On May 17, 2019 this sequence version replaced NM_024114.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001862.2, AF521869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145893,
                                           SAMEA2147596 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417545.5/ ENSP00000402414.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AP005597.2         104913-104939
            28-580              BC001862.2         1-553
            581-581             AP005597.2         108366-108366
            582-1251            BC001862.2         555-1224
            1252-1252           AP005597.2         113657-113657
            1253-1467           BC001862.2         1226-1440
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1467
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /note="tripartite motif containing 48"
                     /db_xref="GeneID:79097"
                     /db_xref="HGNC:HGNC:19021"
     exon            1..157
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..788
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 48; RING finger
                     protein 101"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM48"
                     /protein_id="NP_077019.2"
                     /db_xref="CCDS:CCDS7947.2"
                     /db_xref="GeneID:79097"
                     /db_xref="HGNC:HGNC:19021"
                     /translation="MSRRIIVGTLQRTQRNMNSGISQVFQRELTCPICMNYFIDPVTI
                     DCGHSFCRPCFYLNWQDIPILTQCFECIKTIQQRNLKTNIRLKKMASLARKASLWLFL
                     SSEEQMCGIHRETKKMFCEVDRSLLCLLCSSSQEHRYHRHCPAEWAAEEHWEKLLKKM
                     QSLWEKACENQRNLNVETTRISHWKAFGDILYRSESVLLHMPQPLNLALRAGPITGLR
                     DRLNQF"
     exon            158..572
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     exon            573..668
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     exon            669..691
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     exon            692..789
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1467
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /note="hexamer: ATTAAA"
     polyA_site      1467
                     /gene="TRIM48"
                     /gene_synonym="RNF101"
                     /note="major polyA site"
ORIGIN      
        1 agttttctcc aaaggagaag gagtgcactt agagggagct gtgttttggt gacctctgaa
       61 actcagtact gcagcgaatg agctcctgac cttgaggagt acttaacaga attatgtctc
      121 gaagaatcat tgtgggaacc cttcaaagaa cccagcgaaa catgaattct ggaatctcgc
      181 aagtcttcca gagggaactc acctgcccca tctgcatgaa ctacttcata gacccggtca
      241 ccatagactg tgggcacagc ttttgcaggc cctgtttcta cctcaactgg caagacatcc
      301 caattcttac tcagtgcttt gaatgcataa agacaataca gcagagaaac ctcaaaacta
      361 acattcgatt gaagaagatg gcttcccttg ccagaaaagc cagtctctgg ctattcctga
      421 gctctgagga gcaaatgtgt ggcattcaca gggagacaaa gaagatgttc tgtgaagtgg
      481 acaggagcct gctctgtttg ctgtgctcca gctctcagga gcaccggtat cacagacact
      541 gtcccgctga gtgggctgct gaggaacact gggagaagct tttaaagaaa atgcagtctt
      601 tatgggaaaa agcttgtgaa aatcagagaa acctgaatgt ggaaaccacc agaatcagcc
      661 actggaaggc ttttggagac atattataca ggagtgagtc cgtgctgctg cacatgcccc
      721 agcctctgaa tctagcgctc agggcagggc ccatcactgg actgagggac aggctcaacc
      781 aattctgagt ggatattact ctgcatcaca atgaagccaa cagtcatatc ttccgatgtg
      841 gagatttgag aagcatttgt attggatgtg accgtcaaaa tccgccccat atcactgcaa
      901 cacctacaag ttttcttgca tggggtgctc agactttcac ctctggcaaa tattactggg
      961 aggtccatgt gggggactct tggaattggg cttttggtgt ctgtaataag tattggaaag
     1021 ggaagaatca gaatggcaat atatatggag aggagggact ctttagtctt gggtgtgtta
     1081 agaacgacat tcagtgcagt ctctttacca cctccccaat tacactgcag tatgtcccaa
     1141 gacctaccaa ccatgtagaa ttattcctgg attgtgaagc tagaactgtg agcttcgttg
     1201 atgttagtca aagctcccct atatacacca tccctaattg ctccttctca cttcctctca
     1261 gacctatctt tttctgtatt ctcctctgac cagagacaaa tcagaaatgt gttcatctgc
     1321 tgtgggaacc cctttatccc agaaagccct cttccttgtg ccttatcaaa caggacaaat
     1381 aggttcggtt ttatgtcttg aattgcattc taatgttatt aaaactcatt tattgtgtta
     1441 ctattaaatg tagtaaaaac actaaaa
//
