LOCUS       NM_033452               2269 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 47 (TRIM47), mRNA.
ACCESSION   NM_033452
VERSION     NM_033452.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Yeung,S.H., Lee,R.H., Cheng,G.W., Ma,I.W., Kofler,J., Kent,C.,
            Ma,F., Herrup,K., Fornage,M., Arai,K. and Tse,K.H.
  TITLE     White matter hyperintensity genetic risk factor TRIM47 regulates
            autophagy in brain endothelial cells
  JOURNAL   FASEB J 38 (19), e70059 (2024)
   PUBMED   39331575
  REMARK    GeneRIF: White matter hyperintensity genetic risk factor TRIM47
            regulates autophagy in brain endothelial cells.
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Zhang,J., Yimamu,M., Cheng,Z., Ji,J., Wu,L., Feng,J., Xu,X., Wu,J.
            and Guo,C.
  TITLE     TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by
            modulating ferroptotic cell death through the ubiquitin-proteasome
            system
  JOURNAL   Free Radic Biol Med 219, 31-48 (2024)
   PUBMED   38614226
  REMARK    GeneRIF: TRIM47-CDO1 axis dictates hepatocellular carcinoma
            progression by modulating ferroptotic cell death through the
            ubiquitin-proteasome system.
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Wang,X., Fu,Y. and Xing,Y.
  TITLE     TRIM47 promotes ovarian cancer cell proliferation, migration, and
            invasion by activating STAT3 signaling
  JOURNAL   Clinics (Sao Paulo) 77, 100122 (2022)
   PUBMED   36288633
  REMARK    GeneRIF: TRIM47 promotes ovarian cancer cell proliferation,
            migration, and invasion by activating STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Wang,Z., Li,Z., Han,C., Cheng,Y. and Wang,K.
  TITLE     TRIM47 promotes glioma angiogenesis by suppressing Smad4
  JOURNAL   In Vitro Cell Dev Biol Anim 58 (9), 771-779 (2022)
   PUBMED   36203070
  REMARK    GeneRIF: TRIM47 promotes glioma angiogenesis by suppressing Smad4.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Azuma,K., Ikeda,K., Suzuki,T., Aogi,K., Horie-Inoue,K. and Inoue,S.
  TITLE     TRIM47 activates NF-kappaB signaling via PKC-epsilon/PKD3
            stabilization and contributes to endocrine therapy resistance in
            breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34433666
  REMARK    GeneRIF: TRIM47 activates NF-kappaB signaling via PKC-epsilon/PKD3
            stabilization and contributes to endocrine therapy resistance in
            breast cancer.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Huang,W.Q., Ye,H.M., Li,F.F., Yi,K.H., Zhang,Y., Cai,L.L.,
            Lin,H.N., Lin,Q. and Tzeng,C.M.
  TITLE     Analysis of genetic polymorphisms associated with leukoaraiosis in
            the southern Chinese population: A case-control study
  JOURNAL   Medicine (Baltimore) 95 (35), e3857 (2016)
   PUBMED   27583843
  REMARK    GeneRIF: These results suggest that rs1055129 in TRIM47 is not
            associated with leukoaraiosis (LA) risk in the Chinese population.
            However, the association of rs1055129 (TRIM47) with LA before
            Bonferroni correction and Sidak correction is worth highlighting.
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Fujimura,T., Inoue,S., Urano,T., Takayama,K., Yamada,Y., Ikeda,K.,
            Obinata,D., Ashikari,D., Takahashi,S. and Homma,Y.
  TITLE     Increased Expression of Tripartite Motif (TRIM) 47 Is a Negative
            Prognostic Predictor in Human Prostate Cancer
  JOURNAL   Clin Genitourin Cancer 14 (4), 298-303 (2016)
   PUBMED   26873435
  REMARK    GeneRIF: Study shows that protein and gene expression level of
            TRIM47 are up-regulated in prostate neoplasm.
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Fornage,M., Debette,S., Bis,J.C., Schmidt,H., Ikram,M.A.,
            Dufouil,C., Sigurdsson,S., Lumley,T., DeStefano,A.L., Fazekas,F.,
            Vrooman,H.A., Shibata,D.K., Maillard,P., Zijdenbos,A., Smith,A.V.,
            Gudnason,H., de Boer,R., Cushman,M., Mazoyer,B., Heiss,G.,
            Vernooij,M.W., Enzinger,C., Glazer,N.L., Beiser,A., Knopman,D.S.,
            Cavalieri,M., Niessen,W.J., Harris,T.B., Petrovic,K., Lopez,O.L.,
            Au,R., Lambert,J.C., Hofman,A., Gottesman,R.F., Garcia,M.,
            Heckbert,S.R., Atwood,L.D., Catellier,D.J., Uitterlinden,A.G.,
            Yang,Q., Smith,N.L., Aspelund,T., Romero,J.R., Rice,K.,
            Taylor,K.D., Nalls,M.A., Rotter,J.I., Sharrett,R., van Duijn,C.M.,
            Amouyel,P., Wolf,P.A., Gudnason,V., van der Lugt,A., Boerwinkle,E.,
            Psaty,B.M., Seshadri,S., Tzourio,C., Breteler,M.M., Mosley,T.H.,
            Schmidt,R., Longstreth,W.T., DeCarli,C. and Launer,L.J.
  TITLE     Genome-wide association studies of cerebral white matter lesion
            burden: the CHARGE consortium
  JOURNAL   Ann Neurol 69 (6), 928-939 (2011)
   PUBMED   21681796
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Vandeputte,D.A., Meije,C.B., van Dartel,M., Leenstra,S.,
            IJlst-Keizers,H., Das,P.K., Troost,D., Bosch,D.A., Baas,F. and
            Hulsebos,T.J.
  TITLE     GOA, a novel gene encoding a ring finger B-box coiled-coil protein,
            is overexpressed in astrocytoma
  JOURNAL   Biochem Biophys Res Commun 286 (3), 574-579 (2001)
   PUBMED   11511098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087289.9, AY026763.1 and BG385464.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033452.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY026763.1, SRR3476690.997518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254816.6/ ENSP00000254816.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC087289.9         74806-74811
            7-594               AY026763.1         2-589
            595-1078            BG385464.1         154-637
            1079-2269           AY026763.1         1074-2264
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2269
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /note="tripartite motif containing 47"
                     /db_xref="GeneID:91107"
                     /db_xref="HGNC:HGNC:19020"
                     /db_xref="MIM:611041"
     exon            1..708
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1950
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 47; RING finger
                     protein 100; gene overexpressed in astrocytoma protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM47"
                     /protein_id="NP_258411.2"
                     /db_xref="CCDS:CCDS32737.1"
                     /db_xref="GeneID:91107"
                     /db_xref="HGNC:HGNC:19020"
                     /db_xref="MIM:611041"
                     /translation="MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASG
                     AGGPGGAARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSGPGSGPGPAPALAPEPSAP
                     SALPSVPEPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHE
                     RSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQEHRGHELVPLE
                     QERALQEAEQSKVLSAVEDRMDELGAGIAQSRRTVALIKSAAVAERERVSRLFADAAA
                     ALQGFQTQVLGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVPEADSVSFLQ
                     ELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVACVNQWEQLRGPGGNED
                     GPQKLDSEADAEPQDLESTNLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVK
                     RVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSMGVMAEDFSPQEPY
                     DRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLEYADRALAFYAVRD
                     GKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAFFLESVDAHLQI
                     GPLKKSCISVLKRR"
     exon            709..804
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1035
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1234
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1309
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..2269
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2249..2254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="TRIM47"
                     /gene_synonym="GOA; RNF100"
                     /note="major polyA site"
ORIGIN      
        1 acaatcggcg gcgccctggg cggccgcgga gtcatggacg gcagtggacc cttcagctgc
       61 cccatctgcc tagagccact ccgggagccg gtgacgctgc cctgcggcca caacttctgt
      121 ctcgcctgcc tgggcgcgct ctggccgcat cgtggcgcga gtggagccgg cggacccgga
      181 ggcgcggccc gctgcccgct gtgccaggag cccttccccg acggccttca gctccgcaag
      241 aaccacacgc tgtccgagct gctgcagctc cgccagggct cgggccccgg gtccggcccc
      301 ggcccggccc ctgccctggc cccggagccc tcggcaccca gcgcgctgcc cagtgtcccg
      361 gagccgtcgg ccccctgcgc tcccgagccg tggcccgcgg gcgaagagcc agtgcgctgc
      421 gacgcgtgcc ccgagggcgc ggccctgccc gccgcgctgt cctgcctctc ctgcctcgcc
      481 tccttttgcc ccgcgcacct gggcccgcac gagcgcagcc ccgccctccg cggacaccgc
      541 ctggtgccgc cgctgcgccg gctagaggag agcctgtgcc cgcgccacct acggccgctc
      601 gagcgctact gccgcgcgga gcgcgtgtgt ctgtgcgagg cctgcgccgc acaggagcac
      661 cgcggccacg agctggtgcc gctggagcag gagcgcgcgc ttcaggaggc tgagcagtcc
      721 aaagtcctga gcgccgtgga ggaccgcatg gacgagctgg gtgctggcat tgcacagtcc
      781 aggcgcacag tggccctcat caagagtgca gccgtagcag agcgggagag ggtgagccgg
      841 ctgtttgcag atgctgcggc cgccctgcag ggcttccaga cccaggtgct gggcttcatc
      901 gaggaggggg aagctgccat gctaggccgc tcccagggtg acctgcggcg acaggaggaa
      961 cagcgcagcc gcctgagccg agcccgccag aatctcagcc aggtccctga agctgactca
     1021 gtcagcttcc tgcaggagct gctggcacta aggctggccc tggaggatgg gtgtggccct
     1081 gggcctggac ccccgaggga gctcagcttc accaaatcat cccaagctgt ccgtgcagtg
     1141 agagacatgc tggccgtggc ctgcgtcaac cagtgggagc agctgagggg gccgggtggc
     1201 aacgaggatg ggccacagaa gctggactcg gaagctgatg ctgagcccca agacctcgag
     1261 agtacgaacc tcttggagag tgaagctccc agggactatt tcctcaagtt tgcctatatt
     1321 gtggatttgg acagcgacac agcagacaag ttcctgcagc tgtttggaac caaaggtgtc
     1381 aagagggtgc tgtgtcctat caactacccc ttgtcgccca cccgcttcac ccattgtgag
     1441 caggtgctgg gcgagggtgc cctggaccga ggcacctact actgggaggt ggagattatc
     1501 gagggctggg tcagcatggg ggtcatggcc gaagacttct ccccacaaga gccctacgac
     1561 cgcggccggc tgggccgcaa cgcccactcc tgctgcctgc agtggaatgg acgcagcttc
     1621 tccgtctggt ttcatgggct ggaggctccc ctgccccacc ccttctcgcc cacggttggg
     1681 gtctgcctgg aatacgctga ccgtgccttg gccttctatg ctgtacggga cggcaagatg
     1741 agcctcctgc ggaggctgaa ggcctcccgg ccccgccggg gtggcatccc ggcctccccc
     1801 attgacccct tccagagccg cctggacagt cactttgcgg ggctcttcac ccacagactc
     1861 aagcctgcct tcttcctgga gagtgtggac gcccacttgc agatcgggcc cctcaagaag
     1921 tcctgcatat ccgtgctgaa gaggaggtga tgccgggcac gggcgctcct gctgccgtct
     1981 ctgctccagg aagctgcctc ctctgggccc tctccttcgt ctgggaaggc accagcatga
     2041 gtcccacaca cccagccttc tcatttctag aggcttccac ctttttatac actcagcctt
     2101 ccctctccca ggcaggagga cccccagacc ctgttcccct gcagacctca cttctgggag
     2161 acagagctac agctgggaca gctccaagct accctaaccc ctcctttccc aggtttctag
     2221 aatagtgtct ggcatgtagt agatgctcaa taaacacttg ttgaatgaa
//
