LOCUS       NM_025188               3536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 45 (TRIM45), transcript
            variant 1, mRNA.
ACCESSION   NM_025188
VERSION     NM_025188.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Li,X., He,W., Chen,X., Zhang,Y., Zhang,J., Liu,F., Li,J., Zhao,D.,
            Xia,P., Ma,W., Wu,T., Wang,H. and Yuan,Y.
  TITLE     TRIM45 facilitates NASH-progressed HCC by promoting fatty acid
            synthesis via catalyzing FABP5 ubiquitylation
  JOURNAL   Oncogene 43 (27), 2063-2077 (2024)
   PUBMED   38755308
  REMARK    GeneRIF: TRIM45 facilitates NASH-progressed HCC by promoting fatty
            acid synthesis via catalyzing FABP5 ubiquitylation.
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Huang,X., Ye,C., Zhao,X., Tong,Y., Lin,W., Huang,Q., Zheng,Y.,
            Wang,J., Zhang,A. and Mo,Y.
  TITLE     TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in
            septic encephalopathy
  JOURNAL   J Neuroinflammation 20 (1), 284 (2023)
   PUBMED   38037161
  REMARK    GeneRIF: TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis
            in septic encephalopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Zhang,J., Cao,L., Gao,A., Ren,R., Yu,L., Li,Q., Liu,Y., Qi,W.,
            Hou,Y., Sui,W., Su,G., Zhang,Y., Zhang,C. and Zhang,M.
  TITLE     E3 ligase RNF99 negatively regulates TLR-mediated inflammatory
            immune response via K48-linked ubiquitination of TAB2
  JOURNAL   Cell Death Differ 30 (4), 966-978 (2023)
   PUBMED   36681779
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Zhang,J., Zhang,C., Cui,J., Ou,J., Han,J., Qin,Y., Zhi,F. and
            Wang,R.F.
  TITLE     TRIM45 functions as a tumor suppressor in the brain via its E3
            ligase activity by stabilizing p53 through K63-linked
            ubiquitination
  JOURNAL   Cell Death Dis 8 (5), e2831 (2017)
   PUBMED   28542145
  REMARK    GeneRIF: These findings suggest that TRIM45 is a novel tumor
            suppressor that stabilizes and activates p53 in glioma.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Sato,T., Takahashi,H., Hatakeyama,S., Iguchi,A. and Ariga,T.
  TITLE     The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and
            negatively regulates PKC-mediated signaling pathway
  JOURNAL   Oncogene 34 (10), 1280-1291 (2015)
   PUBMED   24681954
  REMARK    GeneRIF: The TRIM-FLMN protein TRIM45 directly interacts with RACK1
            and negatively regulates PKC-mediated signaling pathway.
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Shibata,M., Sato,T., Nukiwa,R., Ariga,T. and Hatakeyama,S.
  TITLE     TRIM45 negatively regulates NF-kappaB-mediated transcription and
            suppresses cell proliferation
  JOURNAL   Biochem Biophys Res Commun 423 (1), 104-109 (2012)
   PUBMED   22634006
  REMARK    GeneRIF: These findings suggest that TRIM45 acts as a repressor for
            the NF-kappaB signal and regulates cell growth.
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Sardiello,M., Cairo,S., Fontanella,B., Ballabio,A. and Meroni,G.
  TITLE     Genomic analysis of the TRIM family reveals two groups of genes
            with distinct evolutionary properties
  JOURNAL   BMC Evol Biol 8, 225 (2008)
   PUBMED   18673550
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Wang,Y., Li,Y., Qi,X., Yuan,W., Ai,J., Zhu,C., Cao,L., Yang,H.,
            Liu,F., Wu,X. and Liu,M.
  TITLE     TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional
            activities of ElK-1 and AP-1
  JOURNAL   Biochem Biophys Res Commun 323 (1), 9-16 (2004)
   PUBMED   15351693
  REMARK    GeneRIF: TRIM45 may act as a new transcriptional repressor in
            mitogen-activated protein kinase signaling pathway
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY669488.1, AK222901.1,
            BU165629.1 and EC541819.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025188.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY669488.1, SRR1803614.242051.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256649.9/ ENSP00000256649.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AY669488.1         41-365
            326-326             AK222901.1         310-310
            327-2034            AY669488.1         367-2074
            2035-2035           BU165629.1         811-811
            2036-3531           AY669488.1         2076-3571
            3532-3536           EC541819.1         8-12                c
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..3536
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /note="tripartite motif containing 45"
                     /db_xref="GeneID:80263"
                     /db_xref="HGNC:HGNC:19018"
                     /db_xref="MIM:609318"
     exon            1..1036
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..2291
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 99; E3 ubiquitin-protein ligase TRIM45"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM45 isoform 1"
                     /protein_id="NP_079464.2"
                     /db_xref="CCDS:CCDS893.1"
                     /db_xref="GeneID:80263"
                     /db_xref="HGNC:HGNC:19018"
                     /db_xref="MIM:609318"
                     /translation="MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPC
                     LHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVD
                     LPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQ
                     AHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGE
                     HREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAAD
                     VRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHL
                     LTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTI
                     NTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKD
                     SPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVF
                     HCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTG
                     GQSAPRSLLRTVAL"
     exon            1037..1770
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1900
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2015
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2142
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..3536
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /note="hexamer: ATTAAA"
     polyA_site      2411
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
     regulatory      3510..3515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="TRIM45"
                     /gene_synonym="RNF99"
                     /note="major polyA site"
ORIGIN      
        1 gccagagccc gcgggcgtcc cgggccgagg cgcgggagag gcggtggaca ccgagaagcc
       61 cgccggcggc ttgcaattcc ctcacccggc gcgcgccttt cgcagaggga aggagcaaga
      121 gggcccctac ctcatcgtgc gcgggtgggg tcggcgcttg tcgcgtgtgg cgcgcagtgg
      181 ggcgggcggc gggagggggg tggcagtgga gggagcgaga ggtgcagggg tgactttgtt
      241 ggcagcagga ctagctggag agctagacct ggaagcgcat ccggggagga cttgcggggc
      301 agaggagggc gtgggcgtgt ctggtgtggg atgcagtgga aaggaggggg ccctcctgag
      361 tagatctgtg ggtgattcct tcgaggacgc ctcgtcttcc cgtctgccct tttatttgtc
      421 agcgagggag tccccatggt ctctgttcaa gttctggaga ctttctcttt gggtgggctt
      481 aatcacctgc tactaaatcg tagaactgcc cagggccctt tctaatattg gtcacaaacg
      541 tgaggagtat gtcagaaaac agaaaaccgc tgctgggctt tgtaagcaaa ctcactagtg
      601 ggactgcact tgggaactca ggcaagactc actgccccct gtgcttgggg cttttcaaag
      661 cccccaggct cttgccttgt ttgcatacag tttgcaccac gtgtctggag cagctggagc
      721 ccttctcagt agtggacatc cgagggggag actctgacac aagctctgag gggtcaatat
      781 tccaggaact caagccacga agtctgcagt cgcagatcgg catcctttgt cctgtatgtg
      841 atgctcaggt ggacctgccc atgggtggag tgaaggcttt aaccatagac cacctggccg
      901 tgaatgatgt gatgctggag agcctacgtg gggaaggcca gggcctggtg tgtgacctgt
      961 gcaacgacag ggaagtagag aagaggtgtc agacctgcaa agccaacctc tgccacttct
     1021 gctgccaggc tcataggcgg cagaagaaaa cgacttacca caccatggtg gacctaaaag
     1081 acttgaaagg ctacagccgg attgggaagc ccatcctgtg tcctgttcac cctgcagagg
     1141 aactgaggct gttctgtgag ttctgtgacc ggcccgtgtg ccaggattgt gtggtggggg
     1201 agcatcggga acacccctgt gacttcacca gcaatgtcat ccacaagcat ggggactctg
     1261 tgtgggagct cctcaaaggt actcagcccc acgtggaggc cctggaggaa gccctggctc
     1321 agatccacat aataaacagt gccctccaga agcgagtgga ggcagtggca gctgatgtcc
     1381 ggacattctc ggagggctac attaaggcca ttgaggagca tcgggacaag ctgctgaagc
     1441 agctggaaga catacgggcc cagaaggaaa attccctgca gctgcagaag gcccagctgg
     1501 aacagttact ggcagacatg cggactggag tggagttcac cgagcacttg ctgaccagcg
     1561 gctcagactt ggagatcctc atcaccaaga gggtggtggt agaacggctc aggaagctga
     1621 acaaagttca atatagcacc cgtcctggag taaatgataa gatacgcttc tgtcctcagg
     1681 agaaagcagg ccagtgccgt ggctatgaaa tttatggtac gattaatacc aaagaggttg
     1741 atccagccaa atgtgtccta caaggagaag acctccacag agcccgggag aaacagacgg
     1801 cctctttcac cctgctttgt aaggatgccg caggagaaat catgggcagg ggaggagaca
     1861 acgttcaagt tgccgttgtc cctaaagata agaaagacag cccagtcaga acaatggtcc
     1921 aggataacaa ggatgggaca tactacattt cctacacccc caaggaacct ggcgtctata
     1981 ctgtgtgggt ctgcatcaaa gaacagcatg tgcagggctc gccattcact gtgatggtga
     2041 ggagaaagca ccgcccacac tcaggcgtgt ttcactgctg caccttctgc tccagcgggg
     2101 gccagaaaac cgctcgctgc gcctgtggag gcaccatgcc aggtgggtac ctaggctgtg
     2161 gccatggaca caaaggccac ccaggtcatc cccactggtc atgctgtgga aaatttaatg
     2221 agaaatctga atgcacatgg acaggtgggc agagcgcacc gaggagtcta cttaggactg
     2281 tggctctctg atgggtttgt gctcagcctt ttaaagctgc aggcagcacc acttgagatt
     2341 tccagaggac ccagaccttc gttcattcta aagagactga tagaattaaa aacaaagtgc
     2401 cttatcttgc actggagttc aagtgctctt ttgttagtta ttcactgatt gtacttgtgg
     2461 atggttgagc acaaaaaacc acctctacat ttctcttaaa ggtaggttgg caacgttctt
     2521 tttctaccac aggatactcc ttttcatttt gtacagtatg gaggtatcta ttccattggc
     2581 actgaagggt ctaggtagtt tagttccttt ctgatataac cctttttttt tctttttttt
     2641 ttttttttaa agacagagtc tcactctgtc acccaggctg gagtgcagtg gcatgatctc
     2701 ggctcactgc aacctctgcc tcccggttca aatgattctc gtgccttggt gtcccgagta
     2761 gctgggatta caggttcccc cccaccttcc cccacaccca gctaattttt gtgtttttag
     2821 tagagacggg gtttcaccat gttggccagg ctggtctcaa actcctgacc tcgtgatcca
     2881 cctgcctcgg cctcccaaag tgctggggtt acaagcatga gccaccacac ctggcctatt
     2941 atgacctttt tcatttttct ctgagctaca cattatttag atatttcccc tagagattag
     3001 aaacctcctt tcatcctgtc cactttttgt tagcatactt tcattggatt tactggtaca
     3061 tgttttgtga tcatgataat gtgatcttgt tttggtggtg tccccctact ccgtctctat
     3121 gccatgacag ccttctgccc caaagcctgg aagattactc tttggtcaag ggcatacaaa
     3181 tagaaagtta ataaagggga atggtgttga aatagaacct catacattta ttacagttct
     3241 acttatacag aaaatctaga caccttcatc cttctcacag ctctgttttt tagtagagta
     3301 gtctttagag tagtcttcac tgttatctat atacctagaa agttaactgg gagctttgac
     3361 tcttactgtg ccttcactca tagtgtgcct tcttagctgc tggagaattt ggggagagga
     3421 tgtacacagc actggtgcct cagccctgcc aaggtcttca ctgtatatat tttgtgtgtt
     3481 cttctgaaac tcttgatttc ttatatggca ataaactcag catgtattaa atataa
//
