LOCUS       NM_017583              12994 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 44 (TRIM44), mRNA.
ACCESSION   NM_017583
VERSION     NM_017583.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12994)
  AUTHORS   Wang,Y., Lyu,L., Vu,T. and McCarty,N.
  TITLE     TRIM44 enhances autophagy via SQSTM1 oligomerization in response to
            oxidative stress
  JOURNAL   Sci Rep 14 (1), 18974 (2024)
   PUBMED   39152142
  REMARK    GeneRIF: TRIM44 enhances autophagy via SQSTM1 oligomerization in
            response to oxidative stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12994)
  AUTHORS   Yu,Y., Li,S., Sun,J., Wang,Y., Xie,L., Guo,Y., Li,J. and Han,F.
  TITLE     Overexpression of TRIM44 mediates the NF-kappaB pathway to promote
            the progression of ovarian cancer
  JOURNAL   Genes Genomics 46 (6), 689-699 (2024)
   PUBMED   38691326
  REMARK    GeneRIF: Overexpression of TRIM44 mediates the NF-kappaB pathway to
            promote the progression of ovarian cancer.
REFERENCE   3  (bases 1 to 12994)
  AUTHORS   Zhou,S., Wu,C., Tang,Q., Zhou,X., He,B., Chang,P. and He,X.
  TITLE     Silencing LINC00491 inhibits prostate cancer development through
            the miR-384/TRIM44 axis
  JOURNAL   J Biochem Mol Toxicol 37 (7), e23370 (2023)
   PUBMED   37070216
  REMARK    GeneRIF: Silencing LINC00491 inhibits prostate cancer development
            through the miR-384/TRIM44 axis.
REFERENCE   4  (bases 1 to 12994)
  AUTHORS   Zhang,X., Wu,X., Sun,Y., Chu,Y., Liu,F. and Chen,C.
  TITLE     TRIM44 regulates tumor immunity in gastric cancer through
            LOXL2-dependent extracellular matrix remodeling
  JOURNAL   Cell Oncol (Dordr) 46 (2), 423-435 (2023)
   PUBMED   36512309
  REMARK    GeneRIF: TRIM44 regulates tumor immunity in gastric cancer through
            LOXL2-dependent extracellular matrix remodeling.
REFERENCE   5  (bases 1 to 12994)
  AUTHORS   Goshayeshi,L., Afshar,J. and Mehrad-Majd,H.
  TITLE     Clinical Significance of TRIM44 Expression in Patients with Gastric
            Cancer
  JOURNAL   Asian Pac J Cancer Prev 23 (5), 1725-1731 (2022)
   PUBMED   35633558
  REMARK    GeneRIF: Clinical Significance of TRIM44 Expression in Patients
            with Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12994)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   7  (bases 1 to 12994)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 12994)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 12994)
  AUTHORS   Boutou,E., Matsas,R. and Mamalaki,A.
  TITLE     Isolation of a mouse brain cDNA expressed in developing neuroblasts
            and mature neurons
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 153-167 (2001)
   PUBMED   11165382
REFERENCE   10 (bases 1 to 12994)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI550863.1, AK074242.1,
            DA128342.1, DA158251.1, DA131915.1, CX788887.1, CX871447.1,
            BI222592.1, CA445350.1, BQ014398.1 and AC090692.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017583.5.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family. The TRIM motif includes three zinc-binding domains, namely
            a RING, a B-box type 1 and a B-box type 2, and a coiled-coil
            region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.122251.1,
                                           SRR1803617.221126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299413.7/ ENSP00000299413.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               BI550863.1         29-297
            270-2914            AK074242.1         117-2761
            2915-3212           DA128342.1         257-554
            3213-3220           DA128342.1         561-568
            3221-3781           DA158251.1         6-566
            3782-4143           DA131915.1         207-568
            4144-4779           CX788887.1         119-754
            4780-4839           CX871447.1         59-118
            4840-5371           BI222592.1         1-532
            5372-6038           CA445350.1         19-685              c
            6039-6040           BQ014398.1         18-19               c
            6041-12994          AC090692.9         21993-28946
FEATURES             Location/Qualifiers
     source          1..12994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..12994
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /note="tripartite motif containing 44"
                     /db_xref="GeneID:54765"
                     /db_xref="HGNC:HGNC:19016"
                     /db_xref="MIM:612298"
     exon            1..1006
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1372
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /codon_start=1
                     /product="tripartite motif-containing protein 44"
                     /protein_id="NP_060053.2"
                     /db_xref="CCDS:CCDS31461.1"
                     /db_xref="GeneID:54765"
                     /db_xref="HGNC:HGNC:19016"
                     /db_xref="MIM:612298"
                     /translation="MASGVGAAFEELPHDGTCDECEPDEAPGAEEVCRECGFCYCRRH
                     AEAHRQKFLSHHLAEYVHGSQAWTPPADGEGAGKEEAEVKVEQEREIESEAGEESESE
                     EESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAE
                     SEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTLDEA
                     FEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKMFIQQEFKKVQKVIADEEQK
                     ALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEG
                     PSGASEEEDT"
     exon            1007..1084
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1324
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1344
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..12994
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6017..6022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /note="hexamer: AATAAA"
     polyA_site      6040
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /note="major polyA site"
     regulatory      12974..12979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /note="hexamer: ATTAAA"
     polyA_site      12994
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
ORIGIN      
        1 ggcggctgcc gcgatctctc cctggtagcg ggaggctgag cgggcggcgc gacgcggggg
       61 ccgacggggg cgccgggtgg ccgcgccgga agtgccttgc gcggcagagg aagcgcaggg
      121 acagagcgga gcaggccgag ccggcggaaa gggtctttgc tgctgcgccc gggcaggggc
      181 tgccgcggcc ccaggtcccg cttcgagacg cggcgcggtc caggcgggag gcgactccct
      241 aggaagggac ccggggcggg aggaggaagt gaggccgcgc ggaaggaagg cggcgagccc
      301 cggggccccg aggccttggc cgcgtcacag cacccacatg gcctctggag tgggcgcggc
      361 cttcgaggaa ctgcctcacg acggcacgtg tgacgagtgc gagcccgacg aggctccggg
      421 ggccgaggaa gtgtgccgag aatgcggctt ctgctactgc cgccgccatg ccgaggcgca
      481 caggcagaag ttcctcagtc accatctggc cgaatacgtc cacggctccc aggcctggac
      541 cccgccagct gacggagagg gggcggggaa ggaagaagcg gaggtcaagg tggagcagga
      601 gagggagata gaaagcgagg caggggaaga gagtgagtcg gaggaagaga gcgagtcaga
      661 ggaagagagc gagacagagg aagagagtga ggatgagagc gatgaggaga gtgaagaaga
      721 cagcgaggaa gaaatggagg atgagcaaga aagcgaggcc gaagaagaca accaagaaga
      781 aggggaatcc gaggcggagg gagaaactga ggcagaaagt gaatttgacc cagaaataga
      841 aatggaagca gagagagtgg ccaagaggaa gtgtccggac catgggcttg atttgagtac
      901 ctattgccag gaagataggc agctcatctg tgtcctgtgt ccagtcattg gggctcacca
      961 gggccaccaa ctctccaccc tagacgaagc ctttgaagaa ttaagaagca aagactcagg
     1021 tggactgaag gccgctatga tcgaattggt ggaaaggttg aagttcaaga gctcagaccc
     1081 taaagtaact cgggaccaaa tgaagatgtt tatacagcag gaatttaaga aagttcagaa
     1141 agtgattgct gatgaggagc agaaggccct tcatctagtg gacatccaag aggcaatggc
     1201 cacagctcat gtgactgaga tactggcaga catccaatcc cacatggata ggttgatgac
     1261 tcagatggcc caagccaagg aacaacttga tacctctaat gaatcagctg agccaaaggc
     1321 agagggcgat gaggaaggac ccagtggtgc cagtgaagaa gaggacacat gaaggcttgc
     1381 tacccccagt ggaaaatcat cccctcccct tgtgtgtatg tgacagcgtg tatgtaacgg
     1441 cttctgattt ctgtgaaagc tgctcagcaa caaacgtact tccaccagat gtgtccccag
     1501 atccacagca ggcacatatc tctccaaggg atgaccagtt ttatgcttac tgtgtgcttc
     1561 tcatcccctg gttgtggtag gtcaaggaaa agagcccctt tgatccacca ggagcaatta
     1621 agaaaggtcc ttcaggtaat ccctcaatgg ctgctttgaa cttactcagg aaagccagcc
     1681 cccataatat tgtattacca aacagtatcg ctttgttagg aaggatctgg aataatcttg
     1741 aagggaagtc agagttttct ccctgcctat taacaaaaac ccaattttgt tcatattgaa
     1801 gcatgaaata aatgagagca aggtagggcc aaattaactc ttgtggacag tccctaaaag
     1861 tccagttcta catttgtgaa aattgtggtg ccatgaatta agatggatga ctggaaaaag
     1921 gtgttggaga aagagttaaa gatgaggaag agatattttt agtatatgaa gttatccagg
     1981 acttgatatt cataattcag tgctgtggaa atgaaaaaaa tgattgaaga ggtggaacgg
     2041 aaatgacctt agggggaaaa aaaaggacca aagaagtctg attaaaagtt gaaatcagta
     2101 tttctgaatt caaattgctt gaatttccaa aatagtcagt aaaggatcta atagaaccag
     2161 aattatttgg gtgaattctg caggttttat gggcttgtca caacgtgaag ggctggaatg
     2221 tatattacca aatgggaatt tccattgtag gtttttgcta gtcccacccc cattttagcc
     2281 taatttggct taaacgcagt atggggagaa ttgttcccat tccatgtgtt ctgaattcag
     2341 ctcatctccc agcatataga tatatcctcc tttaactccg accagaaccc ttcttcctgt
     2401 ggcactcccc acccatagac cttcagatca tctcccacac cctggatctc actctcctct
     2461 tagtaacaga gacactcctg aggttggact tccttgcttt tctctacttc caaatcacaa
     2521 tttcttacaa ccaagctttg tgctcccgag taagcaggga tgtactaggg gaatgtaaaa
     2581 ctgcaaactt aaaaacctgc atcttcttga agcatcagtt ttacttacca aatggtttag
     2641 agtcataaga tgacctattt ttatataaaa gttatattat agaataaaat gttcatacgc
     2701 atagactgtt aagataaaaa aataggaatc ttgcaaggta attcttattt gcaagtgggt
     2761 tatgtgttca ctctcctcta cctttatggt attttggtgt tcacttacga agcatacaac
     2821 tagaaccata tccaagcaga ctctgggttg ctgttaaccc agggcctaga cttctagtgc
     2881 ctctgaggca gaaccaaagg agcctgcact gggggaaatc ccttttcctg cctgcctgtc
     2941 tgcctgtgac ctgtgtacgt attacaggct ttaggaccag ctgattgtta tgcttgcagg
     3001 atggttttga aacagaaaca atacttgttt actgtaggaa tcctatttat attatttttc
     3061 agtcctgtga atgctgtgaa aagatttatt cctttgaggc caggaagctc ccaggcatat
     3121 atgcttctag gttaggattg tcctgactca ctaaagatgc caggatattg gggctgaggg
     3181 gagtttgagg tgttaaaaaa aaaaaaaaaa aagcattttt ctctcaaact gatggccaag
     3241 aaatggctag gacaattttg gtgctttacc tatctctgca aagactggag aatttggcat
     3301 accattaatt acaaccacca atcatatcca acaaaagtac cctaaaagaa ggaccagtgg
     3361 ccactctcga aaaaatttaa gtatcagaag attaaaaaga ttttaggatt tggaagcttg
     3421 tattgtcttt ccccaataat cattgtttga tctccaaata gtagccttat attagcaata
     3481 gacagatcat tggttctcca tatctgatca tatgttacta ctttgaatca gtatttggga
     3541 aattcaagca tttatgcagt ggatataaat ggaaatataa aaatatttgc caacctgtct
     3601 cagtaactta tcatatctct gtgatcctca aggaaagcac ttttgctttt acttagaaag
     3661 cgtttcagat ttgctttata gactcctgct gtcttcagta cctgataaaa ctttaaccag
     3721 ggaagcatta aacacagtgc agcagctttt gcccaggctt ctaagttcct gccggcagca
     3781 tttatcaatg taagaactag gatgcttcct gcagtggcac taccttcccc tagagctgga
     3841 gcatgctgct tggccttaag ccccagcatg atgaggcttc cctcctgcca ggtcagtaaa
     3901 agttagagag ctcagaattg ggtcttgcct gggtgcaggt ggcagggttt gctgaaaccc
     3961 ctaaagagaa gtcaccaagg gaggcaggta atgaatgttt ccagaatcag tcggatactc
     4021 atagcaattt ctggctatct ttcaaatgtt gaatttctgg atgctgagag ggactttgat
     4081 ttgatatcat taaatccagg acagtcccaa gaagtgcttg gagtctcggc tctgacagcc
     4141 caagaaggga aataacttgt attaaggaac aactatgagc caggccctga gctgtctctt
     4201 agataataaa acagatgggg agtggaagag tcatttgctt caagttatac agctaggaaa
     4261 tactcaagcc aaatcttgaa cgcagctccc cctaattctg tggacaggca ctttgtacca
     4321 cacaccatgg tccacctaaa aacagaagga taaaaagact tcaggttttc ccactgtgtg
     4381 ctgaccatcc caatttatga atcttcttca aaatgacatt tcacagttat agttagggct
     4441 cagaaatggc attgaggtag ccttatttct cccctttagc agatgcttta agtacacatt
     4501 gctgacttga gcccaccccc aggagttagg agaacatttc ctttttcatg ccatcttcca
     4561 taaataaggt gtttcttggc cttcaaagat atagaacttt gcagcagtag taaaagtgaa
     4621 gggtgttctg ctctctactc aactttattt gaaaatgtct gcagcttcac tcctgtagaa
     4681 aaggaaatct tcatatttta gtaaacttag ccgccagtgt actctgtgag gatgtggcaa
     4741 ttcaaagtcc agtgaatctg gactctctta ctgattcctg gttttagtgt gtgtgtcggg
     4801 ggagtgtgta cctatatata aaggacaagt gtgatatgtg tgtatatgta tatacataca
     4861 tacatgtccg cacacacaca cacaatattt gagagctaag gaaaactcaa agcagcccct
     4921 tcattatctt gcgtactact tcaaagattt ctgtcagccc taattacaag tgtcaccata
     4981 tagttggggc ttaggtactt gcttacagga agagcaattc cctagcaaag gtcattagct
     5041 cctaaggcac tgagtcaaag tgacagccct gaaggaaatt gcactccagc cctcctccag
     5101 gatgtctaat aagatgggaa acttggatgc ccagccattt tggtgacctg agagtctaac
     5161 tactccagtt agacctaagg gcacaaatgc agaattcatg accttgtagt tgtggcaggg
     5221 tctaggaagt cctctctccc caagtagaaa atattctctt gccattcctg aaattccaca
     5281 ttcatataat ggctgtgcaa tacatgcttc tcaataagaa aattaactgc acgtttactg
     5341 tgtgctgatc acatcagatt tttatgttta aaaaaatctc attatggatt gagtccagcc
     5401 cagctctaag agaaaaagaa ggcccatatg ggagacttca gtctcattat tattgccttt
     5461 atccagcagt gcttatgaag ccccctaccc tgtcccattc cagaaaccat aagactcagg
     5521 cagttcttga ttctggaggc ctgcctggta agataagata gtataatttg gaactgagaa
     5581 cataccagaa acagcagaac gagggccaga gcagaaaaat gaaaataagt ggagacactt
     5641 atggatacat tggtgcaaaa aaagccacgg agcccatact gggcttgata tgactttgag
     5701 gggacagcag attaatactt aatgagggtt aaacctgacc agtctttcta cagtgacagg
     5761 ccacactgca tgaatgggga gaaccaatga atccattgtc ctctgcctat tttcctgtgc
     5821 acagtcacat tccctcctta ggaatcttcc ccttccaccc tttacattaa acaagggaac
     5881 actgaatctt tcaagggaat tacacgtttg ggttaatgtt tcagtatatc attttcatac
     5941 tgtaaattat tttgtaagag agatttactg ctatcccagg atgttcggac ttggtgcccc
     6001 tgtgcatttg gaaatcaata aactattact ggaaatgcca tttgtctctc agagttgtgc
     6061 acaaaggacc ctgcaaggtg taaatattta tgacgagctg catacttgac tgtggtaatg
     6121 ctggagatga tggtgttttg gttactagat gtgggagtct aatttactcc tgacttttcc
     6181 acagtgcctt aggagagagc tctgggaagt ggcaaaagaa cagacttaag atcattatta
     6241 tttagtgata agttttctcc tcaaagtaaa atgatccagg cctagattac attttatgag
     6301 caacttagat tataacctaa agaatacttg gtgccaaatt atgttttcaa ataacattaa
     6361 agttttagaa tttggatgaa ctagaaggaa ggtaaaattg taatttttgc catattttct
     6421 agaaaaaaaa atgtctttta gagcaaatta cagttaggcc aacaaaatct ttgttttgtg
     6481 aaactttaga aatacatatt tgcatgtaat tgatgaaaac atagaatgag ttgtaaatga
     6541 agcaattcca agctggtttg aaggaccaga ggttgcattg aaatcagaag tcatatactc
     6601 agaggccttc aggagccaaa tgtgaagact caagatggta gatactgtgt gaattagaaa
     6661 ataccaagcc ctgcctaaat gcattaaaat ttaatgttta aaaatcctaa aacccaccag
     6721 caggtgtatc tggagggaca gtttgtggac tctcctctaa attttctttt aacacattta
     6781 tcttcatcag acccttttag ttagctaggg actgtgtgag aaccttgaga aaattgtcca
     6841 agagagggag ataagtcact caaggtcacc caacaagcca ggctggtaaa gcccaggaca
     6901 gcagactctc tgtctccgag agcaatcatt aggccctact tcctcttccc cagttgcgga
     6961 ggacactgct gcctggtggg gtggcactgc ctgccactgt agcacttagg agtcttcagt
     7021 gttttaacaa accacaatgt gtttggaggt tttcttccct gcttcctggt gccagtatct
     7081 caacaccaca tccattgccc cagccctttc ttgttttatc tttccctctg aaagctacaa
     7141 ctctatattt tattttatta ctctttgttt ggtccaacat ggccccattt cctttatact
     7201 cataaaaagg tagaatttca gcttgtctgg aatatctcct ggccttcaca aggcaccaga
     7261 gttagagaca cccaacagaa agtcgtaata agagaagatg tcacagaaat agaaacaaaa
     7321 gcaaaagact gcttgaagtc agtaacagac tgcactaagt gtctgtgctt gttaactatt
     7381 gtaatctcca ggtttaaatc attcatttat gttaataaga gctgtcactt agctctttct
     7441 ctgggccagg tactctcctg ttgtttttca cattatcata atagtaacag caccaatact
     7501 atcattcccc actttgttgc tcaggaatca aatttagaga attaagtact gtgaccacgg
     7561 ttacacccta ataagcggga agccagaatt taaacccagg tctagcagac ttcacagcct
     7621 ctttccttaa tctcttctct cctagctgca ctgattccat cttgtattgg tgaataacaa
     7681 cactgatccc cctacaacta cccccacaca tgtacagtat ggccttgggg caaaggagtt
     7741 tgccttttgc aaagaaggtc ttgctttgta tagcctgtaa aatgcaatgt acagtgaggg
     7801 aaagaaagtc taagggtagc agtcaaatct tctggcctga aactgtactt ttggaaggga
     7861 gaactgttag acttgcttta tcttctttat tccaaggcca taaataagaa aatcaacgag
     7921 aggcaaaacc atgtcttctt ttgctatagc gttagaatcc tgaaagtcag ccagctctga
     7981 cactgagtct gtgatttaat taaacatgtt gaaggctctc caacagcttg acgtcaggcc
     8041 agcttcatat tcttggaaag ggacaacagc aaaaggagct tatctgtttt aaagttcact
     8101 tactgagttc agctgtcacg gccacagcat accatttgcc ttataaaaat ggcccacaac
     8161 cttcacaata ttttaggatt catggcaact catttaccta gggcttagcc acctgatagc
     8221 tttacctatc cctatttcct gaacacaaaa tctaaaccag tggtttgaca atgagtaact
     8281 gagacagaac tagaaaaatc tagaacctct gctgaaccca tcaaaagtga ctgagaatta
     8341 agaagtaagc aaacaaggct tccaaccaat tgaaataaat accatgaagc aaacgcataa
     8401 gacaaaggcc atacatctag tcatcaggca cctcctcaga acctatttgc tcttccttca
     8461 cacatatttc taactgtaaa ggaaagaaac agacttttag aggaaacaag aaggaaaaag
     8521 gaggacagca atagagaaaa tggaaatttt gagtagactg caaagctcca aagccctgat
     8581 atatgggtta tttagtgtca aaaacagtct atacacatct caatctttaa gagcctcact
     8641 gtatcatggg acaatattct atttaaaatg atgaccctgt gcaccataca taaaaaaact
     8701 atgcttagaa gacaaaaata tgtatatcaa acattttaga aatatttaca tcccaatggt
     8761 taaaaaaaaa aacttttagg aattaaaagg aataaacctt tgaccatcca gaatatttag
     8821 ctaaatcaaa cagtgtatat ccccctagct gacttttatt gtttcatgag cctctggtgt
     8881 tcagagagtt tttttcacag ctttgtaagt gactttcatg ctacagtgct ttgcatataa
     8941 tggcatgaac agtggaggtg ccaactttcc aatgtgatga ataaaactaa taactagaat
     9001 acagatcaaa ttctgttaca acaaatactg ctaccataaa agtcacttaa gcatccctgt
     9061 tagttctaag cccctgtcga ttgcccattt attttaggca atagtcattc aacaaaattg
     9121 gagcataata aaaagaaact ggacctcagc gcaagttgag tgttacacaa tttaacctgt
     9181 aataacaggt tctcacttgt atttctccag ctctttgctg taagaagaat aaacgttatg
     9241 tagatataat accagcgtga cagcttgtgg ttggtggttt ctagaagaaa taattcagaa
     9301 gcaaaagaca catgaagtta tgtggcagtt cctcactagg gaatttggtc tccagggcca
     9361 cttttgacct taatccatgt tggagccatc aatcaaagaa ttgcttgcat ctaataatgg
     9421 tgtaatgcca atactaagcc ctggaacgaa gataggattc atttctcatg gattattgag
     9481 cactctgggg taacctggcc ctgatctgat gacgctaaga tttaaaaacc cagatgcatg
     9541 tgactagaac tatcttttct cccatgatgc actgctttca acactgcatg actgtaaaaa
     9601 catgtgccac gctgattata tatagagatg gtctaaatca gctgcatccc atttggtacc
     9661 caggcaagga tttttccata cctatctttt tgctggtggt aatgatgagt tttgtcactt
     9721 gctataacat tctctgtccg tcttttttct tttatgtaaa tacttttgtg acttcattgt
     9781 aaccagcatt ttgtaatact cttaacagca gaggggatta aatcatgatt cacttctgaa
     9841 cagtacaatc agcagtagga aaacgaggag ggagggagag ggaaattgtc caccacttcc
     9901 caatgataat gcctggctcg gaccccagat tcacatcata cttgaagttc ataaattctg
     9961 ggcactgctc agcttgagga ggcaggcatt gctccttcat atttcagggt gagacaaatg
    10021 ctctgttgaa gccatgccac tacaggatac attcacctct gcttgctttc ctccctaagc
    10081 cagagtgtag ttaaacattt atatgtccca ggccaggaga tcaaattaag aggaggttag
    10141 ctactttccc tggctcttaa aaacatttga gtccaagtat ggttctctgg cttgagggtg
    10201 gccatttgtt gcctcactgt ttttattagg acatctggag attagaggtg ttaattggaa
    10261 gtaacttttc tatatttggt ttctctccac acattatgag accttttaga cccagttgga
    10321 tggctgtatc ctagtatgaa attcagcttc taagtaggaa gaactatgat agaggaacaa
    10381 gattgctctt tgacttggtg atagtagggc aatagggagt gtcagtaggg tagtttcagg
    10441 tggggaggat gacaaaccac tgataacaat aaaaatgggt atttctcaac actcaagcca
    10501 atttcccatt tgataacaag taggttctga tctattttcc ccaaattaat attttccctg
    10561 gaagattctg acctgtctga tcaaataaag gcattcctct gagagtatac ctagcccact
    10621 tgtggccaaa ttatacttga ctgttatgta ctcaaaacaa gctttcctgt taatctcttt
    10681 ctcttacctc tattatgagg acaagacgtg gaagaattag gtcaccgggg catctgccat
    10741 tgcatatgtt taagtggtat aaagaagcca ggattcctag aatggtctgt cttttgccat
    10801 ttctgggaca atgagaaaat ccatctggag tgtttatgcc cctctgaata gccaagtcat
    10861 gggcttgttt gctttcagtc actgccttca gaaaaagaca attttacaat gacttacttc
    10921 taataatcac tgaaacagcc tcatgaggac atgcaaaact gctgtctatc ttcagacctg
    10981 gcccattgtc aaatggcaga cttgcagagc aaataaggga cctggcctag ttcacaaggc
    11041 agtcagaagt gatccaaagt tcaggctccc cctccctttt atcactccac cctgcctcta
    11101 ctcctccgcc tcctattctt ccggcctttc catctggaaa ccatgagcct catggattcc
    11161 aggcacaaat tctcagattt cagatgtttg ggaaatttct cagcttgggt cattcttcaa
    11221 gagtaagaaa ttgaatttgt gagaaaaaaa aacagctgag actgtttcac agaagagaaa
    11281 ataaataagg tgtggtgcgt atccatcctc ttcccaactc agctccaaaa ccacacacaa
    11341 tgtctaactt caaaaagagt atttagatcc cccctgggaa ggaacagaat ggaaaaacaa
    11401 tctccactca taaaaacact tttctgcctt ctacagtata aacacaactg gcatcagata
    11461 atacaatgta attgatttta tgtgtgtaat tggggaacag aagggtctct agagggtaga
    11521 cctaagagta atggaatgga gtgaaaagta aaatttagac taaattgttg ggaggaaact
    11581 gttaacattg tgaaccactt gaccctagtg ttgcatcttc acaaaaaaga gcaatgtgcc
    11641 gtcttctgtc tttggaaaat gggacaagct tgctcctgat actaggtttt agaagcatac
    11701 agacttggtt ttagtactgg ctttgttctt tactaactct gaacaattaa atgagcagat
    11761 ggtctacagg gcttagtaca gtgcctgaca catagtaagc acttagaaat ggtagcttct
    11821 gactgttgtg ctggagtcct gttagagatt cagtagatgg agccaccttc atgttgcccc
    11881 tcactgagct gctctgctca cctctagatg ctccccatgg ctgtttcata gccctctgta
    11941 ccacatcccc atgtactttt tcatatcaac ggtaagtacc tcaaattacc gtatgtattt
    12001 acttgttcat aaggttgatg tctgtaactc tttgaaggtt gtattagtcg tttgctccta
    12061 tattactaat gatgacaaag tcgcctgaca gagtagatgt tcaaatttat ggacttaaac
    12121 tgactgacat cttgataatg cccatatcca gaggtactcc agatattata tcttcatgca
    12181 gaaaactgaa agataccttt agctacatct accccagaat gagtgtccaa agcaggtggc
    12241 accaccaaaa ggcaccttct tttcccatga aaagagggaa gagagttgag aagcctcact
    12301 cccatccctg ctctgccact gacaagttgt gtggcatttg gcacatcatg ttctctctct
    12361 acatgcgcct aaaatgacgg gtagggtcag agacattgga ggatctctct tttctcttcc
    12421 acctctaaca cggtaagatc ttagcaaagt aaaaaggaca gtgataacag aaaaattgtt
    12481 cctctaagag tcccaagtca tcttttttct ctccgtgtgt gttagcattt gtgtgtgtct
    12541 gtgggtgtgt atgcatgtgt gtggaagcta tacaaggaaa gctgaatcca tatgtagact
    12601 tcatggagac tagtactgct ccaaatgtgc acaagccatg tgatatggtt tgcctctgtg
    12661 tccccaccca aatctcatgt tgaaatgtaa tccccaatgc tggaggtggg acctggtggg
    12721 aagattggat catgggggag ttttctcatg atttaacaac atccgccctt tgttgtcatg
    12781 atagtgagtt cttgtgagat ctggttgttt aaaaatatgt gacacctccc cccaccttcc
    12841 ttctgctctg gccatgtaaa gtgctcactc cccctttgcc ttccaccatg attgtaagtt
    12901 tcctgaagcc tccctagaag ctgagcagat gccagcatca tgcttgctgt gcagcctgca
    12961 gaactgtgag ccaattaaac ctctttatga atta
//
