LOCUS       NM_138800               1699 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 43 (TRIM43), mRNA.
ACCESSION   NM_138800
VERSION     NM_138800.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Full,F., van Gent,M., Sparrer,K.M.J., Chiang,C., Zurenski,M.A.,
            Scherer,M., Brockmeyer,N.H., Heinzerling,L., Sturzl,M., Korn,K.,
            Stamminger,T., Ensser,A. and Gack,M.U.
  TITLE     Centrosomal protein TRIM43 restricts herpesvirus infection by
            regulating nuclear lamina integrity
  JOURNAL   Nat Microbiol 4 (1), 164-176 (2019)
   PUBMED   30420784
  REMARK    GeneRIF: TRIM43 ubiquitinates the centrosomal protein pericentrin,
            thereby targeting it for proteasomal degradation, which
            subsequently leads to alterations of the nuclear lamina that
            repress active viral chromatin states.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009237.3, BC015353.1 and AW015073.1.
            
            On May 17, 2019 this sequence version replaced NM_138800.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015353.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272395.3/ ENSP00000272395.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC009237.3         115618-115634
            18-1644             BC015353.1         1-1627
            1645-1692           AW015073.1         17-64               c
            1693-1699           AC009237.3         123389-123395
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..1699
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /note="tripartite motif containing 43"
                     /db_xref="GeneID:129868"
                     /db_xref="HGNC:HGNC:19015"
     exon            1..149
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     exon            150..564
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1494
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /codon_start=1
                     /product="tripartite motif-containing protein 43"
                     /protein_id="NP_620155.1"
                     /db_xref="CCDS:CCDS2015.1"
                     /db_xref="GeneID:129868"
                     /db_xref="HGNC:HGNC:19015"
                     /translation="MDSDFSHAFQKELTCVICLNYLVDPVTICCGHSFCRPCLCLSWE
                     EAQSPANCPACREPSPKMDFKTNILLKNLVTIARKASLWQFLSSEKQICGTHRQTKKM
                     FCDMDKSLLCLLCSNSQEHGAHKHHPIEEAAEEHREKLLKQMRILWKKIQENQRNLYE
                     EGRTAFLWRGNVVLRAQMIRNEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVK
                     MDQKSKHLKEMYQELMEMCHKPDVELLQDLGDIVARSESVLLHMPQPVNPELTAGPIT
                     GLVYRLNRFRVEISFHFEVTNHNIRLFEDVRSWMFRRGPLNSDRSDYFAAWGARVFSF
                     GKHYWELDVDNSCDWALGVCNNSWIRKNSTMVNSEDIFLLLCLKVDNHFNLLTTSPVF
                     PHYIEKPLGRVGVFLDFESGSVSFLNVTKSSLIWSYPAGSLTFPVRPFFYTGHR"
     exon            565..660
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     exon            661..891
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     exon            892..914
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1012
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1699
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /note="hexamer: AATAAA"
     polyA_site      1644
                     /gene="TRIM43"
                     /gene_synonym="TRIM43A"
                     /note="major polyA site"
ORIGIN      
        1 attcttctcc agagcccaca gagtagcttt gcaactggct ttggggactt ccgaaagcta
       61 ccagcactgc actgtgagac tctcatccct gagctgaatt catctgattc gacggcaagc
      121 tttggtgaga acatagatat atttctgagg aaaatggact cagacttctc acatgccttc
      181 cagaaggaac tcacctgcgt catctgtttg aactacctgg tagaccctgt caccatctgc
      241 tgtgggcaca gcttctgtag gccctgtctc tgcctttcgt gggaggaagc ccaaagtcct
      301 gcaaactgcc ctgcatgcag ggaaccatca ccgaaaatgg acttcaaaac caatattctt
      361 ctgaagaatt tagtgaccat tgccagaaaa gccagtctct ggcaattcct gagctctgag
      421 aaacaaatat gtgggaccca taggcaaaca aagaagatgt tctgtgacat ggacaagagt
      481 ctcctctgct tgctgtgctc caactctcag gagcacgggg ctcacaaaca ccatcccatc
      541 gaagaggcag ctgaggaaca ccgggagaaa ctcttaaagc aaatgaggat tttatggaaa
      601 aagattcaag aaaatcagag aaatctatat gaggagggaa gaacagcctt cctctggagg
      661 ggcaatgtgg ttttacgggc acagatgatc aggaatgagt ataggaagct gcatccggtt
      721 ctccataagg aagaaaaaca acatttagag agactgaaca aggaatacca agagattttt
      781 cagcaactcc agagaagttg ggtcaaaatg gatcaaaaga gtaaacactt gaaagaaatg
      841 tatcaggaac taatggaaat gtgtcataaa ccagatgtgg agctgctcca ggatttggga
      901 gacatcgtgg caaggagtga gtccgtgctg ctgcacatgc cccagcctgt gaatccagag
      961 ctcactgcag gacccatcac tggactggtg tacaggctca accgcttccg agtggaaatt
     1021 tccttccatt ttgaagtaac caatcacaat atcaggctct ttgaggatgt gagaagttgg
     1081 atgtttagac gtggaccttt gaattctgac agatctgact attttgctgc atggggagcc
     1141 agggtcttct cctttgggaa acactactgg gagctggatg tggacaactc ttgtgactgg
     1201 gctctgggag tctgtaacaa ctcctggata aggaagaata gcacaatggt taactctgag
     1261 gacatatttc ttcttttgtg tctgaaggtg gataatcatt tcaatctctt gaccacctcc
     1321 ccagtgtttc ctcactacat agagaaacct ctgggccggg ttggtgtgtt tcttgatttt
     1381 gaaagtggaa gtgtgagttt tttgaatgtc accaagagtt ccctcatatg gagttaccca
     1441 gctggctcct taacttttcc tgtcaggcct ttcttttaca ctggccacag atgatcagga
     1501 ttaagaaaac ttactgtttg ggaactccat atacaaggga gcccttcact gttgatacaa
     1561 agaaatcata ctgttcaggc ttttttgtac tttagtgtca cttcatttta ttgctattaa
     1621 ataaaaaatt tgtaaaaggc aaaacttttt gtacattttc ttacaattaa aataatctct
     1681 tatggaccat tacctaaaa
//
