LOCUS       NM_033549               3645 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tripartite motif containing 41 (TRIM41), transcript
            variant 1, mRNA.
ACCESSION   NM_033549
VERSION     NM_033549.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Zhen,Z., Chen,Y., Wang,H., Tang,H., Zhang,H., Liu,H., Jiang,Y. and
            Mao,Z.
  TITLE     Nuclear cGAS restricts L1 retrotransposition by promoting
            TRIM41-mediated ORF2p ubiquitination and degradation
  JOURNAL   Nat Commun 14 (1), 8217 (2023)
   PUBMED   38086852
  REMARK    GeneRIF: Nuclear cGAS restricts L1 retrotransposition by promoting
            TRIM41-mediated ORF2p ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3645)
  AUTHORS   Zhang,X., Hu,Z., Wang,X., Li,L., Zhu,B., Lin,X., Zhang,J. and
            Hua,Z.
  TITLE     ANXA10 promotes melanoma metastasis by suppressing E3 ligase
            TRIM41-directed PKD1 degradation
  JOURNAL   Cancer Lett 519, 237-249 (2021)
   PUBMED   34324862
  REMARK    GeneRIF: ANXA10 promotes melanoma metastasis by suppressing E3
            ligase TRIM41-directed PKD1 degradation.
            Erratum:[Cancer Lett. 2023 Aug 10;569:216310. doi:
            10.1016/j.canlet.2023.216310.. PMID: 37474390]
REFERENCE   3  (bases 1 to 3645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3645)
  AUTHORS   Yu,Z., Li,X., Yang,M., Huang,J., Fang,Q., Jia,J., Li,Z., Gu,Y.,
            Chen,T. and Cao,X.
  TITLE     TRIM41 is required to innate antiviral response by
            polyubiquitinating BCL10 and recruiting NEMO
  JOURNAL   Signal Transduct Target Ther 6 (1), 90 (2021)
   PUBMED   33640899
  REMARK    GeneRIF: TRIM41 is required to innate antiviral response by
            polyubiquitinating BCL10 and recruiting NEMO.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3645)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3645)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 3645)
  AUTHORS   Chen,D., Gould,C., Garza,R., Gao,T., Hampton,R.Y. and Newton,A.C.
  TITLE     Amplitude control of protein kinase C by RINCK, a novel E3
            ubiquitin ligase
  JOURNAL   J Biol Chem 282 (46), 33776-33787 (2007)
   PUBMED   17893151
  REMARK    GeneRIF: RINCK is an E3 ligase that specifically recognizes the C1
            domain of PKC isoforms
REFERENCE   8  (bases 1 to 3645)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 3645)
  AUTHORS   Tanaka,M., Fukuda,Y., Mashima,K. and Hanai,R.
  TITLE     Intracellular localization and domain organization of human TRIM41
            proteins
  JOURNAL   Mol Biol Rep 32 (2), 87-93 (2005)
   PUBMED   16022281
  REMARK    GeneRIF: observed in the cytoplasm and the nucleus; nuclear
            transport is mediated by an N-terminal segment common to both alpha
            and beta isoforms, but independent of a classical nuclear
            localization signal sequence.
REFERENCE   10 (bases 1 to 3645)
  AUTHORS   Kobayashi,M. and Hanai,R.
  TITLE     M phase-specific association of human topoisomerase IIIbeta with
            chromosomes
  JOURNAL   Biochem Biophys Res Commun 287 (1), 282-287 (2001)
   PUBMED   11549288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA341383.1, BC090953.1 and
            BC018765.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_033549.4.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family. The TRIM family is characterized by a signature motif
            composed of a RING finger, one or more B-box domains, and a
            coiled-coil region. This encoded protein may play a role in protein
            kinase C signaling. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2011].
            
            Transcript Variant: This variant (1, also referred to as alpha)
            represents the longest transcript and encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018765.1, BC090953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315073.10/ ENSP00000320869.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               DA341383.1         5-564
            561-1765            BC090953.1         122-1326
            1766-3365           BC018765.1         815-2414
            3366-3642           BC090953.1         2925-3201
            3643-3645           BC018765.1         2692-2694
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3645
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /note="tripartite motif containing 41"
                     /db_xref="GeneID:90933"
                     /db_xref="HGNC:HGNC:19013"
                     /db_xref="MIM:610530"
     exon            1..1532
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     CDS             720..2612
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRIM41; RING-finger protein that
                     interacts with C kinase; RING finger-interacting protein
                     with C kinase; RING-type E3 ubiquitin transferase TRIM41"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM41 isoform 1"
                     /protein_id="NP_291027.3"
                     /db_xref="CCDS:CCDS4466.1"
                     /db_xref="GeneID:90933"
                     /db_xref="HGNC:HGNC:19013"
                     /db_xref="MIM:610530"
                     /translation="MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCV
                     TQLWGGEDEEDRDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEE
                     EEGVFWTSGMSRSSWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEV
                     EEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRG
                     SRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQG
                     HVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERR
                     LREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEV
                     QLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDR
                     RGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTH
                     HKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTE
                     QTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGT
                     RIKLCP"
     exon            1533..1628
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1859
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1882
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2010
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..3645
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /note="hexamer: AATAAA"
     polyA_site      3645
                     /gene="TRIM41"
                     /gene_synonym="RINCK"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggca tcggctgtgg ggagtaccgg ctgcagtcgg ctgtgccggg agggtaggat
       61 ggcgtctggc cgatgcggtg atagcaccga aagcagacgg ccgccaggcg ctccccctac
      121 cccccgaagt ttctccccag cggcggggga tgggggtagg cggttcctct gttctttctg
      181 cgttccccgc ggcctcttac cacagagacg cgggcctcca ccgtcctagc cctcccgccc
      241 tgttctctag tgcggactag agcgtctcct cgccatttcc tgtcgccctg gggccccgcg
      301 gggaaaaagg gggagtagca ggacagcgga gggaagtcgc gagcttaggt ggtgtgtaga
      361 cgccggaagt gttgggaagg aggccggaag ctaggggcgg ggccaggaag tgaggagggg
      421 cgggggttta tgaggagtcc aagggagcat tggggcagac ttgtactcag agccacctga
      481 gggacttggc ggtggcgccc agcactgtcc cctcccctcg tagagacacg gttgtcgttt
      541 gggagtaggg aacactgtgt tggggtgggt tgtcggcagg acatctctct ggctgctctt
      601 ggggcgaggt gtggaggggc agggctgggg gtggagccgg gtcgccaggg cgtcggtagg
      661 gaagaccccc gcccctcgcc cccccaccga acctctacac tggctggctg gacactaaga
      721 tggctgccgt tgccatgaca cccaaccctg tgcagaccct tcaggaggag gcggtgtgcg
      781 ccatctgcct cgattacttc acggaccccg tgtccatcgg ctgcgggcac aacttctgcc
      841 gagtttgtgt aacccagttg tggggtgggg aggatgagga ggacagagat gagttagatc
      901 gggaggagga ggaggaggac ggagaggagg aggaagtgga ggctgtgggg gctggcgcgg
      961 ggtgggacac ccccatgcgg gatgaagact acgagggtga catggaggag gaggtcgagg
     1021 aggaagaaga gggtgtgttc tggaccagtg gcatgagcag gtccagctgg gacaacatgg
     1081 actatgtgtg ggaggaggag gacgaggagg aagacctgga ctactacttg ggggacatgg
     1141 aggaggagga cctgaggggg gaggatgagg aggacgagga ggaagtgctg gaggaggttg
     1201 aggaagagga tctagacccc gtcaccccac tgcccccgcc tccagcccct cggaggtgct
     1261 tcacatgccc tcagtgccga aagagctttc ctcggcggag cttccgcccc aacctgcagc
     1321 tggccaatat ggtccaggtg attcggcaga tgcacccaac ccctggtcga gggagccgcg
     1381 tgaccgatca gggcatctgt cccaaacacc aagaagccct gaagctcttc tgcgaggtag
     1441 acgaagaggc catctgtgtg gtgtgccgag aatccaggag ccacaaacag cacagcgtgg
     1501 tgccattgga ggaggtggtg caggagtaca aggccaaact gcaggggcac gtggaaccac
     1561 tgaggaagca cctggaggca gtgcagaaga tgaaagccaa ggaggagagg cgagtgacag
     1621 aactgaagag ccagatgaag tcagagctgg cagcggtggc ctcggagttt gggcgactga
     1681 cacggtttct ggctgaagag caggcagggc tggaacggcg tctcagagag atgcatgaag
     1741 cccagctggg gcgtgcggga gccgcggcta gtcgccttgc agaacaggcc gcccagctca
     1801 gccgcctgct ggcagaggcc caggagcgga gccagcaggg gggtctccgg ctgctccagg
     1861 acatcaagga gactttcaat aggtgtgaag aggtacagct gcagccccca gaggtctggt
     1921 cccctgaccc gtgccaaccc catagccatg acttcctgac agatgccatc gtgaggaaaa
     1981 tgagccggat gttctgtcag gctgcgagag tggacctgac gctggaccct gacacggctc
     2041 acccggccct gatgctgtcc cctgaccgcc ggggggtccg cctggcagag cggcggcagg
     2101 aggttgctga ccatcccaag cgcttctcgg ccgactgctg cgtactgggg gcccagggct
     2161 tccgctccgg ccggcactac tgggaggtag aggtgggcgg gcggcggggc tgggcggtgg
     2221 gtgctgcccg tgaatcaacc catcataagg aaaaggtggg ccctgggggt tcctccgtgg
     2281 gcagcgggga tgccagctcc tcgcgccatc accatcgccg ccgccggctc cacctgcccc
     2341 agcagcccct gctccagcgg gaagtgtggt gcgtgggcac caacggcaaa cgctatcagg
     2401 cccagagctc cacagaacag acgctgctga gccccagtga gaaaccaagg cgctttggtg
     2461 tgtacctgga ctatgaagct gggcgcctgg gcttctacaa cgcagagact ctagcccacg
     2521 tgcacacctt ctcggctgcc ttcctgggcg agcgtgtctt tcctttcttc cgggtgctct
     2581 ccaagggcac ccgcatcaag ctctgccctt gattatcctg ccacccgcag gggcccctct
     2641 gtcagcactt ggggggtggg tggtggaggg tggcccgtaa gtttgagggc tcaaaggctc
     2701 ttcccactgc ttgttactgt gttgcttccc actccccctt gaccccaggc ccctgcttct
     2761 ccctctagga gcctaaagaa ccctcctggc ctccagctca gccttctctc acctactatg
     2821 tctgtccaac aggtctgcat gggtccctga taatgagaac agctgcctgg tcttctctcc
     2881 cagtctgcct agcccagccc tgggactgga atttgagtag gggatgaggg gaaattgtaa
     2941 tttcattcct taacttcctt ttccccaccc ctgctcttca acctctttat cagttctgag
     3001 gctggagggt ttgggcaagg caacatcccc attccaattc cattttctga tgcagatttt
     3061 agctgaggga tttggaagcc atttggggag gcaggctggg ccaaagggta gagctgggta
     3121 ataaatgtct attctcctgg ggaggaggga ttctaaactt tccttccgtc ctcaatttct
     3181 acctccatag accggccaga atttagcttc acttgagaga gatctggaat ggtcgccatg
     3241 attgaaacca cgcaccatta catcatcatt acattaatta catcaacata aattatttct
     3301 tcccccttcc cttttccagc actcaaccaa ggagcaaagc tcatcccacc ccacacccct
     3361 cccaggtctg ctcactgcca ggctcctctc ccctttgttc agtggagctg gcttttctcc
     3421 cagccccttt ccatgccttt cactccattt ggcaagctct gagggggagc ctggggacgg
     3481 gtttgggtcc ccaggaggag agccttgggt ataatctatt tttctaggag cctcttgcct
     3541 tgtcacttgc agctttcgcc ctctgctttg atggctgagg tgaactcatg ttctttggga
     3601 aaagggaagg cgtgctgtgg aaataaaatg tttatttgct tctct
//
