LOCUS       NM_033091               3314 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens tripartite motif containing 4 (TRIM4), transcript
            variant beta, mRNA.
ACCESSION   NM_033091
VERSION     NM_033091.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Bansod,S., Dodhiawala,P.B., Geng,Y., Bulle,A., Liu,P., Li,L.,
            Townsend,R., Grierson,P.M., Held,J.M., Adhikari,H. and Lim,K.H.
  TITLE     The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by
            oncogenic KRAS
  JOURNAL   Cell Rep 43 (9), 114667 (2024)
   PUBMED   39178114
  REMARK    GeneRIF: The TRIM4 E3 ubiquitin ligase degrades TPL2 and is
            modulated by oncogenic KRAS.
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Li,Y., Gao,J., Wang,D., Liu,Z. and Zhang,H.
  TITLE     TRIM4 Expression Related to Malignant Progression and Cisplatin
            Resistance in Osteosarcoma
  JOURNAL   Appl Biochem Biotechnol 196 (1), 233-244 (2024)
   PUBMED   37115387
  REMARK    GeneRIF: TRIM4 Expression Related to Malignant Progression and
            Cisplatin Resistance in Osteosarcoma.
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Zhang,X., Yang,Z., Pan,T., Sun,Q., Chen,Q., Wang,P.H., Li,X. and
            Kuang,E.
  TITLE     SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by
            impairing TRIM4-mediated K63-linked polyubiquitination
  JOURNAL   PLoS Pathog 19 (11), e1011792 (2023)
   PUBMED   37956198
  REMARK    GeneRIF: SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses
            by impairing TRIM4-mediated K63-linked polyubiquitination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3314)
  AUTHORS   Han,D., Wang,L., Long,L., Su,P., Luo,D., Zhang,H., Li,Z., Chen,B.,
            Zhao,W., Zhang,N., Wang,X., Liang,Y., Li,Y., Hu,G. and Yang,Q.
  TITLE     The E3 Ligase TRIM4 Facilitates SET Ubiquitin-Mediated Degradation
            to Enhance ER-alpha Action in Breast Cancer
  JOURNAL   Adv Sci (Weinh) 9 (25), e2201701 (2022)
   PUBMED   35843886
  REMARK    GeneRIF: The E3 Ligase TRIM4 Facilitates SET Ubiquitin-Mediated
            Degradation to Enhance ER-alpha Action in Breast Cancer.
REFERENCE   5  (bases 1 to 3314)
  AUTHORS   Huang,Y., Li,S., Jia,Z., Li,S., He,W., Zhou,C., Zhang,R., Xu,R.,
            Sun,B., Ali,D.W., Michalak,M., Chen,X.Z. and Tang,J.
  TITLE     TRIM4 interacts with TRPM8 and regulates its channel function
            through K423-mediated ubiquitination
  JOURNAL   J Cell Physiol 236 (4), 2934-2949 (2021)
   PUBMED   33037615
  REMARK    GeneRIF: TRIM4 interacts with TRPM8 and regulates its channel
            function through K423-mediated ubiquitination.
REFERENCE   6  (bases 1 to 3314)
  AUTHORS   Oshiumi,H., Matsumoto,M., Hatakeyama,S. and Seya,T.
  TITLE     Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to
            promote interferon-beta induction during the early phase of viral
            infection
  JOURNAL   J Biol Chem 284 (2), 807-817 (2009)
   PUBMED   19017631
REFERENCE   7  (bases 1 to 3314)
  AUTHORS   Gack,M.U., Shin,Y.C., Joo,C.H., Urano,T., Liang,C., Sun,L.,
            Takeuchi,O., Akira,S., Chen,Z., Inoue,S. and Jung,J.U.
  TITLE     TRIM25 RING-finger E3 ubiquitin ligase is essential for
            RIG-I-mediated antiviral activity
  JOURNAL   Nature 446 (7138), 916-920 (2007)
   PUBMED   17392790
REFERENCE   8  (bases 1 to 3314)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 3314)
  AUTHORS   Thompson,E.E., Kuttab-Boulos,H., Yang,L., Roe,B.A. and Di Rienzo,A.
  TITLE     Sequence diversity and haplotype structure at the human CYP3A
            cluster
  JOURNAL   Pharmacogenomics J 6 (2), 105-114 (2006)
   PUBMED   16314882
REFERENCE   10 (bases 1 to 3314)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011904.3.
            
            On Jun 2, 2019 this sequence version replaced NM_033091.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies. Its function has not been identified. Alternatively spliced
            transcript variants that encode different isoforms have been
            described.[provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (beta) lacks an in-frame exon in
            the 5' coding region compared to variant alpha. The resulting
            protein (isoform beta) is shorter but has the same N- and C-termini
            compared to isoform alpha.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2307605.1, AF220024.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349062.7/ ENSP00000275736.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AC011904.3         13536-14057
            523-618             AC011904.3         23406-23501
            619-849             AC011904.3         24254-24484
            850-872             AC011904.3         29468-29490
            873-970             AC011904.3         29751-29848
            971-3314            AC011904.3         40320-42663
FEATURES             Location/Qualifiers
     source          1..3314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..3314
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /note="tripartite motif containing 4"
                     /db_xref="GeneID:89122"
                     /db_xref="HGNC:HGNC:16275"
     exon            1..522
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1554
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /EC_number="2.3.2.27"
                     /note="isoform beta is encoded by transcript variant beta;
                     tripartite motif protein 4; RING finger protein 87; E3
                     ubiquitin-protein ligase TRIM4; RING-type E3 ubiquitin
                     transferase TRIM4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM4 isoform beta"
                     /protein_id="NP_149082.1"
                     /db_xref="CCDS:CCDS5678.1"
                     /db_xref="GeneID:89122"
                     /db_xref="HGNC:HGNC:16275"
                     /translation="MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGG
                     GPFPCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQ
                     RPVCLVCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNAT
                     QWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIA
                     SLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEAVKVKTVCQIPLMKEML
                     KRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFV
                     ERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWA
                     IYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV
                     SRLRPFFWLSPLASLVIPPVTDRK"
     exon            523..618
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     exon            619..849
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     exon            850..872
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     exon            873..970
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     exon            971..3314
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /note="hexamer: ATTAAA"
     polyA_site      2774
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /note="hexamer: AGTAAA"
     polyA_site      2817
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /note="major polyA site"
     regulatory      3291..3296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
                     /note="hexamer: AATATA"
     polyA_site      3314
                     /gene="TRIM4"
                     /gene_synonym="RNF87"
ORIGIN      
        1 gcgttgtacc cttttacgtg aggcggtgac ggcggttcgg aagtcgtctg gcctccccgc
       61 ggccgctcgc agcttgctgg cctctcccgc gcctcacgtc ggactccgtc tccgcggcag
      121 ggaagcagca tggaagctga ggacatccag gaggagttga cctgccccat ctgcctggac
      181 tatttccagg acccggtgtc catcgagtgc ggccacaact tctgccgcgg ctgcctgcac
      241 cgcaactggg cgccgggcgg cggcccgttc ccctgccccg aatgtcggca cccatcggcg
      301 cccgccgcgc tgcgacccaa ctgggccctg gccaggctga ctgagaagac gcagcgccgg
      361 cgcctgggcc ccgtgccccc gggcctgtgc ggccgccact gggagccgct gcggctcttc
      421 tgcgaggacg accagcggcc agtgtgcctg gtgtgcaggg agtcccagga gcaccagact
      481 cacgccatgg cacccatcga cgaggccttc gagagctacc gggagaaact tcttaagtct
      541 cagcgtaatc tcgtggccaa gatgaagaaa gtcatgcatt tacaggatgt agaagtgaag
      601 aacgccacac agtggaagga taagataaag agtcagcgaa tgagaatcag cacggagttt
      661 tcaaagctgc acaacttcct ggttgaagaa gaggacctgt ttcttcagag attgaacaaa
      721 gaagaagaag agacgaagaa gaagctgaat gagaacacgt taaaactcaa tcaaactatc
      781 gcttcattga agaagctcat cttagaggtg ggggagaaga gccaggctcc caccctggag
      841 ctgcttcaga atccaaaaga agtgttgacc aggagtgaga tccaggatgt gaactattct
      901 cttgaagctg taaaggtgaa gacagtgtgc cagataccat tgatgaagga aatgctaaag
      961 cgattccaag tggctgtaaa cctagctgaa gacacagctc atcccaaact cgtcttctcc
     1021 caggaaggga gatacgtgaa aaatacagca tcagccagtt cttggccagt gttttcttca
     1081 gcatggaact actttgctgg atggaggaat cctcagaaga ctgcttttgt agagagattt
     1141 cagcacttac cctgtgttct gggaaaaaac gttttcacct cagggaaaca ttactgggaa
     1201 gttgagagta gagatagtct ggaggttgct gttggggtgt gtcgggagga cgtcatggga
     1261 attactgatc gttcaaaaat gtccccagat gtgggcatct gggcgattta ttggagtgct
     1321 gctggctatt ggcccttgat aggcttccct ggaactccca cccagcaaga gccagctctc
     1381 caccgagtgg gggtttacct ggatcgtggg actgggaatg tctccttcta cagcgctgtg
     1441 gacggagtgc acctgcacac cttttcttgt tcttctgtct cacgcctccg gccatttttt
     1501 tggttgagtc cattagcatc tttagtcatt ccaccagtga ctgataggaa atgaggcttt
     1561 tcttcccctg accaaaactc cttccctgta gtccagctga gggacacaca tccctgggcc
     1621 ctcttctgcc cttcatgtct ctatcctgga tggtccatct tctgggtctc cctaacggta
     1681 ccgtttggta tctgcccttt gtgtgcttca caagaggcag tcccatggga ggtgggtctg
     1741 gccaatggag atgggacagg aaattttcca agacgctttt gggaaatctt tttgtagctt
     1801 ttaaagagat gtgcggggaa gacatatgga tgttagcagc catattggaa ctgagaacac
     1861 aggaatggtg gaaaggtaga agaaacagag tttttgttgc cgttgtgaaa ttgttgaaat
     1921 ttccttcatg ccaagcttct tgttatatga gataattacg cccttattgt ataagacaat
     1981 tttagttgta tttggttact tgcagcctga agtaccgtaa ctgcactaaa gggacgtagt
     2041 gtgaacatcc cgcagtatag gcttaagtca cttttgtgaa atttgacaaa ggcatagaat
     2101 ctttttctat ccagtcaggc attgcctatt ctttccagta actactgatt cccccacttt
     2161 tctgtcttag aaaattgtgg gaatcccccc tcactctgcc tatgttgcac tctctctctt
     2221 cccaaccata actctgccct cagctattaa ctgtgctgtg tatttatcaa gttggtatgt
     2281 tgtatgtaca gtgttattca tgtcatcatg agaatgttga acgcttgtta aatatctttt
     2341 gctagcctct tcatatgctg ttgcatatga ctctcatcac aactcagtga gatggaaagt
     2401 caaatcctat ttgtacaaat gagaaaactg aactctttag agtaactagc tcagtattgg
     2461 ccagctggta aatggcagtg ttgggattaa aatccagttc ttatctactc tccctttatt
     2521 cagaagcatt tattggatgt tgatctttgt ttcaggtttt gattttgtta cttttttata
     2581 ctgtgtatat tttcctcagt ctacccttct gctctagatt gtctggactc aggagattgt
     2641 ggcagttact ggatagttat ttttaagata atgattgctt ttctctgttt atataagtca
     2701 tgtgtactta ttgtagaaag tttgtaagat gcaaaaagta taaaaattaa agttatgcac
     2761 tactaacatt tcaatatatt ttctcccaga ttttcagtaa agactttcag gcagtgattt
     2821 aacgaggatt ttattttaac ttatatttta gtttaagggg aacacgtgca ggtttgttct
     2881 atagatcaat tacatgtcac aggggtttgg tgtacatatt atttcattac ccaggtaata
     2941 agcatagtac ccaatagata cttttttgat accccaccct cctccaccct ctaccctcaa
     3001 gtagtccctg gtgtctgttg ttcccttttt tgtgtccatg ggtactcaat gtttagctct
     3061 cccttatacg tgagaacatg tgatgtttgg ttttctgttc atgtgttggt ttgcttaggg
     3121 taatggcctc cagctccatc catgttgctg caaagacatg atctcattct ttttttatgg
     3181 ctgcatagta ttccatggtg tatatgtact atgttttctt tatccagtct actgttgatg
     3241 ggcatttagg ttgattccat gtctttgcta ttgtgaatag tgctgcaatg aatatataca
     3301 tgcatatgtc tcta
//
