LOCUS       NM_006355               9418 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 38 (TRIM38), mRNA.
ACCESSION   NM_006355
VERSION     NM_006355.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9418)
  AUTHORS   Zhang,K., Lin,G., Nie,Z., Jin,S., Bing,X., Li,Z. and Li,M.
  TITLE     TRIM38 suppresses migration, invasion, metastasis, and
            proliferation in non-small cell lung cancer (NSCLC) via regulating
            the AMPK/NF-kappaB/NLRP3 pathway
  JOURNAL   Mol Cell Biochem 479 (8), 2069-2079 (2024)
   PUBMED   37566200
  REMARK    GeneRIF: TRIM38 suppresses migration, invasion, metastasis, and
            proliferation in non-small cell lung cancer (NSCLC) via regulating
            the AMPK/NF-kappaB/NLRP3 pathway.
REFERENCE   2  (bases 1 to 9418)
  AUTHORS   Liu,J., Deng,Y., Wang,A., Liu,B., Zhou,X., Yin,T., Wang,Y.,
            Tang,T., Qiu,Y., Chen,J. and Yang,J.
  TITLE     Investigation into the role of the MITA-TRIM38 interaction in
            regulating pyroptosis and maintaining immune tolerance at the
            maternal-fetal interface
  JOURNAL   Cell Death Dis 14 (11), 780 (2023)
   PUBMED   38012139
  REMARK    GeneRIF: Investigation into the role of the MITA-TRIM38 interaction
            in regulating pyroptosis and maintaining immune tolerance at the
            maternal-fetal interface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9418)
  AUTHORS   Yao,X., Dong,R., Hu,S., Liu,Z., Cui,J., Hu,F., Cheng,X., Wang,X.,
            Ma,T., Tian,S., Zhang,X.J., Hu,Y., Bai,L., Li,H. and Zhang,P.
  TITLE     Tripartite motif 38 alleviates the pathological process of
            NAFLD-NASH by promoting TAB2 degradation
  JOURNAL   J Lipid Res 64 (7), 100382 (2023)
   PUBMED   37116711
  REMARK    GeneRIF: Tripartite motif 38 alleviates the pathological process of
            NAFLD-NASH by promoting TAB2 degradation.
REFERENCE   4  (bases 1 to 9418)
  AUTHORS   Luo,H., Hu,X., Li,Y., Lei,D., Tan,G., Zeng,Y. and Qin,B.
  TITLE     The antiviral activity of tripartite motif protein 38 in hepatitis
            B virus replication and gene expression and its association with
            treatment responses during PEG-IFN-alpha antiviral therapy
  JOURNAL   Virology 579, 84-93 (2023)
   PUBMED   36623352
  REMARK    GeneRIF: The antiviral activity of tripartite motif protein 38 in
            hepatitis B virus replication and gene expression and its
            association with treatment responses during PEG-IFN-alpha antiviral
            therapy.
REFERENCE   5  (bases 1 to 9418)
  AUTHORS   Wang,X., He,H., Rui,W., Zhang,N., Zhu,Y. and Xie,X.
  TITLE     TRIM38 triggers the uniquitination and degradation of glucose
            transporter type 1 (GLUT1) to restrict tumor progression in bladder
            cancer
  JOURNAL   J Transl Med 19 (1), 508 (2021)
   PUBMED   34906161
  REMARK    GeneRIF: TRIM38 triggers the uniquitination and degradation of
            glucose transporter type 1 (GLUT1) to restrict tumor progression in
            bladder cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9418)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   7  (bases 1 to 9418)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   8  (bases 1 to 9418)
  AUTHORS   Chen,D., Li,X., Zhai,Z. and Shu,H.B.
  TITLE     A novel zinc finger protein interacts with receptor-interacting
            protein (RIP) and inhibits tumor necrosis factor (TNF)- and
            IL1-induced NF-kappa B activation
  JOURNAL   J Biol Chem 277 (18), 15985-15991 (2002)
   PUBMED   11854271
REFERENCE   9  (bases 1 to 9418)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 9418)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313248.1, U91328.1 and
            KC877159.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006355.4.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family. The encoded protein contains a RING-type zinc finger, B
            box-type zinc finger and SPRY domain. The function of this protein
            has not been identified. A pseudogene of this gene is located on
            the long arm of chromosome 4. [provided by RefSeq, Jul 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313248.1, SRR1803615.184496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357085.5/ ENSP00000349596.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1707              AK313248.1         1-1707
            1708-4602           U91328.1           154644-157538       c
            4603-5158           KC877159.1         1-556
            5159-9418           U91328.1           149828-154087       c
FEATURES             Location/Qualifiers
     source          1..9418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..9418
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="tripartite motif containing 38"
                     /db_xref="GeneID:10475"
                     /db_xref="HGNC:HGNC:10059"
     exon            1..54
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            55..288
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            289..887
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1874
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /EC_number="2.3.2.27"
                     /note="Ro/SSA ribonucleoprotein homolog; ring finger
                     protein 15; tripartite motif-containing protein 38; zinc
                     finger protein RoRet; RING-type E3 ubiquitin transferase
                     TRIM38"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM38"
                     /protein_id="NP_006346.1"
                     /db_xref="CCDS:CCDS4568.1"
                     /db_xref="GeneID:10475"
                     /db_xref="HGNC:HGNC:10059"
                     /translation="MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFF
                     KNPSQKQLRQETFCCPQCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHL
                     FCEDEGQLICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLS
                     TAMRITKWKEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAG
                     LGLKSNELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNV
                     SKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFP
                     CVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKG
                     YVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYF
                     QVYQYSPLFLPPPGD"
     exon            888..983
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1214
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1237
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1350
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..9418
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2106
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="major polyA site"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="hexamer: AGTAAA"
     polyA_site      2590
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="major polyA site"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="hexamer: AATAAA"
     polyA_site      4115
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
     regulatory      7034..7039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="hexamer: AATAAA"
     polyA_site      7056
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
     regulatory      9391..9396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
                     /note="hexamer: ATTAAA"
     polyA_site      9418
                     /gene="TRIM38"
                     /gene_synonym="RNF15; RORET"
ORIGIN      
        1 gttaacttcc tgacccagga agtggcagca acagagggga ctagcagcga atatacttta
       61 caccaaatct cagaagattc agaacttaga tgagtggggc ccaggacagg aaccctggag
      121 ccttggaagg aggggagccc catctcccca gaagagcagt gaccccagca gagaggggcc
      181 tggtgtatca ctggaggaaa tagcctgcca aggaatacac gtcttcagaa gaaattctgt
      241 gtggcttcaa gagactgatc aaattgtgag aggaaaacag cctacccggt cctcttttct
      301 tcaatacaaa atgagataat aggggttgga aggaaaacct tcaagaccta tggaagtcag
      361 ttgcagccag ctcatcacat agaggtgcag gtgaggtgta ttttcatcac ggtggaaaat
      421 tctggctgct tcatctccat ctctagagcc aatattggag cttttcaata aaagctatgg
      481 cctcaaccac cagcaccaag aagatgatgg aggaagccac ctgctccatc tgcctgagcc
      541 tgatgacgaa cccagtaagc atcaactgtg gacacagcta ctgccacttg tgtataacag
      601 acttctttaa aaacccaagc caaaagcaac tgaggcagga gacattctgc tgtccccagt
      661 gtcgggctcc atttcatatg gatagcctcc gacccaacaa gcagctggga agcctcattg
      721 aagccctcaa agagacggat caagaaatgt catgtgagga acacggagag cagttccacc
      781 tgttctgcga agacgagggg cagctcatct gctggcgctg tgagcgggca ccacagcaca
      841 aagggcacac cacagctctt gttgaagacg tatgccaggg ctacaaggaa aagctccaga
      901 aagctgtgac aaaactgaag caacttgaag acagatgtac ggagcagaag ctgtccacag
      961 caatgcgaat aactaaatgg aaagagaagg tacagattca gagacaaaaa atccggtctg
     1021 actttaagaa tctccagtgt ttcctacatg aggaagagaa gtcttatctc tggaggctgg
     1081 agaaagaaga acaacagact ctgagtagac tgagggacta tgaggctggt ctggggctga
     1141 agagcaatga actcaagagc cacatcctgg aactggagga aaaatgtcag ggctcagccc
     1201 agaaattgct gcagaatgtg aatgacactt tgagcaggag ttgggctgtg aagctggaaa
     1261 catcagaggc tgtctccttg gaacttcata ctatgtgcaa tgtttccaag ctttacttcg
     1321 atgtgaagaa aatgttaagg agtcatcaag ttagtgtgac tctggatcca gatacagctc
     1381 atcacgaact aattctctct gaggatcgga gacaagtgac tcgtggatac acccaggaga
     1441 atcaggacac atcttccagg agatttactg ccttcccctg tgtcttgggt tgtgaaggct
     1501 tcacctcagg aagacgttac tttgaagtgg atgttggcga aggaaccgga tgggatttag
     1561 gagtttgtat ggaaaatgtg cagaggggca ctggcatgaa gcaagagcct cagtctggat
     1621 tctggaccct caggctgtgc aaaaagaaag gctatgtagc acttacttct cccccaactt
     1681 cccttcatct gcatgagcag cccctgcttg tgggaatttt tctggactat gaggccggag
     1741 ttgtatcctt ttataacggg aatactggct gccacatctt tactttcccg aaggcttcct
     1801 tctctgatac tctccggccc tatttccagg tttatcaata ttctcctttg tttctgcctc
     1861 ccccaggtga ctaaggaaaa gagcagaagc tccttggttt aaccagcaca gagaaaataa
     1921 tataaatccc ataagggcag acgtttggtc tgttttcttc gctgtcattt ccttagtagt
     1981 tagactagtg ctgagatttt agtggatata taattgattt atgttgaata tatggactta
     2041 gcaactaaaa ataccacaga tggttaacct ggactggggc aaagcaagat aatagtgatg
     2101 atcgtatgtt gctgtctcca tccgtcttta atgggtcagg gctttgattt ccaagggtct
     2161 tcaggtgatg agtaggggta cccacaagtc agaaggtctg cgttctccta gtttgtttgc
     2221 tgccatttga actcatgtag ggaatgaaag aaagctgcaa ttatccgcca actgcattta
     2281 aaacaaaaca aaacagaaaa atcaaaataa cattgactct tccaaccact gacatgttgt
     2341 ttaataatct aagcggcagt cctggaggct accagactta ctgagttcta cctgagaaac
     2401 agccaagcaa agtgtgagag aagggttaag actggcttac aatgagatgc ttcaaatgaa
     2461 aagggaatta tgagtaaaat tgaactttga tgggggattc agttctggaa aagaatttgg
     2521 tattttccag tctgctagga ccaattacct tgaaatattt taaaatctca gtaaatagtt
     2581 attgctgaaa tggctgttgg cagttcttat tatgattcag agaagagcaa atagacctta
     2641 acttcatttt gaaaaagacc aaattaccat acccgagtga gtaatgacag gactacaact
     2701 aaaacataaa caacattaat gatgaccata aaaagtcaca aaattgctaa atgttataat
     2761 ttagagttga cataaaaatt gatggccagg catggtggct cacgcctgta atcccagaac
     2821 tatgtgaggc tgaggcaggt ggatcacttg aggtcaggag ttcaacacca gcctggccaa
     2881 catggtgaaa ccctgtctct actaaaaata caaaaattag ccgggcatgg tggtaggggc
     2941 ctgtaaccca gctactcgtg aggccaaggc aggagaattg cttgagcctg cagcagctgc
     3001 agtaagccaa gatcatgctg tgcctcaagg aaaaaaaaaa ttaatgttta ctgatatttg
     3061 ttgaagtcct acaacatcac ctctgagaat aggagaaatg aagcaacagt tgtgtctaga
     3121 tgtcagaggc atggctgggc ctccatctct gcctaaggga gatataaaag agttcaaact
     3181 attgcccatg ttccccaggg tcagaagttc taattatgat gatagaggct gggttgtaag
     3241 tagtaagtga agggtagcag aatatgccat ctttggcata agaagtattt tgagttgaag
     3301 acaattgaga aaaaaaatag attaaaaaca aacaaacacc tctgccctct ccctatttgc
     3361 ctaaaagcag gatatgaaat tgtgaaggtg tcttcttact cggggaagaa caaaagttag
     3421 tcaccagaga ctttagactc ttatcagcct ggacatagca ccagagaagt cttttttttt
     3481 aaaaaaaaaa aaaaaaaaag ggaaagaaaa agttgccttc ccacaattta ctgcactaga
     3541 aactcaaagt ccttttcgtc ttccttgtca cttaaaaaat gtattctttt cttaaaatgc
     3601 tatataagcc caagttctaa atcctctttt gagtattcat ctcagtactc ccctgtgttt
     3661 gtacaatgca catgctttgt ttctgtcttg tcaatctgtc ttttgttagt ctacttgata
     3721 gggccacaga tggagaacct aagatgaata gaaaaaaaag atttttctcc ccaacagaag
     3781 gattatcgcc agttgcactt gttctatata cccgtagtct cggtatgctg acccagactt
     3841 gggtaatagg acccagtggg taaccgagga accccacctt tgtgcaggat cagtgaagat
     3901 gtaatctgga tattcataag ctcttctcta cctcttggca tcccacagtc ctgtgttaat
     3961 gtaagtgtgg tcttccccag aaaggggagg cctccctaac attgttaaag cctagcatat
     4021 gctgcttaga ggaaattcta tatccctaag cacttagatt gctgaataag aaagaatgat
     4081 aataaaataa acaattaaat aaaagtttta aaaaatgaat aaaataaacc tgtggaaact
     4141 ataaggaagg ccagaagaaa tataaaattg gagattaatt ggggtgcagg aaagttatgg
     4201 aaagaatata agtcctgcta gataaatcat tagctatttt aataaagaat acagaagaaa
     4261 ataggaacaa aagaatatat actggaataa ttttgagagt aatttgaaga attagatgca
     4321 aataaatttg aaaaccttta aaaagaaacc aatggcctaa ctgacccaag aagggaaaga
     4381 aaatctaaac agactgataa atacaaaatg aaattcagac acttacagag cagccaggca
     4441 tggtggctca cacctgtaat cctgtcactt tgggaggctg agatgggagg atcacttgag
     4501 gctaggagtt tgagactagc ctgggcaagg ctcccatctc taaaagaaaa gaaattagct
     4561 gggcatggtg gcatgtgcct tagtttcagc tactcaggag gctgagacga ggattgcttg
     4621 agcctaggag ggcaaggctg cagtgagcca tggtcatgcc actgaattcc agcctaagtg
     4681 acagagcaag accttgtctc aaaaaaaaaa aaaaaaaaag ttacagagct ccaactaaat
     4741 aatgtgggga acaaaagaaa aaagaagatg attttatggc tgattttttt tttaaggaaa
     4801 agcaattcat gtacccttga agattagatt aagttctata aaatagccca aaatgacagt
     4861 ggctgaaaca agtttatttc tctcccattt aaagcaagtc tagatgtgga agtctgggaa
     4921 gcccagaaaa tccaggtctt gtttgtgtat ggaaactcca gaaaatcaca gattccttcc
     4981 agccacccct caattacccc tgggatccaa gagagccact aaagttccag ccatcatact
     5041 cacaacccaa gttgtaggat ggaaaaaagg acacaaaagt agggtgaaga gcatgtgtgc
     5101 aacagctctc ttttactcta gtgtcctaaa acctatcata aaacctttgg cttgccttgc
     5161 attagccaga atttagtaca tggccacact taagaagtca gaaagattag ctttttttcc
     5221 agggtagttg gctgaaaatc aggagttctc atattaaaaa acagagaagg gacatcgaat
     5281 agatgaccaa caatctcctt cacactcata ctatttaaac tgtcctagtc aatgaccaaa
     5341 aaagaaaagc ctacaaactc attgatataa aagcttaaca aaggtactcc ccgccccccg
     5401 cccgccacac accatcccca aaaggaaatt tctaatccaa ttaacagtct taggttgggc
     5461 tgctgaaaca aaataccaca gcctgagtga cttaaacaac gacaatttat ctctcactgt
     5521 tctgaggtct gagttgattc tttgtgaagg ccctttccta gcttgcagat ggctaccttc
     5581 ctgctatgtc ttcacatggc aaagagagag ctagctttct ggtcttttct tataagggac
     5641 cagtcccatc atgcccatca tgaagactcg atctgctagg atctcaacta aacctaacta
     5701 tcacccaaag agcccacctc caaagaccat cacattgaat gtgagagttt ctacatatgc
     5761 attgtgggaa acacaaacat ttacttcaac tgtaactatt gaagcaaaaa tgtcccccca
     5821 ccatagacat ccagcaccac agtagtacat ttattacaat tgaacttaca ttgacacgtc
     5881 attatcaacg aaagtctgta atttacatta gggtttattc ttggtgttgt gctttctatg
     5941 ggttttgaca aatgtataat gtcatgtatt caccattata gtatcacaga agtttcactg
     6001 ccctaaaaat cctgtgttct gccttttcaa cacttcctgt cacccaattt ctatcaacta
     6061 atcttttgac tgtgtccata gttactgtct tttctagagt gtcatacagt tgtgaagcag
     6121 gaagcaggag tgaactccgg aggcagggac tttactccgg accagattga agactagccg
     6181 aaacagggac gaggttaaag cacctctcca taagacacgc ccaccagcgc catgtcagtt
     6241 tttcgttgcc atggcaacaa caggacatta tcgacttctt tcctctgtac ctactccgaa
     6301 gttaccactc tttttctaga aatttctgca taatccccct taacatgcac ttaactaaaa
     6361 gcaggtatat tactgcagaa ctgcccctga gctgctactc tgggcacatt acttatgggt
     6421 tagccctgct cagcaaggag cagtacctgt tctgctgttg tacactgctg cttcagtaaa
     6481 agttgctaac accaccactt cacccttgaa ttcttcccgg gctaagccct aatttttggc
     6541 ttgcttgccc tgcatcagtt ggagtcatat agtatgcagt cttttcaggt tggcttttta
     6601 gtaacataca tttaagtttc cttcatgtgt tttcatggct tgatcgtttc ttttcttttt
     6661 ctttttcttt tttcttttct ttcttttttt tttttttttt gagacagagg agtcttgctc
     6721 tgttgcccag gctgaagtgc agtggcactg gctcactgca acctccatct cccaggttca
     6781 aacgattctc atatctcagc ctcccgagta gctgggatta caggctcacg ccactatgcc
     6841 cggctaattg gggttttccc atgttgacca ggctggtctc aaactcctgg cctcaagcaa
     6901 tccacccact tcggcctccc aaagtgaatg catttctttt taactctaaa taacattcca
     6961 ttattcagaa gtaccacagt tatccactta cctactgaaa gacatcttgt ttccaagttt
     7021 tggataaatt atgaataaag ctgctataaa catctatgtg caggtttttg tgtggagata
     7081 agttttcaat tcctttggat aaatactaag gagtgtgatt ggtgaatctt atggtaaaag
     7141 tatggttact tttgtaagaa accaccaaac tgtcttccaa agtgattgca cattttgcat
     7201 tctcaccagt aatgaacaag ttactattgc tacatatctt tgcaaccttt ggtgctgaca
     7261 gtgttctaaa ttttggtcat tctactaggt atgcagtggt atctacttgt tttaatttgc
     7321 agttccctaa tgacatgatg tcaagcatct tttcatatgc atacttgcat ctgtgtatct
     7381 tctttggtga acagatgttc aggtcattgg cctgctttaa atcaggttat tttcttactg
     7441 ttgagtttta agtattcttt gtatattcta aaaatattgt tcttcatcag atctgtcttt
     7501 tgcaaacatt acctgccaat gtgtggcttt tcttcaacac ttctttgtaa atttgcaagt
     7561 cctttgagaa aagaaatgca cccaaagtat taatttggca atctcatatc acgagagtac
     7621 tctaaagcta aataaattac agtttttcaa attttgaatt aattgatctt tgctattgtt
     7681 agcaaggtct tgtattcttt tttttttttt tttttttttt taatagagac gggtcttgct
     7741 acagtgccca ggctggtctc gaactccagg cctaaaatga tcctcctgcc ttggccttcc
     7801 aaagtactgg gattacaggc ataagtcacc acgctcagcc atctggtatt ctttagcaac
     7861 tgtttggtaa cttaatcttt cactttttga aaacaaaaaa tagttttttt ctcatagttt
     7921 tctaacaaaa tcttcataac tgaaataatt tctctttatc acctcttctt ataaatatgg
     7981 ttttcttttt ttaaataaaa atttaagaca ttttataact ggccaaattt actagcttag
     8041 atactattag atagtcaata ttttttgttg gatatttgat ttttatttca ggcaactaat
     8101 atctattcat ttttgcactg ttggaagaaa attactgatc aaattcacta tgtatttgca
     8161 gaaaatggct ttcaatattg tctactttat catccttttt ttttttttct ttcttccttt
     8221 ttagatacag ggtctcacta tgttgcccag gctggtctcc aacttctggg ctcaaacaat
     8281 cctccctcct tggccttcca aagggttgga tatgttttat ctacagtttt gttgttttgt
     8341 tctgctacag gatatttgca attgccattt atcatgaaat tcatgacata ccttcttcca
     8401 ctctcctttt tatctttatt gttctggtta taggactagc tttgcatctc tactcaattc
     8461 tgtatcagta gtatgctttc attttaaatt ttaagtttgt ccatatgtat attgacacag
     8521 ggtcttgctc tgttgcccag actggagtgc agtggcaaga tcagggctca ctgcagcctt
     8581 gactgcctag gctcaagtca tcctcccacc tcagcctcca gaatggctgg gactacaggc
     8641 acgcaccacc acacatggct catttttttg tattgagaca gggtttctcc atgttgccca
     8701 ggctggtctt gaactactgg gctcaagcaa tcctcccacc ttagcctccc aaagtgttgg
     8761 gattacaggc ttgagccacc atgcctcgct tctacactta tttttaattc taaaataatt
     8821 tataataata aatattaaca attagattta attactgata aatattaaat gttaaatagg
     8881 ttttattaaa taattaaata aaaatgaaaa taatcagtat ttcaatttaa ttactaatta
     8941 taattcacag ttatccttgt aactcctaat gtctatataa aagattttta tattttttaa
     9001 ttcttaaaat tttattattt atttcacacc aggccatcac tgtgatacat tttttaaaac
     9061 acattaaatt atcaccagaa aagtgctgtg atggaaaata taaattgaaa taccttttct
     9121 ggttaggaga gtaattctgt ttttctgata gagaatagaa gagtccttca ggcccctcca
     9181 aactgtcata ttccgggcat cgggtgtccc catcctcact tcagtccaca ggcagggtcc
     9241 tcagtcttca gcgctccttc tctttcccct ttgtcttgtg tctccttggg tctcttttct
     9301 ccaagaccta aactccctga ggacaggact attttttaca tcttgatgtc actcctgagc
     9361 acttgcttta atgtgttgga cactgggtcc attaaagatt gtatgtgaaa ttataaaa
//
