LOCUS       NM_015294               4489 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 37 (TRIM37), transcript
            variant 1, mRNA.
ACCESSION   NM_015294
VERSION     NM_015294.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4489)
  AUTHORS   Cai,L., Liu,Y., Li,Y., Liu,B., Cao,Y., Yang,W., Wang,B. and Sun,T.
  TITLE     TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and
            regulate stemness in glioma stem cells through sonic hedgehog
            pathway
  JOURNAL   J Neurooncol 169 (2), 269-279 (2024)
   PUBMED   38884661
  REMARK    GeneRIF: TRIM37 interacts with EZH2 to epigenetically suppress
            PTCH1 and regulate stemness in glioma stem cells through sonic
            hedgehog pathway.
REFERENCE   2  (bases 1 to 4489)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   3  (bases 1 to 4489)
  AUTHORS   Li,D. and Zhang,Z.
  TITLE     TRIM37 promotes the aggressiveness of ovarian cancer cells and
            increases c-Myc expression by binding to HUWE1
  JOURNAL   Arch Biochem Biophys 728, 109372 (2022)
   PUBMED   35921902
  REMARK    GeneRIF: TRIM37 promotes the aggressiveness of ovarian cancer cells
            and increases c-Myc expression by binding to HUWE1.
REFERENCE   4  (bases 1 to 4489)
  AUTHORS   Cui,G., Gao,Z., Chang,S., Narwade,N., Chen,Y., Poudel,B.,
            Lei,K.M.K., Zhang,W., Li,G., Poon,T.C.W. and Cheung,E.
  TITLE     TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular
            Localization via K63-linked Ubiquitination to Drive Breast Cancer
            Progression
  JOURNAL   Int J Biol Sci 18 (11), 4316-4328 (2022)
   PUBMED   35864973
  REMARK    GeneRIF: TRIM37 Augments AP-2gamma Transcriptional Activity and
            Cellular Localization via K63-linked Ubiquitination to Drive Breast
            Cancer Progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4489)
  AUTHORS   Sivunen,J., Karlberg,S., Kivisaari,R., Lohi,J., Karlberg,N.,
            Jokinen,E., Sarkola,T., Jahnukainen,T., Lipsanen-Nyman,M. and
            Jalanko,H.
  TITLE     Liver pathology and biochemistry in patients with mutations in
            TRIM37 gene (Mulibrey nanism)
  JOURNAL   Liver Int 42 (6), 1369-1378 (2022)
   PUBMED   35220664
  REMARK    GeneRIF: Liver pathology and biochemistry in patients with
            mutations in TRIM37 gene (Mulibrey nanism).
REFERENCE   6  (bases 1 to 4489)
  AUTHORS   Lehesjoki,A.E., Reed,V.A., Mark Gardiner,R. and Greene,N.D.
  TITLE     Expression of MUL, a gene encoding a novel RBCC family ring-finger
            protein, in human and mouse embryogenesis
  JOURNAL   Mech Dev 108 (1-2), 221-225 (2001)
   PUBMED   11578880
REFERENCE   7  (bases 1 to 4489)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   8  (bases 1 to 4489)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 4489)
  AUTHORS   Avela,K., Lipsanen-Nyman,M., Idanheimo,N., Seemanova,E.,
            Rosengren,S., Makela,T.P., Perheentupa,J., Chapelle,A.D. and
            Lehesjoki,A.E.
  TITLE     Gene encoding a new RING-B-box-Coiled-coil protein is mutated in
            mulibrey nanism
  JOURNAL   Nat Genet 25 (3), 298-301 (2000)
   PUBMED   10888877
REFERENCE   10 (bases 1 to 4489)
  AUTHORS   Avela,K., Lipsanen-Nyman,M., Perheentupa,J.,
            Wallgren-Pettersson,C., Marchand,S., Faure,S., Sistonen,P., de la
            Chapelle,A. and Lehesjoki,A.E.
  TITLE     Assignment of the mulibrey nanism gene to 17q by linkage and
            linkage-disequilibrium analysis
  JOURNAL   Am J Hum Genet 60 (4), 896-902 (1997)
   PUBMED   9106536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC351295.1, AK289674.1,
            AB020705.1 and CN388771.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015294.5.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family, whose members are involved in diverse cellular functions
            such as developmental patterning and oncogenesis. The TRIM motif
            includes zinc-binding domains, a RING finger region, a B-box motif
            and a coiled-coil domain. The RING finger and B-box domains chelate
            zinc and might be involved in protein-protein and/or
            protein-nucleic acid interactions. Mutations in this gene are
            associated with mulibrey (muscle-liver-brain-eye) nanism, an
            autosomal recessive disorder that involves several tissues of
            mesodermal origin. TRIM37 localizes in peroxisomal membranes, and
            has been implicated in human peroxisomal biogenesis disorders.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.21840.1,
                                           SRR1660805.90286.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262294.12/ ENSP00000262294.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               DC351295.1         26-169
            145-3481            AK289674.1         1-3337
            3482-4485           AB020705.1         3108-4111
            4486-4489           CN388771.1         345-348
FEATURES             Location/Qualifiers
     source          1..4489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..4489
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /note="tripartite motif containing 37"
                     /db_xref="GeneID:4591"
                     /db_xref="HGNC:HGNC:7523"
                     /db_xref="MIM:605073"
     exon            1..440
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..3314
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     RING-B-box-coiled-coil protein; E3 ubiquitin-protein
                     ligase TRIM37; mulibrey nanism protein; RING-type E3
                     ubiquitin transferase TRIM37"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM37 isoform a"
                     /protein_id="NP_056109.1"
                     /db_xref="CCDS:CCDS32694.1"
                     /db_xref="GeneID:4591"
                     /db_xref="HGNC:HGNC:7523"
                     /db_xref="MIM:605073"
                     /translation="MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWL
                     TEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKL
                     SVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISL
                     VQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELL
                     ESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSY
                     DSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAG
                     LPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNP
                     QNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKS
                     RDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNED
                     YHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNN
                     MELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLD
                     LKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQM
                     AEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELL
                     AKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSP
                     GSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMV
                     TLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEE
                     QEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR"
     exon            441..542
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..583
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..700
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..788
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..911
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1035
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1103
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1228
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1279
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1361
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1438
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1618
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1733
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1949
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2086
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2172
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2367
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2676
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2805
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2995
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3114
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3231
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..4489
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4469..4474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="TRIM37"
                     /gene_synonym="MUL; POB1; TEF3"
                     /note="major polyA site"
ORIGIN      
        1 gcagcttctc tcgccgccgc gcccccagct gctctggtta cggttggtgt ttgcgaattc
       61 tctgcggcac cttcttcgct gaactccacc gtcagttcca taggcgcgcg cccgcgtcac
      121 gtgggccgag gttccggcgc ggctgctggc cggcggctga gccgggagaa aggagctgcg
      181 gccaccgttc gccctacttc tgcgcctcgg ggcgggcgcg ccggtaaaaa tggcgaaatg
      241 ggggtaggcg gcgctggacc tgaagagatg gggcgcgcag gtggggcggt tgtcagagcc
      301 ccctgacgtg ggcgccgggc ttttatcggc gatttgatct ggcgacctcg ggccggcgcc
      361 taagaggtca gactgcggag cctgcgggtc gccagcggcc ccgccgagag ccggaggcaa
      421 tggatgaaca gagcgtggag agcattgctg aggttttccg atgtttcatt tgtatggaga
      481 aattgcggga tgcacgcctg tgtcctcatt gctccaaact gtgttgtttc agctgtatta
      541 ggcgctggct gacagagcag agagctcaat gtcctcattg ccgtgctcca ctccagctac
      601 gagaactagt aaattgtcgt tgggcagaag aagtaacaca acagcttgat actcttcaac
      661 tctgcagtct caccaaacat gaagaaaatg aaaaggacaa atgtgaaaat caccatgaaa
      721 aacttagtgt attttgctgg acttgtaaga agtgtatctg ccatcagtgt gcactttggg
      781 gaggaatgca tggcggacat acctttaaac ctttggcaga aatttatgag caacacgtca
      841 ctaaagtgaa tgaagaggta gccaaacttc gtcggcgtct catggaactg atcagcttag
      901 ttcaagaagt ggaaaggaat gtagaagctg taagaaatgc aaaagatgag cgtgttcggg
      961 aaattaggaa tgcagtggag atgatgattg cacggttaga cacacagctg aagaataagc
     1021 ttataacact gatgggtcag aagacatctc taacccaaga aacagagctt ttggaatcct
     1081 tacttcagga ggtggagcac cagttgcggt cttgtagtaa gagtgagttg atatctaaga
     1141 gctcagagat ccttatgatg tttcagcaag ttcatcggaa gcccatggca tcttttgtta
     1201 ccactcctgt tccaccagac tttaccagtg aattagtgcc atcttacgat tcagctactt
     1261 ttgttttaga gaatttcagc actttgcgtc agagagcaga tcctgtttac agtccacctc
     1321 ttcaagtttc aggactttgc tggaggttaa aagtttaccc agatggaaat ggagttgtgc
     1381 gaggttacta cttatctgtg tttctggagc tctcagctgg cttgcctgaa acttctaaat
     1441 atgaatatcg tgtagagatg gttcaccagt cctgtaatga tcctacaaaa aatatcattc
     1501 gagaatttgc atctgacttt gaagttggag aatgctgggg ctataataga tttttccgtt
     1561 tggacttact cgcaaatgaa ggatacttga atccacaaaa tgatacagtg attttaaggt
     1621 ttcaggtacg ttcaccaact ttctttcaaa aatcccggga ccagcattgg tacattactc
     1681 agttggaagc tgcacagact agttatatcc aacaaataaa caaccttaaa gagagactta
     1741 ctattgagct gtctcgaact cagaagtcaa gagatttgtc accaccagat aaccatctta
     1801 gcccccaaaa tgatgatgct ctggagacac gagctaagaa gtctgcatgc tctgacatgc
     1861 ttctcgaagg tggtcctact acagcttctg taagagaggc caaagaggat gaagaagatg
     1921 aggagaagat tcagaatgaa gattatcatc acgagctttc agatggagat ctggatctgg
     1981 atcttgttta tgaggatgaa gtaaatcagc tcgatggcag cagttcctct gctagttcca
     2041 cagcaacaag taatacagaa gaaaatgata ttgatgaaga aactatgtct ggagaaaatg
     2101 atgtggaata taacaacatg gaattagaag agggagaact catggaagat gcagctgctg
     2161 caggacccgc aggtagtagc catggttatg tgggttccag tagtagaata tcaagaagaa
     2221 cacatttatg ctccgctgct accagtagtt tactagacat tgatccatta attttaatac
     2281 atttgttgga ccttaaggac cggagcagta tagaaaattt gtggggctta cagcctcgcc
     2341 cacctgcttc acttctgcag cccacagcat catattctcg aaaagataaa gaccaaagga
     2401 agcaacaggc aatgtggcga gtgccctctg atttaaagat gctaaaaaga ctcaaaactc
     2461 aaatggccga agttcgatgt atgaaaactg atgtaaagaa tacactttca gaaataaaaa
     2521 gcagcagtgc tgcttctgga gacatgcaga caagcctttt ttctgctgac caggcagctc
     2581 tggctgcatg tggaactgaa aactctggca gattgcagga tttgggaatg gaactcctgg
     2641 caaagtcatc agttgccaat tgttacatac gaaactccac aaataagaag agtaattcgc
     2701 ccaagccagc tcgatccagt gtagcaggta gtctatcact tcgaagagca gtggaccctg
     2761 gagaaaatag tcgttcaaag ggagactgtc agactctgtc tgaaggctcc ccaggaagct
     2821 ctcagtctgg gagcaggcac agttctcccc gagccttgat acatggcagt atcggtgata
     2881 ttctgccaaa aactgaagac cggcagtgta aagctttgga ttcagatgct gttgtggttg
     2941 cagttttcag tggcttgcct gcggttgaga aaaggaggaa aatggtcacc ttgggggcta
     3001 atgctaaagg aggtcatctg gaaggactgc agatgactga tttggaaaat aattctgaaa
     3061 ctggagagtt acagcctgta ctacctgaag gagcttcagc tgcccctgaa gaaggaatga
     3121 gtagcgacag tgacattgaa tgtgacactg agaatgagga gcaggaagag cataccagtg
     3181 tgggcgggtt tcacgactcc ttcatggtca tgacacagcc cccggatgaa gatacacatt
     3241 ccagttttcc tgatggtgaa caaataggcc ctgaagatct cagcttcaat acagatgaaa
     3301 atagtggaag gtaattgcca aatcaagaga actgacttgc aagctacctt gaccctgaat
     3361 tttgctgtag ttggtgctca aatttgtcat cagtcagata atcagatttg gtcttatttc
     3421 ttcattatct cgacctgaaa tagtaatttg gaaactgttg gaaggtggca cagtttagtc
     3481 taagacagca gtagtacatg ggaaaaacag tatgggaaga gttctttgta atgtaaggaa
     3541 ataacaatgt agttctctat taatttagca aatttgtaca ttcacaaaag gcagtttgtc
     3601 tactacagca gaaggctggt taactgccag aaaatgtacc tccaggccct gcatgccgtc
     3661 agtaacccgc ccggcattgg tgctctactg tctttggcta gagcttagtt gtgtttaaat
     3721 aatcatcttt atatttgggg ttttaattac agttccatta gtgcctgtag attagtgaac
     3781 agaaaattgc tttggaagag attctgccct gtagacacta tgtgaataac tgaagtaaca
     3841 ctagactgaa tctccttttt ggagtatgta tcttctctca cttgttcaag tacaggcaca
     3901 ctgttcaacc gcatggtatc tttctgttgt gtgacttcta caaatgtaat tttaaatgaa
     3961 attaagttaa catggattca ttacgttcct ggccctgtag acacgtgtaa gattatttaa
     4021 aattctttca tttttttctg cctcttacta tacgactgta gtgcaacaaa tattttaaag
     4081 cccccttttc ttctttattt tcattagttg tacattgatt tcagtgtcaa cacatttaaa
     4141 gattcattca tgttgcacag tggcttacat gaacgtgaaa ctgtgatata aggttttctt
     4201 tcatactcat aattagccca aaacagttgc caaactttgc cattgtgctc ctgcatttgt
     4261 gtttgagctg ctatatattt gtggaaatta cactgaaagt tgactaagag actattgaaa
     4321 aagcatgaat aattaaatat acatgtgaga gacatctcat ctgctgtatt ttacttagtg
     4381 aatattgttc actcttccgt gtctgatgtc ttgctgaatg ctgtgactca tagtttactt
     4441 ttgttcaaaa tagtttgcac tttttgttaa taaaatcaac ttgagaaaa
//
