LOCUS       NM_001300759            4156 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 36 (TRIM36), transcript
            variant 5, mRNA.
ACCESSION   NM_001300759 XM_005272031
VERSION     NM_001300759.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4156)
  AUTHORS   Liu,X., Yan,C., Chang,C., Meng,F., Shen,W., Wang,S. and Zhang,Y.
  TITLE     FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal
            Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis
  JOURNAL   Adv Sci (Weinh) 10 (35), e2304521 (2023)
   PUBMED   37875418
  REMARK    GeneRIF: FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in
            Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
REFERENCE   2  (bases 1 to 4156)
  AUTHORS   Cao,Z., Ma,L., Cai,W., Niu,X., Yang,N., Ni,J., Wang,X., Wei,M.,
            Chen,S. and Li,Y.
  TITLE     Genome-wide association study reveals HSF2, GJA1 and TRIM36 as
            susceptibility genes for preeclampsia: a community-based population
            study in Tianjin, China
  JOURNAL   Hypertens Pregnancy 42 (1), 2256863 (2023)
   PUBMED   37735976
  REMARK    GeneRIF: Genome-wide association study reveals HSF2, GJA1 and
            TRIM36 as susceptibility genes for preeclampsia: a community-based
            population study in Tianjin, China.
REFERENCE   3  (bases 1 to 4156)
  AUTHORS   Zhao,X., Zhou,T., Wang,Y., Bao,M., Ni,C., Ding,L., Sun,S., Dong,H.,
            Li,J. and Liang,C.
  TITLE     Trigred motif 36 regulates neuroendocrine differentiation of
            prostate cancer via HK2 ubiquitination and GPx4 deficiency
  JOURNAL   Cancer Sci 114 (6), 2445-2459 (2023)
   PUBMED   36799474
  REMARK    GeneRIF: Trigred motif 36 regulates neuroendocrine differentiation
            of prostate cancer via HK2 ubiquitination and GPx4 deficiency.
REFERENCE   4  (bases 1 to 4156)
  AUTHORS   Yu,S., Li,W., Liu,X., Zhang,H., Liu,X. and Zhang,L.W.
  TITLE     TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits
            tumorigenesis through promoting RAD51 ubiquitination and
            antagonizing hsa-miR-376a-5p
  JOURNAL   Biochem Biophys Res Commun 628, 1-10 (2022)
   PUBMED   36058131
  REMARK    GeneRIF: TRIM36 enhances lung adenocarcinoma radiosensitivity and
            inhibits tumorigenesis through promoting RAD51 ubiquitination and
            antagonizing hsa-miR-376a-5p.
REFERENCE   5  (bases 1 to 4156)
  AUTHORS   Zhao,B., Qiao,G., Li,J., Wang,Y., Li,X., Zhang,H. and Zhang,L.
  TITLE     TRIM36 suppresses cell growth and promotes apoptosis in human
            esophageal squamous cell carcinoma cells by inhibiting
            Wnt/beta-catenin signaling pathway
  JOURNAL   Hum Cell 35 (5), 1487-1498 (2022)
   PUBMED   35768649
  REMARK    GeneRIF: TRIM36 suppresses cell growth and promotes apoptosis in
            human esophageal squamous cell carcinoma cells by inhibiting
            Wnt/beta-catenin signaling pathway.
REFERENCE   6  (bases 1 to 4156)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 4156)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
  REMARK    GeneRIF: TRIM36 has a ubiquitin ligase activity and interacts with
            centromere protein-H, potentially associated with chromosome
            segregation and its excess may cause chromosomal instability.
REFERENCE   8  (bases 1 to 4156)
  AUTHORS   Kitamura,K., Nishimura,H., Nishimune,Y. and Tanaka,H.
  TITLE     Identification of human HAPRIN potentially involved in the acrosome
            reaction
  JOURNAL   J Androl 26 (4), 511-518 (2005)
   PUBMED   15955891
  REMARK    GeneRIF: molecular cloning and characterization of a human haprin
            ortholog.
REFERENCE   9  (bases 1 to 4156)
  AUTHORS   Balint,I., Muller,A., Nagy,A. and Kovacs,G.
  TITLE     Cloning and characterisation of the RBCC728/TRIM36 zinc-binding
            protein from the tumor suppressor gene region at chromosome 5q22.3
  JOURNAL   Gene 332, 45-50 (2004)
   PUBMED   15145053
  REMARK    GeneRIF: The overexpression of the TRIM36 in the vast majority of
            prostate cancer suggest that this gene might be involved in the
            prostate tumorigenesis.
REFERENCE   10 (bases 1 to 4156)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296389.1, AK316422.1,
            AC094104.2 and AJ272269.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001300759.1.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. Multiple alternatively spliced transcript
            variants that encode different protein isoforms have been described
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5) has an alternate 5' terminal
            exon, compared to variant 1. The resulting isoform (5) is shorter
            and has a distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296389.1, SRR11853566.22643.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513154.6/ ENSP00000423934.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1174              AK296389.1         54-1227
            1175-2269           AK316422.1         1133-2227
            2270-4045           AC094104.2         186369-188144       c
            4046-4156           AJ272269.1         3935-4045
FEATURES             Location/Qualifiers
     source          1..4156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..4156
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /note="tripartite motif containing 36"
                     /db_xref="GeneID:55521"
                     /db_xref="HGNC:HGNC:16280"
                     /db_xref="MIM:609317"
     exon            1..301
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..2425
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 5;
                     zinc-binding protein Rbcc728; tripartite motif protein 36;
                     E3 ubiquitin-protein ligase TRIM36; RING finger protein
                     98; tripartite motif-containing protein 36; RING-type E3
                     ubiquitin transferase TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 5"
                     /protein_id="NP_001287688.1"
                     /db_xref="CCDS:CCDS75287.1"
                     /db_xref="GeneID:55521"
                     /db_xref="HGNC:HGNC:16280"
                     /db_xref="MIM:609317"
                     /translation="MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKC
                     VKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFP
                     CPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCM
                     DCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRP
                     VCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKET
                     ECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENN
                     GLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQT
                     ELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMS
                     WNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEK
                     CGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
                     RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLV
                     TIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVD
                     CSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM"
     exon            302..536
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            537..862
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1009
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1105
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1359
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1484
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1772
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2070
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..4156
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2556..2561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /note="hexamer: AATACA"
     polyA_site      2576
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /note="major polyA site"
     regulatory      4115..4120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /note="hexamer: AATAAA"
     polyA_site      4156
                     /gene="TRIM36"
                     /gene_synonym="ANPH; ANPH1; HAPRIN; RBCC728; RNF98"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccgca ggagccgctg ctgcagccgg cagctgggcg ggattcccgg ggtagtcgct
       61 gggagcaaag ctcgcttctc ccgcgcctgt gcttttgcct gccccggctt acttctcccc
      121 gcgtcggtcc gctggccacg tacagctgac cagctcatct tccagcttcg gaccgaggct
      181 ccacggccgc cgcagggacc cgcccaccag accctgcgct cggtagccgg tgtgagtgga
      241 acgtgccgct gatgacacct ggcagaaggc agccatggag ggcgatggct cagattcgcc
      301 ggttaccatt aagaatatcg aaagggagct catttgccca gcatgcaagg agctgtttac
      361 ccacccattg attctccctt gccaacatag tatctgtcat aaatgtgtaa aagaactcct
      421 gctgactctc gatgattcat tcaacgatgt gggatcagac aactccaatc aaagcagtcc
      481 tcgacttcgg ctcccctccc ctagtatgga taaaattgac cgaattaaca gaccaggctg
      541 gaagcgcaat tcattgaccc cgaggacaac tgttttccct tgccctggct gtgagcatga
      601 tgtggatctt ggagaacgag gaatcaatgg tctgtttcga aacttcactt tggaaactat
      661 tgtggaaaga tatcgtcaag cagctagggc agccacagcc attatgtgtg acctttgtaa
      721 accaccacct caagaatcca caaaaagctg catggactgt agtgcaagtt actgcaatga
      781 atgcttcaaa attcatcacc cttggggtac tataaaagct caacatgagt atgttggtcc
      841 aactactaac ttcagaccca agattttaat gtgcccagaa catgaaacag agagaataaa
      901 catgtactgt gaattatgta ggaggccagt ttgccatctg tgtaagttgg gtggtaatca
      961 tgccaaccac cgtgtaacca ctatgagcag tgcctacaaa accttaaagg aaaagctttc
     1021 aaaggatatt gattacctta ttggtaagga aagccaggtg aagagtcaaa tatctgaact
     1081 aaacttgtta atgaaagaaa cagagtgtaa tggagagagg gctaaagaag aagcaattac
     1141 acattttgaa aagctctttg aagttctgga agagaggaaa tcatctgttt tgaaagcaat
     1201 tgactcctct aagaaactaa gattagacaa atttcagact caaatggaag agtaccaggg
     1261 acttctagag aacaatggac ttgtgggata tgctcaagaa gtgctaaagg agacagatca
     1321 gtcttgcttt gtgcagacag caaagcagct ccacctcaga atacagaaag ccacagaatc
     1381 tttgaagagc tttagacctg cagctcagac ttcttttgaa gactatgttg ttaatacctc
     1441 taaacaaaca gaacttcttg gagaattatc ctttttctct agtggcatag acgtgccaga
     1501 gatcaatgag gaacagagca aagtttataa caatgccttg ataaattggc accatccaga
     1561 aaaggataaa gctgatagct atgttcttga atatcggaaa atcaatagag atgatgaaat
     1621 gtcatggaat gagatagaag tgtgtggaac aagtaaaata attcaagact tggaaaacag
     1681 tagtacctat gctttcagag taagagctta caagggttca atctgtagtc cttgcagcag
     1741 agaattgatt cttcatactc ctccagctcc agttttcagc ttcctctttg atgaaaaatg
     1801 tggctataat aatgaacacc tcctgctgaa cttgaagaga gaccgtgtag agagtagagc
     1861 tggatttaat cttctgcttg ctgcagaacg catccaagtg ggttattaca caagcttaga
     1921 ctacatcatt ggagatactg gcattacaaa aggaaaacac ttctgggcct tccgtgtgga
     1981 accatattca tacctggtaa aagtgggagt tgcttctagc gataaactac aagaatggct
     2041 ccgttctccc cgggatgcag ttagtccaag atatgagcaa gacagtgggc atgacagtgg
     2101 aagtgaggat gcctgttttg attcttcaca accatttacc ttagttacta taggcatgca
     2161 gaaatttttt atacccaagt cacctacttc ttctaatgaa cctgaaaata gagttctccc
     2221 tatgccaaca agtattggga ttttccttga ctgtgataaa ggcaaagtag atttctatga
     2281 tatggatcag atgaaatgcc tttatgaacg ccaagtggac tgttcacata cactgtatcc
     2341 agcatttgca ttaatgggca gtggaggaat tcagcttgaa gaacccatca cagcaaaata
     2401 tctggaatac caagaggaca tgtagttgaa acatctgatg tgactcagga taaaaactgt
     2461 aaacaaagca atgccttagc gttaaccttc gtaactaatt acatatcgct gagtgttctg
     2521 tcaccccact tgtgtttgag tatgattctt cttgaaatac agaaaatcta aacagccttg
     2581 tgtcttcatg tcgttgttct gcctttcaca aatgatgaaa gtgaagatgt tctttccaag
     2641 ttaatactga agtggttaac tttgcaactg gactgtcttt tactttatgt acaggatatc
     2701 taatttattt ctgtcagctg gtgttgctga cactttcctt atggtggggg ggatacaaaa
     2761 gtatttatta tgattctctt ctgtttgact tttcattttt atatcatgtt tatgtcctaa
     2821 gagaagatat tttttaaatg ccttatggat aggaattagt actaagcaat gtgtcttgca
     2881 tttgttttca ataggaaaac aaagttctag ataggttaaa agaaaaacac cataaaagtg
     2941 gtagtatatt taagtggaaa attatgtatt ttaaagtgtg taactattaa aaatatattg
     3001 cctggaaaag gaatactact gttttgtttt gttaagacca caaactgtat tgctaaggac
     3061 attttaagag tctgcttagc cataacactc atttaacagc atgggtagta agcatggttt
     3121 cttgcagaaa acacaaagtt ctcagctaac acattaaact tctcacttta tatacttttt
     3181 ttcagagaaa tttatcttta gtttttctta ttctgtgaaa atatttgttc ttatgtcaaa
     3241 gaattatttt tcagatatat tggtaaagat ggactgatat taaaagtcat atttattctt
     3301 ttaccccctt actgtgtttt gtgattttca tttttggccc aattattaca tatcaggttt
     3361 tcctgattta tatttacatg tttgaaaagt tcattatata ttttagtagc gttacatata
     3421 ttataaattt ttgtaacatt taaatgttca cttatgtggc attttctgtt tctcattggt
     3481 aataagcatt tctaatataa gcaagtaaaa atacaaattt aattacttag aaatgataac
     3541 taagatcaca atgactgtgt accctttaaa atatctttta atttgaggaa ttacattcta
     3601 tctaaattgt gtgtctgttt ttgaaaggtg ttgctttcaa gtaggtggtt tttatttaaa
     3661 gtacttattt ttttgaggtt aaaatattca gaaactactt ttatgcattg tagcagtaat
     3721 catttatgga atgcttttga catgttttaa cagggtaacc aaaactttta ggcctgtttt
     3781 ttttggttgt ccttgttgtt atatttttaa tggaaatctg ttactcaggc tggtagcatt
     3841 aaattagctt tttaccctca actcaagtag caaatatcat ggagaacttc agtgtttagc
     3901 aggctgttaa tttcccatct atgaatagca ctttatgatg taggctaaac taagcaaata
     3961 atgcagcgtt atgtggatca ttatgcaata aagctgctaa agtcacattt gtggttgata
     4021 ctcaagcctt gtacaagcac atatgatgta gacattttta aatgtgaagc tttaacagga
     4081 ataggatagc tgtttcaaac cttgtgcaat tgtaaataaa ttgtttagct gtgtttcttt
     4141 catttttaat aaaaaa
//
