LOCUS       NM_171982               4183 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 35 (TRIM35), transcript
            variant 1, mRNA.
ACCESSION   NM_171982 NM_015066
VERSION     NM_171982.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Yang,B., Wang,Z., Niu,K., Li,T., Tong,T., Li,S., Su,L., Wang,Y.,
            Shen,C., Jin,X., Song,J. and Lu,X.
  TITLE     TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated
            amino acid transport and mTORC1 activation in fibroblasts
  JOURNAL   Cell Commun Signal 22 (1), 444 (2024)
   PUBMED   39304904
  REMARK    GeneRIF: TRIM35 triggers cardiac remodeling by regulating
            SLC7A5-mediated amino acid transport and mTORC1 activation in
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Sun,N., Zhang,J., Zhang,C., Xie,T., Zhang,Z., Wang,X., Li,W.,
            Zhang,Y., Chen,Z., Zheng,J., Fang,L. and Wang,G.
  TITLE     Inhibition of human adenovirus replication by TRIM35-mediated
            degradation of E1A
  JOURNAL   J Virol 97 (8), e0070023 (2023)
   PUBMED   37578239
  REMARK    GeneRIF: Inhibition of human adenovirus replication by
            TRIM35-mediated degradation of E1A.
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Fang,Y., Lu,Z.H., Liu,B.Z., Li,N., Yang,M.Z. and Wang,P.
  TITLE     IRF5 promotes glycolysis in the progression of hepatocellular
            carcinoma and is regulated by TRIM35
  JOURNAL   J Dig Dis 24 (8-9), 480-490 (2023)
   PUBMED   37594849
  REMARK    GeneRIF: IRF5 promotes glycolysis in the progression of
            hepatocellular carcinoma and is regulated by TRIM35.
REFERENCE   4  (bases 1 to 4183)
  AUTHORS   Wu,H., Guo,X., Jiao,Y., Wu,Z. and Lv,Q.
  TITLE     TRIM35 ubiquitination regulates the expression of PKM2 tetramer and
            dimer and affects the malignant behaviour of breast cancer by
            regulating the Warburg effect
  JOURNAL   Int J Oncol 61 (6) (2022)
   PUBMED   36196894
  REMARK    GeneRIF: TRIM35 ubiquitination regulates the expression of PKM2
            tetramer and dimer and affects the malignant behaviour of breast
            cancer by regulating the Warburg effect.
REFERENCE   5  (bases 1 to 4183)
  AUTHORS   Wang,R., Huang,K.L. and Xing,L.X.
  TITLE     TRIM35 functions as a novel tumor suppressor in breast cancer by
            inducing cell apoptosis through ubiquitination of PDK1
  JOURNAL   Neoplasma 69 (2), 370-382 (2022)
   PUBMED   35081724
  REMARK    GeneRIF: TRIM35 functions as a novel tumor suppressor in breast
            cancer by inducing cell apoptosis through ubiquitination of PDK1.
REFERENCE   6  (bases 1 to 4183)
  AUTHORS   Chen,Z., Wang,Z., Guo,W., Zhang,Z., Zhao,F., Zhao,Y., Jia,D.,
            Ding,J., Wang,H., Yao,M. and He,X.
  TITLE     TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the
            Warburg effect and tumorigenicity in hepatocellular carcinoma
  JOURNAL   Oncogene 34 (30), 3946-3956 (2015)
   PUBMED   25263439
  REMARK    GeneRIF: TRIM35 regulates the Warburg effect and tumorigenicity
            through interaction with PKM2 in hepatocellular carcinoma.
REFERENCE   7  (bases 1 to 4183)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 4183)
  AUTHORS   Lalonde,J.P., Lim,R., Ingley,E., Tilbrook,P.A., Thompson,M.J.,
            McCulloch,R., Beaumont,J.G., Wicking,C., Eyre,H.J.,
            Sutherland,G.R., Howe,K., Solomon,E., Williams,J.H. and
            Klinken,S.P.
  TITLE     HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member
            isolated from a hemopoietic lineage switch, is a candidate tumor
            suppressor
  JOURNAL   J Biol Chem 279 (9), 8181-8189 (2004)
   PUBMED   14662771
  REMARK    GeneRIF: gene located on chromosome 8p21, a region implicated in
            leukemias and solid tumors; enforced expression inhibited cell
            growth, clonogenicity, and tumorigenicity; conceivable HLS5 is one
            of the tumor suppressor genes thought to reside at the 8p21 locus
REFERENCE   9  (bases 1 to 4183)
  AUTHORS   Kimura,F., Suzu,S., Nakamura,Y., Nakata,Y., Yamada,M., Kuwada,N.,
            Matsumura,T., Yamashita,T., Ikeda,T., Sato,K. and Motoyoshi,K.
  TITLE     Cloning and characterization of a novel RING-B-box-coiled-coil
            protein with apoptotic function
  JOURNAL   J Biol Chem 278 (27), 25046-25054 (2003)
   PUBMED   12692137
REFERENCE   10 (bases 1 to 4183)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF492463.1, AC124649.6 and BU622420.1.
            
            On Nov 23, 2018 this sequence version replaced NM_171982.4.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The function of this protein has not been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.161349.1, AB029021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305364.9/ ENSP00000301924.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3402              AF492463.1         46-3447
            3403-3446           AC124649.6         104180-104223       c
            3447-4183           BU622420.1         18-754              c
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4183
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="tripartite motif containing 35"
                     /db_xref="GeneID:23087"
                     /db_xref="HGNC:HGNC:16285"
                     /db_xref="MIM:617007"
     exon            1..472
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1519
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hemopoietic lineage switch protein 5; tripartite
                     motif-containing protein 35; E3 ubiquitin-protein ligase
                     TRIM35"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM35 isoform 1"
                     /protein_id="NP_741983.2"
                     /db_xref="CCDS:CCDS6056.2"
                     /db_xref="GeneID:23087"
                     /db_xref="HGNC:HGNC:16285"
                     /db_xref="MIM:617007"
                     /translation="MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGC
                     VSRCWEVQVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCR
                     LHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAK
                     AFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQL
                     LADEKMKQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGM
                     LIDVCKYLGSLQYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVE
                     NPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDT
                     RSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHL
                     YTFHARFGEVRPYFYLGGARGAGPPEPLRICPLHISVKEELDG"
     exon            473..568
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     exon            569..799
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     exon            800..822
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     exon            823..941
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     exon            942..4183
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3298..3303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="hexamer: AATAAA"
     polyA_site      3318
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="major polyA site"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="hexamer: ATTATA"
     polyA_site      3657
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="major polyA site"
     regulatory      4110..4115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="hexamer: TATAAA"
     polyA_site      4129
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
                     /note="hexamer: ACTAAA"
     polyA_site      4183
                     /gene="TRIM35"
                     /gene_synonym="HLS5; MAIR"
ORIGIN      
        1 gcaaaagttc cgggcgcccg agccggctgc tcgtgccatg gagcggagtc ccgacgtgtc
       61 ccccgggcct tcccgctcct tcaaggagga gttgctctgc gccgtctgct acgacccctt
      121 ccgcgacgca gtcactctgc gctgcggcca caacttctgc cgcgggtgcg tgagccgctg
      181 ctgggaggtg caggtgtcgc ccacctgccc agtgtgcaaa gaccgcgcgt cacccgccga
      241 cctgcgcacc aaccacaccc tcaacaacct ggtggagaag ctgctgcgcg aggaggccga
      301 gggcgcgcgc tggaccagct accgcttctc gcgtgtctgc cgcctgcacc gcggacagct
      361 cagcctcttc tgcctcgagg acaaggagct gctgtgctgc tcctgccagg ccgacccccg
      421 acaccagggg caccgcgtgc agccggtgaa ggacactgcc cacgactttc gggccaagtg
      481 caggaacatg gagcatgcac tgcgggagaa ggccaaggcc ttctgggcca tgcggcgctc
      541 ctatgaggcc atcgccaagc acaatcaggt ggaggctgca tggctggaag gccggatccg
      601 gcaggagttt gataagcttc gcgagttctt gagagtggag gagcaggcca ttctggatgc
      661 catggccgag gagacaaggc agaagcaact tctggccgac gagaagatga agcagctcac
      721 agaggagacg gaggtgctgg cacatgagat cgagcggctg cagatggaga tgaaggagga
      781 cgacgtttct tttctcatga aacacaagag ccgaaaacgc cgactcttct gcaccatgga
      841 gccagagcca gtccagcccg gcatgcttat cgatgtctgc aagtacctgg gctccctgca
      901 gtaccgcgtc tggaagaaga tgcttgcatc tgtggaatct gtacccttca gctttgaccc
      961 caacaccgca gctggctggc tctccgtgtc tgacgacctc accagcgtca ccaaccatgg
     1021 ctaccgcgtg caggtggaga acccggaacg cttctcctcg gcgccctgcc tgctgggctc
     1081 ccgtgtcttc tcacagggct cgcacgcctg ggaggtggcc cttggggggc tgcagagctg
     1141 gagggtgggc gtggtacgtg tgcgccagga ctcgggcgct gagggccact cacacagctg
     1201 ctaccacgac acacgctcgg gcttctggta tgtctgccgc acgcagggcg tggaggggga
     1261 ccactgcgtg acctcggacc cagccacgtc gcccctggtc ctggccatcc cacgccgcct
     1321 gcgtgtggag ctggagtgtg aggagggcga gctgtctttc tatgacgcgg agcgccactg
     1381 ccacctgtac accttccacg cccgctttgg ggaggttcgc ccctacttct acctgggggg
     1441 tgcacggggc gccgggcctc cagagccttt gcgcatctgc cccttgcaca tcagtgtcaa
     1501 ggaagaactg gatggctgag ctggcccggg gctgccccgg tcttgtgcca cagcactgtt
     1561 ttctttctgc cctcttccta atgcccacac tgcttgggca ctattgcgcc cctgcctcct
     1621 tgccaggctc ttcctcctgt cctgcctggt ccttttccat gactccaggc tgtgcctctc
     1681 tccatgtttg gtcccttctg tgcccatggt caggagctat tcgggtggca cctcgctggc
     1741 caggctctcc cgagtcgtgg cacctccaca atgtgaattt tctgaatccc tattccagga
     1801 tttctgggaa taatgtttac ttctagaatg ggcctgttgt aaaccatctc atcgaggtgt
     1861 ggtaaagcca ttggatgagg aggggactgc catggaaagg agagtttgtt acttacggtt
     1921 ctgagaggag gggccacata ggaaagcccc acggtgggtc agaaggcgga aggagggagg
     1981 ggaacgtgtg ggcaagagac ttcctctggt ttcctcagga ggaaatgggc aaggcagagt
     2041 aagcagggga gacaggttta agggtagctg gcttgagtaa tttcagtggc tctcaggata
     2101 ggggctgccc tttttgtctg atacctggcc ccgggatagt caggacaggt gaatgttggc
     2161 ctggggtgtg acagccctgg gagagccatg tgaaggaggc agctggcgcc atcgctccgg
     2221 attagttggt ttccatagga aaggcatgct ttcagccaga tgcttgccat ctctagggat
     2281 tgggggattg gctagcctgg gaggatcagt ctgtccaggt cagcgaggcc ccagatacca
     2341 gagcatcaag agtacaggaa atacagttaa tgcagggcct ctgtgtggct ggatcctccg
     2401 tctccatcag atcagctctg attgatctat tcttgcacga tttcctctga acacagggtt
     2461 ccagagtact taaacacaac attttttaaa tcgtgatttc ggcctatttc cttgccaggc
     2521 ctgtttcccc accaggaaat gagataggag gactggatga ggatgtcctg ttatagttgc
     2581 tgtggaggaa gttcctctgg ttaattctca tcagcgtctg cagaaaagaa ggaaagaggg
     2641 cacccttttc agttgggaag aaaggagagg ggtggcgcca tggacgtggc cctaaacgct
     2701 gtgggagagg gaagaggagg ctgggcctcg ctgccctctt gtctctgctg acttcagcct
     2761 ggtcatgctt gctctgccac ttgcgatttc atccctaatt tcttcctcca ccatgcctgc
     2821 agacttttcc ctgggcttgt tttttctcgc acatctctga agagttttta atcttcagct
     2881 catcatgtcc caggaagtgg catcataaaa ggaaatattt ttttttccta ggagcagtgt
     2941 taaaatctgg gtcacattcc tgaccaagga cagcatcctg ccttctgccc atccccttca
     3001 gttcacaaaa gctgacattt taaacaaatc atgactcaca cgtattaatt ggttataaat
     3061 atgttgtgta cactggttag ataaaactta aggccacaag gagggcccag gtaggcgatg
     3121 tcagtgtgtg aaggggctgg attgggcgtg gtgaggatgt tggcaaacca gtgcatgcac
     3181 ctggttggaa gatgctcagc ctcacaaaag ctccaagccc tttgggagcc aaagtgtctg
     3241 agagtgtgac cctctcctgt aaagtattta tcccacccat taatataatt tctgtataat
     3301 aaacttgacc tgaaattatt tcattcttta tattaaactt ttaaaaatgt tttttatttt
     3361 caccttagat atgggaagag tttttttttt tttttttttt ttaacaggat aacttgagca
     3421 ggctaggcct cttaaaaaaa aatttgagct aaaactcatt tttcttttgg cattttcttt
     3481 tcaatgttct tataagcaaa gttcatccat gttgtagcat gtgttcaact ttattttttc
     3541 atcgggtaat attccattgt atggaatggt agtactacat tttatttatc atgcatcgat
     3601 tggtggacat ttggatcgtt tctacttctt gactattata cataatgctg ctaggaactt
     3661 ttgtgtatga gtttttgtgt ggacatatgt tttcatttct ctttggtata tgcctgggag
     3721 cagatttgct ggatcatatg aaactctatt taacccttga gggactccca aactgttttc
     3781 caatgtggtg acacaatttt atatcccatc aacagggcat gagggttctg atgactccac
     3841 atccctcagt gctttttatt atctatcttt taacttagcc atcctagtag gggtaatgtg
     3901 gcatctcatt gtgattttgg tttgcatttc cctgatggcg aatgatattg agcatctttt
     3961 catgagctta ttggccattt gcatatcttc ttaggacagc tatctttaga tcacttgctc
     4021 attttttaat tgggttattt gtctttttat tattgagttg taagagtcct tttatagcct
     4081 ggcacaagtc cctttaactg gtatatgatt ataaaatttt tctccgtgag ctgtttcatt
     4141 tccttgatga tgtcctttga aatactaaag cttttaattt tga
//
