LOCUS       NM_021616               2293 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 34 (TRIM34), transcript
            variant 1, mRNA.
ACCESSION   NM_021616
VERSION     NM_021616.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Zhang,P., Chen,Z., Li,J., Mao,H. and Hu,Y.
  TITLE     TRIM34 suppresses non-small-cell lung carcinoma via inducing
            mTORC1-dependent glucose utilization and promoting cellular death
  JOURNAL   Arch Biochem Biophys 754, 109925 (2024)
   PUBMED   38336254
  REMARK    GeneRIF: TRIM34 suppresses non-small-cell lung carcinoma via
            inducing mTORC1-dependent glucose utilization and promoting
            cellular death.
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Wang,X., Xiong,J., Zhou,D., Zhang,S., Wang,L., Tian,Q., Li,C.,
            Liu,J., Wu,Y., Li,J. and Wang,J.
  TITLE     TRIM34 modulates influenza virus-activated programmed cell death by
            targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination
  JOURNAL   J Biol Chem 298 (3), 101611 (2022)
   PUBMED   35065966
  REMARK    GeneRIF: TRIM34 modulates influenza virus-activated programmed cell
            death by targeting Z-DNA-binding protein 1 for K63-linked
            polyubiquitination.
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Ohainle,M., Kim,K., Komurlu Keceli,S., Felton,A., Campbell,E.,
            Luban,J. and Emerman,M.
  TITLE     TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent
            manner
  JOURNAL   PLoS Pathog 16 (4), e1008507 (2020)
   PUBMED   32282853
  REMARK    GeneRIF: TRIM34 restricts HIV-1 and SIV capsids in a
            TRIM5alpha-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Sun,D., An,X. and Ji,B.
  TITLE     TRIM34 facilitates the formation of multinucleated giant cells by
            enhancing cell fusion and phagocytosis in epithelial cells
  JOURNAL   Exp Cell Res 384 (1), 111594 (2019)
   PUBMED   31487507
  REMARK    GeneRIF: TRIM34 proteins contribute to the formation of MGCs.
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Sun,D., An,X., Ji,B., Cheng,Y., Gao,H. and Tian,M.
  TITLE     [Tripartite motif-containing protein 34 (TRIM34) colocalized with
            micronuclei chromosome and hampers its movement to equatorial plate
            during the metaphase stage of mitosis]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (6), 755-759 (2016)
   PUBMED   27371841
  REMARK    GeneRIF: Data show there was no distinguished colocalization
            relationship between the complex of tripartite motif-containing
            protein 34 (TRIM34)-micronulei and mitochondria.
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Zhang,F., Hatziioannou,T., Perez-Caballero,D., Derse,D. and
            Bieniasz,P.D.
  TITLE     Antiretroviral potential of human tripartite motif-5 and related
            proteins
  JOURNAL   Virology 353 (2), 396-409 (2006)
   PUBMED   16828831
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Li,X., Li,Y., Stremlau,M., Yuan,W., Song,B., Perron,M. and
            Sodroski,J.
  TITLE     Functional replacement of the RING, B-box 2, and coiled-coil
            domains of tripartite motif 5alpha (TRIM5alpha) by heterologous
            TRIM domains
  JOURNAL   J Virol 80 (13), 6198-6206 (2006)
   PUBMED   16775307
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Orimo,A., Tominaga,N., Yoshimura,K., Yamauchi,Y., Nomura,M.,
            Sato,M., Nogi,Y., Suzuki,M., Suzuki,H., Ikeda,K., Inoue,S. and
            Muramatsu,M.
  TITLE     Molecular cloning of ring finger protein 21
            (RNF21)/interferon-responsive finger protein (ifp1), which
            possesses two RING-B box-coiled coil domains in tandem
  JOURNAL   Genomics 69 (1), 143-149 (2000)
   PUBMED   11013086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB024660.1, AF220143.1 and
            BG682537.1.
            
            On Jun 2, 2019 this sequence version replaced NM_021616.5.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain,
            and a coiled-coil region. Expression of this gene is up-regulated
            by interferon. This gene is mapped to chromosome 11p15, where it
            resides within a TRIM gene cluster. Alternative splicing results in
            multiple transcript variants. A read-through transcript from the
            upstream TRIM6 gene has also been observed, which results in a
            fusion product from these neighboring family members. [provided by
            RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1, also known as alpha)
            represents the longest transcript and encodes the longer isoform
            (1, also known as the middle form). Both variants 1 and 4 encode
            the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220143.1, SRR1803613.15911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429814.3/ ENSP00000402595.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB024660.1         25-40
            17-1638             AF220143.1         24-1645
            1639-1898           BG682537.1         426-685
            1899-2293           AF220143.1         1906-2300
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2293
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /note="tripartite motif containing 34"
                     /db_xref="GeneID:53840"
                     /db_xref="HGNC:HGNC:10063"
                     /db_xref="MIM:605684"
     exon            1..60
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            61..560
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1604
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 21, interferon-responsive;
                     interferon-responsive finger protein 1; E3
                     ubiquitin-protein ligase TRIM34"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM34 isoform 1"
                     /protein_id="NP_067629.2"
                     /db_xref="CCDS:CCDS31391.1"
                     /db_xref="GeneID:53840"
                     /db_xref="HGNC:HGNC:10063"
                     /db_xref="MIM:605684"
                     /translation="MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNK
                     EAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGE
                     KLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEK
                     LEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAE
                     AEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKT
                     VFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCY
                     NYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYR
                     PLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVT
                     SHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS"
     exon            561..656
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            657..887
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            888..910
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1011
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1038
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..2293
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="TRIM34"
                     /gene_synonym="IFP1; RNF21"
                     /note="major polyA site"
ORIGIN      
        1 acccaccctg gcttttcttc acctcttcaa ccaggagccg agatttctgt tgctctgaag
       61 ccatccaggg gtctttaacc agaagagaga ggagagcctc aggagttagg accagaagaa
      121 gccagggaag cagtgcaatg gcttcaaaaa tcttgcttaa cgtacaagag gaggtgacct
      181 gtcccatctg cctggagctg ttgacagaac ccttgagtct agactgtggc cacagcctct
      241 gccgagcctg catcactgtg agcaacaagg aggcagtgac cagcatggga ggaaaaagca
      301 gctgtcctgt gtgtggtatc agttactcat ttgaacatct acaggctaat cagcatctgg
      361 ccaacatagt ggagagactc aaggaggtca agttgagccc agacaatggg aagaagagag
      421 atctctgtga tcatcatgga gagaaactcc tactcttctg taaggaggat aggaaagtca
      481 tttgctggct ttgtgagcgg tctcaggagc accgtggtca ccacacagtc ctcacggagg
      541 aagtattcaa ggaatgtcag gagaaactcc aggcagtcct caagaggctg aagaaggaag
      601 aggaggaagc tgagaagctg gaagctgaca tcagagaaga gaaaacttcc tggaagtatc
      661 aggtacaaac tgagagacaa aggatacaaa cagaatttga tcagcttaga agcatcctaa
      721 ataatgagga gcagagagag ctgcaaagat tggaagaaga agaaaagaag acgctggata
      781 agtttgcaga ggctgaggat gagctagttc agcagaagca gttggtgaga gagctcatct
      841 cagatgtgga gtgtcggagt cagtggtcaa caatggagct gctgcaggac atgagtggaa
      901 tcatgaaatg gagtgagatc tggaggctga aaaagccaaa aatggtttcc aagaaactga
      961 agactgtatt ccatgctcca gatctgagta ggatgctgca aatgtttaga gaactgacag
     1021 ctgtccggtg ctactgggtg gatgtcacac tgaattcagt caacctaaat ttgaatcttg
     1081 tcctttcaga agatcagaga caagtgatat ctgtgccaat ttggcctttt cagtgttata
     1141 attatggtgt cttgggatcc caatatttct cctctgggaa acattactgg gaagtggacg
     1201 tgtccaagaa aactgcctgg atcctggggg tatactgtag aacatattcc cgccatatga
     1261 agtatgttgt tagaagatgt gcaaatcgtc aaaatcttta caccaaatac agacctctat
     1321 ttggctactg ggttataggg ttacagaata aatgtaagta tggtgtcttt gaagagtctt
     1381 tgtcctctga tcccgaggtt ttgactctct ccatggctgt gcctccctgc cgtgttgggg
     1441 ttttcctcga ctatgaagca ggcattgtct catttttcaa tgtcacaagc catggctccc
     1501 tcatttacaa gttctctaaa tgttgctttt ctcagcctgt ttatccatat ttcaatcctt
     1561 ggaactgtcc agctcccatg actctatgcc caccaagctc ttgaattttc tcatttcttc
     1621 acctacaacc ctttgtcttg acttatctcc tgcaactgac tcatctgcaa cattcacacc
     1681 attgcttcct tgtggtttcc cttctttaga acttttactc atccttgaga tgtatggtgt
     1741 atttggcttg agttatgaga gatgcttatt tattcattta ctctttttca tattttcaga
     1801 gaaagttacc taatccctcc taaagacaca gcagtatggg tataacatcc ttgccttccc
     1861 atttatccat gtttcacttt atcactgata tgaagaggcc caaagcctgt tagccaccat
     1921 ccatgctacc taggtagtcc ataggaacca cccccatgac caccaccaac atcaactaaa
     1981 ggttcttgga gggtatgtca gtgtgttgct caggataccc caggtacatc aaggaatcaa
     2041 ggagaggaaa atatgagcaa tatgtgtatt cagagtgaag attttatgtc cagagtattt
     2101 gagctcaaac cttgcctgtt gttttctaat catgatgaat actttctcag tttctttttc
     2161 ctgaaatata aattgggatt taagactgta cctaactatt aagatcactg tgtaaaacta
     2221 agtgtctcta aatgtaatgc atcgatttag tgtctggaac ataataaata tttgctctca
     2281 tgattgctaa aaa
//
