LOCUS       NM_012210               3715 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens tripartite motif containing 32 (TRIM32), transcript
            variant 1, mRNA.
ACCESSION   NM_012210
VERSION     NM_012210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Zhang,Y., Dong,Z., Gu,F., Xu,Y., Li,Y., Sun,W., Rao,W., Du,S.,
            Zhu,C., Wang,Y., Wei,F. and Cai,Q.
  TITLE     Degradation of TRIM32 is induced by RTA for Kaposi's
            sarcoma-associated herpesvirus lytic replication
  JOURNAL   J Virol 98 (6), e0000524 (2024)
   PUBMED   38717113
  REMARK    GeneRIF: Degradation of TRIM32 is induced by RTA for Kaposi's
            sarcoma-associated herpesvirus lytic replication.
REFERENCE   2  (bases 1 to 3715)
  AUTHORS   He,L., Cai,Y., Du,H., Shu,M. and Zhu,C.
  TITLE     Adipose stem cell-derived exosomes promote high glucose-induced
            wound healing by regulating the TRIM32/STING axis
  JOURNAL   Arch Dermatol Res 316 (6), 323 (2024)
   PUBMED   38822901
  REMARK    GeneRIF: Adipose stem cell-derived exosomes promote high
            glucose-induced wound healing by regulating the TRIM32/STING axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3715)
  AUTHORS   Goyani,S., Shinde,A., Shukla,S., Saranga,M.V., Currim,F., Mane,M.,
            Singh,J., Roy,M., Gohel,D., Chandak,N., Vasiyani,H. and Singh,R.
  TITLE     Enhanced translocation of TRIM32 to mitochondria sensitizes
            dopaminergic neuronal cells to apoptosis during stress conditions
            in Parkinson's disease
  JOURNAL   FEBS J 291 (12), 2636-2655 (2024)
   PUBMED   38317520
  REMARK    GeneRIF: Enhanced translocation of TRIM32 to mitochondria
            sensitizes dopaminergic neuronal cells to apoptosis during stress
            conditions in Parkinson's disease.
REFERENCE   4  (bases 1 to 3715)
  AUTHORS   Wang,L., Song,Y.Y., Wang,Y., Liu,X.X., Yin,Y.L., Gao,S., Zhang,F.,
            Li,L.Y. and Zhang,Z.S.
  TITLE     RHBDF1 deficiency suppresses melanoma glycolysis and enhances
            efficacy of immunotherapy by facilitating glucose-6-phosphate
            isomerase degradation via TRIM32
  JOURNAL   Pharmacol Res 198, 106995 (2023)
   PUBMED   37979663
  REMARK    GeneRIF: RHBDF1 deficiency suppresses melanoma glycolysis and
            enhances efficacy of immunotherapy by facilitating
            glucose-6-phosphate isomerase degradation via TRIM32.
REFERENCE   5  (bases 1 to 3715)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   6  (bases 1 to 3715)
  AUTHORS   Weiler,T., Greenberg,C.R., Zelinski,T., Nylen,E., Coghlan,G.,
            Crumley,M.J., Fujiwara,T.M., Morgan,K. and Wrogemann,K.
  TITLE     A gene for autosomal recessive limb-girdle muscular dystrophy in
            Manitoba Hutterites maps to chromosome region 9q31-q33: evidence
            for another limb-girdle muscular dystrophy locus
  JOURNAL   Am J Hum Genet 63 (1), 140-147 (1998)
   PUBMED   9634523
REFERENCE   7  (bases 1 to 3715)
  AUTHORS   Fridell,R.A., Harding,L.S., Bogerd,H.P. and Cullen,B.R.
  TITLE     Identification of a novel human zinc finger protein that
            specifically interacts with the activation domain of lentiviral Tat
            proteins
  JOURNAL   Virology 209 (2), 347-357 (1995)
   PUBMED   7778269
REFERENCE   8  (bases 1 to 3715)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   9  (bases 1 to 3715)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   10 (bases 1 to 3715)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133284.13.
            
            On Mar 19, 2020 this sequence version replaced NM_012210.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies. The protein has also been localized to the nucleus, where
            it interacts with the activation domain of the HIV-1 Tat protein.
            The Tat protein activates transcription of HIV-1 genes. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.33811.1,
                                           SRR11853564.27727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450136.2/ ENSP00000408292.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL133284.13        121008-121084
            78-3715             AL133284.13        131365-135002
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.1"
     gene            1..3715
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /note="tripartite motif containing 32"
                     /db_xref="GeneID:22954"
                     /db_xref="HGNC:HGNC:16380"
                     /db_xref="MIM:602290"
     exon            1..77
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /inference="alignment:Splign:2.1.0"
     exon            78..3715
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2120
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /EC_number="2.3.2.27"
                     /note="TAT-interactive protein, 72-KD; zinc-finger protein
                     HT2A; tripartite motif-containing protein 32; RING-type E3
                     ubiquitin transferase TRIM32; 72 kDa Tat-interacting
                     protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM32"
                     /protein_id="NP_036342.2"
                     /db_xref="CCDS:CCDS6817.1"
                     /db_xref="GeneID:22954"
                     /db_xref="HGNC:HGNC:16380"
                     /db_xref="MIM:602290"
                     /translation="MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTIC
                     RQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRS
                     CGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELM
                     GELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNS
                     QVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTLQ
                     DVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVA
                     SPRASPAKQRGPEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGN
                     YRIQVFTRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDN
                     SLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYS
                     CLCSAVRPKFVTCDAEGTVYFTQGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQIS
                     HFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIAL
                     TPKGQLLVLDCWDHCIKIYSYHLRRYSTP"
     regulatory      2451..2456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2473
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /note="hexamer: ATTAAA"
     polyA_site      3166
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /note="major polyA site"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
                     /note="hexamer: ATTAAA"
     polyA_site      3715
                     /gene="TRIM32"
                     /gene_synonym="BBS11; HT2A; LGMD2H; LGMDR8; TATIP"
ORIGIN      
        1 gctcaacggc gcgtgcgcag agggaggcag gcgggtgggc tgccggcggt ggactcgtcg
       61 gagccgcggg cggtcagcag gaatttgacc ctctagggca tgaatactgt gctgttcagt
      121 tctgagctgt gctagcaata cccttcaaag gaagagcaat ggctgcagca gcagcttctc
      181 acctgaacct ggatgccctc cgggaagtgc tagaatgccc catctgcatg gagtccttca
      241 cagaagagca gctgcgtccc aagcttctgc actgtggcca taccatctgc cgccagtgcc
      301 tggagaagct attggccagt agcatcaatg gtgtccgctg tcccttttgc agcaagatta
      361 cccgcataac cagcttgacc cagctgacag acaatctgac agtgctaaag atcattgata
      421 cagctgggct cagcgaggct gtggggctgc tcatgtgtcg gtcctgtggg cggcgtctgc
      481 cccggcaatt ctgccggagc tgtggtttgg tgttatgtga gccctgccgg gaggcagacc
      541 atcagcctcc tggccactgt acactccctg tcaaagaagc agctgaggag cggcgtcggg
      601 actttggaga gaagttaact cgtctgcggg aacttatggg ggagctgcag cggcggaagg
      661 cagccttgga aggtgtctcc aaggaccttc aggcaaggta taaagcagtt ctccaggagt
      721 atgggcatga ggagcgcagg gtccaggatg agctggctcg ctctcggaag ttcttcacag
      781 gctctttggc tgaagttgag aagtccaata gtcaagtggt agaggagcag agttacctgc
      841 ttaacattgc agaggtgcag gctgtgtctc gctgtgacta cttcctggcc aagatcaagc
      901 aggcagatgt agcactactg gaggagacag ctgatgagga ggagccagag ctcactgcca
      961 gcttgcctcg ggagctcacc ctgcaagatg tggagctcct taaggtaggt catgttggcc
     1021 ccctccaaat tggacaagct gttaagaagc cccggacagt taacgtggaa gattcctggg
     1081 ccatggaggc cacagcgtct gctgcctcta cctctgttac ttttagagag atggacatga
     1141 gcccggagga agtggttgcc agccctaggg cctcacctgc taaacagcgg ggtcctgagg
     1201 cagcctccaa tatccagcag tgcctctttc tcaagaagat gggggccaaa ggcagcactc
     1261 caggaatgtt caatcttcca gtcagtctct acgtgaccag tcaaggtgaa gtactagtcg
     1321 ctgaccgtgg taactatcgt atacaagtct ttacccgcaa aggctttttg aaggaaatcc
     1381 gccgcagccc cagtggcatt gatagctttg tgctaagctt ccttggggca gatctaccca
     1441 acctcactcc tctctcagtg gcaatgaact gccaggggct gattggtgtg actgacagct
     1501 atgataactc cctcaaggta tataccttgg atggccactg cgtggcctgt cacaggagcc
     1561 agctgagcaa accatggggt atcacagcct tgccatctgg ccagtttgta gtaaccgatg
     1621 tggaaggtgg aaagctttgg tgtttcacag ttgatcgagg atcaggggtg gtcaaataca
     1681 gctgcctatg tagtgctgtg cggcccaaat ttgtcacctg tgatgctgag ggcaccgtct
     1741 acttcaccca gggcttaggc ctcaatctgg agaatcggca gaatgagcac cacctggagg
     1801 gtggcttttc cattggctct gtaggccctg atgggcagct gggtcgccag attagccact
     1861 tcttctcgga gaatgaggat ttccgctgca ttgctggcat gtgtgtggat gctcgtggtg
     1921 atctcatcgt ggctgacagt agtcgcaagg aaattctcca ttttcctaag ggtgggggct
     1981 atagtgtcct tattcgagag ggacttacct gtccggtggg catagcccta actcctaagg
     2041 ggcagctgct ggtcttggac tgttgggatc attgcatcaa gatctacagc taccatctga
     2101 gaagatattc caccccatag gggatgagaa attatcagtt tcttctgctc ccaagccaac
     2161 ttcccttccc ttagttcttg gttgttagtg gcacatgcag aatagactca gcctatgtcc
     2221 tgattccagc tgggtagttc tagaacttca gaagctccat cttttaatgt ttttatttgt
     2281 tatgtccccc tccccgcttc ccacctaaat ttagagcttt aaaagatgca ctgcccaaat
     2341 aggacacacg atggtgttag ctgaagtttg attagcaatt aggcacttcc aaggctttag
     2401 tagagagagc cactttagcc ctttgtgcca tgtttgaaat ttgcccttgt attaaatcct
     2461 tgattttttc ccatttggct ttgatgccct tgatccattg tttccttcct actataatgt
     2521 gcttcatctg tgacactttc tcttgaactc tgattggatt cactgtgcat gcttcagtgg
     2581 gatctgctcc acctttcagt gacatttaag acatcatatt cccgtaacat tatgtctcag
     2641 tctgatcgtc tttaccagta tgaaagtcat tcatttagtg ctaccaaagg ggatacacaa
     2701 gccctttagg aagcagtacc tctcgcctgg aggatctgtg ccatcttgga ttgagaattg
     2761 cagatgtgac agaatggatt gaccctagtt ggttggtatt gatgacttca gcctggaaat
     2821 tgcttgcctt ttaaagaagc atatatgggt tggaattatg ccaaagcata ggaagctggg
     2881 aataagcaaa caaatgctga tatagtcagc aaatttggat agtctctagg gctcatcatt
     2941 tttcatacta cctctctctt ctggcctgtg tctaaggaat tgtacaacat aggccagggc
     3001 caacaaagtg gagaggtgga cacattttca tgttcattac taaaacaaac agcaaaacta
     3061 ttggtttgtt attctgtgtt ttcctcaagt cagtacatac tatttggttt caggatttct
     3121 ttccatttct ctatcaagca ttaaataatt gagaactgtt tcttcatctc tggtgttcat
     3181 gtcttttaat taaatacgga attttggaga tgataagagg gataacctgc gctatgccat
     3241 tttgcttcct tatctcactg tgttctttca gagtgtagat atctacccag gtcaaaattc
     3301 agccaaaagc actattatgt aaagataata atccaaatct ttctcccaaa tacatgtgta
     3361 cagaatcatc ccccaaggtt tagagtcacc aataccctat tctgagcttc tgctgtatgt
     3421 tttatgttta taattacagt tcacaaaaag gaagttagtc ttgtttttaa gatcagaagt
     3481 gggtgagagg acctgtgatg aggttcctga gggtttggtg tttactaagt aatatatctt
     3541 actctaggtg cagggctgat ggcaagccaa agagcaactg ccttactttg atgtaaacaa
     3601 aatttgctaa actgagctgc tcaaaattgt ttttatggta gtagtgtttc tttggattgt
     3661 atcataatag ctgccaaagg ataggtaaag aggtcattaa aatgatgttg aacta
//
