LOCUS       NM_007028               2027 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 31 (TRIM31), transcript
            variant 1, mRNA.
ACCESSION   NM_007028
VERSION     NM_007028.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2027)
  AUTHORS   Ding,Y., Lu,Y., Guo,J., Chen,S., Han,X., Wang,S., Zhang,M.,
            Wang,R., Song,J., Wang,K., Qiu,W. and Qi,W.
  TITLE     An investigation of the molecular characterization of the
            tripartite motif (TRIM) family and primary validation of TRIM31 in
            gastric cancer
  JOURNAL   Hum Genomics 18 (1), 77 (2024)
   PUBMED   38978046
  REMARK    GeneRIF: An investigation of the molecular characterization of the
            tripartite motif (TRIM) family and primary validation of TRIM31 in
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2027)
  AUTHORS   Sang,S.Q., Zhao,Y.J., Wang,M., Zhong,X.Q., Yang,Z.C. and Lu,M.M.
  TITLE     TRIM31 promotes the progression of oral squamous cell carcinoma
            through upregulating AKT phosphorylation and subsequent cellular
            glycolysis
  JOURNAL   Neoplasma 70 (3), 402-415 (2023)
   PUBMED   37498068
  REMARK    GeneRIF: TRIM31 promotes the progression of oral squamous cell
            carcinoma through upregulating AKT phosphorylation and subsequent
            cellular glycolysis.
REFERENCE   3  (bases 1 to 2027)
  AUTHORS   Huang,L., Huang,L., Ming,X., Wu,J., Liu,W. and Xiao,Y.
  TITLE     CircNFIX knockdown inhibited AML tumorigenicity by the
            miR-876-3p/TRIM31 axis
  JOURNAL   Hematology 27 (1), 1046-1055 (2022)
   PUBMED   36094501
  REMARK    GeneRIF: CircNFIX knockdown inhibited AML tumorigenicity by the
            miR-876-3p/TRIM31 axis.
REFERENCE   4  (bases 1 to 2027)
  AUTHORS   Yang,Z., Xu,B., Wu,S., Yang,W., Luo,R., Geng,S., Xin,Z., Jin,W.,
            Shen,X., Gu,X., Zhang,H. and Wang,H.
  TITLE     Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal
            stromal cells inhibits breast cancer progression via regulating
            TRIM31/Akt signaling
  JOURNAL   Hum Cell 35 (6), 1797-1812 (2022)
   PUBMED   35941326
  REMARK    GeneRIF: Exosomal microRNA-551b-3p from bone marrow-derived
            mesenchymal stromal cells inhibits breast cancer progression via
            regulating TRIM31/Akt signaling.
REFERENCE   5  (bases 1 to 2027)
  AUTHORS   Temena,M.A. and Acar,A.
  TITLE     Increased TRIM31 gene expression is positively correlated with
            SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal
            cancers
  JOURNAL   Sci Rep 12 (1), 11763 (2022)
   PUBMED   35970857
  REMARK    GeneRIF: Increased TRIM31 gene expression is positively correlated
            with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in
            gastrointestinal cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2027)
  AUTHORS   Sugiura,T. and Miyamoto,K.
  TITLE     Characterization of TRIM31, upregulated in gastric adenocarcinoma,
            as a novel RBCC protein
  JOURNAL   J Cell Biochem 105 (4), 1081-1091 (2008)
   PUBMED   18773414
REFERENCE   7  (bases 1 to 2027)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2027)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   9  (bases 1 to 2027)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 2027)
  AUTHORS   el Kahloun,A., Chauvel,B., Mauvieux,V., Dorval,I., Jouanolle,A.M.,
            Gicquel,I., Le Gall,J.Y. and David,V.
  TITLE     Localization of seven new genes around the HLA-A locus
  JOURNAL   Hum Mol Genet 2 (1), 55-60 (1993)
   PUBMED   8490624
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG403536.1, BM847963.1,
            AF230386.1 and CB142265.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007028.4.
            
            Summary: This gene encodes a protein that functions as an E3
            ubiquitin-protein ligase. This gene shows altered expression in
            certain tumors and may be a negative regulator of cell growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1, also known as alpha)
            represents the longest transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF230386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376734.4/ ENSP00000365924.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BG403536.1         17-18
            3-465               BM847963.1         1-463
            466-958             AF230386.1         465-957
            959-1315            CB142265.1         68-424
            1316-2027           AF230386.1         1315-2026
FEATURES             Location/Qualifiers
     source          1..2027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2027
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /note="tripartite motif containing 31"
                     /db_xref="GeneID:11074"
                     /db_xref="HGNC:HGNC:16289"
                     /db_xref="MIM:609316"
     exon            1..27
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            28..527
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1388
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 31; RING-type
                     E3 ubiquitin transferase TRIM31"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM31"
                     /protein_id="NP_008959.3"
                     /db_xref="CCDS:CCDS34374.1"
                     /db_xref="GeneID:11074"
                     /db_xref="HGNC:HGNC:16289"
                     /db_xref="MIM:609316"
                     /translation="MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIG
                     ETSCGFFKCPLCKTSVRKNAIRFNSLLRNLVEKIQALQASEVQSKRKEATCPRHQEMF
                     HYFCEDDGKFLCFVCRESKDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVK
                     AQGVHRVDVFTDQVEHEKQRILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYV
                     ASTEPQLNDLKKLVDSLKTKQNMPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKL
                     SEAKSRHDSITGSLKKFKDQLQADRKKDENRFFKSMNKNDMKSWGLLQKNNHKMNKTS
                     EPGSSSAGGRTTSGPPNHHSSAPSHSLFRASSAGKVTFPVCLLASYDEISGQGASSQD
                     TKTFDVALSEELHAALSEWLTAIRAWFCEVPSS"
     exon            528..623
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            624..854
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            855..877
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            878..993
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1068
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1134
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2027
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="TRIM31"
                     /gene_synonym="C6orf13; HCG1; HCGI; RNF"
                     /note="major polyA site"
ORIGIN      
        1 atccatttgt tctcaagagg tagcaagaaa cagtatccac agtggactcc ggggctccta
       61 cagacttggc acagcttcct acagtcttga aacagccctg ttgttctgtc atggccagtg
      121 ggcagtttgt gaacaaactg caagaggaag tgatctgccc catctgcctg gacattctgc
      181 agaaacctgt caccatcgac tgtgggcaca atttctgcct caaatgcatc actcagattg
      241 gggaaacatc atgtggattt ttcaaatgtc ccctctgcaa aacttccgta aggaagaacg
      301 caatcaggtt caactcgctg ttgcggaatc tggtggagaa aatccaagct ctacaagcct
      361 ctgaggtgca gtccaaaagg aaagaggcta catgcccgag gcaccaggag atgttccact
      421 atttctgcga ggatgatggg aagttcctct gttttgtgtg tcgtgaatcc aaggaccaca
      481 aatcccataa tgtcagcttg atcgaagaag ctgcccagaa ttatcagggg cagattcaag
      541 agcagatcca agtcttgcag caaaaggaga aggagacagt acaagtgaag gcacaaggtg
      601 tacacagggt cgatgtcttc acggaccagg tagaacatga gaagcaaagg atcctcacag
      661 aatttgaact cctgcatcaa gtcctagagg aggagaagaa tttcctgcta tcacggattt
      721 actggctggg tcatgaggga acggaagcgg ggaaacacta tgttgcctcc actgagccac
      781 agttgaacga tctcaagaag ctcgttgatt ccctgaagac caagcagaac atgccaccca
      841 ggcagctgct ggaggatatc aaagtcgtct tgtgcagaag tgaagagttt cagtttctca
      901 acccaacccc tgttcctctg gaactggaga aaaaactcag tgaagcaaaa tcaagacatg
      961 actccatcac agggagccta aaaaaattca aagaccaact ccaggctgat aggaaaaaag
     1021 atgaaaacag attcttcaaa agcatgaata aaaatgacat gaagagctgg ggcttgttac
     1081 agaaaaataa tcataaaatg aacaaaacct cagagcccgg gtcatcttct gcaggcggca
     1141 gaactacatc ggggccacca aatcaccact cttcagcccc atcccactcc ctgtttcggg
     1201 cctcgtctgc tgggaaagtc acttttccag tatgtctcct ggcctcttat gatgagattt
     1261 ctggtcaagg agcgagctct caggatacga agacatttga cgttgcgctg tccgaggagc
     1321 tccatgcggc actgagtgag tggctgacag cgatccgggc ttggttttgt gaggttcctt
     1381 caagctaagc cagctcagag aacacgggga gcggtggtgc tacacggact tcggagcata
     1441 gagtggcgct gagtgagtgg ctgagaccga ccacggttct tgacttagtg gaattgggtc
     1501 gaaggagtgg agaatgggag ggctcgggct actgagagtg gagatggggg cgggggtggt
     1561 ggtgaagaga gttggagaag gaatggacga attcttgagc aaaaggaggg gaagagacaa
     1621 tctccagcca cccgccccac gcttgacttc ttatcacttt ggctgtggtg ccgcctagtg
     1681 gaaaaaggaa gtccctgcag cagtccccgc actctttaag cagctgttta ccgaaggcac
     1741 cagttcagcc aggagtgaaa tccggagagg agcaacgcca gcctgggtca cagtccatca
     1801 aaccccatga gcccgaccac tctcgctctt ccttacattc ccacgtcccc cttctctccc
     1861 aacccctcat atcagcaagg gaaattaatt aatgagattt gataaatcag tagatagaat
     1921 gaggtcccca ttctgaaata tttagcagac tggaaccacc acgcaagcct ctgtaggggg
     1981 tggatggaga cacttctaac tttaataaac tgcgactgaa cgtggaa
//
