LOCUS       NM_033278               2838 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tripartite motif containing 3 (TRIM3), transcript
            variant 2, mRNA.
ACCESSION   NM_033278
VERSION     NM_033278.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Cong,Y., Cui,X., Shi,Y., Pan,X., Huang,K., Geng,Z., Xu,P., Ge,L.,
            Zhu,J., Xu,J. and Jia,X.
  TITLE     Tripartite-motif 3 represses ovarian cancer progression by
            downregulating lactate dehydrogenase A and inhibiting AKT signaling
  JOURNAL   Mol Cell Biochem 479 (12), 3405-3424 (2024)
   PUBMED   38367118
  REMARK    GeneRIF: Tripartite-motif 3 represses ovarian cancer progression by
            downregulating lactate dehydrogenase A and inhibiting AKT
            signaling.
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Teng,W., Ling,Y., Liu,Z., Jiang,L., Fu,G., Zhou,X., Long,N., Liu,J.
            and Chu,L.
  TITLE     Advances in the antitumor mechanisms of tripartite motif-containing
            protein 3
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 105 (2024)
   PUBMED   38411731
  REMARK    GeneRIF: Advances in the antitumor mechanisms of tripartite
            motif-containing protein 3.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Diaz,L.R., Gil-Ranedo,J., Jaworek,K.J., Nsek,N., Marques,J.P.,
            Costa,E., Hilton,D.A., Bieluczyk,H., Warrington,O., Hanemann,C.O.,
            Futschik,M.E., Bossing,T. and Barros,C.S.
  TITLE     Ribogenesis boosts controlled by HEATR1-MYC interplay promote
            transition into brain tumour growth
  JOURNAL   EMBO Rep 25 (1), 168-197 (2024)
   PUBMED   38225354
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Wang,Z., Shen,N., Wang,Z., Yu,L., Yang,S., Wang,Y., Liu,Y., Han,G.
            and Zhang,Q.
  TITLE     TRIM3 facilitates ferroptosis in non-small cell lung cancer through
            promoting SLC7A11/xCT K11-linked ubiquitination and degradation
  JOURNAL   Cell Death Differ 31 (1), 53-64 (2024)
   PUBMED   37978273
  REMARK    GeneRIF: TRIM3 facilitates ferroptosis in non-small cell lung
            cancer through promoting SLC7A11/xCT K11-linked ubiquitination and
            degradation.
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Esposito,D., Dudley-Fraser,J., Garza-Garcia,A. and Rittinger,K.
  TITLE     Divergent self-association properties of paralogous proteins TRIM2
            and TRIM3 regulate their E3 ligase activity
  JOURNAL   Nat Commun 13 (1), 7583 (2022)
   PUBMED   36481767
  REMARK    GeneRIF: Divergent self-association properties of paralogous
            proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Yan,Q., Sun,W., Kujala,P., Lotfi,Y., Vida,T.A. and Bean,A.J.
  TITLE     CART: an Hrs/actinin-4/BERP/myosin V protein complex required for
            efficient receptor recycling
  JOURNAL   Mol Biol Cell 16 (5), 2470-2482 (2005)
   PUBMED   15772161
  REMARK    GeneRIF: the endosome-associated protein hrs is a subunit of a
            protein complex containing actinin-4, BERP, and myosin V that is
            necessary for efficient TfR recycling but not for EGFR degradation
REFERENCE   7  (bases 1 to 2838)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   8  (bases 1 to 2838)
  AUTHORS   El-Husseini,A.E., Fretier,P. and Vincent,S.R.
  TITLE     Cloning and characterization of a gene (RNF22) encoding a novel
            brain expressed ring finger protein (BERP) that maps to human
            chromosome 11p15.5
  JOURNAL   Genomics 71 (3), 363-367 (2001)
   PUBMED   11170753
REFERENCE   9  (bases 1 to 2838)
  AUTHORS   El-Husseini,A.E., Kwasnicka,D., Yamada,T., Hirohashi,S. and
            Vincent,S.R.
  TITLE     BERP, a novel ring finger protein, binds to alpha-actinin-4
  JOURNAL   Biochem Biophys Res Commun 267 (3), 906-911 (2000)
   PUBMED   10673389
REFERENCE   10 (bases 1 to 2838)
  AUTHORS   El-Husseini,A.E. and Vincent,S.R.
  TITLE     Cloning and characterization of a novel RING finger protein that
            interacts with class V myosins
  JOURNAL   J Biol Chem 274 (28), 19771-19777 (1999)
   PUBMED   10391919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC096827.1, DA089323.1,
            BM758857.1, DA347370.1, DB344600.1 and AL122053.1.
            
            On Nov 24, 2018 this sequence version replaced NM_033278.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family, also called the
            'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins.
            The TRIM motif includes three zinc-binding domains, a RING, a B-box
            type 1 and a B-box type 2, and a coiled-coil region. This protein
            localizes to cytoplasmic filaments. It is similar to a rat protein
            which is a specific partner for the tail domain of myosin V, a
            class of myosins which are involved in the targeted transport of
            organelles. The rat protein can also interact with alpha-actinin-4.
            Thus it is suggested that this human protein may play a role in
            myosin V-mediated cargo transport. Alternatively spliced transcript
            variants encoding the same isoform have been identified. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 4 encode the same protein (isoform
            1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096827.1, SRR14038192.641752.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345851.8/ ENSP00000340797.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BC096827.1         44-194
            152-659             DA089323.1         70-577
            660-974             BM758857.1         155-469
            975-1467            DA347370.1         48-540
            1468-2623           BC096827.1         1511-2666
            2624-2827           DB344600.1         11-214              c
            2828-2838           AL122053.1         1644-1654
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2838
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /note="tripartite motif containing 3"
                     /db_xref="GeneID:10612"
                     /db_xref="HGNC:HGNC:10064"
                     /db_xref="MIM:605493"
     exon            1..151
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            152..319
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2423
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2; ring
                     finger protein 22; brain expressed ring finger; tripartite
                     motif protein TRIM3; tripartite motif-containing protein
                     3; RING finger protein 97; brain-expressed RING finger
                     protein"
                     /codon_start=1
                     /product="tripartite motif-containing protein 3 isoform 1"
                     /protein_id="NP_150594.2"
                     /db_xref="CCDS:CCDS7764.1"
                     /db_xref="GeneID:10612"
                     /db_xref="HGNC:HGNC:10064"
                     /db_xref="MIM:605493"
                     /translation="MAKREDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCER
                     CLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDP
                     HPLSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKA
                     ALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQA
                     LVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRE
                     RLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQ
                     ALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGTYELVYTA
                     RTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAV
                     RRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQ
                     CIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKF
                     KTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAG
                     PHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGN
                     IIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAY
                     RYLQ"
     exon            320..551
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            552..703
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            704..884
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1617
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1721
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1889
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2058
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2129
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2270
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2838
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2819..2824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /note="hexamer: AATAAA"
     polyA_site      2838
                     /gene="TRIM3"
                     /gene_synonym="BERP; HAC1; RNF22; RNF97"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgcggct agtccggcgg cggcgccggc gcggggacag gcggaggcgc gggcagggcc
       61 gggcggacgg gcgctggcag cagtagcagc gccgcgggcc cttcagagtg gccgcagtcc
      121 gagctttgcc ctcgcatcct gttccaacgc gaggctggtg tgagtggcgg gagccatctg
      181 tgggcgccat ggcaaagagg gaggacagcc ctggcccaga ggtccagcca atggacaagc
      241 agttcctggt atgcagcatc tgcctggatc ggtaccagtg ccccaaggtt cttccttgcc
      301 tgcacacctt ctgtgagaga tgtctccaaa actatatccc tgcccagagc ctgacgctat
      361 cctgtccagt atgccggcag acgtccatcc tcccagagca gggcgtctcg gcactgcaga
      421 acaacttctt catcagcagc ctcatggagg caatgcagca ggcacctgat ggggcccacg
      481 acccggagga cccccacccc ctcagtgtag tggctggccg ccctctctcc tgccccaacc
      541 atgaaggcaa gacgatggag ttttactgtg aggcctgtga gacggccatg tgtggtgagt
      601 gccgcgccgg ggagcatcgt gagcatggca cagtgctgct gagggatgtg gtggagcagc
      661 acaaggcggc cctgcagcgc cagctcgagg ctgtgcgtgg ccgattgcca cagctgtccg
      721 cagcaattgc cttagtcggg ggcatcagcc agcagctgca ggagcgcaag gcagaggccc
      781 tggcccagat cagtgcagcg ttcgaggacc tggagcaagc actgcagcag cgcaagcagg
      841 ctctggtcag cgacctggag accatttgtg gggccaaaca gaaggtgttg caaagccagc
      901 tggacacact gcgccagggt caggaacaca tcggcagtag ctgcagcttt gcagagcagg
      961 cactgcgcct gggctcggcc ccggaggtgt tgctggtgcg caagcacatg cgagagcggc
     1021 tggctgcatt ggcggcacag gccttcccgg agcggccaca tgagaatgca cagctggaac
     1081 tggtccttga ggtggacggt ctgcggcgat cggtgctcaa tctgggcgca ctgctcacca
     1141 cgagcgccac tgcacacgaa acggtggcca cgggagaggg cctgcgccag gcgctagtgg
     1201 gccagcctgc ctcgctcact gtcactacca aagacaagga cgggcggttg gtgcgcacag
     1261 gcagcgctga gctgcgtgca gagatcaccg gcccggacgg cacgcgcctt ccggtgccag
     1321 tggtggacca caagaatggc acatatgagc tagtgtacac agcgcgcacg gaaggcgagc
     1381 tgctcctctc ggtgctgctc tacggacagc cagtgcgcgg cagccccttc cgcgtgcgtg
     1441 ccctgcgtcc gggggacctg ccaccttccc cggacgatgt gaagcgccgt gtcaagtccc
     1501 ctggcggccc cggcagccat gtgcgccaga aggcagtgcg taggcccagc tccatgtaca
     1561 gcacaggcgg caaacgaaag gacaacccaa ttgaggatga gctcgtcttc cgtgttggca
     1621 gtcgtggaag ggagaaaggt gaattcacca atttacaagg tgtgtccgca gccagcagcg
     1681 gccgcatcgt ggtagcagac agcaacaacc agtgtattca ggttttctcc aatgagggcc
     1741 agttcaagtt ccgttttggg gtccgaggac gctcacctgg gcagctgcag cgccccacag
     1801 gtgtggcagt ggacaccaat ggagacataa ttgtggcaga ctatgacaac cgttgggtca
     1861 gcatcttctc ccctgagggc aagttcaaga ccaagattgg agctggccgc ctcatgggcc
     1921 ccaagggagt ggccgtagac cggaatggac atatcattgt ggtcgacaac aagtcttgct
     1981 gcgtctttac cttccagccc aatggcaaac tggttggccg ttttgggggc cgtggggcca
     2041 ctgaccgcca ctttgcaggg ccccattttg tggctgtgaa caacaagaat gaaattgtag
     2101 taacggactt ccataaccat tcagtgaagg tgtacagtgc cgatggagag ttcctcttca
     2161 agtttggctc ccatggcgag ggcaatgggc agttcaatgc ccccacagga gtagctgtgg
     2221 actccaatgg aaacatcatt gtggctgact ggggcaacag ccgcatccag gtattcgaca
     2281 gctctggctc cttcctgtcc tatatcaaca catctgcaga accactgtat ggtccacagg
     2341 gcctggcact gacctcggat ggccatgtgg tggtggctga tgctggcaac cactgcttta
     2401 aagcctatcg ctacctccag tagctgtaca gaggccctgc ctggcttgtg gagggacaga
     2461 cattggggtg attggacaag agggtctggc tgggaggtgg gccagacctg gcagcactga
     2521 atgtgggctg tgggcatggg tgcacccggt gccctccctc tcctaccccc acccccacgg
     2581 ttgcacttta tttattcggt tcttgctttg gtgactgggt gagcctggac tgtggtccca
     2641 aggatgtgtg cagagcttca ccctaccctt cttacacacc tccccacccc tgtcagtctg
     2701 ctccccatcc cccagcctgg ggccagaaca gcctacccca ggacaggagt ccctctagtt
     2761 gtctccctac caccctatac acactgacag agacagcaat accccacccc ccatattaaa
     2821 taaatgtctt caccaaga
//
