LOCUS       NM_012101               2977 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 29 (TRIM29), transcript
            variant 1, mRNA.
ACCESSION   NM_012101
VERSION     NM_012101.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Sun,Z., Li,X., Shi,Y. and Yao,Y.
  TITLE     LncRNA PVT1 facilitates the growth and metastasis of colorectal
            cancer by sponging with miR-3619-5p to regulate TRIM29 expression
  JOURNAL   Cancer Rep (Hoboken) 7 (6), e2085 (2024)
   PUBMED   38837682
  REMARK    GeneRIF: LncRNA PVT1 facilitates the growth and metastasis of
            colorectal cancer by sponging with miR-3619-5p to regulate TRIM29
            expression.
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Zhao,F.Y., Chen,X., Wang,J.M., Yuan,Y., Li,C., Sun,J. and Wang,H.Q.
  TITLE     O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop
            to promote adaptive response of PDAC cells to glucose deficiency
  JOURNAL   Cell Oncol (Dordr) 47 (3), 1025-1041 (2024)
   PUBMED   38345749
  REMARK    GeneRIF: O-GlcNAcylation of TRIM29 and OGT translation forms a
            feedback loop to promote adaptive response of PDAC cells to glucose
            deficiency.
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Huang,W., Hu,X., He,X., Pan,D., Huang,Z., Gu,Z., Huang,G., Wang,P.,
            Cui,C. and Fan,Y.
  TITLE     TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and
            is modulated by circRPS29/miR-770-5p axis in PDAC
  JOURNAL   Drug Resist Updat 74, 101079 (2024)
   PUBMED   38518727
  REMARK    GeneRIF: TRIM29 facilitates gemcitabine resistance via MEK/ERK
            pathway and is modulated by circRPS29/miR-770-5p axis in PDAC.
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Yin,Y.T., Shi,L., Wu,C., Zhang,M.Y., Li,J.X., Zhou,Y.F., Wang,S.C.,
            Wang,H.Y. and Mai,S.J.
  TITLE     TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3
            signaling pathway and suppresses the progression of hepatocellular
            carcinoma
  JOURNAL   Med Oncol 41 (3), 79 (2024)
   PUBMED   38393440
  REMARK    GeneRIF: TRIM29 modulates proteins involved in PTEN/AKT/mTOR and
            JAK2/STAT3 signaling pathway and suppresses the progression of
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2977)
  AUTHORS   Jiang,T., Xia,Y., Li,Y., Lu,C., Lin,J., Shen,Y., Lv,J., Xie,L.,
            Gu,C., Xu,Z. and Wang,L.
  TITLE     TRIM29 promotes antitumor immunity through enhancing IGF2BP1
            ubiquitination and subsequent PD-L1 downregulation in gastric
            cancer
  JOURNAL   Cancer Lett 581, 216510 (2024)
   PUBMED   38029830
  REMARK    GeneRIF: TRIM29 promotes antitumor immunity through enhancing
            IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in
            gastric cancer.
REFERENCE   6  (bases 1 to 2977)
  AUTHORS   Brzoska,P.M., Chen,H., Zhu,Y., Levin,N.A., Disatnik,M.H.,
            Mochly-Rosen,D., Murnane,J.P. and Christman,M.F.
  TITLE     The product of the ataxia-telangiectasia group D complementing
            gene, ATDC, interacts with a protein kinase C substrate and
            inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7824-7828 (1995)
   PUBMED   7644499
REFERENCE   7  (bases 1 to 2977)
  AUTHORS   Murnane,J.P., Zhu,Y., Young,B.R. and Christman,M.F.
  TITLE     Expression of the candidate A-T gene ATDC is not detectable in a
            human cell line with a normal response to ionizing radiation
  JOURNAL   Int J Radiat Biol 66 (6 Suppl), S77-S84 (1994)
   PUBMED   7836856
REFERENCE   8  (bases 1 to 2977)
  AUTHORS   Hosoi,Y. and Kapp,L.N.
  TITLE     Expression of a candidate ataxia-telangiectasia group D gene in
            cultured fibroblast cell lines and human tissues
  JOURNAL   Int J Radiat Biol 66 (6 Suppl), S71-S76 (1994)
   PUBMED   7530755
REFERENCE   9  (bases 1 to 2977)
  AUTHORS   Leonhardt,E.A., Kapp,L.N., Young,B.R. and Murnane,J.P.
  TITLE     Nucleotide sequence analysis of a candidate gene for
            ataxia-telangiectasia group D (ATDC)
  JOURNAL   Genomics 19 (1), 130-136 (1994)
   PUBMED   8188213
REFERENCE   10 (bases 1 to 2977)
  AUTHORS   Kapp,L.N., Painter,R.B., Yu,L.C., van Loon,N., Richard,C.W. 3rd,
            James,M.R., Cox,D.R. and Murnane,J.P.
  TITLE     Cloning of a candidate gene for ataxia-telangiectasia group D
  JOURNAL   Am J Hum Genet 51 (1), 45-54 (1992)
   PUBMED   1609804
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000679.7 and BC017352.2.
            
            On Nov 22, 2018 this sequence version replaced NM_012101.3.
            
            Summary: The protein encoded by this gene belongs to the TRIM
            protein family. It has multiple zinc finger motifs and a leucine
            zipper motif. It has been proposed to form homo- or heterodimers
            which are involved in nucleic acid binding. Thus, it may act as a
            transcriptional regulatory factor involved in carcinogenesis and/or
            differentiation. It may also function in the suppression of
            radiosensitivity since it is associated with ataxia telangiectasia
            phenotype. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017352.2, AK223090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341846.10/ ENSP00000343129.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-886               AP000679.7         24819-25704         c
            887-982             AP000679.7         15991-16086         c
            983-2977            BC017352.2         964-2958
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..2977
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /note="tripartite motif containing 29"
                     /db_xref="GeneID:23650"
                     /db_xref="HGNC:HGNC:17274"
                     /db_xref="MIM:610658"
     exon            1..886
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1849
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif protein TRIM29; ataxia-telangiectasia
                     group D-associated protein; tripartite motif-containing
                     protein 29"
                     /codon_start=1
                     /product="tripartite motif-containing protein 29 isoform
                     1"
                     /protein_id="NP_036233.2"
                     /db_xref="CCDS:CCDS8428.1"
                     /db_xref="GeneID:23650"
                     /db_xref="HGNC:HGNC:17274"
                     /db_xref="MIM:610658"
                     /translation="MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTN
                     GHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGK
                     RSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGL
                     FSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIR
                     DFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKE
                     QLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQ
                     REQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPP
                     LPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRY
                     VNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSSPGRFTKETTQKNFNNLYGT
                     KGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQSPKAQPQTWKSGKQT
                     MLSHYRPFYVNKGNGIGSNEAP"
     exon            887..982
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1216
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1415
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1517
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1610
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1709
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1786
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2977
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /note="hexamer: AATAAA"
     polyA_site      2977
                     /gene="TRIM29"
                     /gene_synonym="ATDC"
                     /note="major polyA site"
ORIGIN      
        1 actccctgcc gagacgcctg ccagaaaggt cacctatcct gaaccccagc aagcctgaaa
       61 cagctcagcc aagcaccctg cgatggaagc tgcagatgcc tccaggagca acgggtcgag
      121 cccagaagcc agggatgccc ggagcccgtc gggccccagt ggcagcctgg agaatggcac
      181 caaggctgac ggcaaggatg ccaagaccac caacgggcac ggcggggagg cagctgaggg
      241 caagagcctg ggcagcgccc tgaagccagg ggaaggtagg agcgccctgt tcgcgggcaa
      301 tgagtggcgg cgacccatca tccagtttgt cgagtccggg gacgacaaga actccaacta
      361 cttcagcatg gactctatgg aaggcaagag gtcgccgtac gcagggctcc agctgggggc
      421 tgccaagaag ccacccgtta cctttgccga aaagggcgag ctgcgcaagt ccattttctc
      481 ggagtcccgg aagcccacgg tgtccatcat ggagcccggg gagacccggc ggaacagcta
      541 cccccgggcc gacacgggcc ttttttcacg gtccaagtcc ggctccgagg aggtgctgtg
      601 cgactcctgc atcggcaaca agcagaaggc ggtcaagtcc tgcctggtgt gccaggcctc
      661 cttctgcgag ctgcatctca agccccacct ggagggcgcc gccttccgag accaccagct
      721 gctcgagccc atccgggact ttgaggcccg caagtgtccc gtgcatggca agacgatgga
      781 gctcttctgc cagaccgacc agacctgcat ctgctacctt tgcatgttcc aggagcacaa
      841 gaatcatagc accgtgacag tggaggaggc caaggccgag aaggagacgg agctgtcatt
      901 gcaaaaggag cagctgcagc tcaagatcat tgagattgag gatgaagctg agaagtggca
      961 gaaggagaag gaccgcatca agagcttcac caccaatgag aaggccatcc tggagcagaa
     1021 cttccgggac ctggtgcggg acctggagaa gcaaaaggag gaagtgaggg ctgcgctgga
     1081 gcagcgggag caggatgctg tggaccaagt gaaggtgatc atggatgctc tggatgagag
     1141 agccaaggtg ctgcatgagg acaagcagac ccgggagcag ctgcatagca tcagcgactc
     1201 tgtgttgttt ctgcaggaat ttggtgcatt gatgagcaat tactctctcc ccccacccct
     1261 gcccacctat catgtcctgc tggaggggga gggcctggga cagtcactag gcaacttcaa
     1321 ggacgacctg ctcaatgtat gcatgcgcca cgttgagaag atgtgcaagg cggacctgag
     1381 ccgtaacttc attgagagga accacatgga gaacggtggt gaccatcgct atgtgaacaa
     1441 ctacacgaac agcttcgggg gtgagtggag tgcaccggac accatgaaga gatactccat
     1501 gtacctgaca cccaaaggtg gggtccggac atcataccag ccctcgtctc ctggccgctt
     1561 caccaaggag accacccaga agaatttcaa caatctctat ggcaccaaag gtaactacac
     1621 ctcccgggtc tgggagtact cctccagcat tcagaactct gacaatgacc tgcccgtcgt
     1681 ccaaggcagc tcctccttct ccctgaaagg ctatccctcc ctcatgcgga gccaaagccc
     1741 caaggcccag ccccagactt ggaaatctgg caagcagact atgctgtctc actaccggcc
     1801 attctacgtc aacaaaggca acgggattgg gtccaacgaa gccccatgag ctcctggcgg
     1861 aaggaacgag gcgccacacc cctgctcttc ctcctgaccc tgctgctctt gccttctaag
     1921 ctactgtgct tgtctgggtg ggagggagcc tggtcctgca cctgccctct gcagccctct
     1981 gccagcctct tgggggcagt tccggcctct ccgacttccc cactggccac actccattca
     2041 gactcctttc ctgccttgtg acctcagatg gtcaccatca ttcctgtgct cagaggccaa
     2101 cccatcacag gggtgagata ggttggggcc tgccctaacc cgccagcctc ctcctctcgg
     2161 gctggatctg ggggctagca gtgagtaccc gcatggtatc agcctgcctc tcccgcccac
     2221 gccctgctgt ctccaggcct atagacgttt ctctccaagg ccctatcccc caatgttgtc
     2281 agcagatgcc tggacagcac agccacccat ctcccattca catggcccac ctcctgcttc
     2341 ccagaggact ggccctacgt gctctctctc gtcctaccta tcaatgccca gcatggcaga
     2401 acctgcagcc cttggccact gcagatggaa acctctcagt gtcttgacat caccctaccc
     2461 aggcggtggg tctccaccac agccactttg agtctgtggt ccctggaggg tggcttctcc
     2521 tgactggcag gatgacctta gccaagatat tcctctgttc cctctgctga gataaagaat
     2581 tcccttaaca tgatataatc cacccatgca aatagctact ggcccagcta ccatttacca
     2641 tttgcctaca gaatttcatt cagtctacac tttggcattc tctctggcga tggagtgtgg
     2701 ctgggctgac cgcaaaaggt gccttacaca ctgcccccac cctcagccgt tgccccatca
     2761 gaggctgcct cctccttctg attacccccc atgttgcata tcagggtgct caaggattgg
     2821 agaggagaca aaaccaggag cagcacagtg gggacatctc ccgtctcaac agccccaggc
     2881 ctatgggggc tctggaagga tgggccagct tgcaggggtt ggggagggag acatccagct
     2941 tgggctttcc cctttggaat aaaccattgg tctgtca
//
