LOCUS       NM_005762               3364 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens tripartite motif containing 28 (TRIM28), mRNA.
ACCESSION   NM_005762
VERSION     NM_005762.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Lam,S.Y., van der Lugt,R., Cerutti,A., Yalcin,Z., Thouin,A.M.,
            Simonetta,M. and Jacobs,J.J.L.
  TITLE     OTUD5 promotes end-joining of deprotected telomeres by promoting
            ATM-dependent phosphorylation of KAP1S824
  JOURNAL   Nat Commun 15 (1), 8960 (2024)
   PUBMED   39420004
  REMARK    GeneRIF: OTUD5 promotes end-joining of deprotected telomeres by
            promoting ATM-dependent phosphorylation of KAP1[S824].
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Liu,Z., Hu,Q., Luo,Q., Zhang,G., Yang,W., Cao,K., Fang,R., Wang,R.,
            Shi,H. and Zhang,B.
  TITLE     NUP37 accumulation mediated by TRIM28 enhances lipid synthesis to
            accelerate HCC progression
  JOURNAL   Oncogene 43 (44), 3255-3267 (2024)
   PUBMED   39294431
  REMARK    GeneRIF: NUP37 accumulation mediated by TRIM28 enhances lipid
            synthesis to accelerate HCC progression.
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Xue,C., Meng,H., Niu,W., Li,M., Wei,J., Chen,S., Zheng,L., Duan,Y.,
            Deng,H., Tang,F., Fan,S., Tan,M., Xiong,W. and Zhou,M.
  TITLE     TRIM28 promotes tumor growth and metastasis in breast cancer by
            targeting the BRD7 protein for ubiquitination and degradation
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1973-1993 (2024)
   PUBMED   39222175
  REMARK    GeneRIF: TRIM28 promotes tumor growth and metastasis in breast
            cancer by targeting the BRD7 protein for ubiquitination and
            degradation.
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Lin,K.H., Hibbert,J.E., Flynn,C.G., Lemens,J.L., Torbey,M.M.,
            Steinert,N.D., Flejsierowicz,P.M., Melka,K.M., Lindley,G.T.,
            Lares,M., Setaluri,V., Wagers,A.J. and Hornberger,T.A.
  TITLE     Satellite cell-derived TRIM28 is pivotal for mechanical load- and
            injury-induced myogenesis
  JOURNAL   EMBO Rep 25 (9), 3812-3841 (2024)
   PUBMED   39143258
  REMARK    GeneRIF: Satellite cell-derived TRIM28 is pivotal for mechanical
            load- and injury-induced myogenesis.
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Yang,Y., Zhang,Y., Chen,G., Sun,B., Luo,F., Gao,Y., Feng,H. and
            Li,Y.
  TITLE     KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity
            by protecting the RNA m6A reader YTHDC1 protein degradation
  JOURNAL   J Exp Clin Cancer Res 43 (1), 141 (2024)
   PUBMED   38745192
  REMARK    GeneRIF: KAP1 stabilizes MYCN mRNA and promotes neuroblastoma
            tumorigenicity by protecting the RNA m[6]A reader YTHDC1 protein
            degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Chang,C.J., Chen,Y.L. and Lee,S.C.
  TITLE     Coactivator TIF1beta interacts with transcription factor C/EBPbeta
            and glucocorticoid receptor to induce alpha1-acid glycoprotein gene
            expression
  JOURNAL   Mol Cell Biol 18 (10), 5880-5887 (1998)
   PUBMED   9742105
REFERENCE   7  (bases 1 to 3364)
  AUTHORS   Kim,S.S., Chen,Y.M., O'Leary,E., Witzgall,R., Vidal,M. and
            Bonventre,J.V.
  TITLE     A novel member of the RING finger family, KRIP-1, associates with
            the KRAB-A transcriptional repressor domain of zinc finger proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15299-15304 (1996)
   PUBMED   8986806
REFERENCE   8  (bases 1 to 3364)
  AUTHORS   Moosmann,P., Georgiev,O., Le Douarin,B., Bourquin,J.P. and
            Schaffner,W.
  TITLE     Transcriptional repression by RING finger protein TIF1 beta that
            interacts with the KRAB repressor domain of KOX1
  JOURNAL   Nucleic Acids Res 24 (24), 4859-4867 (1996)
   PUBMED   9016654
REFERENCE   9  (bases 1 to 3364)
  AUTHORS   Friedman,J.R., Fredericks,W.J., Jensen,D.E., Speicher,D.W.,
            Huang,X.P., Neilson,E.G. and Rauscher,F.J. 3rd.
  TITLE     KAP-1, a novel corepressor for the highly conserved KRAB repression
            domain
  JOURNAL   Genes Dev 10 (16), 2067-2078 (1996)
   PUBMED   8769649
REFERENCE   10 (bases 1 to 3364)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016630.6 and BC004978.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005762.2.
            
            Summary: The protein encoded by this gene mediates transcriptional
            control by interaction with the Kruppel-associated box repression
            domain found in many transcription factors. The protein localizes
            to the nucleus and is thought to associate with specific chromatin
            regions. The protein is a member of the tripartite motif family.
            This tripartite motif includes three zinc-binding domains, a RING,
            a B-box type 1 and a B-box type 2, and a coiled-coil region.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004978.1, SRR1163658.177162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253024.10/ ENSP00000253024.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AC016630.6         20520-20924         c
            406-3364            BC004978.1         1-2959
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3364
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /note="tripartite motif containing 28"
                     /db_xref="GeneID:10155"
                     /db_xref="HGNC:HGNC:16384"
                     /db_xref="MIM:601742"
     exon            1..1034
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             695..3202
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /EC_number="2.3.2.27"
                     /note="transcriptional intermediary factor 1-beta; nuclear
                     corepressor KAP-1; KRIP-1; TIF1-beta; protein phosphatase
                     1, regulatory subunit 157; KRAB [Kruppel-associated box
                     domain]-associated protein 1; RING finger protein 96;
                     KRAB-interacting protein 1; E3 SUMO-protein ligase TRIM28;
                     RING-type E3 ubiquitin transferase TIF1-beta"
                     /codon_start=1
                     /product="transcription intermediary factor 1-beta"
                     /protein_id="NP_005753.1"
                     /db_xref="CCDS:CCDS12985.1"
                     /db_xref="GeneID:10155"
                     /db_xref="HGNC:HGNC:16384"
                     /db_xref="MIM:601742"
                     /translation="MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASA
                     SAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANS
                     SGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNA
                     PATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLV
                     LFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKE
                     VRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWT
                     MTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQ
                     WDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYG
                     FGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKV
                     FPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPP
                     TATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDS
                     ATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSL
                     SLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDL
                     TLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNE
                     AFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP"
     exon            1035..1147
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1280
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1416
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1533
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1648
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1795
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1910
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2017
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2054
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2103
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2356
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2676
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2800
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2887
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3025
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3364
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3346..3351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /note="hexamer: AATAAA"
     polyA_site      3364
                     /gene="TRIM28"
                     /gene_synonym="KAP1; PPP1R157; RNF96; TF1B; TIF1B;
                     TIF1beta"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgcag aggctggaga cgactctacg gcggcgaaga gacgcgggtt gaggaagagg
       61 gacggattgc ccatgcgctt gggcgcacag cggcccgctt ctgtgtggtc tggaggtgga
      121 gctgagaggg gaatcacact ctataaaggt tcgcataccc cactggcgga ttcaattgcg
      181 gcagtgacgt cacagaggcc ccgccccgcc cccacaagag ccccaccgac gtggggttgg
      241 cggtggtgga aggactagga gttggcgcgt gcgtactggc ggcctctccc gcaccgaccg
      301 gcctgggccc cgcccccggg cgtgaggcgc ccaatgcgcg tgcgcggcgg cgtcggcgcc
      361 agttatttct gtcccgcccc ccggcctcgg ctctttctgc gagcgggcgc gcgggcgagc
      421 ggttgtgctt gtgcttgtgg cgcgtggtgc gggtttcggc ggcggctgag gaagaagcgc
      481 gggcggcgcc ttcgggaggc gagcaggcag cagttggccg tgccgtagca gcgtcccgcg
      541 cgcggcgggc agcggcccag gaggcgcgtg gcggcgctcg gcctcgcggc ggcggcggcg
      601 gcagcggccc agcagttggc ggcgagcgcg tctgcgcctg cgcggcgggc cccgcgcccc
      661 tcctcccccc ctgggcgccc ccggcggcgt gtgaatggcg gcctccgcgg cggcagcctc
      721 ggcagcagcg gcctcggccg cctctggcag cccgggcccg ggcgagggct ccgctggcgg
      781 cgaaaagcgc tccaccgccc cttcggccgc agcctcggcc tctgcctcag ccgcggcgtc
      841 gtcgcccgcg gggggcggcg ccgaggcgct ggagctgctg gagcactgcg gcgtgtgcag
      901 agagcgcctg cgacccgaga gggagccccg cctgctgccc tgtttgcact cggcctgtag
      961 tgcctgctta gggcccgcgg cccccgccgc cgccaacagc tcgggggacg gcggggcggc
     1021 gggcgacggc accgtggtgg actgtcccgt gtgcaagcaa cagtgcttct ccaaagacat
     1081 cgtggagaat tatttcatgc gtgatagtgg cagcaaggct gccaccgacg cccaggatgc
     1141 gaaccagtgc tgcactagct gtgaggataa tgccccagcc accagctact gtgtggagtg
     1201 ctcggagcct ctgtgtgaga cctgtgtaga ggcgcaccag cgggtgaagt acaccaagga
     1261 ccatactgtg cgctctactg ggccagccaa gtctcgggat ggtgaacgta ctgtctattg
     1321 caacgtacac aagcatgaac cccttgtgct gttttgtgag agctgtgata ctctcacctg
     1381 ccgagactgc cagctcaatg cccacaagga ccaccagtac cagttcttag aggatgcagt
     1441 gaggaaccag cgcaagctcc tggcctcact ggtgaagcgc cttggggaca aacatgcaac
     1501 attgcagaag agcaccaagg aggttcgcag ctcaatccgc caggtgtctg acgtacagaa
     1561 gcgtgtgcaa gtggatgtca agatggccat cctgcagatc atgaaggagc tgaataagcg
     1621 gggccgtgtg ctggtcaatg atgcccagaa ggtgactgag gggcagcagg agcgcctgga
     1681 gcggcagcac tggaccatga ccaagatcca gaagcaccag gagcacattc tgcgctttgc
     1741 ctcttgggct ctggagagtg acaacaacac agcccttttg ctttctaaga agttgatcta
     1801 cttccagctg caccgggccc tcaagatgat tgtggatccc gtggagccac atggcgagat
     1861 gaagtttcag tgggacctca atgcctggac caagagtgcc gaggcctttg gcaagattgt
     1921 ggcagagcgt cctggcacta actcaacagg ccctgcaccc atggcccctc caagagcccc
     1981 agggcccctg agcaagcagg gctctggcag cagccagccc atggaggtgc aggaaggcta
     2041 tggctttggg tcaggagatg atccctactc aagtgcagag ccccatgtgt caggtgtgaa
     2101 acggtcccgc tcaggtgagg gcgaggtgag cggccttatg cgcaaggtgc cacgagtgag
     2161 ccttgaacgc ctggacctgg acctcacagc tgacagccag ccacccgtct tcaaggtctt
     2221 cccaggcagt accactgagg actacaacct tattgttatt gaacgtggcg ctgccgctgc
     2281 agctaccggc cagccaggga ctgcgcctgc aggaacccct ggtgccccac ccctggctgg
     2341 catggccatt gtcaaggagg aggagacgga ggctgccatt ggagcccctc ctactgccac
     2401 tgagggccct gagaccaaac ctgtgcttat ggctcttgcg gagggtcctg gtgctgaggg
     2461 tccccgcctg gcctcaccta gtggcagcac cagctcaggg ctggaggtgg tggctcctga
     2521 gggtacctca gccccaggtg gtggcccggg aaccctggat gacagtgcca ccatttgccg
     2581 tgtctgccag aagccaggcg atctggttat gtgcaaccag tgtgagtttt gtttccacct
     2641 ggactgtcac ctgccggccc tgcaggatgt accaggggag gagtggagct gctcactctg
     2701 ccatgtgctc cctgacctga aggaggagga tggcagcctc agcctggatg gtgcagacag
     2761 cactggcgtg gtggccaagc tctcaccagc caaccagcgg aaatgtgagc gtgtactgct
     2821 ggccctattc tgtcacgaac cctgccgccc cctgcatcag ctggctaccg actccacctt
     2881 ctccctggac cagcccggtg gcaccctgga tctgaccctg atccgtgccc gcctccagga
     2941 gaagttgtca cctccctaca gctccccaca ggagtttgcc caggatgtgg gccgcatgtt
     3001 caagcaattc aacaagttaa ctgaggacaa ggcagacgtg cagtccatca tcggcctgca
     3061 gcgcttcttc gagacgcgca tgaacgaggc cttcggtgac accaagttct ctgctgtgct
     3121 ggtggagccc ccgccgatga gcctgcctgg tgctggcctg agttcccagg agctgtctgg
     3181 tggccctggt gatggcccct gaggctggag cccccatggc cagcccagcc tggctctgtt
     3241 ctctgtcctg tcaccccatc cccactcccc tggtggcctg actcccactc cctggtggcc
     3301 ccatccccca gttcctcacg atatggtttt tacttctgtg gatttaataa aaacttcacc
     3361 agtt
//
