LOCUS       NM_006510               2963 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens tripartite motif containing 27 (TRIM27), mRNA.
ACCESSION   NM_006510
VERSION     NM_006510.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Zhao,D., Qiang,L., Lei,Z., Ge,P., Lu,Z., Wang,Y., Zhang,X.,
            Qiang,Y., Li,B., Pang,Y., Zhang,L., Liu,C.H. and Wang,J.
  TITLE     TRIM27 elicits protective immunity against tuberculosis by
            activating TFEB-mediated autophagy flux
  JOURNAL   Autophagy 20 (7), 1483-1504 (2024)
   PUBMED   38390831
  REMARK    GeneRIF: TRIM27 elicits protective immunity against tuberculosis by
            activating TFEB-mediated autophagy flux.
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Chen,Y., Xiang,Y., Miao,X., Kuai,L., Ding,X., Ma,T., Li,B. and
            Fan,B.
  TITLE     METTL14 promotes IL-6-induced viability, glycolysis and
            inflammation in HaCaT cells via the m6A modification of TRIM27
  JOURNAL   J Cell Mol Med 28 (3), e18085 (2024)
   PUBMED   38146129
  REMARK    GeneRIF: METTL14 promotes IL-6-induced viability, glycolysis and
            inflammation in HaCaT cells via the m6A modification of TRIM27.
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Kimura,S., Suzuki,M., Nakamaru,Y., Kano,S., Watanabe,M., Honma,A.,
            Nakazono,A., Tsushima,N., Hatakeyama,S. and Homma,A.
  TITLE     TRIM27 expression is associated with poor prognosis in sinonasal
            mucosal melanoma
  JOURNAL   Rhinology 61 (3), 263-271 (2023)
   PUBMED   36891983
  REMARK    GeneRIF: TRIM27 expression is associated with poor prognosis in
            sinonasal mucosal melanoma.
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Smits,D.J., Dekker,J., Schot,R., Tabarki,B., Alhashem,A.,
            Demmers,J.A.A., Dekkers,D.H.W., Romito,A., van der Spek,P.J., van
            Ham,T.J., Bertoli-Avella,A.M. and Mancini,G.M.S.
  TITLE     CLEC16A interacts with retromer and TRIM27, and its loss impairs
            endosomal trafficking and neurodevelopment
  JOURNAL   Hum Genet 142 (3), 379-397 (2023)
   PUBMED   36538041
  REMARK    GeneRIF: CLEC16A interacts with retromer and TRIM27, and its loss
            impairs endosomal trafficking and neurodevelopment.
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Wang,H., Zhang,Y., Yan,L., Lv,Q., Lu,J. and Yun,B.
  TITLE     Analysis of TRIM27 prognosis value and immune infiltrates in
            hepatocellular carcinoma
  JOURNAL   Int J Immunopathol Pharmacol 36, 3946320221132986 (2022)
   PUBMED   36217828
  REMARK    GeneRIF: Analysis of TRIM27 prognosis value and immune infiltrates
            in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Vernet,C., Boretto,J., Mattei,M.G., Takahashi,M., Jack,L.J.,
            Mather,I.H., Rouquier,S. and Pontarotti,P.
  TITLE     Evolutionary study of multigenic families mapping close to the
            human MHC class I region
  JOURNAL   J Mol Evol 37 (6), 600-612 (1993)
   PUBMED   8114113
REFERENCE   7  (bases 1 to 2963)
  AUTHORS   Isomura,T., Tamiya-Koizumi,K., Suzuki,M., Yoshida,S., Taniguchi,M.,
            Matsuyama,M., Ishigaki,T., Sakuma,S. and Takahashi,M.
  TITLE     RFP is a DNA binding protein associated with the nuclear matrix
  JOURNAL   Nucleic Acids Res 20 (20), 5305-5310 (1992)
   PUBMED   1437549
REFERENCE   8  (bases 1 to 2963)
  AUTHORS   Takahashi,M., Buma,Y., Iwamoto,T., Inaguma,Y., Ikeda,H. and Hiai,H.
  TITLE     Cloning and expression of the ret proto-oncogene encoding a
            tyrosine kinase with two potential transmembrane domains
  JOURNAL   Oncogene 3 (5), 571-578 (1988)
   PUBMED   3078962
REFERENCE   9  (bases 1 to 2963)
  AUTHORS   Takahashi,M., Inaguma,Y., Hiai,H. and Hirose,F.
  TITLE     Developmentally regulated expression of a human 'finger'-containing
            gene encoded by the 5' half of the ret transforming gene
  JOURNAL   Mol Cell Biol 8 (4), 1853-1856 (1988)
   PUBMED   3380101
REFERENCE   10 (bases 1 to 2963)
  AUTHORS   Takahashi,M. and Cooper,G.M.
  TITLE     ret transforming gene encodes a fusion protein homologous to
            tyrosine kinases
  JOURNAL   Mol Cell Biol 7 (4), 1378-1385 (1987)
   PUBMED   3037315
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662871.9 and BC013580.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006510.4.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family. The TRIM motif includes three zinc-binding domains, a RING,
            a B-box type 1 and a B-box type 2, and a coiled-coil region. This
            protein localizes to the nuclear matrix. It interacts with the
            enhancer of polycomb protein and represses gene transcription. It
            is also thought to be involved in the differentiation of male germ
            cells. Fusion of the N-terminus of this protein with the truncated
            C-terminus of the RET gene product has been shown to result in
            production of the ret transforming protein. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ420519.1, BC013580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377199.4/ ENSP00000366404.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AL662871.9         59571-59875         c
            306-2095            BC013580.1         235-2024
            2096-2963           AL662871.9         38892-39759         c
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2963
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /note="tripartite motif containing 27"
                     /db_xref="GeneID:5987"
                     /db_xref="HGNC:HGNC:9975"
                     /db_xref="MIM:602165"
     exon            1..773
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1895
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /EC_number="2.3.2.27"
                     /note="ret finger protein; tripartite motif protein
                     TRIM27; RFP transforming protein; RING finger protein 76;
                     tripartite motif-containing protein 27; RING-type E3
                     ubiquitin transferase TRIM27"
                     /codon_start=1
                     /product="zinc finger protein RFP"
                     /protein_id="NP_006501.1"
                     /db_xref="CCDS:CCDS4654.1"
                     /db_xref="GeneID:5987"
                     /db_xref="HGNC:HGNC:9975"
                     /db_xref="MIM:602165"
                     /translation="MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCW
                     GTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP
                     LKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRR
                     RAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGA
                     ITQFSCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEK
                     IHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDN
                     LRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSV
                     CRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFY
                     NVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHS
                     METSP"
     exon            774..869
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1100
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1123
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1239
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1272
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1299
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2963
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /note="hexamer: AATAAA"
     polyA_site      2963
                     /gene="TRIM27"
                     /gene_synonym="RFP; RNF76"
                     /note="major polyA site"
ORIGIN      
        1 acgctgccgc cggcatccgc tcggacgcgg ccacgttgtc ttgcgcgctt tgcccgcctg
       61 gccctgggac tctgaccctc ggctaccctt tcctgcccca ctagcgtggc cgcgagcctc
      121 ggtgagccgg ccgtattccc gctctcgctt agggggcaca ggcgcaggca tcggcccggc
      181 cactccaagc cttcggtgcg cgggcgcgtc tgggatacgg gcccgggagg cgccgccctc
      241 cgtccgcccg gtgcctctca ggaacagcga accggagaga gcgccggaga gttgggctca
      301 gtgcagagct cggcgccggg gcccatgccc gtgcgccccc gcaggccggc gccatggcct
      361 ccgggagtgt ggccgagtgc ctgcagcagg agaccacctg ccccgtgtgc ctgcagtact
      421 tcgcagagcc catgatgctc gactgcggcc ataacatctg ttgcgcgtgc ctcgcccgct
      481 gctggggcac ggcagagact aacgtgtcgt gcccgcagtg ccgggagacc ttcccgcaga
      541 ggcacatgcg gcccaaccgg cacctggcca acgtgaccca actggtaaag cagctgcgca
      601 ccgagcggcc gtcggggccc ggcggcgaga tgggcgtgtg cgagaagcac cgcgagcccc
      661 tgaagctgta ctgcgaggag gaccagatgc ccatctgcgt ggtgtgcgac cgctcccgcg
      721 agcaccgcgg ccacagcgtg ctgccgctcg aggaggcggt ggagggcttc aaggagcaaa
      781 tccagaacca gctcgaccat ttaaaaagag tgaaagattt aaagaagaga cgtcgggccc
      841 agggggaaca ggcacgagct gaactcttga gcctaaccca gatggagagg gagaagattg
      901 tttgggagtt tgagcagctg tatcactcct taaaggagca tgagtatcgc ctcctggccc
      961 gccttgagga gctagacttg gccatctaca atagcatcaa tggtgccatc acccagttct
     1021 cttgcaacat ctcccacctc agcagcctga tcgctcagct agaagagaag cagcagcagc
     1081 ccaccaggga gctcctgcag gacattgggg acacattgag cagggctgaa agaatcagga
     1141 ttcctgaacc ttggatcaca cctccagatt tgcaagagaa aatccacatt tttgcccaaa
     1201 aatgtctatt cttgacggag agtctaaagc agttcacaga aaaaatgcag tcagatatgg
     1261 agaaaatcca agaattaaga gaggctcagt tatactcagt ggacgtgact ctggacccag
     1321 acacggccta ccccagcctg atcctctctg ataatctgcg gcaagtgcgg tacagttacc
     1381 tccaacagga cctgcctgac aaccccgaga ggttcaatct gtttccctgt gtcttgggct
     1441 ctccatgctt catcgccggg agacattatt gggaggtaga ggtgggagat aaagccaagt
     1501 ggaccatagg tgtctgtgaa gactcagtgt gcagaaaagg tggagtaacc tcagcccccc
     1561 agaatggatt ctgggcagtg tctttgtggt atgggaaaga atattgggct cttacctccc
     1621 caatgactgc cctacccctg cggaccccgc tccagcgggt ggggattttc ttggactatg
     1681 atgctggtga ggtctccttc tacaacgtga cagagaggtg tcacaccttc actttctctc
     1741 atgctacctt ttgtgggcct gtccggccct acttcagtct gagttactcg ggagggaaaa
     1801 gtgcagctcc tctgatcatc tgccccatga gtgggataga tgggttttct ggccatgttg
     1861 ggaatcatgg tcattccatg gagacctccc cttgaggagg tgaattcagg ccaaaagggc
     1921 tgttggctgt aatcctacgc caggcacaag gcatcttgtt gccttgccac gtcctgtcac
     1981 agctgggtat ccttaccatg ttccacgccc ttgcagtggg agacaggatg tccatgttct
     2041 ctaccatcct tttccttccc atgcagattg tgaaatgtaa tgagatgtat caagatatcc
     2101 tagaaataaa aaccagatgt ccacctccag tgtttcatac tttctggttt tacacatcgc
     2161 tggagggata aagagtatgg ataatctttg gatttggaga gccgttcaag atacttccag
     2221 cttcttggct cagcctggct tcctctggtt cagccccaca taatgattat ggctatttgc
     2281 tgtcatttct gggctagggc tcctttctaa caacctagac tggaataagg ccctgtcagc
     2341 atggctccct ttatcccagt tttccgtctg ggaacagtac ctctgcccct gattcccaat
     2401 gtgccatagt tttattaact ccattaaaga agcctgtatg tgttttggtt agttacagtt
     2461 attttacaat aatggtgggt aatggcccca cctctgttat gagataatgt tctaatcaat
     2521 gtctctgcct ttgtatcttt tctgagggct ttgtctgttc tcttcattct aatgaaaggt
     2581 gtattctagt gctgggtgca tatcatccag gataatattc tgcccaactc catcctctgt
     2641 tactagatcc cttaccagtc acatttgtgg actggtggcc agtcgtatac catccctgga
     2701 aggattctgg gacaatattc cagggattca ttgacttctt ggctcctttt ctccatttcc
     2761 tttgggggaa gggggaattg accatgctta agtgcatcct atcaaggggc agctccgtcc
     2821 ccatggccat tggatcatga gacactctga agtcagaagg ctggggcaga tcacttcaag
     2881 caagccccca tgatggttct cagtcctgct tctctgtggg tacgtgcccc tctgtttaaa
     2941 aataaactga atatggatgt tta
//
