LOCUS       NM_003449               3518 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens tripartite motif containing 26 (TRIM26), transcript
            variant 1, mRNA.
ACCESSION   NM_003449
VERSION     NM_003449.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Zheng,D., Ning,J., Deng,H., Ruan,Y. and Cheng,F.
  TITLE     TRIM26 inhibits clear cell renal cell carcinoma progression through
            destabilizing ETK and thus inactivation of AKT/mTOR signaling
  JOURNAL   J Transl Med 22 (1), 481 (2024)
   PUBMED   38773612
  REMARK    GeneRIF: TRIM26 inhibits clear cell renal cell carcinoma
            progression through destabilizing ETK and thus inactivation of
            AKT/mTOR signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Zhang,M., Tan,H., Gong,Y., Faleti,O.D., Li,D., Yang,J., Huang,J.,
            Long,J., Luo,Q., Wu,G., Zheng,L. and Lyu,X.
  TITLE     TRIM26 restricts Epstein-Barr virus infection in nasopharyngeal
            epithelial cells through K48-linked ubiquitination of HSP-90beta
  JOURNAL   FASEB J 38 (1), e23345 (2024)
   PUBMED   38038978
  REMARK    GeneRIF: TRIM26 restricts Epstein-Barr virus infection in
            nasopharyngeal epithelial cells through K48-linked ubiquitination
            of HSP-90beta.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Wang,Z., Xia,Y., Wang,Y., Zhu,R., Li,H., Liu,Y. and Shen,N.
  TITLE     The E3 ligase TRIM26 suppresses ferroptosis through catalyzing
            K63-linked ubiquitination of GPX4 in glioma
  JOURNAL   Cell Death Dis 14 (10), 695 (2023)
   PUBMED   37872147
  REMARK    GeneRIF: The E3 ligase TRIM26 suppresses ferroptosis through
            catalyzing K63-linked ubiquitination of GPX4 in glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Xia,K., Zheng,D., Wei,Z., Liu,W. and Guo,W.
  TITLE     TRIM26 inhibited osteosarcoma progression through destabilizing
            RACK1 and thus inactivation of MEK/ERK signaling
  JOURNAL   Cell Death Dis 14 (8), 529 (2023)
   PUBMED   37591850
  REMARK    GeneRIF: TRIM26 inhibited osteosarcoma progression through
            destabilizing RACK1 and thus inactivation of MEK/ERK signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Lu,T. and Wu,Y.
  TITLE     Tripartite Motif Containing 26 is a Positive Predictor for
            Endometrial Carcinoma Patients and Regulates Cell Survival in
            Endometrial Carcinoma
  JOURNAL   Horm Metab Res 54 (12), 859-865 (2022)
   PUBMED   36108622
  REMARK    GeneRIF: Tripartite Motif Containing 26 is a Positive Predictor for
            Endometrial Carcinoma Patients and Regulates Cell Survival in
            Endometrial Carcinoma.
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Chu,T.W., Capossela,A., Coleman,R., Goei,V.L., Nallur,G. and
            Gruen,J.R.
  TITLE     Cloning of a new 'finger' protein gene (ZNF173) within the class I
            region of the human MHC
  JOURNAL   Genomics 29 (1), 229-239 (1995)
   PUBMED   8530076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA234548.1 and BC024039.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003449.4.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies. Although the function of the protein is unknown, the RING
            domain suggests that the protein may have DNA-binding activity. The
            gene localizes to the major histocompatibility complex (MHC) class
            I region on chromosome 6. Alternatively spliced transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024039.1, SRR1803615.231287.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454678.7/ ENSP00000410446.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA234548.1         89-146
            59-3518             BC024039.1         1-3460
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3518
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /note="tripartite motif containing 26"
                     /db_xref="GeneID:7726"
                     /db_xref="HGNC:HGNC:12962"
                     /db_xref="MIM:600830"
     exon            1..102
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            103..212
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            213..316
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            317..915
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..2097
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 173; acid finger protein;
                     widely expressed acid zinc finger protein; RING finger
                     protein 95"
                     /codon_start=1
                     /product="tripartite motif-containing protein 26"
                     /protein_id="NP_003440.1"
                     /db_xref="CCDS:CCDS4678.1"
                     /db_xref="GeneID:7726"
                     /db_xref="HGNC:HGNC:12962"
                     /db_xref="MIM:600830"
                     /translation="MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVR
                     PISGSRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLC
                     ERHREKLHYYCEDDGKLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDR
                     DKIQGFQAKGEADILAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELT
                     EGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIA
                     RVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKC
                     VTYTSLYKSAYLHPQQFDCEPGVLGSKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEG
                     EEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEVLESCMVGVARDSVKRKG
                     DLSLRPEDGVWALRLSSSGIWANTSPEAELFPALRPRRVGIALDYEGGTVTFTNAESQ
                     ELIYTFTATFTRRLVPFLWLKWPGTRLLLRP"
     exon            916..1011
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1242
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1265
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1381
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1414
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..3518
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3498..3503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="TRIM26"
                     /gene_synonym="AFP; RNF95; ZNF173"
                     /note="major polyA site"
ORIGIN      
        1 gagctgtcgc gctggttgct cgtgcaggag cgggacccgg aacagaccgc cgtgagagag
       61 gaggggtgcc ggccgggatt cgcggcccgg agctcgggac cggagtcagg aatggagaga
      121 agggtaatgg ttttacctct tattgtggaa acctgttgag atcacagaga atatactgac
      181 ggcataaaag ggcagaacca tagcagggtg cggttgcttc attccagcct cgcagtcacc
      241 tctgtgccct gctggttgtc ttcccagcgc tgctgtagtt gccttccatg gatctatagg
      301 agagcaagtc ctccaggagc tggtggtgtc tgtcgattga ctgagtgctg gagctggcag
      361 ccctgtgcag gctgccacct ttgccccttt actgtgcttg ctcctgactc tatgtcgcgt
      421 ctccaaggag aagaagtcct caccagtgaa cggagacctc tctgaactaa ggataccatg
      481 gccacgtcag ccccactacg gagcctggaa gaggaggtga cctgctccat ctgtcttgat
      541 tacctgcggg accctgtgac cattgactgt ggccacgtct tctgccgcag ctgcaccaca
      601 gacgtccgcc ccatctcagg gagccgcccc gtctgcccac tctgcaagaa gccttttaag
      661 aaggagaaca tccgacccgt gtggcaactg gccagcctgg tggagaacat tgagcggctg
      721 aaggtggaca agggcaggca gccgggagag gtgacccggg agcagcagga tgcaaagttg
      781 tgcgagcgac accgagagaa gctgcactac tactgtgagg acgacgggaa gctgctgtgc
      841 gtgatgtgcc gggagtcccg ggagcacagg ccccacacgg ccgtcctcat ggagaaggcc
      901 gcccagcccc acagggaaaa aatcctgaac cacctgagta ccctaaggag ggacagagac
      961 aaaattcagg gcttccaggc aaagggagaa gctgatatcc tggccgcgct gaagaagctc
     1021 caggaccaga ggcagtacat tgtggctgag tttgagcagg gtcatcagtt cctgagggag
     1081 cgggaggaac acctgctgga acagctggcg aagctggagc aggagctcac ggagggcagg
     1141 gagaagttca agagccgggg cgtcggggag cttgcccggc tggccctggt catctccgaa
     1201 ctggagggca aggcgcagca gccagctgca gagctcatgc aggacacgag agacttccta
     1261 aacaggtatc cacggaagaa gttctgggtt gggaaaccca ttgctcgagt ggttaaaaaa
     1321 aagaccggag aattctcaga taaactcctc tctctgcaac gaggcctgag ggaattccag
     1381 gggaagctgc tgagagactt ggaatataag acagtgagcg tcaccctgga cccacagtcg
     1441 gccagtgggt acctgcagct gtcagaggac tggaagtgcg tgacctacac cagcctgtac
     1501 aagagtgcct acctgcaccc ccagcagttt gactgtgagc ctggggtgct aggcagcaag
     1561 ggcttcacct ggggcaaggt ctactgggaa gtggaagtgg agagggaggg ctggtctgag
     1621 gatgaagaag agggggatga ggaggaagag ggagaagagg aggaggagga agaggaggcc
     1681 ggctatgggg atggatatga cgactgggaa acggacgaag atgaggaatc gttgggcgat
     1741 gaagaggaag aagaggagga ggaagaggag gaagttctgg aaagctgcat ggtgggggtg
     1801 gctagagact ctgtgaagag gaagggagac ctctccctgc ggccagagga tggcgtgtgg
     1861 gcgctgcgcc tctcctcctc cggcatctgg gccaacacca gccccgaggc tgagcttttc
     1921 ccagcactgc ggccccggag agtgggcatc gccctggatt atgaaggggg caccgtgact
     1981 ttcaccaacg cagagtcaca ggaactcatc tacaccttca ctgccacctt cacccggcgc
     2041 ctggtcccct tcctgtggct caagtggcca ggaacacgcc tcctgctaag accctgagcc
     2101 ctgacatctg cccccagccc caaccctcag atgcttcact tctttggaat tccaggactc
     2161 tcaatggggg gacgggatgc ctggcctaag cacctggagc aggggacccc atatccactg
     2221 gtagccacct ccccattgct gtggccccct gaaatctcac tcagtgctgt tgctccatct
     2281 actgccctaa tggggctctt ttcccacctc ctgctggttt cccgagggaa cttctgaccc
     2341 tggagtccat gagggctcct ttcctttttg accacgacct tggccccagc tctgcactct
     2401 ctggaataag ggcccgatgc agcattttct tgcccagtgt ggcaagacct cagaaaaacc
     2461 agtcaattac gcctaagatc attttgctgt ccttaaaccc cccaggttcc ttcttgcaca
     2521 aatccactct gctgcccacc ttccctggca ttttaaacag acctacccca ccccaactca
     2581 gagttaagca tacatggcaa tgctgaaaat aaacaaaatc cactgaggct tcccaggcca
     2641 tttaaagcct ggagtaccag cgcatatcat ctcatggggt ccagagtgga gtccaggctt
     2701 ctctgaaacc agggctgagc atatttccat agccaaggag gtgggactcc ctggagctat
     2761 ctgtggtctt agggaaggat ccagacatac acggctttgg ggtacaagct gtgatcactg
     2821 atcaataaat tatctctaga ttggtccttg tgaggggagt tttaagaatc cagaacatct
     2881 tgctcttgat cagcacatcc aaaaacacca agacaaacat ccagtggagc agaacctctc
     2941 ctgcctcggg agttctgacc gggttcccca gcagggtgtt aagcctctgt ctctggccct
     3001 accagcatcc aggttccact ttcctaggag agagtggaga tgggaagaca gggaaaggaa
     3061 ggcagcagga ggccacaagc ccaccaggtc ttcatgtcaa gagagggagt aacatgtctt
     3121 ctcattgccc acggacccaa cctctgtcca ggtgcccctc atcatcacag tttaacacaa
     3181 gctcccctgc tccagccaaa ttgatctccc agtcttgtcc ttacccattc caagtgctct
     3241 gccagcccct gttcatccaa gttttaagtc ctccaccctg ttctaagaga ctgttccaac
     3301 ggctctgggc ctcagtggtc acttgaccac cattgtctca gagctgccca ctttgtgtgt
     3361 gtcacatgct gcctgagtca catgtacatc ttatttctgc ctctagtttt gtaagctcct
     3421 ggagggcgga taacatctta tactactctt gtattctcat ggcacctagt gcagtgctgg
     3481 gcacagagta ggtgctcaat aaagacttgt tgaatgaa
//
