LOCUS       NM_005082               5745 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens tripartite motif containing 25 (TRIM25), mRNA.
ACCESSION   NM_005082 XM_498674
VERSION     NM_005082.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5745)
  AUTHORS   Han,S., Guo,J., Kong,C., Li,J., Lin,F., Zhu,J., Wang,T., Chen,Q.,
            Liu,Y., Hu,H., Qiu,T., Cheng,F. and Zhou,J.
  TITLE     ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting
            TRIM25-mediated ubiquitination of ACSL3
  JOURNAL   Clin Transl Med 14 (9), e70024 (2024)
   PUBMED   39285846
  REMARK    GeneRIF: ANKRD1 aggravates renal ischaemia-reperfusion injury via
            promoting TRIM25-mediated ubiquitination of ACSL3.
REFERENCE   2  (bases 1 to 5745)
  AUTHORS   Wu,H., Gao,W., Ma,Y., Zhong,X., Qian,J., Huang,D. and Ge,J.
  TITLE     TRIM25-mediated XRCC1 ubiquitination accelerates atherosclerosis by
            inducing macrophage M1 polarization and programmed death
  JOURNAL   Inflamm Res 73 (9), 1445-1458 (2024)
   PUBMED   38896288
  REMARK    GeneRIF: TRIM25-mediated XRCC1 ubiquitination accelerates
            atherosclerosis by inducing macrophage M1 polarization and
            programmed death.
REFERENCE   3  (bases 1 to 5745)
  AUTHORS   Tavakoli,R., Rahimi,P., Fateh,A., Hamidi-Fard,M., Eaybpoosh,S.,
            Bahramali,G., Sadeghi,S.A., Doroud,D. and Aghasadeghi,M.
  TITLE     Exploring the impression of TRIM25 gene expression on COVID-19
            severity and SARS-CoV-2 viral replication
  JOURNAL   J Infect Public Health 17 (8), 102489 (2024)
   PUBMED   38964175
  REMARK    GeneRIF: Exploring the impression of TRIM25 gene expression on
            COVID-19 severity and SARS-CoV-2 viral replication.
REFERENCE   4  (bases 1 to 5745)
  AUTHORS   Shang,Z., Zhang,S., Wang,J., Zhou,L., Zhang,X., Billadeau,D.D.,
            Yang,P., Zhang,L., Zhou,F., Bai,P. and Jia,D.
  TITLE     TRIM25 predominately associates with anti-viral stress granules
  JOURNAL   Nat Commun 15 (1), 4127 (2024)
   PUBMED   38750080
  REMARK    GeneRIF: TRIM25 predominately associates with anti-viral stress
            granules.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5745)
  AUTHORS   Yan,Y., Zhou,S., Chen,X., Yi,Q., Feng,S., Zhao,Z., Liu,Y.,
            Liang,Q., Xu,Z., Li,Z. and Sun,L.
  TITLE     Suppression of ITPKB degradation by Trim25 confers TMZ resistance
            in glioblastoma through ROS homeostasis
  JOURNAL   Signal Transduct Target Ther 9 (1), 58 (2024)
   PUBMED   38438346
  REMARK    GeneRIF: Suppression of ITPKB degradation by Trim25 confers TMZ
            resistance in glioblastoma through ROS homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5745)
  AUTHORS   Chaudhary,P.M., Eby,M.T., Jasmin,A., Kumar,A., Liu,L. and Hood,L.
  TITLE     Activation of the NF-kappaB pathway by caspase 8 and its homologs
  JOURNAL   Oncogene 19 (39), 4451-4460 (2000)
   PUBMED   11002417
REFERENCE   7  (bases 1 to 5745)
  AUTHORS   Ikeda,K., Orimo,A., Higashi,Y., Muramatsu,M. and Inoue,S.
  TITLE     Efp as a primary estrogen-responsive gene in human breast cancer
  JOURNAL   FEBS Lett 472 (1), 9-13 (2000)
   PUBMED   10781795
REFERENCE   8  (bases 1 to 5745)
  AUTHORS   Ikeda,K., Inoue,S., Orimo,A., Sano,M., Watanabe,T., Tsutsumi,K. and
            Muramatsu,M.
  TITLE     Multiple regulatory elements and binding proteins of the
            5'-flanking region of the human estrogen-responsive finger protein
            (efp) gene
  JOURNAL   Biochem Biophys Res Commun 236 (3), 765-771 (1997)
   PUBMED   9245730
REFERENCE   9  (bases 1 to 5745)
  AUTHORS   Inoue,S., Orimo,A., Matsuda,Y., Inazawa,J., Emi,M., Nakamura,Y.,
            Hori,T. and Muramatsu,M.
  TITLE     Chromosome mapping of human (ZNF147) and mouse genes for
            estrogen-responsive finger protein (efp), a member of the RING
            finger family
  JOURNAL   Genomics 25 (2), 581-583 (1995)
   PUBMED   7789997
REFERENCE   10 (bases 1 to 5745)
  AUTHORS   Inoue,S., Orimo,A., Hosoi,T., Kondo,S., Toyoshima,H., Kondo,T.,
            Ikegami,A., Ouchi,Y., Orimo,H. and Muramatsu,M.
  TITLE     Genomic binding-site cloning reveals an estrogen-responsive gene
            that encodes a RING finger protein
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11117-11121 (1993)
   PUBMED   8248217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015912.16, BM146967.1,
            BC042541.1 and CF121587.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005082.4.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein is an RNA binding protein,
            functions as a ubiquitin E3 ligase and is involved in multiple
            cellular processes, including regulation of antiviral innate
            immunity. [provided by RefSeq, Sep 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042541.1, ERR4368410.424130.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000316881.9/ ENSP00000323889.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC015912.16        101315-101315       c
            2-17                BM146967.1         2-17
            18-1133             BC042541.1         1-1116
            1134-1623           CF121587.1         100-589
            1624-5745           AC015912.16        75175-79296         c
FEATURES             Location/Qualifiers
     source          1..5745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..5745
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /note="tripartite motif containing 25"
                     /db_xref="GeneID:7706"
                     /db_xref="HGNC:HGNC:12932"
                     /db_xref="MIM:600453"
     exon            1..658
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1954
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /EC_number="6.3.2.n3"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 147 (estrogen-responsive finger
                     protein); tripartite motif protein TRIM25; zinc finger
                     protein-147; RING finger protein 147; tripartite
                     motif-containing protein 25; ubiquitin/ISG15-conjugating
                     enzyme TRIM25; RING-type E3 ubiquitin transferase TRIM25"
                     /codon_start=1
                     /product="E3 ubiquitin/ISG15 ligase TRIM25"
                     /protein_id="NP_005073.2"
                     /db_xref="CCDS:CCDS11591.1"
                     /db_xref="GeneID:7706"
                     /db_xref="HGNC:HGNC:12932"
                     /db_xref="MIM:600453"
                     /translation="MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQ
                     GSPYLCPQCRAVYQARPQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPN
                     AQVACDHCLKEAAVKTCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQH
                     NRLREFFCPEHSECICHICLVEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASR
                     ALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDT
                     IYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLI
                     KGIHQSTIDLKNELKQCIGRLQEPTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKK
                     PPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRP
                     ELLEYYIKVILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYK
                     KGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASWCVEWFNTKISAWHNNVE
                     KTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAFWVFSAGATL
                     SICSPK"
     exon            659..754
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            755..988
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1148
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1214
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1241
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1325
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1424
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..5745
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5724..5729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /note="hexamer: AATAAA"
     polyA_site      5745
                     /gene="TRIM25"
                     /gene_synonym="EFP; RNF147; Z147; ZNF147"
                     /note="major polyA site"
ORIGIN      
        1 cgtttcctcg gcggcctcgg agcgcgggtg cagcagttgt gtcccgaccc ctgggagcgc
       61 catggcagag ctgtgccccc tggccgagga gctgtcgtgc tccatctgcc tggagccctt
      121 caaggagccg gtcaccactc cgtgcggcca caacttctgc gggtcgtgcc tgaatgagac
      181 gtgggcagtc cagggctcgc catacctgtg cccgcagtgc cgcgccgtct accaggcgcg
      241 accgcagctg cacaagaaca cggtgctgtg caacgtggtg gagcagttcc tgcaggccga
      301 cctggcccgg gagccacccg ccgacgtctg gacgccgccc gcccgcgcct ctgcacccag
      361 cccgaatgcc caggtggcct gcgaccactg cctgaaggag gccgccgtga agacgtgctt
      421 ggtgtgcatg gcctccttct gtcaggagca cctgcagccg cacttcgaca gccccgcctt
      481 ccaggaccac ccgctgcagc cgcccgttcg cgacctgttg cgccgcaaat gttcccagca
      541 caatcggctg cgggaatttt tctgccccga gcacagcgag tgcatctgcc acatctgcct
      601 ggtggagcat aagacctgct ctcccgcgtc cctgagccag gccagcgccg acctggaggc
      661 caccctgagg cacaaactaa ctgtcatgta cagtcagatc aacggggcgt cgagagcact
      721 ggatgatgtg agaaacaggc agcaggatgt gcggatgact gcaaacagaa aggtggagca
      781 gctacaacaa gaatacacgg aaatgaaggc tctcttggac gcctcagaga ccacctcgac
      841 aaggaagata aaggaagagg agaagagggt caacagcaag tttgacacca tttatcagat
      901 tctcctcaag aagaagagtg agatccagac cttgaaggag gagattgaac agagcctgac
      961 caagagggat gagttcgagt ttctggagaa agcatcaaaa ctgcgaggaa tctcaacaaa
     1021 gccagtctac atccccgagg tggaactgaa ccacaagctg ataaaaggca tccaccagag
     1081 caccatagac ctcaaaaacg agctgaagca gtgcatcggg cggctccagg agcccacccc
     1141 cagttcaggt gaccctggag agcatgaccc agcgtccaca cacaaatcca cacgccctgt
     1201 gaagaaggtc tccaaagagg aaaagaaatc caagaaacct ccccctgtcc ctgccttacc
     1261 cagcaagctt cccacgtttg gagccccgga acagttagtg gatttaaaac aagctggctt
     1321 ggaggctgca gccaaagcca ccagctcaca tccgaactca acatctctca aggccaaggt
     1381 gctggagacc ttcctggcca agtccagacc tgagctcctg gagtattaca ttaaagtcat
     1441 cctggactac aacaccgccc acaacaaagt ggctctgtca gagtgctata cagtagcttc
     1501 tgtggctgag atgcctcaga actaccggcc gcatccccag aggttcacat actgctctca
     1561 ggtgctgggc ctgcactgct acaagaaggg gatccactac tgggaggtgg agctgcagaa
     1621 gaacaacttc tgtggggtag gcatctgcta cggaagcatg aaccggcagg gcccagaaag
     1681 caggctcggc cgcaacagcg cctcctggtg cgtggagtgg ttcaacacca agatctctgc
     1741 ctggcacaat aacgtggaga aaaccctgcc ctccaccaag gccacgcggg tgggcgtgct
     1801 tctcaactgt gaccacggct ttgtcatctt cttcgctgtt gccgacaagg tccacctgat
     1861 gtataagttc agggtggact ttactgaggc tttgtacccg gctttctggg tattttctgc
     1921 tggtgccaca ctctccatct gctcccccaa gtaggcaggc tgtaggcact tgggctgact
     1981 gcctgcagaa gtcccaagac cctagtgaaa atacagcagg cagaactctc cttggataat
     2041 tccccaagag gtcccaagga ttgggagcat gggaggggag ctggcgggag ggtgggaggt
     2101 gggatttagc caggaaaggg gtgagagtga ttgtgttgtg ggcgaggagg cgtttccacc
     2161 ccctggtgcc tatcagggca gggtgaccta ctccccattg ttctggaaat ctccaggctg
     2221 ctgggcagct gggcagagct ctgggaagtg aagtcatgag tgcccgattc ctcttagaga
     2281 aaatccatag ctactgtagg ttctgtcttg ggccacttgg atctgaaggc tgcccctttg
     2341 ctctctgggg tagccttcag atcttggtgt tttgaattct tactatagat gtttttaaag
     2401 ttccaaagtc attgagtttc aatgttacat aaactccatt acccgcatgt tggggcttga
     2461 tctcctggtt attatctgtg cttgaggaaa cacccacagc agtctctacc cagaacagtt
     2521 tcctaaagag gcataccctc ttcctccact ggaaaatagt gcgttccctt cctaccctgc
     2581 acacccatcg cccccacatt gatggttttc aaacagcaaa cttttcagct aaagcttcaa
     2641 accatgattg gaatcagcct gtgttggatt tgtgattcag ggtcatggtg accctgatcc
     2701 agtttgggtg gaaatccttc ctaagtatca taagaagcat cttggcagag atgctttggt
     2761 ggcagccatg agctttgctg gaggccttgc ttcccatagc cttggctgtg gggcaaggaa
     2821 ctctgccagg cgagggggat gctgccctgg atcaacagaa gcctggtggg tttgctcgtg
     2881 ttagagtgtc ctgccttctt actgacaact cttctcggtg atagcctctc ttccctggat
     2941 tgtgacatat ggaatgacag tgcaggtacc accgaggcta gcacagtcaa gcctccagct
     3001 aagctggatc cctgaagcct gctatcatgc agacaggcta tgcggctgcc tcggaccatg
     3061 ctaggccact tgctggggtg tcaacctacc accaaagggg tcttttagca aacctcatgg
     3121 ggaacaggaa cattcctgtt catccctggc cacaggctgc agacccagca ctggcccttg
     3181 cgtgagtcag agcctggggc tggccctagc cccttctact gacttcctca tttaagccaa
     3241 ttatataagc tcacattgat cagggaggga gggaaagagc taaagagggt cacacaagtg
     3301 gctattttcc ctgcagtgtt tctgtgtggt gaaaataacc cagtccacta aggggcggga
     3361 gtgaatggat ggctggattt tccccaagct ccttatagcc taatgttgtc aggatgtgag
     3421 tatgaggaat ttagcctctt atagtgaaat gagtccaact ctgggctttg cttagaggag
     3481 agctcctgtc aggcttccta taatatgaaa agaagtcacc attggggaac tagagacccc
     3541 agaccttttc atatggatat ttgagaatgt aatgcatctc aggcctcgtg ctggaactct
     3601 agggcactct aggcaggctc agaacacttg atattcctga cagctacaca cctgacatgc
     3661 aggtacatac ctgatcggtg tcatctccta acaaggattt tcagttcctc gggagagcaa
     3721 taatctttgt aggaaagaca tccctgcaat aggtgatatg tggtccttag aagttttatt
     3781 cctttactac ttggaagaaa agttctttgg tgattcttct ctgcttttga agatgatcaa
     3841 aagcatcttc attgattttc tgaaacgaaa gccttgtctg aaaccaatta atacttggga
     3901 aacagctggg cttggaggag tagaatgcca gagataaatc catggctcct gctctggctc
     3961 tcttctgcag aaatgagggc aacagtgagg ccacttccct ggcaaatgtg cagctcagga
     4021 tagggaagca taagaccctc tgtttaaaag agagtcaagt aggtaaccaa agccaagctc
     4081 tgtgcaaggt gctttggagt tgtaaattga ggagtgcatc cttgctgtct tgaaccattc
     4141 tgtttgcaat ggtgagacct tacataacct agccttgcag ggccgccaca caaccctgga
     4201 gtcctagagt tggaggaacc tttgtatcca tctgacttct cattttgcag aatatgatga
     4261 gaaagtagag gatcgctctg ttcaccactc ttgctattcc attagtgggg agatgcctgc
     4321 tagcatgtgt gaggggaaca ctctgataca ctgggaagta tcggaaattc ccagaaacac
     4381 aaacataaaa taactctcct agacccaggt actggggact gtctcagtcc gtgtggcatg
     4441 ataaataaaa ggttaggatc aagtctttgt atttttcaag atgtggtagc tgattattcc
     4501 tgttttaagt actctgaaat tgatctgtga tcaataatac taatatgtta tcttttaccg
     4561 tattctgcct ctcactattg attttaatta gttaggagta tttgagctgt tatttcttga
     4621 gcttaatatt tttttagagt taactcttta aggagataat catggctgta gacaaggcca
     4681 gggctggctg acgtgcctta gaaggtttga atgcaataaa gcggtgtttg gcgttctcct
     4741 gcattgtagt gcgggtacaa aatgctattt gttcgtcata ctgttgtcag cagatgagcc
     4801 gcccactaca gacggctact gcccagggac ctgcccaggc cccacccaag ggctcccaag
     4861 ggttgagatt tctgcagacc tatagccagc acacttagtc ctgccctata tagagttcct
     4921 cttcgggaag cttttgataa ggaattctca gaccgatagg atgtctgtct gggctttgct
     4981 gcgggacagt ctaactgtgg gggctagggg aaagcaggag agtatcgatc aaagagtaag
     5041 ccacacacgg ataatcagtt actagggatg gaggtgtgag ggttcattat attattcatt
     5101 ttactgttgt atatgtttga aaatgtctat aataaaaagc tttaaaaaaa aaaaagaaac
     5161 aaaaatagtt caggccagca atgggccctc catgttcagt ggattttatc cttgtttcaa
     5221 ttggggtagg agttccagga ggtgtggatt ggaggttgtc taaagaattg aactggcctt
     5281 tgtccctgct tcctgggagg gagactttca gtccttgaca tttccagggt aataggagtg
     5341 tctttgttat ttgtgaggcc atgggatcac acctgagctt atgctaaaag gtgggatgac
     5401 tcagagctgg ggctggtcac cagacagact gaccatgtga ttagaggttt gaggctttga
     5461 gtcagcctga cctatggggc gggggactgg aggctgagtt taatcatctg gccagtgctt
     5521 taatcagtac atcatgaaac cctaataaaa actctggaca ctaaagctca gcatagcttc
     5581 ctgggtggtg aagctgtggc tatgccggca gggcagtgtg ccctaattcc acgaagaggg
     5641 ggcatgggag cactgtgctc aagacccttc cagacctttc cctgtgtctt ccttggcttg
     5701 tggagctgat ttgtatcctt tataataaaa ctaatcataa gtata
//
