LOCUS       NM_001656               3863 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tripartite motif containing 23 (TRIM23), transcript
            variant alpha, mRNA.
ACCESSION   NM_001656
VERSION     NM_001656.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3863)
  AUTHORS   Liu,X., Acharya,D., Krawczyk,E., Kangas,C., Gack,M.U. and He,B.
  TITLE     Herpesvirus-mediated stabilization of ICP0 expression neutralizes
            restriction by TRIM23
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34903664
  REMARK    GeneRIF: Herpesvirus-mediated stabilization of ICP0 expression
            neutralizes restriction by TRIM23.
            Erratum:[Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2202103119.
            doi: 10.1073/pnas.2202103119.. PMID: 35320048]
REFERENCE   2  (bases 1 to 3863)
  AUTHORS   Cao,X., Zhou,Z., Tian,Y., Liu,Z., Cheng,K.O., Chen,X., Hu,W.,
            Wong,Y.M., Li,X., Zhang,H., Hu,R. and Huang,P.
  TITLE     Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion
            channel ANO1 protein levels
  JOURNAL   J Biol Chem 296, 100738 (2021)
   PUBMED   33957127
  REMARK    GeneRIF: Opposing roles of E3 ligases TRIM23 and TRIM21 in
            regulation of ion channel ANO1 protein levels.
REFERENCE   3  (bases 1 to 3863)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3863)
  AUTHORS   Han,Y., Tan,Y., Zhao,Y., Zhang,Y., He,X., Yu,L., Jiang,H., Lu,H.
            and Tian,H.
  TITLE     TRIM23 overexpression is a poor prognostic factor and contributes
            to carcinogenesis in colorectal cancer
  JOURNAL   J Cell Mol Med 24 (10), 5491-5500 (2020)
   PUBMED   32227572
  REMARK    GeneRIF: TRIM23 overexpression is a poor prognostic factor and
            contributes to carcinogenesis in colorectal cancer.
REFERENCE   5  (bases 1 to 3863)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3863)
  AUTHORS   Vitale,N., Horiba,K., Ferrans,V.J., Moss,J. and Vaughan,M.
  TITLE     Localization of ADP-ribosylation factor domain protein 1 (ARD1) in
            lysosomes and Golgi apparatus
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8613-8618 (1998)
   PUBMED   9671726
REFERENCE   7  (bases 1 to 3863)
  AUTHORS   Vitale,N., Moss,J. and Vaughan,M.
  TITLE     Molecular characterization of the GTPase-activating domain of
            ADP-ribosylation factor domain protein 1 (ARD1)
  JOURNAL   J Biol Chem 273 (5), 2553-2560 (1998)
   PUBMED   9446556
REFERENCE   8  (bases 1 to 3863)
  AUTHORS   Vitale,N., Moss,J. and Vaughan,M.
  TITLE     Characterization of a GDP dissociation inhibitory region of
            ADP-ribosylation factor domain protein ARD1
  JOURNAL   J Biol Chem 272 (40), 25077-25082 (1997)
   PUBMED   9312116
REFERENCE   9  (bases 1 to 3863)
  AUTHORS   Vitale,N., Moss,J. and Vaughan,M.
  TITLE     ARD1, a 64-kDa bifunctional protein containing an 18-kDa
            GTP-binding ADP-ribosylation factor domain and a 46-kDa
            GTPase-activating domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1941-1944 (1996)
   PUBMED   8700863
REFERENCE   10 (bases 1 to 3863)
  AUTHORS   Mishima,K., Tsuchiya,M., Nightingale,M.S., Moss,J. and Vaughan,M.
  TITLE     ARD 1, a 64-kDa guanine nucleotide-binding protein with a
            carboxyl-terminal ADP-ribosylation factor domain
  JOURNAL   J Biol Chem 268 (12), 8801-8807 (1993)
   PUBMED   8473324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI859501.1, L04510.1 and
            BC022510.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001656.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This protein is also a member of the ADP
            ribosylation factor family of guanine nucleotide-binding family of
            proteins. Its carboxy terminus contains an ADP-ribosylation factor
            domain and a guanine nucleotide binding site, while the amino
            terminus contains a GTPase activating protein domain which acts on
            the guanine nucleotide binding site. The protein localizes to
            lysosomes and the Golgi apparatus. It plays a role in the formation
            of intracellular transport vesicles, their movement from one
            compartment to another, and phopholipase D activation. Three
            alternatively spliced transcript variants for this gene have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha) encodes the longest
            isoform. It has a unique C-terminus compared to isoforms beta and
            gamma of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.201601.1,
                                           SRR1660803.193769.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231524.14/ ENSP00000231524.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               BI859501.1         282-438
            158-2995            L04510.1           121-2958
            2996-3863           BC022510.1         2963-3830
FEATURES             Location/Qualifiers
     source          1..3863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..3863
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="tripartite motif containing 23"
                     /db_xref="GeneID:373"
                     /db_xref="HGNC:HGNC:660"
                     /db_xref="MIM:601747"
     exon            1..140
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1784
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /EC_number="2.3.2.27"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; ADP-ribosylation factor domain protein 1, 64kDa;
                     ARF domain protein 1; GTP-binding protein ARD-1;
                     tripartite motif protein TRIM23; E3 ubiquitin-protein
                     ligase TRIM23; RING finger protein 46; tripartite
                     motif-containing protein 23; ADP-ribosylation factor
                     domain-containing protein 1; RING-type E3 ubiquitin
                     transferase TRIM23"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM23 isoform
                     alpha"
                     /protein_id="NP_001647.1"
                     /db_xref="CCDS:CCDS3987.1"
                     /db_xref="GeneID:373"
                     /db_xref="HGNC:HGNC:660"
                     /db_xref="MIM:601747"
                     /translation="MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDK
                     VPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERL
                     QNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTL
                     AKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSV
                     LEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEH
                     VPGTAENARSCIRAYFYDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSE
                     VSAACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFT
                     KDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKF
                     TIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALL
                     LIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLV
                     AAGVLDVA"
     exon            141..303
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            304..425
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            426..704
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            705..887
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1103
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1238
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1368
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1479
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1604
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..3863
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3347..3352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="hexamer: AATAAA"
     polyA_site      3374
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="major polyA site"
     regulatory      3561..3566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="hexamer: AAGAAA"
     polyA_site      3585
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="major polyA site"
     regulatory      3846..3851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="hexamer: AATAAA"
     polyA_site      3863
                     /gene="TRIM23"
                     /gene_synonym="ARD1; ARFD1; RNF46"
                     /note="major polyA site"
ORIGIN      
        1 aaccccgcct ctcagttgag gactctgaag gctgtttctg tggcgcttcc cctgcgagga
       61 tggctaccct ggttgtaaac aagctcggag cgggagtaga cagtggccgg cagggcagcc
      121 gggggacagc tgtagtgaag gtgctagagt gtggagtttg tgaagatgtc ttttctttgc
      181 aaggagacaa agttccccgt cttttgcttt gtggccatac cgtctgtcat gactgtctca
      241 ctcgcctacc tcttcatgga agagcaatcc gttgcccatt tgatcgacaa gtaacagacc
      301 taggtgattc aggtgtctgg ggattgaaaa aaaattttgc tttattggag cttttggaac
      361 gactgcagaa tgggcctatt ggtcagtatg gagctgcaga agaatccatt gggatatctg
      421 gagagagcat cattcgttgt gatgaagatg aagctcacct tgcctctgta tattgcactg
      481 tgtgtgcaac tcatttgtgc tctgagtgtt ctcaagttac tcattctaca aagacattag
      541 caaagcacag gcgagttcct ctagctgata aacctcatga gaaaactatg tgctctcagc
      601 accaggtgca tgccattgag tttgtttgct tggaagaagg ttgtcaaact agcccactca
      661 tgtgctgtgt ctgcaaagaa tatggaaaac accagggtca caagcattca gtattggaac
      721 cagaagctaa tcagatccga gcatcaattt tagatatggc tcactgcata cggaccttca
      781 cagaggaaat ctcagattat tccagaaaat tagttggaat tgtgcagcac attgaaggag
      841 gagaacaaat cgtggaagat ggaattggaa tggctcacac agaacatgta ccagggactg
      901 cagagaatgc ccggtcatgt attcgagctt atttttatga tctacatgaa actctgtgtc
      961 gtcaagaaga aatggctcta agtgttgttg atgctcatgt tcgtgaaaaa ttgatttggc
     1021 tcaggcagca acaagaagat atgactattt tgttgtcaga ggtttctgca gcctgcctcc
     1081 actgtgaaaa gactttgcag caggatgatt gtagagttgt cttggcaaaa caggaaatta
     1141 caaggttact ggaaacattg cagaaacagc agcagcagtt tacagaagtt gcagatcaca
     1201 ttcagttgga tgccagcatc cctgtcactt ttacaaagga taatcgagtt cacattggac
     1261 caaaaatgga aattcgggtc gttacgttag gattggatgg tgctggaaaa actactatct
     1321 tgtttaagtt aaaacaggat gaattcatgc agcccattcc aacaattggt tttaacgtgg
     1381 aaactgtaga atataaaaat ctaaaattca ctatttggga tgtaggtgga aaacacaaat
     1441 taagaccatt gtggaaacat tattacctca atactcaagc tgttgtgttt gttgtagata
     1501 gcagtcatag agacagaatt agtgaagcac acagcgaact tgcaaagttg ttaacggaaa
     1561 aagaactccg agatgctctg ctcctgattt ttgctaacaa acaggatgtt gctggagcac
     1621 tgtcagtaga agaaatcact gaactactca gtctccataa attatgctgt ggccgtagct
     1681 ggtatattca gggctgtgat gctcgaagtg gtatgggact gtatgaaggg ttggactggc
     1741 tctcacggca acttgtagct gctggagtat tggatgttgc ttgattttaa aggcagcagt
     1801 tgtttgaagt tttgtggtta aaagtaactt tgcacatagt atgttttaag aaattataca
     1861 tctcaaaaga tggtaattta ggatgcatat atatatatat atatataaag gaatcttgga
     1921 ttgggaattc agtactttgc tttaaaaaaa ttttgtggca gaattaaatt tctaattgag
     1981 cagattagat tgaattaaat agaaacttat tgaatataca ttcttttaaa aagtatattt
     2041 gttatttaag tttttcagat aatatgtgac caatatactg ggaaagaggt agtcacagag
     2101 aaagggtaag tgaaggttta ttctttcagt gaaaaaagaa tagccaattg agtgcctaat
     2161 gagacctctg tgtgaagcaa gtgaagtata gctgcttctt ttaacctgcc ttttcactga
     2221 atgttggcag catttagtag tagaaatgac agttgcttaa tgaaatagaa tccaaactac
     2281 atatttggat aataggatta ctttatgttt atgttcagag ttaacagaac acctttaatg
     2341 ctaagaacta taaggtacag aaaattaata ctttatatag tgttttatta actttctcct
     2401 acagcatttt gtataaaaca caatgaggga gtgaaatgtt acccaattag gcttgtcagg
     2461 ttagtaataa actgaacagt aataaaactg tggaagtaat tggatctgaa tttatgaaag
     2521 acccatttcc aggactgaac ctaggtcaga gctctaaatt ggtccttcta tttttcaaca
     2581 aatttaaagt aatatttctt tctaatataa tattgcatcc tttgtgggaa tgactatagg
     2641 taaaatgtag taagtaacgc agaaccaggg ttggctttat ttaaaagcta gtgacctaaa
     2701 tagaaagcga acttcaagag aagttgtaag tacagtggca aatgcttatt acttacttca
     2761 aactgtttcc caaaataagt gcatttattt tgacaataaa acttaaggct gttcatgaga
     2821 aggccttgaa aagttactct agaggaaaaa tgtctaaaga aaaaaaaaat tcaaaaagtt
     2881 tacattaatt attcagtgtt gtgagtaaat aaaaatgtgt gctctttact gtttttcatt
     2941 tttaaagaat attattatgg aagcacgatt tatttaaata ggtacattga gacttttttt
     3001 tttttaatgt tctgatacat taggatgaag ttaaatctta aatcttatta gttgaattgt
     3061 tgtaaggaca gtgatgtctg gtaacaagat gtgacttttt ggtagcactg ttgtggttca
     3121 ttcttttcaa atctattttt gtttaaaaac aatacaagtt ttagaaaaca aagcattaaa
     3181 aaaaaagcct atcagtatta tgggcaatat gtaaataaat aaatgtaata tttcatcctt
     3241 tatttttcag gtaaaaggtc atgctgttac aggtgtagtt tgtgtgcata aataatactt
     3301 ccgaattaaa ttatttaata tttgactgat ttcaataact gtgaaaaata aaaaaggtgt
     3361 tgtattgctt gtgagaactt gaactgttta ctagttaatt gaagaaaaag tgtaacacta
     3421 aggtgaactt gcttcccttt tcactaattt tgctaaactt tgtaatgcac attcttagca
     3481 tataactgaa cacagttgaa aaattgtgcc tgattataat gtatgtataa tggtaggtgt
     3541 ttgtgtgtga ttcattttta aagaaatatt tttctcaagc tcctattact atttgtggtt
     3601 gtattatttc actaatcatt agttaagact gtgctagtct tccctgggaa actaagaaga
     3661 gagctttttt atatacagta tattagaatt ttcctagtag ctgaatttct gtattaggtc
     3721 taaatattac tgtatgttat ataaagcagg tatgtcaagt gtatagccgt agtctataat
     3781 tcaggaatgc tttataacca tcagaagcca ttatttgcac tacatatatg ataagtatag
     3841 acagcaataa aatgttaaga tca
//
