LOCUS       NM_006074               2888 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 22 (TRIM22), transcript
            variant 1, mRNA.
ACCESSION   NM_006074
VERSION     NM_006074.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Yang,Y., Hao,X., Zhang,J., Gao,T., Huo,M., Liu,W., Hu,T., Ma,T.,
            Yuan,B., Zhang,M., Teng,X., Yu,H., Huang,W. and Wang,Y.
  TITLE     The E3 ligase TRIM22 functions as a tumor suppressor in breast
            cancer by targeting CCS for proteasomal degradation to inhibit
            STAT3 signaling
  JOURNAL   Cancer Lett 600, 217157 (2024)
   PUBMED   39127340
  REMARK    GeneRIF: The E3 ligase TRIM22 functions as a tumor suppressor in
            breast cancer by targeting CCS for proteasomal degradation to
            inhibit STAT3 signaling.
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Fan,L., Zhou,Y., Wei,X., Feng,W., Guo,H., Li,Y., Gao,X., Zhou,J.,
            Wen,Y., Wu,Y., Shen,X., Liu,L., Xu,G. and Zhang,Z.
  TITLE     The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting
            proteasomal degradation of NSP8
  JOURNAL   mBio 15 (2), e0232023 (2024)
   PUBMED   38275298
  REMARK    GeneRIF: The E3 ligase TRIM22 restricts SARS-CoV-2 replication by
            promoting proteasomal degradation of NSP8.
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Kang,D., Hwang,H.J., Baek,Y., Sung,J.Y., Kim,K., Park,H.J.,
            Ko,Y.G., Kim,Y.N. and Lee,J.S.
  TITLE     TRIM22 induces cellular senescence by targeting PHLPP2 in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 15 (1), 26 (2024)
   PUBMED   38199981
  REMARK    GeneRIF: TRIM22 induces cellular senescence by targeting PHLPP2 in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Fei,X., Dou,Y.N., Sun,K., Wei,J., Guo,Q., Wang,L., Wu,X., Lv,W.,
            Jiang,X. and Fei,Z.
  TITLE     TRIM22 promotes the proliferation of glioblastoma cells by
            activating MAPK signaling and accelerating the degradation of Raf-1
  JOURNAL   Exp Mol Med 55 (6), 1203-1217 (2023)
   PUBMED   37258577
  REMARK    GeneRIF: TRIM22 promotes the proliferation of glioblastoma cells by
            activating MAPK signaling and accelerating the degradation of
            Raf-1.
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Ren,Y., Dong,H., Jin,R., Jiang,J. and Zhang,X.
  TITLE     TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through
            enhancing cell proliferation and inflammation and inhibiting
            autophagy
  JOURNAL   Cutan Ocul Toxicol 41 (4), 304-309 (2022)
   PUBMED   36170453
  REMARK    GeneRIF: TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis
            through enhancing cell proliferation and inflammation and
            inhibiting autophagy.
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Gongora,C., Tissot,C., Cerdan,C. and Mechti,N.
  TITLE     The interferon-inducible Staf50 gene is downregulated during T cell
            costimulation by CD2 and CD28
  JOURNAL   J Interferon Cytokine Res 20 (11), 955-961 (2000)
   PUBMED   11096452
REFERENCE   9  (bases 1 to 2888)
  AUTHORS   Tissot,C., Taviaux,S.A., Diriong,S. and Mechti,N.
  TITLE     Localization of Staf50, a member of the Ring finger family, to
            11p15 by fluorescence in situ hybridization
  JOURNAL   Genomics 34 (1), 151-153 (1996)
   PUBMED   8661041
REFERENCE   10 (bases 1 to 2888)
  AUTHORS   Tissot,C. and Mechti,N.
  TITLE     Molecular cloning of a new interferon-induced factor that represses
            human immunodeficiency virus type 1 long terminal repeat expression
  JOURNAL   J Biol Chem 270 (25), 14891-14898 (1995)
   PUBMED   7797467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC364428.1, BC035582.1,
            BC022281.1 and AL360190.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006074.4.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This protein localizes to the cytoplasm
            and its expression is induced by interferon. The protein is
            involved in innate immunity against different DNA and RNA viruses.
            [provided by RefSeq, Oct 2021].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.197150.1,
                                           SRR1163657.47350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379965.8/ ENSP00000369299.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               DC364428.1         181-556
            377-817             BC035582.1         353-793
            818-2043            BC022281.1         828-2053
            2044-2801           AL360190.1         658-1415
            2802-2888           BC035582.1         2777-2863
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2888
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /note="tripartite motif containing 22"
                     /db_xref="GeneID:10346"
                     /db_xref="HGNC:HGNC:16379"
                     /db_xref="MIM:606559"
     exon            1..110
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            111..599
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1673
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stimulated trans-acting factor (50 kDa); tripartite motif
                     protein TRIM22; E3 ubiquitin-protein ligase TRIM22;
                     tripartite binding motif 22; staf-50; RING-type E3
                     ubiquitin transferase TRIM22; RING finger protein 94; 50
                     kDa-stimulated trans-acting factor; tripartite
                     motif-containing protein 22"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM22 isoform 1"
                     /protein_id="NP_006065.2"
                     /db_xref="CCDS:CCDS41612.1"
                     /db_xref="GeneID:10346"
                     /db_xref="HGNC:HGNC:16379"
                     /db_xref="MIM:606559"
                     /translation="MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIK
                     ESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGK
                     KLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEK
                     LEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAA
                     ATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKS
                     VFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNS
                     NPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSV
                     NYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYE
                     AGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS"
     exon            600..695
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            696..926
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            927..949
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1050
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1077
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..2888
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /note="hexamer: AATAAA"
     polyA_site      2801
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /note="major polyA site"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="TRIM22"
                     /gene_synonym="GPSTAF50; RNF94; STAF50"
ORIGIN      
        1 atttgtggag accagccctc tggcttggtg agtgaatctg gtttacaccg gctcctgccc
       61 tgccttcact cttctcccct gattcaagac tcctctgctt tggactgaag cactgcagga
      121 gtttgtgacc aagaacttca agagtcaaga cagaaggaag ccaagggagc agtgcaatgg
      181 atttctcagt aaaggtagac atagagaagg aggtgacctg ccccatctgc ctggagctcc
      241 tgacagaacc tctgagccta gattgtggcc acagcttctg ccaagcctgc atcactgcaa
      301 agatcaagga gtcagtgatc atctcaagag gggaaagcag ctgtcctgtg tgtcagacca
      361 gattccagcc tgggaacctc cgacctaatc ggcatctggc caacatagtt gagagagtca
      421 aagaggtcaa gatgagccca caggaggggc agaagagaga tgtctgtgag caccatggaa
      481 aaaaactcca gatcttctgt aaggaggatg gaaaagtcat ttgctgggtt tgtgaactgt
      541 ctcaggaaca ccaaggtcac caaacattcc gcataaacga ggtggtcaag gaatgtcagg
      601 aaaagctgca ggtagccctg cagaggctga taaaggagga tcaagaggct gagaagctgg
      661 aagatgacat cagacaagag agaaccgcct ggaagaatta tatccagatc gagagacaga
      721 agattctgaa agggttcaat gaaatgagag tcatcttgga caatgaggag cagagagagc
      781 tgcaaaagct ggaggaaggt gaggtgaatg tgctggataa cctggcagca gctacagacc
      841 agctggtcca gcagaggcag gatgccagca cgctcatctc agatctccag cggaggttga
      901 ggggatcgtc agtagagatg ctgcaggatg tgattgacgt catgaaaagg agtgaaagct
      961 ggacattgaa gaagccaaaa tctgtttcca agaaactaaa gagtgtattc cgagtaccag
     1021 atctgagtgg gatgctgcaa gttcttaaag agctgacaga tgtccagtac tactgggtgg
     1081 acgtgatgct gaatccaggc agtgccactt cgaatgttgc tatttctgtg gatcagagac
     1141 aagtgaaaac tgtacgcacc tgcacattta agaattcaaa tccatgtgat ttttctgctt
     1201 ttggtgtctt cggctgccaa tatttctctt cggggaaata ttactgggaa gtagatgtgt
     1261 ctggaaagat tgcctggatc ctgggcgtac acagtaaaat aagtagtctg aataaaagga
     1321 agagctctgg gtttgctttt gatccaagtg taaattattc aaaagtttac tccagatata
     1381 gacctcaata tggctactgg gttataggat tacagaatac atgtgaatat aatgcttttg
     1441 aggactcctc ctcttctgat cccaaggttt tgactctctt tatggctgtg cctccctgtc
     1501 gtattggggt tttcctagac tatgaggcag gcattgtctc atttttcaat gtcacaaacc
     1561 acggagcact catctacaag ttctctggat gtcgcttttc tcgacctgct tatccgtatt
     1621 tcaatccttg gaactgccta gtccccatga ctgtgtgccc accgagctcc tgagtgttct
     1681 cattccttta cccacttctg catagtagcc cttgtgctga gactcagatt ctgcacctga
     1741 gttcatctct actgagacca tctcttcctt tctttcccct tcttttactt agaatgtctt
     1801 tgtattcatt tgctagggct tccatagcaa agcatcatag attgctgatt taaactgtaa
     1861 ttgtattgcc gtactgtggg ctggaaatcc caaatctaga ttccagcaga gttggttctt
     1921 tctgaggtct gcaaggaagg gctctgttcc atgcctctct ccttggcttg tagaaggcat
     1981 cttgtcccta tgactcttca cattgtcttt atgtacatct ctgtgcccaa gttttccctt
     2041 tttattaaga caccagtcat actggctcag ggcccaccgc taatgcctta atgaaatcat
     2101 tttaacatta tattctctac aaagacctta tttccaaata agataatatt tggaggtatt
     2161 gggaataaaa actccaacat ataaatttga ggaaggcacg atttcactca taacaatctt
     2221 accctttctt gcaagagatg cttgtacatt attttcctaa taccttggtt tcactagtag
     2281 taaacattat tatttttttt atatttgcaa aggaaacata tctaatcctt cctatagaaa
     2341 gaacagtatt gctgtaattc cttttctttt cttcctcatt tcctctgccc cttaaaagat
     2401 tgaagaaaga gaaacttgtc aactcatatc cacgttatct agcaaagtac ataagaatct
     2461 atcactaagt aatgtatcct tcagaatgtg ttggtttacc agtgacaccc catattcatc
     2521 acaaaattaa agcaagaagt ccatagtaat ttatttgcta atagtggatt tttaatgctc
     2581 agagtttctg aggtcaaatt ttatcttttc acttacaagc tctatgatct taaataattt
     2641 acttaatgta ttttggtgta ttttcctcaa attaatattg gtgttcaaga ctatatctaa
     2701 ttcctctgat cactttgaga aacaaacttt tattaaatgt aaggcacttt tctatgaatt
     2761 ttaaatataa aaataaatat tgttctgatt attactgaaa agatgtcagc catttcaatg
     2821 tcttgggaaa caattttttg tttttgttct gttttctttt tgcttcaata aaacaatagc
     2881 tggctcta
//
