LOCUS       NM_003141               1935 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 21 (TRIM21), mRNA.
ACCESSION   NM_003141
VERSION     NM_003141.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Wu,Z., Zhang,J., Jia,Z., Yang,Z., Liu,S., Wang,H., Zhao,C.,
            Zhao,J., Tang,Q., Xiong,Y., Yang,Y., Zhang,Y., Zhou,Z., Yue,J.,
            Xiao,F., Sun,Q., Gong,A., Yao,W., Li,H., Song,X., Ye,Y., Zhu,Y.,
            Dong,P., Ma,F., Wu,X. and Gong,W.
  TITLE     TRIM21-mediated ubiquitylation of TAT suppresses liver metastasis
            in gallbladder cancer
  JOURNAL   Cancer Lett 592, 216923 (2024)
   PUBMED   38697462
  REMARK    GeneRIF: TRIM21-mediated ubiquitylation of TAT suppresses liver
            metastasis in gallbladder cancer.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Reusch,J., Franken,L.E., Then,J., Ringler,P., Butzer,J.,
            Juroschek,T., Klein,C., Schlothauer,T. and Lariviere,L.
  TITLE     TRIM21 and Fc-engineered antibodies: decoding its complex antibody
            binding mode with implications for viral neutralization
  JOURNAL   Front Immunol 15, 1401471 (2024)
   PUBMED   38938560
  REMARK    GeneRIF: TRIM21 and Fc-engineered antibodies: decoding its complex
            antibody binding mode with implications for viral neutralization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Chen,L., Lian,Q., Zhang,G., Wu,J., Zeng,G. and Gao,X.
  TITLE     [TRIM21 Inhibits the Proliferation and Migration of Lung
            Adenocarcinoma Cells by Interacting with ZSWIM1]
  JOURNAL   Zhongguo Fei Ai Za Zhi 27 (5), 337-344 (2024)
   PUBMED   38880921
  REMARK    GeneRIF: [TRIM21 Inhibits the Proliferation and Migration of Lung
            Adenocarcinoma Cells by Interacting with ZSWIM1].
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Zhang,R., Zhang,D., Han,F., Song,X., Zhang,Y., Zhang,J., Zhu,Q. and
            Qin,Y.
  TITLE     The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic
            mimicry and malignant progression of RMS by balancing SNAI2
            homeostasis
  JOURNAL   J Exp Clin Cancer Res 43 (1), 135 (2024)
   PUBMED   38702792
  REMARK    GeneRIF: The deubiquitinase USP7 and E3 ligase TRIM21 regulate
            vasculogenic mimicry and malignant progression of RMS by balancing
            SNAI2 homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Wei,Y., Gu,Y., Zhou,Z., Wu,C., Liu,Y. and Sun,H.
  TITLE     TRIM21 Promotes Oxidative Stress and Ferroptosis through the
            SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly
            Pathogenic Avian Influenza Virus
  JOURNAL   Int J Mol Sci 25 (6), 3315 (2024)
   PUBMED   38542289
  REMARK    GeneRIF: TRIM21 Promotes Oxidative Stress and Ferroptosis through
            the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly
            Pathogenic Avian Influenza Virus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Chan,E.K., Di Donato,F., Hamel,J.C., Tseng,C.E. and Buyon,J.P.
  TITLE     52-kD SS-A/Ro: genomic structure and identification of an
            alternatively spliced transcript encoding a novel leucine
            zipper-minus autoantigen expressed in fetal and adult heart
  JOURNAL   J Exp Med 182 (4), 983-992 (1995)
   PUBMED   7561701
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Jones,S.K.
  TITLE     Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen
            expression by human keratinocytes in vitro: a possible mechanism
            for the UVR induction of cutaneous lupus lesions
  JOURNAL   Br J Dermatol 126 (6), 546-553 (1992)
   PUBMED   1610705
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Chan,E.K., Hamel,J.C., Buyon,J.P. and Tan,E.M.
  TITLE     Molecular definition and sequence motifs of the 52-kD component of
            human SS-A/Ro autoantigen
  JOURNAL   J Clin Invest 87 (1), 68-76 (1991)
   PUBMED   1985112
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Itoh,K., Itoh,Y. and Frank,M.B.
  TITLE     Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The
            52- and 60-kD Ro/SSA autoantigens are encoded by separate genes
  JOURNAL   J Clin Invest 87 (1), 177-186 (1991)
   PUBMED   1985094
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Miyagawa,S., Okada,N., Inagaki,Y., Kitano,Y., Ueki,H., Sakamoto,K.
            and Steinberg,M.L.
  TITLE     SSA/Ro antigen expression in simian virus 40-transformed human
            keratinocytes
  JOURNAL   J Invest Dermatol 90 (3), 342-345 (1988)
   PUBMED   2450143
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009758.8, BP280435.1,
            BP288941.1, BC010861.1, BU594670.1 and AW575137.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003141.3.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            family. The TRIM motif includes three zinc-binding domains, a RING,
            a B-box type 1 and a B-box type 2, and a coiled-coil region. The
            encoded protein is part of the RoSSA ribonucleoprotein, which
            includes a single polypeptide and one of four small RNA molecules.
            The RoSSA particle localizes to both the cytoplasm and the nucleus.
            RoSSA interacts with autoantigens in patients with Sjogren syndrome
            and systemic lupus erythematosus. Alternatively spliced transcript
            variants for this gene have been described but the full-length
            nature of only one has been determined. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010861.1, M62800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254436.8/ ENSP00000254436.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC009758.8         111279-111284
            7-31                BP280435.1         1-25
            32-83               BP288941.1         8-59
            84-1829             BC010861.1         49-1794
            1830-1924           BC010861.1         1796-1890
            1925-1929           BU594670.1         592-596
            1930-1935           AW575137.1         18-23               c
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1935
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /note="tripartite motif containing 21"
                     /db_xref="GeneID:6737"
                     /db_xref="HGNC:HGNC:11312"
                     /db_xref="MIM:109092"
     exon            1..70
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..527
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1547
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /EC_number="2.3.2.27"
                     /note="Sjogren syndrome antigen A1 (52kDa,
                     ribonucleoprotein autoantigen SS-A/Ro); Sicca syndrome
                     antigen A; 52 kDa Ro protein; ro(SS-A); RING finger
                     protein 81; Ro/SSA 52kDa; sjoegren syndrome type A
                     antigen; tripartite motif-containing protein 21; 52 kDa
                     ribonucleoprotein autoantigen Ro/SS-A; RING-type E3
                     ubiquitin transferase TRIM21"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM21"
                     /protein_id="NP_003132.2"
                     /db_xref="CCDS:CCDS44525.1"
                     /db_xref="GeneID:6737"
                     /db_xref="HGNC:HGNC:11312"
                     /db_xref="MIM:109092"
                     /translation="MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVG
                     KGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLF
                     CEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEI
                     AIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKL
                     AQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVP
                     GLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGA
                     QHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGT
                     YPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGF
                     NDGGKNTAPLTLCPLNIGSQGSTDY"
     exon            528..623
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..854
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..877
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..978
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1935
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /note="hexamer: AATAAA"
     polyA_site      1921
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /note="major polyA site"
     polyA_site      1935
                     /gene="TRIM21"
                     /gene_synonym="RNF81; Ro/SSA; RO52; SSA; SSA1"
                     /note="major polyA site"
ORIGIN      
        1 agacttgctt ctgagcggaa actgaaagtg aaatagggag ctggctacca gcgttgagtc
       61 ccctgtaaag ccaaaccccc taaaggtctc cacactgctg tttaacggca cacttgacaa
      121 tggcttcagc agcacgcttg acaatgatgt gggaggaggt cacatgccct atctgcctgg
      181 accccttcgt ggagcctgtg agcatcgagt gtggccacag cttctgccag gaatgcatct
      241 ctcaggttgg gaaaggtggg ggcagcgtct gtcctgtgtg ccggcagcgc tttctgctca
      301 agaatctccg gcccaatcga cagctagcca acatggtgaa caaccttaaa gaaatcagcc
      361 aggaggccag agagggcaca cagggggaac ggtgtgcagt gcatggagag agacttcacc
      421 tgttctgtga gaaagatggg aaggcccttt gctgggtatg tgcccagtct cggaaacacc
      481 gtgaccacgc catggtccct cttgaggagg ctgcacagga gtaccaggag aagctccagg
      541 tggcattagg ggaactgaga agaaagcagg agttggctga gaagttggaa gtggaaattg
      601 caataaagag agcagactgg aagaaaacag tggaaacaca gaaatctagg attcacgcag
      661 agtttgtgca gcaaaaaaac ttcctggttg aagaagaaca gaggcagctg caggagctgg
      721 agaaggatga gagggagcag ctgagaatcc tgggggagaa agaggccaag ctggcccagc
      781 agagccaggc cctacaggag ctcatctcag agctagatcg aaggtgccac agctcagcac
      841 tggaactgct gcaggaggtg ataattgtcc tggaaaggag tgagtcctgg aacctgaagg
      901 acctggatat tacctctcca gaactcagga gtgtgtgcca tgtgccaggg ctgaagaaga
      961 tgctgaggac atgtgcagtc cacatcactc tggatccaga cacagccaat ccgtggctga
     1021 tactttcaga agatcggaga caagtgaggc ttggagacac ccagcagagc atacctggaa
     1081 atgaagagag atttgatagt tatcctatgg tcctgggtgc ccagcacttt cactctggaa
     1141 aacattactg ggaggtagat gtgacaggaa aggaggcctg ggacctgggt gtctgcagag
     1201 actctgtgcg caggaagggg cactttttgc ttagttccaa gagtggcttc tggacaattt
     1261 ggttgtggaa caaacaaaaa tatgaggctg gcacctaccc ccagactccc ctccaccttc
     1321 aggtgcctcc atgccaagtt gggattttcc tggactatga ggctggcatg gtctccttct
     1381 acaacatcac tgaccatggc tccctcatct actccttctc tgaatgtgcc tttacaggac
     1441 ctctgcggcc cttcttcagt cctggtttca atgatggagg aaaaaacaca gcccctctaa
     1501 ccctctgtcc actgaatatt ggatcacaag gatccactga ctattgatgg ctttctctgg
     1561 acactgccac tctccccatt ggcaccgctt ctcagccaca aaccctgcct cttttcccca
     1621 tgaactctga accacctttg tctctgcaga ggcatccgga tcccagcaag cgagctttag
     1681 cagggaagtc acttcaccat caacattcct gccccagatg gctttgtgat tccctccagt
     1741 gaagcagcct ccttatattt ggcccaaact catcttgatc aaccaaaaac atgtttctgc
     1801 cttctttatg ggacttaagt tttttttttc tcctctccat ctctaggatg tcgtctttgg
     1861 tgagatctct attatatctt gtatggtttg caaaagggct tcctaaaaat aaaaaataaa
     1921 atttaaaaaa ctgtg
//
