LOCUS       NM_015271               6755 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 2 (TRIM2), transcript
            variant 1, mRNA.
ACCESSION   NM_015271
VERSION     NM_015271.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6755)
  AUTHORS   Lv,R., Lu,F. and Xu,S.
  TITLE     Hsa_circ_0001361 facilitates cell progression and glycolytic
            metabolism in neuroblastoma via interacting with mir-490-5p to
            induce TRIM2 upregulation
  JOURNAL   Metab Brain Dis 38 (5), 1621-1632 (2023)
   PUBMED   36920626
  REMARK    GeneRIF: Hsa_circ_0001361 facilitates cell progression and
            glycolytic metabolism in neuroblastoma via interacting with
            mir-490-5p to induce TRIM2 upregulation.
REFERENCE   2  (bases 1 to 6755)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 6755)
  AUTHORS   Esposito,D., Dudley-Fraser,J., Garza-Garcia,A. and Rittinger,K.
  TITLE     Divergent self-association properties of paralogous proteins TRIM2
            and TRIM3 regulate their E3 ligase activity
  JOURNAL   Nat Commun 13 (1), 7583 (2022)
   PUBMED   36481767
  REMARK    GeneRIF: Divergent self-association properties of paralogous
            proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6755)
  AUTHORS   Xiao,M., Li,J., Liu,Q., He,X., Yang,Z. and Wang,D.
  TITLE     Expression and Role of TRIM2 in Human Diseases
  JOURNAL   Biomed Res Int 2022, 9430509 (2022)
   PUBMED   36051486
  REMARK    GeneRIF: Expression and Role of TRIM2 in Human Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6755)
  AUTHORS   Ylikallio,E., Poyhonen,R., Zimon,M., De Vriendt,E., Hilander,T.,
            Paetau,A., Jordanova,A., Lonnqvist,T. and Tyynismaa,H.
  TITLE     Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal
            neuropathy
  JOURNAL   Hum Mol Genet 22 (15), 2975-2983 (2013)
   PUBMED   23562820
REFERENCE   6  (bases 1 to 6755)
  AUTHORS   Galligan,C.L., Baig,E., Bykerk,V., Keystone,E.C. and Fish,E.N.
  TITLE     Distinctive gene expression signatures in rheumatoid arthritis
            synovial tissue fibroblast cells: correlates with disease activity
  JOURNAL   Genes Immun 8 (6), 480-491 (2007)
   PUBMED   17568789
REFERENCE   7  (bases 1 to 6755)
  AUTHORS   Miyatake,T., Ueda,Y., Nakashima,R., Yoshino,K., Kimura,T.,
            Murata,T., Nomura,T., Fujita,M., Buzard,G.S. and Enomoto,T.
  TITLE     Down-regulation of insulin-like growth factor binding protein-5
            (IGFBP-5): novel marker for cervical carcinogenesis
  JOURNAL   Int J Cancer 120 (10), 2068-2077 (2007)
   PUBMED   17290407
REFERENCE   8  (bases 1 to 6755)
  AUTHORS   Ohkawa,N., Kokura,K., Matsu-Ura,T., Obinata,T., Konishi,Y. and
            Tamura,T.A.
  TITLE     Molecular cloning and characterization of neural activity-related
            RING finger protein (NARF): a new member of the RBCC family is a
            candidate for the partner of myosin V
  JOURNAL   J Neurochem 78 (1), 75-87 (2001)
   PUBMED   11432975
REFERENCE   9  (bases 1 to 6755)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 6755)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 2 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301462
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA631098.1, AF220018.1,
            BC011052.1 and AL110178.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015271.4.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            filaments. It plays a neuroprotective role and functions as an
            E3-ubiquitin ligase in proteasome-mediated degradation of target
            proteins. Mutations in this gene can cause early-onset axonal
            neuropathy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.170114.1,
                                           SRR1660803.250228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338700.10/ ENSP00000339659.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA631098.1         30-52
            24-2715             AF220018.1         1-2692
            2716-3796           BC011052.1         2748-3828
            3797-4930           AF220018.1         3776-4909
            4931-5171           AL110178.1         758-998
            5172-6403           AF220018.1         5151-6382
            6404-6755           AF220018.1         6384-6735
FEATURES             Location/Qualifiers
     source          1..6755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..6755
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /note="tripartite motif containing 2"
                     /db_xref="GeneID:23321"
                     /db_xref="HGNC:HGNC:15974"
                     /db_xref="MIM:614141"
     exon            1..118
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2404
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif protein TRIM2; RING finger protein 86; E3
                     ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin
                     transferase TRIM2; Charcot-Marie-Tooth disease, type 2R"
                     /codon_start=1
                     /product="tripartite motif-containing protein 2 isoform 1"
                     /protein_id="NP_056086.2"
                     /db_xref="CCDS:CCDS3781.2"
                     /db_xref="GeneID:23321"
                     /db_xref="HGNC:HGNC:15974"
                     /db_xref="MIM:614141"
                     /translation="MHRSGRYGTQQQRAGSKTAGPPCQWSRMASEGTNIPSPVVRQID
                     KQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVA
                     ALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSC
                     ETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIH
                     QLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQE
                     SIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEG
                     LKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYL
                     TAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIR
                     SADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGR
                     NKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGV
                     AVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKAC
                     CVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEF
                     MLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPL
                     YGPQGLALTSDGHVVVADSGNHCFKVYRYLQ"
     exon            119..303
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            304..541
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            542..693
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            694..874
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1598
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1702
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1870
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2039
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2110
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2251
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..6755
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6736..6741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /note="hexamer: AATAAA"
     polyA_site      6755
                     /gene="TRIM2"
                     /gene_synonym="CMT2R; RNF86"
                     /note="major polyA site"
ORIGIN      
        1 ggcagcttga tgactataat gggcccagtt gtctgcgggc tgcggggagc taagtcccca
       61 gattggagga ggctggctct ggtcttcgat gcacaggagt ggccgttatg gaacgcagca
      121 gcagcgtgca gggtcaaaga cagccggccc cccatgtcag tggtctagga tggccagtga
      181 aggcaccaac atcccaagtc ctgtggtgcg ccagattgac aagcagtttc tgatttgcag
      241 tatatgcctg gaacggtaca agaatcccaa ggttctcccc tgtctgcaca ctttctgcga
      301 gaggtgcctg cagaactaca ttcctgccca cagtttaacc ctctcctgcc cagtgtgccg
      361 ccagacctcc atcctgcccg agaaaggggt ggccgcgctc cagaacaatt tcttcatcac
      421 aaacctgatg gacgtgctgc agcgaactcc aggcagcaac gctgaggagt cttccatcct
      481 ggagacagtc actgctgtgg ctgcgggaaa gcctctctct tgcccaaacc acgatgggaa
      541 tgtgatggaa ttttactgcc agtcctgtga gactgccatg tgtcgggagt gcacggaggg
      601 ggagcacgca gagcacccca cagttccact caaggatgtg gtggaacagc acaaggcctc
      661 gctccaggtc cagctggatg ctgtcaacaa aaggctccca gaaatagatt ctgctcttca
      721 gttcatctct gaaatcattc atcagttaac caaccaaaag gccagcatcg tggatgacat
      781 tcattccacc tttgatgagc tccagaagac tttaaatgtg cgcaagagtg tgctgcttat
      841 ggaattggag gtcaactatg gcctcaaaca caaagtcctc cagtcgcagc tggatactct
      901 gctccagggg caggagagca ttaagagctg cagcaacttc acagcgcagg ccctcaacca
      961 tggcacggag accgaggtcc tactggtgaa gaagcagatg agcgagaagc tgaacgagct
     1021 ggccgaccag gacttcccct tgcacccgcg ggagaacgac cagctggatt tcatcgtgga
     1081 aaccgagggg ctgaagaagt ccatccacaa cctcgggacg atcttaacca ccaacgccgt
     1141 tgcctcagag acagtggcca cgggcgaggg gctgcggcag accatcatcg ggcagcccat
     1201 gtccgtcacc atcaccacca aggacaaaga cggtgagctg tgcaaaaccg gcaacgccta
     1261 cctcaccgcc gaactgagca cccccgacgg gagcgtggca gacggggaga tcctggacaa
     1321 caagaacggc acctatgagt ttttgtacac tgtccagaag gaaggggact ttaccctgtc
     1381 tctgagactc tatgaccagc acatccgagg cagcccgttt aagctgaaag tgatccgatc
     1441 cgctgatgtg tctcccacca cagaaggcgt gaagaggcgc gttaagtccc cggggagcgg
     1501 ccacgtcaag cagaaagctg tgaaaagacc cgcaagcatg tacagcactg gaaaacgaaa
     1561 agagaatccc atcgaagacg atttgatctt tcgagtgggt accaaaggaa gaaataaagg
     1621 agagtttaca aatcttcagg gggtagctgc atctacaaat ggaaagatat taattgcaga
     1681 cagtaacaac caatgtgtgc agatattttc caatgatggc cagttcaaaa gtcgttttgg
     1741 catacgggga cgctctccgg ggcagctgca gcggcccaca ggagtggctg tacatcccag
     1801 tggggacata atcattgccg attatgataa taaatgggtc agcattttct cctccgatgg
     1861 gaaatttaag acaaaaattg gatcaggaaa gctgatggga cccaaaggag tttctgtgga
     1921 ccgcaatggg cacattattg ttgtggacaa caaggcgtgc tgcgtgttta tcttccagcc
     1981 aaacgggaaa atagtcacca ggtttggtag ccgaggaaat ggggacaggc agtttgcagg
     2041 tccccatttt gcagctgtaa atagcaataa tgagattatt attacagatt tccataatca
     2101 ttctgtcaag gtgtttaatc aggaaggaga attcatgttg aagtttggct caaatggaga
     2161 aggaaatggg cagtttaatg ctccaacagg tgtagcagtg gattcaaatg gaaacatcat
     2221 tgtggccgac tggggaaaca gcaggatcca ggtttttgat gggagtggat catttttgtc
     2281 ctacattaac acatctgctg acccactcta tggcccccaa ggcctggccc taacttcaga
     2341 tggtcatgtt gtggttgcag actctggaaa tcactgtttc aaagtctatc gatacttaca
     2401 gtaatggtgg gcaggtggat acccgcttcc atggtcttgc actataaact ggaatggatt
     2461 tctcaatgcg ggaccagatt atgactagag tttttatgcc agaaggaatc attggtgaac
     2521 tttccaaggt tatttctgaa tgtaacaatt tccttaaaaa tgacttatcc aatttctgta
     2581 tttcaccttt agggttaaaa aaaactcttc tactgaatct ataaaaactg cagttttaca
     2641 tctgtgaact atggcttaag ggacaggatt tatgtagcta aactaatttt gcaaatcaaa
     2701 cagacactta aaaaactagc atatgtaaag gtattcgtta atcctgtgaa tggtagcttt
     2761 tgcacagaac ttccaaaagc aaaacaaaaa caaaatctat tgtagttata tacttcattt
     2821 aacctaggtc acaagaccca gggaatcttc taacctcact tttacagtag gtattactct
     2881 tgtgacattt ttttggttat caacaactaa atataaatta ctttggaaaa agtaaggctg
     2941 tcttgcaaaa tgatcccagc tctgattagc agccctctgg agttcagaac ttaagtatca
     3001 gtgcaaattt ctcaaccttt ctgggttaga caaagatcct tttttgtgtg ttcttttcac
     3061 cacccctttg gctcaccttg tatcagcaaa caaagtactt cttcagggaa acctgaaatt
     3121 tctaatgcct tgaaaagcat attacaaaag taatgctacc ttttgggaaa caaactgccc
     3181 cgttaactcc agatcattgc actggaatgt aatcaagaaa gttagtcatg ttttatgtac
     3241 catgttttca cacgtgtctc ttctcttcga cttcctgaaa gcgaaagctt tacctcctgc
     3301 aaatgtcagc acatgtagta ggacaccagt atcctaggac agagagccat aagtagccct
     3361 ttggaggact gatggtgtca accaaaggca tgtgattgat taatgattcc cccttagaaa
     3421 gcaagtgtta ccaaagttgt gttatcttga aagcattaca ggtaagggca tgttatggtt
     3481 atttatcatt gtttaatgaa tagtagaggt gtcaagggac tatgtataca tgattagggt
     3541 aagatagaat gtattatata tatatatata tacacacaca catatatata gctgaatctt
     3601 tggtgtattg aaataggcag cactctgaaa gacagaagct tcgtccagcc actcttcagc
     3661 acattccttt actaagcagt ttaaagccgt cctagtggag caagccctaa agcagattta
     3721 atttttgcca ttttccaaga atgacggtgg tggcttttag tcagaaaatg gccttctgtg
     3781 ctttcaaaaa aaaaaacaaa aaaaaaacca cacacacaca taaaaaaccc aacaggtcaa
     3841 aataaaagtt gaacttgagt tacatttaat ttaaatataa atgcattttg agaaatgtta
     3901 agaacaattt agtcaatcgt tcatctgtca ttggtactgt aaaataagct gtggtctatt
     3961 tccactgttt aattttctac tcagttctac caaataggat gtcatgtttg acatttttga
     4021 tagtgacttt ggggtcttct tcactgaaag caccttagaa ctgtactata agaaaacatt
     4081 tcccctatgt ataattatat gaatgtgatg tttattgctt attaatttat aattcagtca
     4141 ttctctatat aggacttctt aaaatttaga agggaaatct agctacttca aattgtctgt
     4201 taaatttatt atgcccaaat caacctctga aaaaaggttt ttccaggaag atttacattt
     4261 aggtttaata tttttttagt taggtagagt tttaaaaaat acttgagcct gtccgtgata
     4321 aagctataaa attcaataac tttttagaat gttaaatgaa gacactgttt cctaacatca
     4381 gtgagataca tctttgaatt taaacattca tatttactga gtacctacta ggtaccaagt
     4441 actcttttag gcactggaaa tacagtgatg gacaaaacag gtaaaaaatc gctgccccct
     4501 cagagctgac attctggggt gggaatttca ttttgccacg tactaacgtt ctgcacaaaa
     4561 gacaggctag actcttgtct agattgttta aaagaaactt ttcaaattgg ttacattaat
     4621 tttagtttat tttcacaagt aaaaatggct ttttatttag attctttctg tcccaggctg
     4681 ttgatcttaa aactagttga tttaaagagt ttttttgcac aacatttcaa ttatatttgt
     4741 gaacttagaa attaacttac aatctaacca gccatcatat catatcctat caggctagat
     4801 atctcaatag tagactgaat acaaagctaa ttttttttac atgtcaatat tggcacaaac
     4861 tggaatgaaa gaatagtttg attcagacct gctccactat gtgttgctaa aacacatgct
     4921 atgagcactc caggaaacac tatatttttt ccaaaaaata tgtgattata tatgttaaag
     4981 tatagataac atttcacact tggatacata tgtgcattta ctgtatttct tggtaagcat
     5041 atttttgggg gaaagtgctg ctgatatgat acaagtagac aaaatttaaa tgaaattttg
     5101 tcacattcta tggaaaatgg tttctggtaa actgagaagg atattaaaat aagtggcttt
     5161 tttctgggct accattattg tttgatttct ctttgtcaag tgtatagaac ctgtcataca
     5221 ttcatgataa gtagcactga aaaattactc attcaaattt cccctgggca cgtaaggcaa
     5281 aatattgccg gttgggattt caaggtcagt gacgacgcat ttcctcccag tacagacccc
     5341 ccagcccccc ttgctggaca tggggaggca gagagtcact tgaccatcca gaaatacatg
     5401 actacaagtc ctttatgact gtttgccatt ttttttaatg gtacttagta ttttgatcaa
     5461 actttagtct ccagaactaa acaagtccct aagtttcctt attttaattt actgtgacta
     5521 gatttgaagc aaataaatac tccagatcca tgcagctaga acacacttgc ttccactact
     5581 aaatatacag ggtatgtcct aacatggagt taactggaat agcagtacac tagcaagtat
     5641 ctgtgaatcc ttagcactga cgggttaaca gaaatgcttt ggtaatacct acttagttaa
     5701 ttggaggaag tagtaaataa acattaggta atctgcagat tacttcaaat gggaaaaatc
     5761 tttttgtaga ctctatagta ccctctctat tcactagctt ctgaaaaggg aggagtattt
     5821 ttagtttgac aatttaataa tttaaaaaca agacatctcc aggtaggaaa aaatgaaagc
     5881 tatttcatgc aaacattatc taatttagct taaaagtgaa agtggtaata ctgttggttt
     5941 ctgtaaatgt tgcagggttt taaactttat aattacttta atatttttga taactagaaa
     6001 tctagtattg ccataaagga aactaagtgc ccatcaaaga tttgtttggt ataaataaag
     6061 aattatttgt tttgttttca atgacagtaa gctacaaatc atgatgctta aaaactttct
     6121 aaagatgaat tgtgtggcag tgattggtct gtttgtggag aatgtatgaa agctattaat
     6181 attctagaat agattaataa attggctatg ttgttccaat gaatgtacag cacttccatt
     6241 aacttttgaa agcaacacag ccttaaactc aatgcttttg ctttatgaca tgggaatgtt
     6301 ctgtcatcaa tggagtgtat tcttgtaata gaattcttta tatcgttctc aattctatag
     6361 actttcaagc ctatgtatga atatgaaggg gttttttttt tttgctttgt tttcttttta
     6421 gattttgtac attccatctt tataggtctg tttcatatgt tttatgtata gaacactaag
     6481 tcttgcactc tctgacattg atactgatat attctcgtca tttgttcttt tatgaatcaa
     6541 aatgttgact gcctatttaa agaaaagaat gaacgctgtg catcaaagtg tttgtatgtt
     6601 cgtagctaca tacgtaccac agtattttgg atgctttagt ctacaatgaa actttcaatt
     6661 aattctgtct tgaaacatag gagaaacagg attcatgtgt atctctttac catgcacaaa
     6721 atctcaaatc attataataa agcttgtttt ctcca
//
