LOCUS       NM_016102               2064 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 17 (TRIM17), transcript
            variant 1, mRNA.
ACCESSION   NM_016102
VERSION     NM_016102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Zhong,T., Zhang,J., Liu,X. and Li,H.
  TITLE     TRIM17-mediated ubiquitination and degradation of RBM38 promotes
            cisplatin resistance in non-small cell lung cancer
  JOURNAL   Cell Oncol (Dordr) 46 (5), 1493-1507 (2023)
   PUBMED   37219768
  REMARK    GeneRIF: TRIM17-mediated ubiquitination and degradation of RBM38
            promotes cisplatin resistance in non-small cell lung cancer.
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Liu,Z., Zhao,W. and Yang,R.
  TITLE     MiR-1246 is responsible for lung cancer cells-derived
            exosomes-mediated promoting effects on lung cancer stemness via
            targeting TRIM17
  JOURNAL   Environ Toxicol 37 (11), 2651-2659 (2022)
   PUBMED   35894553
  REMARK    GeneRIF: MiR-1246 is responsible for lung cancer cells-derived
            exosomes-mediated promoting effects on lung cancer stemness via
            targeting TRIM17.
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Hu,X., Xiang,D., Xie,Y., Tao,L., Zhang,Y., Jin,Y., Pinello,L.,
            Wan,Y., Yuan,G.C. and Li,Z.
  TITLE     LSD1 suppresses invasion, migration and metastasis of luminal
            breast cancer cells via activation of GATA3 and repression of
            TRIM37 expression
  JOURNAL   Oncogene 38 (44), 7017-7034 (2019)
   PUBMED   31409898
  REMARK    GeneRIF: data suggest LSD1 largely plays a tumor suppressor role in
            luminal breast cancer and the oncogenic program associated with
            LSD1-inhibition may be suppressed via TRIM37-inhibition
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Urano,T., Usui,T., Takeda,S., Ikeda,K., Okada,A., Ishida,Y.,
            Iwayanagi,T., Otomo,J., Ouchi,Y. and Inoue,S.
  TITLE     TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3
            ligase
  JOURNAL   Biochem Biophys Res Commun 383 (2), 263-268 (2009)
   PUBMED   19358823
  REMARK    GeneRIF: terf interacts with TRIM44;TRIM44 inhibited ubiquitination
            of terf, and thus stabilized the protein.
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Aurino,S., Piluso,G., Saccone,V., Cacciottolo,M., D'Amico,F.,
            Dionisi,M., Totaro,A., Belsito,A., Di Vicino,U. and Nigro,V.
  TITLE     Candidate-gene testing for orphan limb-girdle muscular dystrophies
  JOURNAL   Acta Myol 27 (3), 90-97 (2008)
   PUBMED   19472918
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Ogawa,S., Saito,T., Matsuda,Y., Seki,N., Hayashi,A., Orimo,A.,
            Hosoi,T., Ouchi,Y., Muramatsu,M., Hori,T. and Inoue,S.
  TITLE     Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes
            coding for testis RING finger protein (terf), a member of the RING
            finger family
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 56-58 (2000)
   PUBMED   10894938
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Ogawa,S., Goto,W., Orimo,A., Hosoi,T., Ouchi,Y., Muramatsu,M. and
            Inoue,S.
  TITLE     Molecular cloning of a novel RING finger-B box-coiled coil (RBCC)
            protein, terf, expressed in the testis
  JOURNAL   Biochem Biophys Res Commun 251 (2), 515-519 (1998)
   PUBMED   9792805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA270450.1, DB031719.1,
            BC033788.1 and AW770403.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016102.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies. The protein is expressed almost exclusively in the testis,
            but its function is unknown. Multiple alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033788.1, AF156271.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366698.7/ ENSP00000355659.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               DA270450.1         57-284
            229-808             DB031719.1         1-580
            809-1963            BC033788.1         594-1748
            1964-2064           AW770403.1         2-102               c
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2064
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /note="tripartite motif containing 17"
                     /db_xref="GeneID:51127"
                     /db_xref="HGNC:HGNC:13430"
                     /db_xref="MIM:606123"
     exon            1..323
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            324..793
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1798
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 16; RING finger protein terf; testis RING
                     finger protein; E3 ubiquitin-protein ligase TRIM17;
                     tripartite motif-containing protein 17; RING-type E3
                     ubiquitin transferase TRIM17"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM17 isoform 1"
                     /protein_id="NP_057186.1"
                     /db_xref="CCDS:CCDS1571.1"
                     /db_xref="GeneID:51127"
                     /db_xref="HGNC:HGNC:13430"
                     /db_xref="MIM:606123"
                     /translation="MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSW
                     EKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQHPGLQKQDLCQEH
                     HEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRT
                     GNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRL
                     RESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTR
                     PRTVCRVPGQIEVLRGFLEDVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRF
                     VAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQ
                     LSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPG
                     PLQPFFCLGAPKSGQMVISTVTMWVKG"
     exon            794..889
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1120
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1143
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1247
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..2064
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1937..1942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /note="hexamer: AATATA"
     polyA_site      1969
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /note="major polyA site"
     polyA_site      2064
                     /gene="TRIM17"
                     /gene_synonym="RBCC; RNF16; terf"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcacc cgctgcgcct gtccccggct cgtccagagc cttccacccc ctgccgcctt
       61 ccttccccaa gccaccccca acctctccta agaggcgccg ccccagtccc ggccgccgaa
      121 cactccctcg cccagcattc ccctcccccg ccgcccccca gcccccgctg acgccacaaa
      181 gtccctaggc ctcccgaccc caggtcccca cgccccgggc cgggccgcag cctcctgggc
      241 ttcgtggggg cagacccagc ctttcccggc agcgagcgct cggccaggtg cactaggcgc
      301 tgtgcgggcc ccccttcccc gcgagtccct caagcgggaa cctgcctcgt gtctcccagg
      361 agccatggag gctgtggaac tcgccagaaa actgcaggag gaagctacgt gctccatctg
      421 tctggattac ttcacagacc ctgtgatgac cacctgtggc cacaacttct gccgagcctg
      481 catccagctg agctgggaaa aggcgagggg caagaagggg aggcggaagc ggaagggctc
      541 cttcccctgc cccgagtgca gagagatgtc cccgcagagg aacctgctgc ccaaccggct
      601 gctgaccaag gtggccgaga tggcgcagca gcatcctggt ctgcagaagc aagacctgtg
      661 ccaggagcac cacgagcccc tcaagctttt ctgccagaag gaccagagcc ccatctgtgt
      721 ggtgtgcagg gagtcccggg agcaccggct gcacagggtg ctgcccgccg aggaggcagt
      781 gcaggggtac aagttgaagc tggaggagga catggagtac cttcgggagc agatcaccag
      841 gacagggaat ctgcaggcca gggaggagca gagcttagcc gagtggcagg gcaaggtgaa
      901 ggagcggaga gaacgcattg tgctggagtt tgagaagatg aacctctacc tggtggaaga
      961 agagcagagg ctcctccagg ctctggagac ggaagaagag gagactgcca gcaggctccg
     1021 ggagagcgtg gcctgcctgg accggcaggg tcactctctg gagctgctgc tgctgcagct
     1081 ggaggagcgg agcacacagg ggcccctcca gatgctgcag gacatgaagg aacccctgag
     1141 caggaagaac aacgtgagtg tgcagtgccc agaggttgcc cccccaacca gacccaggac
     1201 tgtgtgcaga gttcccggac agattgaagt gctaagaggc tttctagagg atgtggtgcc
     1261 tgatgccacc tccgcgtacc cctacctcct cctgtatgag agccgccaga ggcgctacct
     1321 cggctcttcg ccggagggca gtgggttctg cagcaaggac cgatttgtgg cttacccctg
     1381 tgctgtgggc cagacggcct tctcctctgg gaggcactac tgggaggtgg gcatgaacat
     1441 caccggggac gcgttgtggg ccctgggtgt gtgcagggac aacgtgagcc ggaaagacag
     1501 ggtccccaag tgccccgaaa acggcttctg ggtggtgcag ctgtccaagg ggaccaagta
     1561 cttatccacc ttctctgccc taaccccggt catgctgatg gagcctccca gccacatggg
     1621 catcttcctg gacttcgaag ccggggaagt gtccttctac agtgtaagcg atgggtccca
     1681 cctgcacacc tactcccagg ccaccttccc aggccccctg cagcctttct tctgcctggg
     1741 ggctccgaag tctggtcaga tggtcatctc cacagtgacc atgtgggtga aaggatagac
     1801 acagaccggg ggactcgggc actgctcctg gctctgcaga aggtgtgggc cttctgctta
     1861 ctgcaggcca cctgccaggg ttctctggca tcacgctggc agccattaga cacacagggg
     1921 ggtttctcaa attctaaata taattgtgat tagaactgtc aaacattaag agggtatact
     1981 gacagatgct tcctagagga aacttttgaa agcccctgcg ttctgagtgg accgatttct
     2041 aaatccatac ctacacacca ggaa
//
