LOCUS       NM_001348119            3358 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 16 (TRIM16), transcript
            variant 1, mRNA.
ACCESSION   NM_001348119
VERSION     NM_001348119.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3358)
  AUTHORS   Guo,D., Zhang,M., Wei,T., Zhang,X., Shi,X., Tang,H., Ding,M.,
            Li,J., Zhang,S. and Guo,W.
  TITLE     NFKBIZ regulates NFkappaB signaling pathway to mediate
            tumorigenesis and metastasis of hepatocellular carcinoma by direct
            interaction with TRIM16
  JOURNAL   Cell Mol Life Sci 81 (1), 167 (2024)
   PUBMED   38581570
  REMARK    GeneRIF: NFKBIZ regulates NFkappaB signaling pathway to mediate
            tumorigenesis and metastasis of hepatocellular carcinoma by direct
            interaction with TRIM16.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3358)
  AUTHORS   Li,S., Wang,J., Chen,H., Hou,J., Shen,T., Li,J., Zhou,B., Zhang,B.,
            Liu,H. and Jiang,D.K.
  TITLE     TRIM16 E121D variant affects the risk and prognosis of
            hepatocellular carcinoma by modulating the Wnt/beta-catenin pathway
  JOURNAL   Mol Carcinog 62 (11), 1686-1699 (2023)
   PUBMED   37477507
  REMARK    GeneRIF: TRIM16 E121D variant affects the risk and prognosis of
            hepatocellular carcinoma by modulating the Wnt/beta-catenin
            pathway.
REFERENCE   3  (bases 1 to 3358)
  AUTHORS   Seifi Inallou,M., Safaralizadeh,R., Rajabi,A., Hosseinpourfeizi,M.
            and Haghi,M.
  TITLE     Changes in the Expression of Long Non-Coding RNA SDMGC and Its
            Target Gene, TRIM16, in Patients with Gastric Cancer
  JOURNAL   J Gastrointest Cancer 54 (1), 44-50 (2023)
   PUBMED   34978663
  REMARK    GeneRIF: Changes in the Expression of Long Non-Coding RNA SDMGC and
            Its Target Gene, TRIM16, in Patients with Gastric Cancer.
REFERENCE   4  (bases 1 to 3358)
  AUTHORS   Roshanazadeh,M.R., Adelipour,M., Sanaei,A., Chenane,H. and
            Rashidi,M.
  TITLE     TRIM3 and TRIM16 as potential tumor suppressors in breast cancer
            patients
  JOURNAL   BMC Res Notes 15 (1), 312 (2022)
   PUBMED   36180926
  REMARK    GeneRIF: TRIM3 and TRIM16 as potential tumor suppressors in breast
            cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3358)
  AUTHORS   Wang,Y., Wu,Y. and Xie,S.
  TITLE     CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting
            miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC)
  JOURNAL   Bioengineered 13 (2), 3651-3664 (2022)
   PUBMED   35230201
  REMARK    GeneRIF: CircPTK2 inhibits cell cisplatin (CDDP) resistance by
            targeting miR-942/TRIM16 axis in non-small cell lung cancer
            (NSCLC).
REFERENCE   6  (bases 1 to 3358)
  AUTHORS   Gwinn,M.R., Whipkey,D.L., Tennant,L.B. and Weston,A.
  TITLE     Differential gene expression in normal human mammary epithelial
            cells treated with malathion monitored by DNA microarrays
  JOURNAL   Environ Health Perspect 113 (8), 1046-1051 (2005)
   PUBMED   16079077
REFERENCE   7  (bases 1 to 3358)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 3358)
  AUTHORS   Beer,H.D., Munding,C., Dubois,N., Mamie,C., Hohl,D. and Werner,S.
  TITLE     The estrogen-responsive B box protein: a novel regulator of
            keratinocyte differentiation
  JOURNAL   J Biol Chem 277 (23), 20740-20749 (2002)
   PUBMED   11919186
  REMARK    GeneRIF: role in regulating keratinocyte differentiation
REFERENCE   9  (bases 1 to 3358)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 3358)
  AUTHORS   Liu,H.L., Golder-Novoselsky,E., Seto,M.H., Webster,L., McClary,J.
            and Zajchowski,D.A.
  TITLE     The novel estrogen-responsive B-box protein (EBBP) gene is
            tamoxifen-regulated in cells expressing an estrogen receptor
            DNA-binding domain mutant
  JOURNAL   Mol Endocrinol 12 (11), 1733-1748 (1998)
   PUBMED   9817599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005324.1.
            
            Summary: The protein encoded by this gene is a tripartite motif
            (TRIM) family member that contains two B box domains and a
            coiled-coiled region that are characteristic of the B box zinc
            finger protein family. While it lacks a RING domain found in other
            TRIM proteins, the encoded protein can homodimerize or
            heterodimerize with other TRIM proteins and has E3 ubiquitin ligase
            activity. This gene is also a tumor suppressor and is involved in
            secretory autophagy. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1, 2, and
            3 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2402253.1,
                                           SRR11853559.13436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649191.2/ ENSP00000497185.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC005324.1         80714-80829
            117-238             AC005324.1         81868-81989
            239-336             AC005324.1         82074-82171
            337-425             AC005324.1         84072-84160
            426-572             AC005324.1         87304-87450
            573-677             AC005324.1         87745-87849
            678-1533            AC005324.1         113079-113934
            1534-1629           AC005324.1         122209-122304
            1630-1863           AC005324.1         128756-128989
            1864-2029           AC005324.1         132351-132516
            2030-2125           AC005324.1         133311-133406
            2126-3358           AC005324.1         135827-137059
FEATURES             Location/Qualifiers
     source          1..3358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3358
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /note="tripartite motif containing 16"
                     /db_xref="GeneID:10626"
                     /db_xref="HGNC:HGNC:17241"
                     /db_xref="MIM:609505"
     exon            1..116
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            117..238
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            239..336
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            337..425
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            426..572
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            573..677
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1533
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1015..2709
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     estrogen-responsive B box protein; tripartite
                     motif-containing protein 16; E3 ubiquitin-protein ligase
                     TRIM16"
                     /codon_start=1
                     /product="tripartite motif-containing protein 16 isoform
                     a"
                     /protein_id="NP_001335048.1"
                     /db_xref="CCDS:CCDS11171.1"
                     /db_xref="GeneID:10626"
                     /db_xref="HGNC:HGNC:17241"
                     /db_xref="MIM:609505"
                     /translation="MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEED
                     VGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCE
                     EHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGH
                     TIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQ
                     FGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAIS
                     NTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQE
                     FSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEEN
                     RKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGID
                     RKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSF
                     YGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP"
     exon            1534..1629
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1863
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2029
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2125
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..3358
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /note="hexamer: AATAAA"
     polyA_site      3358
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggcc cctttctctg gaggatctcc gcgcgtggcg agtctgtgtc ctccctgtcc
       61 cccagagcag acaccctctc tgtgtctgga ccggggagga gcagacgctg gacaggtttc
      121 tggtagaatg ctggcaattt ccaggaagat acgtggagaa cggaaaggtt gctacaccca
      181 aatagtgaag caaaggctat gattatggag gattggacct gcaaactcca gaacagagca
      241 accttgtaaa atgtgtgtgg gcagcacaga gaacttgggc aagttaacag tttcctcatc
      301 tgtgaatact gatttatgga aagcacctgg tgcgtgttct gccctctgag gaccctgccc
      361 tttcccaaaa ggggtatctt aagaaggaaa atatggctgc tctttgccgg acagcagagt
      421 cccagaaccc catgcaggtg tttcagggct ttatgtcatt caaggatgtg gctgtgaact
      481 tcactaggaa gaatggagag aactggacct tgctcagaga gtcttgtaca gggatgtaat
      541 gctggagaac tataggaacc tggtctcctt ggtaggattt ccattttcca aacctggtat
      601 catctcctag ttggaagaag tggtaagccc acgaacacaa atgcaggagg gagaggtgcc
      661 aagaagcagc ggtacacagc aggcacagag acacgtggtc ttcagcagag cctatggggt
      721 tcagatgatt cacataagaa tagaagtttc agggctggac ctggggaggc agcctgagcc
      781 tgagccggct gtcctgagcc tgagtactct agctgccttg tcgtcatcgc atctggctgc
      841 catccagcgc cagcacacag taatgagtgg ccgagcttcc tctgggaggg aggaaacagt
      901 taaaatcttg cagcagctgc aatcatctag gcgtggttct cttgtctgac ttgggctgca
      961 cagatcctgg gccaagggac agaagaaaga cagcctagga gcagagcctc ccagatggct
     1021 gagttggatc taatggctcc agggccactg cccagggcca ctgctcagcc cccagcccct
     1081 ctcagcccag actctgggtc acccagccca gattctgggt cagccagccc agtggaagaa
     1141 gaggacgtgg gctcctcgga gaagcttggc agggagacgg aggaacagga cagcgactct
     1201 gcagagcagg gggatcctgc tggtgagggg aaagaggtcc tgtgtgactt ctgccttgat
     1261 gacaccagaa gagtgaaggc agtgaagtcc tgtctaacct gcatggtgaa ttactgtgaa
     1321 gagcacttgc agccgcatca ggtgaacatc aaactgcaaa gccacctgct gaccgagcca
     1381 gtgaaggacc acaactggcg atactgccct gcccaccaca gcccactgtc tgccttctgc
     1441 tgccctgatc agcagtgcat ctgccaggac tgttgccagg agcacagtgg ccacaccata
     1501 gtctccctgg atgcagcccg cagggacaag gaggctgaac tccagtgcac ccagttagac
     1561 ttggagcgga aactcaagtt gaatgaaaat gccatctcca ggctccaggc taaccaaaag
     1621 tctgttctgg tgtcggtgtc agaggtcaaa gcggtggctg aaatgcagtt tggggaactc
     1681 cttgctgctg tgaggaaggc ccaggccaat gtgatgctct tcttagagga gaaggagcaa
     1741 gctgcgctga gccaggccaa cggtatcaag gcccacctgg agtacaggag tgccgagatg
     1801 gagaagagca agcaggagct ggagaggatg gcggccatca gcaacactgt ccagttcttg
     1861 gaggagtact gcaagtttaa gaacactgaa gacatcacct tccctagtgt ttacgtaggg
     1921 ctgaaggata aactctcggg catccgcaaa gttatcacgg aatccactgt acacttaatc
     1981 cagttgctgg agaactataa gaaaaagctc caggagtttt ccaaggaaga ggagtatgac
     2041 atcagaactc aagtgtctgc cgttgttcag cgcaaatatt ggacttccaa acctgagccc
     2101 agcaccaggg aacagttcct ccaatatgcg tatgacatca cgtttgaccc ggacacagca
     2161 cacaagtatc tccggctgca ggaggagaac cgcaaggtca ccaacaccac gccctgggag
     2221 catccctacc cggacctccc cagcaggttc ctgcactggc ggcaggtgct gtcccagcag
     2281 agtctgtacc tgcacaggta ctattttgag gtggagatct tcggggcagg cacctatgtt
     2341 ggcctgacct gcaaaggcat cgaccggaaa ggggaggagc gcaacagttg catttccgga
     2401 aacaacttct cctggagcct ccaatggaac gggaaggagt tcacggcctg gtacagtgac
     2461 atggagaccc cactcaaagc tggccctttc cggaggctcg gggtctatat cgacttcccg
     2521 ggagggatcc tttccttcta tggcgtagag tatgatacca tgactctggt tcacaagttt
     2581 gcctgcaaat tttcagaacc agtctatgct gccttctggc tttccaagaa ggaaaacgcc
     2641 atccggattg tagatctggg agaggaaccc gagaagccag caccgtcctt ggtggggact
     2701 gctccctaga ctccaggagc catatcccag acctttgcca gctacagtga tgggatttgc
     2761 attttagggt gatttggggg cagaaataac tgctgatggt agctggcttt tgaaatccta
     2821 tggggtctct gaatgaaaac attctccagc tgctctcttt tgctccatat ggtgctgttc
     2881 tctatgtgtt tgcagtaatt cttttttttt tttttgagac ggagtctcgc actgttgccc
     2941 aggctggaga gcagtggcgc gatcttggct cactgcaagc tccgcctccc gagttcaagc
     3001 aattctcctg cctcagcctc ccgagtagct gggattacag gtgcctgcca ccacacccag
     3061 ctaatgtttt gtatttttag tagagatggg gtttcaccat gttggccagg cagatctcaa
     3121 actcctgacc tcgtgatgca cccacctcgg cctcccaaag tgctgggatt acatgcgtga
     3181 gccactgcgc cctgcctgtt tgtagtaatt tttaggcacc aaatctccct catcttctag
     3241 tgccattctc ctctctgttc aggtaaatgt cacactgtgc ccagaatgga tgaccaggaa
     3301 ccttaaagag tggctgaaaa gattgcagag ttatcataat aaattgctaa cttgcgta
//
