LOCUS       NM_033229               1881 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tripartite motif containing 15 (TRIM15), mRNA.
ACCESSION   NM_033229
VERSION     NM_033229.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Yang,C., Jin,X., Liu,X., Wu,G., Yang,W., Pang,B., Jiang,J., Liao,D.
            and Zhang,Y.
  TITLE     TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to
            modulate the sensitivity of HCC cells to TKIs
  JOURNAL   Cell Death Dis 14 (1), 47 (2023)
   PUBMED   36670097
  REMARK    GeneRIF: TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and
            LASP1 to modulate the sensitivity of HCC cells to TKIs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Liang,M., Wang,L., Sun,Z., Chen,X., Wang,H., Qin,L., Zhao,W. and
            Geng,B.
  TITLE     E3 ligase TRIM15 facilitates non-small cell lung cancer progression
            through mediating Keap1-Nrf2 signaling pathway
  JOURNAL   Cell Commun Signal 20 (1), 62 (2022)
   PUBMED   35534896
  REMARK    GeneRIF: E3 ligase TRIM15 facilitates non-small cell lung cancer
            progression through mediating Keap1-Nrf2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Roy,M., Singh,K., Shinde,A., Singh,J., Mane,M., Bedekar,S.,
            Tailor,Y., Gohel,D., Vasiyani,H., Currim,F. and Singh,R.
  TITLE     TNF-alpha-induced E3 ligase, TRIM15 inhibits TNF-alpha-regulated
            NF-kappaB pathway by promoting turnover of K63 linked
            ubiquitination of TAK1
  JOURNAL   Cell Signal 91, 110210 (2022)
   PUBMED   34871740
REFERENCE   4  (bases 1 to 1881)
  AUTHORS   Zhu,G., Herlyn,M. and Yang,X.
  TITLE     TRIM15 and CYLD regulate ERK activation via lysine-63-linked
            polyubiquitination
  JOURNAL   Nat Cell Biol 23 (9), 978-991 (2021)
   PUBMED   34497368
  REMARK    GeneRIF: TRIM15 and CYLD regulate ERK activation via
            lysine-63-linked polyubiquitination.
REFERENCE   5  (bases 1 to 1881)
  AUTHORS   Zhang,L., Qin,B., Zou,B., Wang,S., Quan,X., Wang,J. and Zhao,H.
  TITLE     Knockdown of TRIM15 inhibits the proliferation, migration and
            invasion of esophageal squamous cell carcinoma cells through
            inactivation of the Wnt/beta-catenin signaling pathway
  JOURNAL   J Bioenerg Biomembr 53 (2), 213-222 (2021)
   PUBMED   33515345
  REMARK    GeneRIF: Knockdown of TRIM15 inhibits the proliferation, migration
            and invasion of esophageal squamous cell carcinoma cells through
            inactivation of the Wnt/beta-catenin signaling pathway.
REFERENCE   6  (bases 1 to 1881)
  AUTHORS   Shiina,T., Ota,M., Shimizu,S., Katsuyama,Y., Hashimoto,N.,
            Takasu,M., Anzai,T., Kulski,J.K., Kikkawa,E., Naruse,T., Kimura,N.,
            Yanagiya,K., Watanabe,A., Hosomichi,K., Kohara,S., Iwamoto,C.,
            Umehara,Y., Meyer,A., Wanner,V., Sano,K., Macquin,C., Ikeo,K.,
            Tokunaga,K., Gojobori,T., Inoko,H. and Bahram,S.
  TITLE     Rapid evolution of major histocompatibility complex class I genes
            in primates generates new disease alleles in humans via hitchhiking
            diversity
  JOURNAL   Genetics 173 (3), 1555-1570 (2006)
   PUBMED   16702430
REFERENCE   7  (bases 1 to 1881)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   8  (bases 1 to 1881)
  AUTHORS   Harada,H., Harada,Y., O'Brien,D.P., Rice,D.S., Naeve,C.W. and
            Downing,J.R.
  TITLE     HERF1, a novel hematopoiesis-specific RING finger protein, is
            required for terminal differentiation of erythroid cells
  JOURNAL   Mol Cell Biol 19 (5), 3808-3815 (1999)
   PUBMED   10207104
REFERENCE   9  (bases 1 to 1881)
  AUTHORS   Gruen,J.R., Nalabolu,S.R., Chu,T.W., Bowlus,C., Fan,W.F.,
            Goei,V.L., Wei,H., Sivakamasundari,R., Liu,Y., Xu,H.X., Parimoo,S.,
            Nallur,G., Ajioka,R., Shukla,H., Bray-Ward,P., Pan,J. and
            Weissman,S.M.
  TITLE     A transcription map of the major histocompatibility complex (MHC)
            class I region
  JOURNAL   Genomics 36 (1), 70-85 (1996)
   PUBMED   8812418
REFERENCE   10 (bases 1 to 1881)
  AUTHORS   Goei,V.L., Parimoo,S., Capossela,A., Chu,T.W. and Gruen,J.R.
  TITLE     Isolation of novel non-HLA gene fragments from the hemochromatosis
            region (6p21.3) by cDNA hybridization selection
  JOURNAL   Am J Hum Genet 54 (2), 244-251 (1994)
   PUBMED   8304341
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP270476.1, AL669914.2,
            BC038585.1, U34249.1 and AI739162.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033229.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to the cytoplasm.
            Alternatively spliced transcript variants have been described, but
            their biological validity has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038585.1, U34249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376694.9/ ENSP00000365884.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BP270476.1         341-366
            27-27               AL669914.2         158205-158205
            28-59               BP270476.1         368-399
            60-1109             BC038585.1         1-1050
            1110-1752           U34249.1           1464-2106
            1753-1880           AI739162.1         1-128               c
            1881-1881           U34249.1           2235-2235
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1881
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /note="tripartite motif containing 15"
                     /db_xref="GeneID:89870"
                     /db_xref="HGNC:HGNC:16284"
     exon            1..520
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1537
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 178; tripartite
                     motif-containing protein 15; RING finger protein 93; zinc
                     finger protein B7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM15"
                     /protein_id="NP_150232.2"
                     /db_xref="CCDS:CCDS4677.1"
                     /db_xref="GeneID:89870"
                     /db_xref="HGNC:HGNC:16284"
                     /translation="MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALS
                     QMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLC
                     VFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLT
                     QIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGA
                     QVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPE
                     MMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDG
                     LPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIIS
                     HQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFP
                     FFAVWKKGSCLTLKG"
     exon            521..616
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     exon            617..847
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     exon            848..870
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     exon            871..986
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1019
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1881
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /note="hexamer: AATAAA"
     polyA_site      1881
                     /gene="TRIM15"
                     /gene_synonym="RNF93; ZNF178; ZNFB7"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcttt ctctctctct gtctcttagc cttgcagccg tttccctctg cgattcatgt
       61 aagtgtgact cgatttcagg gaaagggaac tcgcgtgggc tgaggagacc ggagtggacg
      121 ggctggggaa ggcaccgtga tgcccgcaac cccgtccctg aaggtggtcc atgagctgcc
      181 tgcctgtacc ctctgtgcgg ggccgctgga ggatgcggtg accattccct gtggacacac
      241 cttctgccgg ctctgcctcc ccgcgctctc ccagatgggg gcccaatcct cgggcaagat
      301 cctgctctgc ccgctctgcc aagaggagga gcaggcagag actcccatgg cccctgtgcc
      361 cctgggcccg ctgggagaaa cttactgcga ggagcacggc gagaagatct acttcttctg
      421 cgagaacgat gccgagttcc tctgtgtgtt ctgcagggag ggtcccacgc accaggcgca
      481 caccgtgggg ttcctggacg aggccattca gccctaccgg gatcgtctca ggagtcgact
      541 ggaagctctg agcacggaga gagatgagat tgaggatgta aagtgtcaag aagaccagaa
      601 gcttcaagtg ctgctgactc agatcgaaag caagaagcat caggtggaaa cagcttttga
      661 gaggctgcag caggagctgg agcagcagcg atgtctcctg ctggccaggc tgagggagct
      721 ggagcagcag atttggaagg agagggatga atatatcaca aaggtctctg aggaagtcac
      781 ccggcttgga gcccaggtca aggagctgga ggagaagtgt cagcagccag caagtgagct
      841 tctacaagat gtcagagtca accagagcag gtgtgagatg aagacttttg tgagtcctga
      901 ggccatttct cctgaccttg tcaagaagat ccgtgatttc cacaggaaaa tactcaccct
      961 cccagagatg atgaggatgt tctcagaaaa cttggcgcat catctggaaa tagattcagg
     1021 ggtcatcact ctggaccctc agaccgccag ccggagcctg gttctctcgg aagacaggaa
     1081 gtcagtgagg tacacccggc agaagaagag cctgccagac agccccctgc gcttcgacgg
     1141 cctcccggcg gttctgggct tcccgggctt ctcctccggg cgccaccgct ggcaggttga
     1201 cctgcagctg ggcgacggcg gcggctgcac ggtgggggtg gccggggagg gggtgaggag
     1261 gaagggagag atgggactca gcgccgagga cggcgtctgg gccgtgatca tctcgcacca
     1321 gcagtgctgg gccagcacct ccccgggcac cgacctgccg ctgagcgaga tcccgcgcgg
     1381 cgtgagagtc gccctggact acgaggcggg gcaggtgacc ctccacaacg cccagaccca
     1441 ggagcccatc ttcaccttca ctgcctcttt ctccggcaaa gtcttccctt tctttgccgt
     1501 ctggaaaaaa ggttcctgcc ttacgctgaa aggctgaagt ggggcgcgcg aagggcggcg
     1561 aagcggagac ggcggctctc cgggatccag ctccgcccct ggccagtgtg cggcccgggg
     1621 gctccctgtg cccgcgtgag gcgagagaac aggggacttg agtctcgaac agcggttgtt
     1681 tttactttat ttatcttagg ccctcagctc cctgacgtcc tgagcctccc tgtgacgctc
     1741 tggccttctc tgtacctcag agtgcagaac cacagacggc ttcggctgtg cctagggcaa
     1801 cagccaacct aggagccagc gggctttcgg ggaaaaaaaa gaaaaagaca tctaaaataa
     1861 aatgtttaaa ctgtttcaaa a
//
