LOCUS       NM_014788               4480 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 14 (TRIM14), transcript
            variant 1, mRNA.
ACCESSION   NM_014788
VERSION     NM_014788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4480)
  AUTHORS   Jiang,J., Shi,S., Zhang,W., Li,C., Sun,L., Ge,Q. and Li,X.
  TITLE     Circ_RPPH1 facilitates progression of breast cancer via
            miR-1296-5p/TRIM14 axis
  JOURNAL   Cancer Biol Ther 25 (1), 2360768 (2024)
   PUBMED   38816350
  REMARK    GeneRIF: Circ_RPPH1 facilitates progression of breast cancer via
            miR-1296-5p/TRIM14 axis.
REFERENCE   2  (bases 1 to 4480)
  AUTHORS   Niu,Z., Qu,S.T., Zhang,L., Dai,J.H., Wang,K., Liu,Y., Chen,L.,
            Song,Y., Sun,R., Xu,Z.H. and Zhang,H.L.
  TITLE     Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain
            in Rats and Osteoarthritis Patients
  JOURNAL   Neuroscience 548, 39-49 (2024)
   PUBMED   38697463
  REMARK    GeneRIF: Trim14-IkappaBalpha Signaling Regulates Chronic
            Inflammatory Pain in Rats and Osteoarthritis Patients.
REFERENCE   3  (bases 1 to 4480)
  AUTHORS   Wei,S., Ai,M., Zhan,Y., Yu,J., Xie,T., Hu,Q., Fang,Y., Huang,X. and
            Li,Y.
  TITLE     TRIM14 suppressed the progression of NSCLC via hexosamine
            biosynthesis pathway
  JOURNAL   Carcinogenesis 45 (5), 324-336 (2024)
   PUBMED   38267812
  REMARK    GeneRIF: TRIM14 suppressed the progression of NSCLC via hexosamine
            biosynthesis pathway.
REFERENCE   4  (bases 1 to 4480)
  AUTHORS   Xu,W., Zhuang,L., Zhu,H., Mao,A., Zhou,J. and Wang,L.
  TITLE     TRIM14 Overexpression Induces Chemoresistance and Malignant
            Behaviors of Hepatocellular Carcinoma Cells by Activating the
            STAT3/HIF-1alpha Pathway
  JOURNAL   Int J Mol Sci 24 (16), 12589 (2023)
   PUBMED   37628777
  REMARK    GeneRIF: TRIM14 Overexpression Induces Chemoresistance and
            Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating
            the STAT3/HIF-1alpha Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4480)
  AUTHORS   Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.
  TITLE     TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to
            epigenetically regulate inflammation
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35145029
REFERENCE   6  (bases 1 to 4480)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4480)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 4480)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 4480)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 4480)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF797334.1, AK292825.1,
            AL137073.13 and AA469446.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014788.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies and its function has not been determined. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.120926.1, D50919.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341469.7/ ENSP00000344208.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BF797334.1         90-91
            3-1432              AK292825.1         1-1430
            1433-4256           AL137073.13        63749-66572         c
            4257-4480           AA469446.1         19-242              c
FEATURES             Location/Qualifiers
     source          1..4480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..4480
                     /gene="TRIM14"
                     /note="tripartite motif containing 14"
                     /db_xref="GeneID:9830"
                     /db_xref="HGNC:HGNC:16283"
                     /db_xref="MIM:606556"
     exon            1..241
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1363
                     /gene="TRIM14"
                     /note="tripartite motif protein TRIM14"
                     /codon_start=1
                     /product="tripartite motif-containing protein 14"
                     /protein_id="NP_055603.2"
                     /db_xref="CCDS:CCDS6734.1"
                     /db_xref="GeneID:9830"
                     /db_xref="HGNC:HGNC:16283"
                     /db_xref="MIM:606556"
                     /translation="MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVC
                     ALCPVLGAHRGHPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKA
                     NAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMND
                     LSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEA
                     VESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTM
                     HARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAG
                     WWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLG
                     VFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP"
     exon            242..337
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     exon            338..571
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     exon            572..734
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     exon            735..827
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     exon            828..4480
                     /gene="TRIM14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM14"
                     /note="hexamer: AATAAT"
     polyA_site      4480
                     /gene="TRIM14"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgtcccg gggagccgga ggaggtggag atgaatggcg ggcgcggcga ccgggagccg
       61 gacccctggg aggtcggagc ttgtcgaggg atgcggctgg cgctgcccgg agcatggcga
      121 ccgcgtggct gagctcttct gtcgccgctg ccgccgctgc gtgtgcgcgc tttgcccggt
      181 gctgggcgcg caccgtggcc accctgtggg cctggcgctg gaggcagcgg tgcacgtgca
      241 gaaactcagc caagaatgtt taaagcagct ggcaatcaag aagcagcagc acattgacaa
      301 cataacccag atagaagatg ccaccgagaa gctcaaggct aatgcagagt caagtaaaac
      361 ctggctgaag gggaaattca ctgaactcag attactactt gacgaagagg aagcgctggc
      421 caagaaattc attgataaaa acacgcagct taccctccag gtgtacaggg aacaagctga
      481 ctcttgcaga gagcaacttg acatcatgaa tgatctctcc aacagggtct ggagtatcag
      541 ccaggagccc gatcctgtcc agaggcttca ggcatacacg gccaccgagc aggagatgca
      601 gcagcagatg agcctcgggg agctgtgcca tcccgtgccc ctctcctttg agcccgtcaa
      661 gagcttcttt aagggcctcg tggaagccgt ggagagtaca ttacagacgc cattggacat
      721 tcgccttaag gaaagcataa actgccagct ctcagaccct tccagcacca agccaggtac
      781 cttgttgaaa accagcccct caccagagcg atcgctattg ctgaaatacg cgcgcacgcc
      841 cacgctggat cctgacacga tgcacgcgcg cctgcgcctg tccgccgatc gcctgacggt
      901 gcgctgcggc ctgctgggca gcctggggcc cgtgcccgtg ctgcggttcg acgcgctctg
      961 gcaagtgctg gctcgtgact gcttcgccac cggccgccac tactgggagg ttgacgtgca
     1021 ggaggcgggc gccggctggt gggtgggcgc ggcctacgcc tcccttcggc gccgcggggc
     1081 ctcggccgcc gcccgcctgg gctgcaaccg ccagtcctgg tgcctcaagc gctacgacct
     1141 tgagtactgg gccttccacg acggccagcg cagccgcctg cggccccgcg acgacctcga
     1201 ccggctcggc gtcttcctgg actacgaggc cggcgtcctc gccttctacg acgtgacggg
     1261 cggcatgagc cacctgcata ccttccgcgc cacgttccag gagccgctct acccggccct
     1321 gcggctctgg gagggggcca tcagcatccc ccggctgccc taggggccag gaccggcgtg
     1381 acagcctcca ggtacgccgc agctgcccag tctcgcctaa tctacctaga tcagcgtggc
     1441 tggtcccctt actgcctgct tcttagggcc ctctccctgc cccagctttc cccgaccaat
     1501 cacgcctaca gtgctttgaa ggtttcctct cctaggctag tttcaaacag gccctaaaca
     1561 agtctgctgc tgccctctca tcagacctcc gcaccctcac cccaccatca cttacactac
     1621 tttaatccag ttccttcaaa gtgatacccc cacaggtaag ccctcagcat cctgaataca
     1681 tcatccgcag cctgggaacc ttctccctcg tacagcacag gaacctgaca catagtaggc
     1741 acacagtaaa cgtttgtgaa tgaatgggag tcatccagtc ctgactcttc tgtctcttga
     1801 ggtcccttga atcttccgct tcctccccac cgatttcagc gtgtccacat cacagctccc
     1861 tccagaagct gcaagagctt cttagcagtt cctggtctga accctctccc agtcctcatc
     1921 ttccacccta aaactagagt gatcttccta aaacttcact taacccctca gctatgaaaa
     1981 ggcttccagg agtttccatg aaataacaaa aaaaaataca agcgcctcac cttagcattc
     2041 aaggcttgtc tagtctgccc aaaattactt atcctcacct agctcctacc actcttctta
     2101 gagactctcc agtcagaaat gtgtcgcata gttccacctc cacacctctc tgctgccagc
     2161 acattcatgc agaaaagtct tttcacctgt ctcagtcttc cgcaggctta cctgcgccag
     2221 gaagtctaac caaggaacaa gaatctcact atcagagcca caaatctggg acctgtcttt
     2281 ccaactaaat tggaggcttt ggaagggcag ctttgtccta tactctctcc accctgaaaa
     2341 gttcccagaa agccccttcc ctcccaagca gtgaattaat aaccagcagg tgcctatcac
     2401 tgagtaacag aagagctgag ttaggcgggc ctcacaggtc acccagccag atctcatctg
     2461 gggagtctga ggtcctgaaa gaaagcagag ctgcgtaaag ttaccccggg gtgatatagg
     2521 ggggccagac gtgtgccccg ttcacccacc cccaggcaag catctgacct gtcccctggc
     2581 ccagccctta ggcccagctt tcaacctgct tactcatttc tcaggggatt ttgggaagga
     2641 atcagcaggt gacagttgct aagcaaccaa agggggtggt gtttcccaac tgtcttggga
     2701 caaaaagggt aagagcaccc ttagatccag atgttgccaa ggaaacccag agtgcccagc
     2761 tgtctggaat gaagtgacag aggtagaaaa cagtaggccc tcacaggagg ccaccttcgc
     2821 tagcagggag tgggaggctt ctttccaggg atttgtgtct ccgttctgaa ggttctgcgt
     2881 cctgttttgt caattcccta gacggttttg aagttatatt ctgttaaagc atcttcatag
     2941 gtgcttggtg ggaggccaag gtcgccgaat cctcgtggtt taaatagact ttcagtgcat
     3001 tagtttgaac catataaaac tgacaatttt caatagtttt tgagttaaaa atggcacttt
     3061 tgatatgaga caatgtagca gaataccagg cagacagaac cttgcaaaca ccttaacttc
     3121 taaccaaaga ctttaaaact ctggctggac agagttttaa gcactatgct gcaggaatcc
     3181 tgagaaaaag gggaaattaa ttctattagg aatggcccaa actgaattgt gacaggcaga
     3241 gggtgttcct gacagaggga agatgaatac acttgacccc aacatttctg cccatccctg
     3301 atgaccaaga cctcttccca gacccacagc tgcaggggcc aagtaataac agctcttaat
     3361 agtttataat gcactgtttt aatgctttac gactaaactc atctgatcct ttcatcagcc
     3421 ctagagggta gaaagttttc ccaattctac acatggcaaa atggagaccc agagtcactt
     3481 gcccaaggtc gcacagctag tggtggagct ggagtctggg cccaggctgt gagttccagg
     3541 tctgtgctca tggccaccag gccctactgc tcagggtgaa tgcagctggt ctctggccag
     3601 tgcctggtgc tctggcccct ctcgtggagc tactgcccat gatgctttcc tagtgcctgg
     3661 ttactctgcg agacttgagt ctacctttgg actgccttcc ttgggggtct gagatgaggc
     3721 cttatggccc agaggggaac ttgattcaaa aatttgggat tcatgtagca gagacagagc
     3781 tagactgtaa aggtcacaaa ctagctgtgt caaggcccgt gatagccaga aagcggcagt
     3841 ttcagtccat atcaattgtg tgaccagggc tagtcacttt ttacttctca gtgccatcta
     3901 taaaatgggg ataatagcac tacctaccaa gtgctgtgag gctcaaatga gccaaaggtt
     3961 ataaacttgc cttaaaacta tagtcctata caaaaattag ctgggcgtgg tggtgcatgc
     4021 ctgtaatccc agctactagg gaggctgagg caagagagtt gcttgaaccc aggaggcgga
     4081 gattgcagtg agctgagatt gcaccactgc actccagcct ggggacagag caagactctt
     4141 gtctcaaaaa aaacaaaaaa aacatatata ctgctgtatc atgccaggat ttatcagcat
     4201 tcccaaggga gcttgcacgg tactgaccga gtgctgagac tactggtatt cccagctgcc
     4261 atgtggcagc agcaggagct actagaatat tctcagcaca ggaatgaggc ttccttggtt
     4321 tccatgtctg taagggttac tgatcactta ccttcttctc tttcagactt gaatctgtag
     4381 acatttcttt attgatatgg caaattgctt gcagatattt ttaaatgaca gcaattttct
     4441 aatatttggt ttaataaaat gtgaataatg tcccttttaa
//
