LOCUS       NM_145214               2710 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens tripartite motif containing 11 (TRIM11), mRNA.
ACCESSION   NM_145214
VERSION     NM_145214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Xuan,T.
  TITLE     Tripartite Motif-containing Protein 11 Silencing Inhibits
            Proliferation and Glycolysis and Promotes Apoptosis of Esophageal
            Squamous Cell Carcinoma Cells by Inactivating Signal Transduction
            and Activation of Transcription Factor 3/c-Myc Signaling
  JOURNAL   J Physiol Investig 67 (1), 37-46 (2024)
   PUBMED   38780271
  REMARK    GeneRIF: Tripartite Motif-containing Protein 11 Silencing Inhibits
            Proliferation and Glycolysis and Promotes Apoptosis of Esophageal
            Squamous Cell Carcinoma Cells by Inactivating Signal Transduction
            and Activation of Transcription Factor 3/c-Myc Signaling.
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Yu,T., Yang,X., Fu,Q., Liang,J., Wu,X., Sheng,J., Chen,Y., Xiao,L.,
            Wu,Y., Nie,D., You,X., Mai,H., Chen,K. and Hu,S.
  TITLE     TRIM11 attenuates Treg cell differentiation by p62-selective
            autophagic degradation of AIM2
  JOURNAL   Cell Rep 42 (10), 113231 (2023)
   PUBMED   37804507
  REMARK    GeneRIF: TRIM11 attenuates Treg cell differentiation by
            p62-selective autophagic degradation of AIM2.
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Liang,Z., Li,J., Zhang,G. and Chen,M.
  TITLE     TRIM11 promotes cell proliferation of non-small cell lung cancer
            through the inhibition of ferroptosis by AMPK
  JOURNAL   Clin Respir J 17 (10), 1006-1016 (2023)
   PUBMED   37604203
  REMARK    GeneRIF: TRIM11 promotes cell proliferation of non-small cell lung
            cancer through the inhibition of ferroptosis by AMPK.
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Zhang,Z.Y., Harischandra,D.S., Wang,R., Ghaisas,S., Zhao,J.Y.,
            McMonagle,T.P., Zhu,G., Lacuarta,K.D., Song,J., Trojanowski,J.Q.,
            Xu,H., Lee,V.M. and Yang,X.
  TITLE     TRIM11 protects against tauopathies and is down-regulated in
            Alzheimer's disease
  JOURNAL   Science 381 (6656), eadd6696 (2023)
   PUBMED   37499037
  REMARK    GeneRIF: TRIM11 protects against tauopathies and is down-regulated
            in Alzheimer's disease.
REFERENCE   5  (bases 1 to 2710)
  AUTHORS   Pan,Y., Yu,H. and Lu,F.
  TITLE     TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates
            Tumor Growth and Metastasis of Prostate Cancer
  JOURNAL   Technol Cancer Res Treat 22, 15330338231178639 (2023)
   PUBMED   37248611
  REMARK    GeneRIF: TRIM11 Posttranscriptionally Modulated by miR-5193
            Facilitates Tumor Growth and Metastasis of Prostate Cancer.
REFERENCE   6  (bases 1 to 2710)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
  REMARK    GeneRIF: Downregulation of TRIM11 and TRIM15 enhanced virus release
            suggesting that these proteins contribute to the endogenous
            restriction of retroviruses in cells.
REFERENCE   7  (bases 1 to 2710)
  AUTHORS   Ishikawa,H., Tachikawa,H., Miura,Y. and Takahashi,N.
  TITLE     TRIM11 binds to and destabilizes a key component of the
            activator-mediated cofactor complex (ARC105) through the
            ubiquitin-proteasome system
  JOURNAL   FEBS Lett 580 (20), 4784-4792 (2006)
   PUBMED   16904669
  REMARK    GeneRIF: These results suggest that TRIM11, with the
            ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta
            signaling.
REFERENCE   8  (bases 1 to 2710)
  AUTHORS   Cooper,S.T. and Hanson,I.M.
  TITLE     A screen for proteins that interact with PAX6: C-terminal mutations
            disrupt interaction with HOMER3, DNCL1 and TRIM11
  JOURNAL   BMC Genet 6, 43 (2005)
   PUBMED   16098226
  REMARK    GeneRIF: PAX6 interacts with HOMER3, DNCL1, and TRIM11. Three
            C-terminal PAX6 mutations, previously identified in patients with
            eye malformations, all reduced or abolished the interactions.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2710)
  AUTHORS   Niikura,T., Hashimoto,Y., Tajima,H., Ishizaka,M., Yamagishi,Y.,
            Kawasumi,M., Nawa,M., Terashita,K., Aiso,S. and Nishimoto,I.
  TITLE     A tripartite motif protein TRIM11 binds and destabilizes Humanin, a
            neuroprotective peptide against Alzheimer's disease-relevant
            insults
  JOURNAL   Eur J Neurosci 17 (6), 1150-1158 (2003)
   PUBMED   12670303
REFERENCE   10 (bases 1 to 2710)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL670729.19.
            
            On Nov 26, 2018 this sequence version replaced NM_145214.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This protein localizes to the nucleus and
            the cytoplasm. Its function has not been identified. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069227.1, CA916721.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284551.11/ ENSP00000284551.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               AL670729.19        59517-60198         c
            683-778             AL670729.19        55429-55524         c
            779-1009            AL670729.19        54327-54557         c
            1010-1032           AL670729.19        50506-50528         c
            1033-1133           AL670729.19        50310-50410         c
            1134-2710           AL670729.19        47039-48615         c
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2710
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /note="tripartite motif containing 11"
                     /db_xref="GeneID:81559"
                     /db_xref="HGNC:HGNC:16281"
                     /db_xref="MIM:607868"
     exon            1..682
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1681
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 11; RING finger
                     protein 92; RING-type E3 ubiquitin transferase TRIM11"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM11"
                     /protein_id="NP_660215.1"
                     /db_xref="CCDS:CCDS31048.1"
                     /db_xref="GeneID:81559"
                     /db_xref="HGNC:HGNC:16281"
                     /db_xref="MIM:607868"
                     /translation="MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW
                     GQPEGPYACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAF
                     CGDELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQA
                     DETCVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHL
                     GQQSAHLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVP
                     GLVETLRRFRGDVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQ
                     ERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELSAGNGFWILVFLGSYYNSSER
                     ALAPLRDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPT
                     PMTICRPKGGSGDTLAPQ"
     exon            683..778
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1009
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1032
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1133
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..2710
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /note="hexamer: AATAAA"
     polyA_site      2710
                     /gene="TRIM11"
                     /gene_synonym="BIA1; RNF92"
                     /note="major polyA site"
ORIGIN      
        1 gcctcggctc ctcttcctgc cggcatccgg gatccctacg tcccgcgtcc cccgagcgct
       61 cggagcctac gcgcccagcg ctaccgaaac ccagagtcct gcgccctgga gtccccgcgc
      121 cccggagccc gagcacccgg gagtcccgag cctcgcgccc cggagtgccc gagcctgcgc
      181 cgccgcaccc ggataccccg cgtccccgcg agctgccgag gccgcccgcc gccgccccgc
      241 ggacagtacc gccttcctcc cctctgtccg cgccatggcc gcccccgacc tgtccaccaa
      301 cctccaggag gaggccacct gcgccatctg cctcgactac ttcacggatc cggtgatgac
      361 cgactgcggc cacaacttct gccgcgagtg catccggcgc tgctggggcc agcccgaggg
      421 cccgtacgcg tgccccgagt gccgcgagct gtccccgcag aggaacctgc ggcccaaccg
      481 cccgcttgct aagatggccg agatggcgcg gcgcctgcac ccgccgtcgc cggtcccgca
      541 gggcgtgtgc cccgcgcacc gcgagccact ggccgccttc tgtggcgacg agctgcgcct
      601 cctgtgtgcg gcctgcgagc gctctgggga gcactgggcg caccgcgtgc ggccgctgca
      661 ggacgcggcc gaagacctca aggcgaagct ggagaagtca ctggagcatc tccggaagca
      721 gatgcaggat gcgttgctgt tccaagccca ggcggatgag acctgcgtct tgtggcagaa
      781 gatggtggag agccagcggc agaacgtgct gggtgagttc gagcgtcttc gccgtttgct
      841 ggcagaggag gagcagcagc tgctgcagag gctggaggag gaggagctgg aggtgctgcc
      901 ccggctgcgg gagggcgcag cccacctagg ccagcagagc gcccacctag ctgagctcat
      961 cgccgagctc gagggccgct gccagctgcc tgctctgggg ctgctgcagg acatcaagga
     1021 cgccctgcgc agggtccagg atgtgaagct gcagccccca gaagttgtgc ctatggagct
     1081 gaggaccgtg tgcagggtcc cgggactggt agagacactg cggaggtttc gaggggacgt
     1141 gaccttggac ccggacaccg ccaaccctga gctgatcctg tctgaagaca ggcggagcgt
     1201 gcagcggggg gacctacggc aggccctgcc ggacagccca gagcgctttg accccggccc
     1261 ctgcgtgctg ggccaggagc gcttcacctc aggccgccac tactgggagg tggaggttgg
     1321 ggaccgcacc agctgggccc tgggggtgtg cagggagaac gtgaacagga aggagaaggg
     1381 cgagctgtcc gcgggcaacg gcttctggat cctggtcttc ctggggagct attacaattc
     1441 ctcggaacgg gccttggctc cactccggga cccacccagg cgcgtgggga tctttctgga
     1501 ctacgaggct ggacatctct ctttctacag tgccaccgat gggtcactgc tattcatctt
     1561 tcccgagatc cccttctcgg ggacgctgcg gcccctcttc tcacccctgt ccagcagccc
     1621 gaccccgatg actatctgcc ggccgaaagg tgggtccggg gacaccctgg ctccccagtg
     1681 actcgggccc tcctggagga gtcctgttgc ctctcctgcc cctccaggcc actgagtgtt
     1741 ttggccactt ggaggacctg ggaggaggga gtgtgtcctt tgagcaagag gaggaactcc
     1801 tggtgccttt ctgagcctgc gtgggagaac cccaattcta gcactccagg aaactgtggg
     1861 agagtgtggg gcaggctccg tcctccctgg gagacccctc cagccaccgg gtgccactta
     1921 atgccaacag cccttaccaa agctgggagc cccattgccc cggcagctct ggcctgtggt
     1981 tccagaagct gagaaaactc cactggggct tgcagaatcc agggttcacc taagctgcac
     2041 agttcctgca gctttgccag ccccctgaaa gtcttgtgta ccccacctct gaagatgctg
     2101 ggggaggcag ctgggatggg agccagcccc atgcctgtct gtgaccccac agtgggtgag
     2161 agcccgtcac agtcctgggt gtggctgctc tggaagaatt aggaggcagc cataataaga
     2221 gtcttcagag agatgatggg aggggccagt gaggacagga acagagagta gatgtcctat
     2281 aataaagggg cttctgggag gtgcctgggc acagatgtct gttcagcagg tgtgtgggcc
     2341 tagaggagag agcagagccc agaaatgtct tttgcaggcc cacgttctga cttgaagctt
     2401 tcgtgggcat gttgccattg ggttttgccc ttgcaaaggc ttcctaggtc tccagtggcc
     2461 cctcaggacc cagggtccca gctgctgctt ggggatgtgc actgctggcc gccggccttg
     2521 cagtctctct accctgggga ggaacagtgg cttctcagag cctggggcat acagaagaag
     2581 gcaggagttg atttttgtgt tgggtttggg gtttctttgt cctcaaggta ctgttctgtt
     2641 tctctttacc cctctgcttt atttattgta agcattccca cgttaaataa actttggctg
     2701 ttgtctacaa
//
