LOCUS       NM_006778               3825 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 10 (TRIM10), transcript
            variant 1, mRNA.
ACCESSION   NM_006778
VERSION     NM_006778.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3825)
  AUTHORS   Guo,M., Cao,W., Chen,S., Tian,R., Wang,L., Liu,Q., Zhang,L.,
            Wang,Z., Zhao,M., Lu,Q. and Zhu,H.
  TITLE     TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate
            type I IFN signal transduction
  JOURNAL   Eur J Immunol 51 (7), 1762-1773 (2021)
   PUBMED   33811647
  REMARK    GeneRIF: TRIM10 binds to IFN-alpha/beta receptor 1 to negatively
            regulate type I IFN signal transduction.
REFERENCE   2  (bases 1 to 3825)
  AUTHORS   Xi,X., Bao,Y., Zhou,Y., Chen,Y., Zhong,X., Liao,J., Zhou,J., Xu,S.,
            Cao,Z., Hu,K., Hu,Y., He,X., Zhou,L., Lin,H. and Wu,Q.
  TITLE     Oncogenic gene TRIM10 confers resistance to cisplatin in
            osteosarcoma cells and activates the NF-kappaB signaling pathway
  JOURNAL   Cell Biol Int 45 (1), 74-82 (2021)
   PUBMED   32997424
  REMARK    GeneRIF: Oncogenic gene TRIM10 confers resistance to cisplatin in
            osteosarcoma cells and activates the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 3825)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3825)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3825)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3825)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 3825)
  AUTHORS   Orimo,A., Yamagishi,T., Tominaga,N., Yamauchi,Y., Hishinuma,T.,
            Okada,K., Suzuki,M., Sato,M., Nogi,Y., Suzuki,H., Inoue,S.,
            Yoshimura,K., Shimizu,Y. and Muramatsu,M.
  TITLE     Molecular cloning of testis-abundant finger Protein/Ring finger
            protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on
            the class I region of the human MHC
  JOURNAL   Biochem Biophys Res Commun 276 (1), 45-51 (2000)
   PUBMED   11006080
REFERENCE   8  (bases 1 to 3825)
  AUTHORS   Harada,H., Harada,Y., O'Brien,D.P., Rice,D.S., Naeve,C.W. and
            Downing,J.R.
  TITLE     HERF1, a novel hematopoiesis-specific RING finger protein, is
            required for terminal differentiation of erythroid cells
  JOURNAL   Mol Cell Biol 19 (5), 3808-3815 (1999)
   PUBMED   10207104
REFERENCE   9  (bases 1 to 3825)
  AUTHORS   Henry,J., Ribouchon,M., Depetris,D., Mattei,M., Offer,C.,
            Tazi-Ahnini,R. and Pontarotti,P.
  TITLE     Cloning, structural analysis, and mapping of the B30 and B7
            multigenic families to the major histocompatibility complex (MHC)
            and other chromosomal regions
  JOURNAL   Immunogenetics 46 (5), 383-395 (1997)
   PUBMED   9271628
REFERENCE   10 (bases 1 to 3825)
  AUTHORS   Goei,V.L., Parimoo,S., Capossela,A., Chu,T.W. and Gruen,J.R.
  TITLE     Isolation of novel non-HLA gene fragments from the hemochromatosis
            region (6p21.3) by cDNA hybridization selection
  JOURNAL   Am J Hum Genet 54 (2), 244-251 (1994)
   PUBMED   8304341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669914.2, BC093926.1 and AL360163.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006778.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This protein localizes to cytoplasmic
            bodies. Studies in mice suggest that this protein plays a role in
            terminal differentiation of erythroid cells. Alternate splicing of
            this gene generates two transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1, which has a
            distinct C-terminus and is 86 aa longer than isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220122.1, BX405576.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449742.7/ ENSP00000397073.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AL669914.2         155568-155844       c
            278-299             AL669914.2         155546-155567       c
            300-1390            BC093926.1         1-1091
            1391-2139           AL669914.2         148262-149010       c
            2140-3823           AL360163.1         587-2270
            3824-3825           AL669914.2         146576-146577       c
FEATURES             Location/Qualifiers
     source          1..3825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3825
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /note="tripartite motif containing 10"
                     /db_xref="GeneID:10107"
                     /db_xref="HGNC:HGNC:10072"
                     /db_xref="MIM:605701"
     exon            1..782
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1799
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic RING finger 1; ring finger protein 9;
                     tripartite motif protein 10; tripartite motif-containing
                     protein 10; Zn-finger protein; B30-RING finger protein"
                     /codon_start=1
                     /product="tripartite motif-containing protein 10 isoform
                     1"
                     /protein_id="NP_006769.2"
                     /db_xref="CCDS:CCDS34375.1"
                     /db_xref="GeneID:10107"
                     /db_xref="HGNC:HGNC:10072"
                     /db_xref="MIM:605701"
                     /translation="MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYC
                     EIPGPDLEESPTCPLCKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEH
                     GEKIYFFCEDDEMQLCVVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEI
                     QEIQSRENKRMQVLLTQVSTKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQR
                     DEFDLLVAGEICRFSALIEELEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPEL
                     GQRIRDFPQQALPLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQF
                     SYKWQNSPDNPQRFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKG
                     ELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTR
                     EPIYTFTASFTRKVIPFFGLWGRGSSFSLSS"
     exon            783..878
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1109
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1132
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1248
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1281
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..3825
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /note="hexamer: AATAAA"
     polyA_site      3825
                     /gene="TRIM10"
                     /gene_synonym="HERF1; RFB30; RNF9"
                     /note="major polyA site"
ORIGIN      
        1 cttctgacag tggacagctg acatatcacc actttccttc tactgtgagt gtctctggat
       61 gggcagaaag gaatggccag cccctggtta tggtcatcta aggtcacctc tgaaatgctg
      121 tgagcccctc ttccttcctc tcctctgcta tttcccatct ctgctgttgg caggagaata
      181 gaaccctggc tgccagagat gcaagtgtgt gacgatatgg gtgctggtgc atatttagta
      241 tgtgcctgtg tccagccatg tgcatgtgtg ggtgtgtgag tgtgtgaccc agcccttccc
      301 ccgtggccaa gcagagagag tggccttgag gaagccatag cagcaggacc agcatggcct
      361 ctgctgcctc tgtgaccagc ctggcagatg aagtcaactg ccccatctgt cagggtaccc
      421 tgagggagcc ggtcactatc gactgcggcc acaacttctg ccgggcctgc cttacccgct
      481 actgtgagat accaggccca gacctggagg agtcccctac ttgcccactc tgcaaagaac
      541 ccttccgtcc tgggagcttc cggcccaact ggcagctggc taacgtggtg gagaacattg
      601 agcgcctcca gctggtgtcc acactgggtt tgggagagga ggatgtctgc caagagcacg
      661 gagagaagat ctacttcttc tgtgaggatg atgagatgca gttgtgcgtg gtgtgccggg
      721 aggctgggga gcacgctacc cacaccatgc gcttcctgga ggatgcagcg gctccctata
      781 gggaacaaat ccataagtgt cttaaatgtc taagaaaaga gagagaggag attcaagaaa
      841 tccagtcaag agaaaataaa aggatgcaag tcctcctgac tcaggtgtcc accaagagac
      901 aacaggtgat ttctgagttc gcacacctga ggaagtttct agaggaacag cagagcatcc
      961 tcttagcaca attggagagc caggatgggg acatcttgag gcaacgggat gaatttgatt
     1021 tgctggttgc tggggagatc tgccggttta gtgctcttat tgaagaactg gaggagaaga
     1081 atgagaggcc agcaagggag ctcctgacgg acatcagaag cactctaata agatgtgaaa
     1141 ccagaaagtg ccggaaaccg gtggctgtgt cgccagagct gggccagagg attcgggact
     1201 ttccccagca ggccctcccg ctgcagaggg agatgaagat gtttctggaa aaactatgct
     1261 ttgagttgga ctatgagcca gctcacattt ctctagaccc tcagacttcc caccccaagc
     1321 tcctcttgtc cgaggaccac cagcgagctc agttctccta caaatggcag aactcaccag
     1381 acaaccccca acgttttgac cgggccacct gtgttctggc ccacactggc atcacagggg
     1441 ggagacacac gtgggtggtg agtatagacc tggcccatgg gggcagctgc accgtgggcg
     1501 tggtgagcga ggatgtgcag cggaaggggg agcttcggct gcggccagag gagggggtgt
     1561 gggctgtgag gctggcttgg ggcttcgtct cggctctggg ctccttcccc acacggctga
     1621 ccctgaagga gcagccccgg caggtgaggg tgtctcttga ctatgaggtg ggctgggtga
     1681 ccttcaccaa cgctgtcacc cgagagccca tctacacctt cactgcctcc ttcactagga
     1741 aggtcattcc cttctttggg ctctggggcc gagggtccag tttctccctg agctcctgag
     1801 aaggagcagt tacctactct cctctaagta caggactcat atcaacccaa gtaccatgtg
     1861 gacttgatcc ctggctgaat cacctggatg acttggaata gaaatgactg ctttagaaga
     1921 tgggatgggg ccgggtggta agggatagaa gagaggactc tcaatctact gatcaagtcc
     1981 tttccccaat gcccagtgga tggccagggt acctggggac tcaggctgct gccagttctg
     2041 ctcaccacca tccgtgcttg gcacagaagt agctgcatag aaagggcact ggatttgaag
     2101 tcagaagacc tgggttcttg aaccagcctg tcaaccagtt gtatgacttt aaacaaggca
     2161 tctcacctct tttcatcttg ttttcttcca ataatgttag agttcatgta atcacattct
     2221 ctagaaccat ttagtttgtg ttaactatga accaagcagt gtggtggcca ctggtgactt
     2281 gaaaatatag agaaaaaaaa aacctgctct atatctgaaa gagctcttgg gaagacagag
     2341 aaacataaag aggaaattac agcacagtgt ggtgggtgtt acgggaagtc caaccccagc
     2401 attatgggag ttcaggggaa ggggcatagc ccagcctgga aggagagggt gagtggggga
     2461 tggctttctg aaaagggtgg tctaaaggat gcctatggtc aatagggaaa agaggggaag
     2521 aagcatctta agaagaggaa acagcagaga actggctgga tgacctgtga ctctggagca
     2581 ctgggttgtc tccattgtca ttatgggcag atgtgtgcca tccccagccg acgccactca
     2641 ctgcctcctt cctcctggtg ttgccacttc tgggtgagat taaggtgcag ggcctggggg
     2701 caggaggaca taaggtatag ccataaatca taacccaggg accacactca accctaggga
     2761 aattgtcttc ctgatcagtt gattaccatc tgaggtcaag aaatgagata gtgggagcaa
     2821 atgggtcaca aatagctcag ctgtgggctc agaaactgct aggtaaaaga attccagaag
     2881 gaggccaggg cataagttgg atgacctatg aactttagtc taaagaattg agactaccgt
     2941 aattgagact actgtagtga catctgagaa atgggatgga agagtgacca tgttttattt
     3001 tcttgttctt gtcactattg tattttattt tgcataatca tgcccttcac tgacagtctc
     3061 cttaacatca tctgtttact ctgctcagtg taaactacaa tgctctgtca tctccctact
     3121 gggtctcctg ggaggagggg agccatccag ggtgcaaact caaaggcaga gggcacagcg
     3181 tgcttaggcc caagcttaga attcaattga gaagttctgt tgttcatcct tacctcagca
     3241 ggtagaaaag aggtggagat cagaagccag ggattagaga ttgaattgct ttccctggga
     3301 gtgtgcagta tctcattaaa atgttgtata ttcaaaaaaa tacagacaca cacaagtgcc
     3361 tatataatga taaaacatat ccaaagcacc caaacctgtg attccagaaa agtagatcct
     3421 atttttgttt atttttattg gctttagctg tgtcttttga aaggactatt atcctctaaa
     3481 atgtatgtgt atgaagatcc tggcttgcag ctcgggagct ttacacacct tgtgtcactt
     3541 tatcttggta acgagccaag atcatgcaac cagttcatcc atgtctgacc caagagctct
     3601 taactgctat gctgcactgc ctcattcaga gatagatgcc tgcatgggtc ctggcgatta
     3661 ttttaatgct ggctacaccc ccacaggtga cttggattca gaaatacaat ttatatttct
     3721 tctttttaaa ttgttttatt ttatttttct tttaatagtt atatgtcagt gagaacaatt
     3781 tatatgtctt acactgagaa ataaaactgc tcataagtga aaaca
//
