LOCUS       NM_014817               4973 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens TLR4 interactor with leucine rich repeats (TRIL),
            mRNA.
ACCESSION   NM_014817 XM_376588 XM_379800
VERSION     NM_014817.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Liao,J., Chen,H., Qi,M., Wang,J. and Wang,M.
  TITLE     MLLT11-TRIL complex promotes the progression of endometrial cancer
            through PI3K/AKT/mTOR signaling pathway
  JOURNAL   Cancer Biol Ther 23 (1), 211-224 (2022)
   PUBMED   35253622
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   Kim,H.S., Green,Y.S., Xie,Y. and Christian,J.L.
  TITLE     Tril dampens Nodal signaling through Pellino2- and Traf6-mediated
            activation of Nedd4l
  JOURNAL   Proc Natl Acad Sci U S A 118 (36) (2021)
   PUBMED   34475212
  REMARK    GeneRIF: Tril dampens Nodal signaling through Pellino2- and
            Traf6-mediated activation of Nedd4l.
REFERENCE   3  (bases 1 to 4973)
  AUTHORS   Carpenter,S., Wochal,P., Dunne,A. and O'Neill,L.A.J.
  TITLE     Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with
            leucine-rich REPeats (TRIL)
  JOURNAL   J Biol Chem 286 (44), 38795-38804 (2011)
   PUBMED   21911501
  REMARK    GeneRIF: Toll-like receptor 3 (TLR3) signaling requires TLR4
            Interactor with leucine-rich REPeats (TRIL)
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Carpenter,S., Carlson,T., Dellacasagrande,J., Garcia,A.,
            Gibbons,S., Hertzog,P., Lyons,A., Lin,L.L., Lynch,M., Monie,T.,
            Murphy,C., Seidl,K.J., Wells,C., Dunne,A. and O'Neill,L.A.
  TITLE     TRIL, a functional component of the TLR4 signaling complex, highly
            expressed in brain
  JOURNAL   J Immunol 183 (6), 3989-3995 (2009)
   PUBMED   19710467
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Bussow,K., Cahill,D., Nietfeld,W., Bancroft,D., Scherzinger,E.,
            Lehrach,H. and Walter,G.
  TITLE     A method for global protein expression and antibody screening on
            high-density filters of an arrayed cDNA library
  JOURNAL   Nucleic Acids Res 26 (21), 5007-5008 (1998)
   PUBMED   9776767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005013.3 and BC036337.1.
            
            On May 17, 2019 this sequence version replaced NM_014817.3.
            
            Summary: TRIL is a component of the TLR4 (MIM 603030) complex and
            is induced in a number of cell types by lipopolysaccharide (LPS)
            (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr
            2010].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.1907122.1,
                                        SRR7346977.2408340.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539664.3/ ENSP00000479256.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC005013.3         177414-177613       c
            201-1002            BC036337.1         189-990
            1003-4973           AC005013.3         172641-176611       c
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..4973
                     /gene="TRIL"
                     /note="TLR4 interactor with leucine rich repeats"
                     /db_xref="GeneID:9865"
                     /db_xref="HGNC:HGNC:22200"
                     /db_xref="MIM:613356"
     exon            1..4973
                     /gene="TRIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..2720
                     /gene="TRIL"
                     /codon_start=1
                     /product="TLR4 interactor with leucine rich repeats
                     precursor"
                     /protein_id="NP_055632.2"
                     /db_xref="CCDS:CCDS75573.1"
                     /db_xref="GeneID:9865"
                     /db_xref="HGNC:HGNC:22200"
                     /db_xref="MIM:613356"
                     /translation="MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNR
                     GLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKT
                     FEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKL
                     RLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS
                     LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGL
                     EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN
                     NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRH
                     PPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEEL
                     PPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQS
                     LDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGTEHQERAAQS
                     DGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSASVRWAVREHRSPRPLGGARFRLLF
                     DRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLV
                     TLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASRWLRRKLRARRKGGAPVHVRH
                     MYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSAGGGAGGS
                     LRREDRLLQRFAD"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIL"
                     /note="hexamer: AATAAA"
     polyA_site      3697
                     /gene="TRIL"
     regulatory      4004..4009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIL"
                     /note="hexamer: ATTAAA"
     polyA_site      4026
                     /gene="TRIL"
                     /note="major polyA site"
     regulatory      4951..4956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIL"
                     /note="hexamer: AATAAA"
     polyA_site      4973
                     /gene="TRIL"
                     /note="major polyA site"
ORIGIN      
        1 cccgcccgcc gacgcgcacc cggagaaaca gttttataca gaaatgcaac aagtagtacc
       61 cggggtctgc agagcgcccc gcgccgcctg acttggccgg gcgaagcccg cctgcagaga
      121 cccgggccgg cctccggaca aaggacggag gaggggctgg acggcgctgc gaagtccgaa
      181 agaggccatt tagcgactct ggccaggcta aggggaatgc agaggagaca cagagccggc
      241 gggccaagag gacgatccgg ccgctgcacg cagggcggga ggcgatggag gctgcccgcg
      301 ccttgcgcct cctgctcgtg gtgtgcggct gcctcgcgct cccgccgctg gccgagcccg
      361 tgtgcccgga gcgctgcgac tgccagcatc cccagcatct cctgtgcacc aacagggggc
      421 tccgcgtagt gcccaagacc agctcgctgc cgagccccca cgacgtgctc acctacagcc
      481 tcggcggcaa cttcataacc aacatcacgg ccttcgactt ccaccgtctg gggcagctca
      541 gacggctgga cctgcagtac aaccagatcc gctctctgca ccccaagacc ttcgagaagc
      601 tctcgcggct ggaagagctg tacctgggga acaacctctt gcaggcgctc gccccgggca
      661 cgctggcccc gctgcgcaag ctgcgcatcc tctacgccaa cgggaacgag atcagccgcc
      721 taagccgcgg ctccttcgag ggcctggaga gtctagtcaa gctgcggctg gacgggaacg
      781 ccctgggggc gctgccggac gcggtcttcg ctcccttggg caacctgctc tacctacatc
      841 tggagtccaa ccggatccgc tttctgggca agaacgcctt cgcccagcta ggcaagctgc
      901 gcttcctcaa cctctctgcc aacgagctac agccctccct gcgccacgcg gccaccttcg
      961 caccgctgcg ctccctctcc tccctcatcc tctcggccaa caacctgcag cacctcgggc
     1021 cgcgcatctt ccagcacctg ccacgtctcg gcctgctctc gctcaggggc aaccagctca
     1081 cgcacctcgc gcctgaggcc ttttggggct tggaggccct gcgcgagctg cgcctggagg
     1141 gtaatcggct gagccagctg ccaactgcgc tgctggagcc tctgcacagc ctggaggcgc
     1201 tggacctgag cggcaatgag ctgtccgccc tgcacccggc caccttcggc cacctgggcc
     1261 ggctgcgcga gctcagcctg cgcaacaacg cgctcagcgc cctatccggg gacatcttcg
     1321 ccgccagccc agccctttat cggctggatc tagacggcaa cggctggacc tgcgactgcc
     1381 ggctgcgagg cctgaagcgc tggatgggcg actggcactc gcagggccgg ctcctcactg
     1441 tcttcgtgca gtgtcgccac cccccggccc tgcgaggcaa atacctggat tacctggatg
     1501 accagcagct gcaaaatgga tcctgcgcgg atccctcgcc ctcagcttcc ctgaccgctg
     1561 accgcaggcg gcagccccta cccacggccg caggggagga gatgacgcca cctgcaggtc
     1621 tcgcggagga gctgccgccg cagccgcagc tccagcagca ggggcgattt ctagctgggg
     1681 tggcctggga tggggccgcc agggagctgg taggcaaccg cagcgcccta aggctgagtc
     1741 ggcggggccc gggcctccag cagcccagcc cctccgtcgc tgccgccgcg ggcccggctc
     1801 cacagtccct agacctgcac aagaagcccc agcggggccg tccgactcgg gcagatcccg
     1861 ccctcgcgga gcccacccca acggcctctc ctggctctgc gccatcgccc gccggcgacc
     1921 cctggcagcg cgcgacgaag catcgtctgg gcacggagca ccaggagcgt gccgcccagt
     1981 ccgacggtgg ggccgggctg ccgccgctgg tgtccgaccc atgcgacttc aacaagttca
     2041 ttctgtgcaa cctgacggtg gaggcggtgg gcgcagacag cgcctcggtg cgctgggccg
     2101 tgcgcgagca ccgcagtccc cggccgctgg gcggcgcgcg cttccgcctg ctctttgacc
     2161 gctttggcca gcagcccaag ttccaccgct tcgtctacct gcctgagagc agcgactcgg
     2221 ccacgctgcg cgagctgcgc ggggacaccc cctacctggt gtgcgtggag ggcgtgcttg
     2281 ggggccgtgt ctgccctgtg gctccccggg accactgcgc ggggctggtc accctaccgg
     2341 aggccgggag ccggggcggc gtcgactacc agctgctgac cttggccctg ctgacggtca
     2401 acgcgctgct ggtgctcctg gccttggcgg cctgggcgtc tcgctggctg cgtaggaaac
     2461 tgcgggctag gcggaagggc ggggccccgg tccacgttcg gcacatgtac tccacccgac
     2521 ggcccctgcg ctccatgggc accggcgtgt ccgccgactt ctcgggattc cagtcgcacc
     2581 ggccacgcac caccgtgtgc gcgctcagtg aggcggacct catcgaattc ccctgcgacc
     2641 gcttcatgga cagtgcgggc ggcggcgcgg gcggcagcct gagacgggag gaccgtctcc
     2701 tgcagcgatt tgccgactag gtccagggca tatagagacc atctcattgg ccctaaggag
     2761 ccgcctctcc gtgaggccca ccagcccacc tcaggggaag tgccgttttg tgcacttgcc
     2821 agagaggccg gtggggacag agggccaatt cgggcaccat cccccaattc ccaatactcg
     2881 agaagtaaat ggatggtact tggtggtcag agccagagta ggggacaaat ggatggtggg
     2941 atgctgaggt cggaggcttc gcttggaggc tttgacacag ctatgcgaat ggcttttgta
     3001 gcactgcaat gcagaagcca ggctttgggg gtagaaaggg ggtgcttgtg cccccaacat
     3061 ggccagaaat atttgggtgc atgctttttg tttgctcagt gtcaaacaga gaagttttgt
     3121 ttctatttaa ggaaggaact tattaccatt acaaaggagg cttggccagg gactccactg
     3181 gtttggtgat ctctgccaag aagggggatg taaacaggtg gtaaagttta acatacccgc
     3241 caaggaactc gtttatgttg gctgatagag cattcaggat accttaaagt ttaataagag
     3301 acgcattttt ttttttcaaa aatgtgaaaa gctctgacat ttaacgaact gaccaataga
     3361 ctcaaggact gttttagttg gactgggcca ttttattatg ttccttttaa tattaacagt
     3421 acaagagcgc ttgctgactt cgaggataac taagattaca tactttctca ggagaaggct
     3481 gcatgcaaga cttctctgtc agggttgctc ctgtggcttt tttaatttta tttttttaaa
     3541 cctatatatg gaaaaggaaa tttcaatgcc agatttgata aaagaatgtg atgtatatgt
     3601 agctgatgac ccactgggga acaccagtgt tccagttcac ttaccacatc tgtgacagtg
     3661 tgtttagatt ggaataaatg tgatgcatta cttcttatgt ttttatcagt gacatggttg
     3721 actgtgccct aattctcttg agttgcagtt aagcaatgaa ggttatttcc taatagggaa
     3781 gcaaaaggtg attgtcaatt gatagtttaa tgtttgacca cattagtgtc tttatatgaa
     3841 atagtagagg ggaagaaatt atagaaaaca aatgtgaaaa aaatacacca gtgggtatct
     3901 gttctactaa aaccagaaga ttgttatgag tacttaaacc tcactgtgaa ataatgatat
     3961 attttgcaat taatccctcc ccaactgagt gtcttactgt gttattaaat cttatctttt
     4021 agttaatagt tgcagtattt cttttaaatg tttttgtttt aaacttaggg gtaggatcct
     4081 ttatttgttc agttgtttcc aactatttgg gatactttca ttccctgcta tttatgaagt
     4141 acatgtttat cactaagtgt agtggtttgg tttacattaa taattttatg tgtggtctaa
     4201 aaatgcagtc actaagagaa tgtacactgt ggttatggtc acagtggtta tggatttatt
     4261 ggcagtggag taccatggag gtcactgcaa tggtgctaag gctgacagtg gaatcttctg
     4321 tttagggcct taagcccctg agggtcctgg tgactcaggg aatccatcac agccccgggt
     4381 ctttcacccc agttcactcc ttttatgttt ggcctagatt gacccatgcc tgccctcttc
     4441 tcaacagctg agtagggaac cagccatctg aatgagctga tcgttgttta tgttcaaatg
     4501 agtaaatgtc cagaccactt aaaactacag ctgcttttct ggcagtctcg tctgcggggc
     4561 caaaacttaa taaaccacag gaaatagact gtcattctta gtttgctgcc agggcttatt
     4621 ttagattgag agcatactgg tacatgagag cagtagtgtt gtttgctctt attttcaacc
     4681 agggagctat ctggcacctt ttgtgctcct ggcttttttc aatcatagca ctattgcatc
     4741 tcctagctat ttcttttgcc cagcagggta atattgagtc ccattgcaag tatggacaag
     4801 gcctctggtt ctcctcacca cccacctttt cagccataga acatcactga aaatgcctaa
     4861 tgcctggatc tgtgttctac tttagtttca ctgggaagtc tttcagtggg agatgaataa
     4921 atgttataca ttgttatgtc cagttatgtc aataaaccca ctaatagaga taa
//
