LOCUS       NM_021643               4344 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens tribbles pseudokinase 2 (TRIB2), transcript variant 1,
            mRNA.
ACCESSION   NM_021643
VERSION     NM_021643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4344)
  AUTHORS   Wang,D., Kang,X., Zhang,L., Guo,Y., Zhang,Z., Ren,H. and Yuan,G.
  TITLE     TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin
            Resistance
  JOURNAL   Diabetes 73 (8), 1199-1214 (2024)
   PUBMED   38394623
  REMARK    GeneRIF: TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin
            Resistance.
REFERENCE   2  (bases 1 to 4344)
  AUTHORS   Foscarini,A., Tricarico,R., Gentile,F., Satam,S., Mohr,H.,
            Kiss-Toth,E., Ranzani,G.N. and Pellegata,N.S.
  TITLE     Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for
            TRIB2
  JOURNAL   Genes (Basel) 15 (1), 26 (2023)
   PUBMED   38254916
  REMARK    GeneRIF: Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role
            for TRIB2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4344)
  AUTHORS   Popovic,R., Yu,Y., Leal,N.S., Fedele,G., Loh,S.H.Y. and
            Martins,L.M.
  TITLE     Upregulation of Tribbles decreases body weight and increases sleep
            duration
  JOURNAL   Dis Model Mech 16 (4) (2023)
   PUBMED   37083954
  REMARK    GeneRIF: Upregulation of Tribbles decreases body weight and
            increases sleep duration.
REFERENCE   4  (bases 1 to 4344)
  AUTHORS   Cao,W., Sturmlechner,I., Zhang,H., Jin,J., Hu,B., Jadhav,R.R.,
            Fang,F., Weyand,C.M. and Goronzy,J.J.
  TITLE     TRIB2 safeguards naive T cell homeostasis during aging
  JOURNAL   Cell Rep 42 (3), 112195 (2023)
   PUBMED   36884349
  REMARK    GeneRIF: TRIB2 safeguards naive T cell homeostasis during aging.
REFERENCE   5  (bases 1 to 4344)
  AUTHORS   Ma,B., Zhang,W., Wang,X., Jiang,H., Tang,L., Yang,W., Kang,Q. and
            Cao,J.
  TITLE     Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the
            Susceptibility to High Myopia-Induced Cataract in Han Chinese
            Population
  JOURNAL   Med Sci Monit 29, e937702 (2023)
   PUBMED   36710479
  REMARK    GeneRIF: Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the
            Susceptibility to High Myopia-Induced Cataract in Han Chinese
            Population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4344)
  AUTHORS   Zhang,Y., Davis,J.L. and Li,W.
  TITLE     Identification of tribbles homolog 2 as an autoantigen in
            autoimmune uveitis by phage display
  JOURNAL   Mol Immunol 42 (11), 1275-1281 (2005)
   PUBMED   15950723
  REMARK    GeneRIF: Anti-TRB2 antibody activities were detected in several
            autoimmune uveitis patients but not in control subjects, suggesting
            that TRB2 is a uveitis-associated candidate autoantigen.
REFERENCE   7  (bases 1 to 4344)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
REFERENCE   8  (bases 1 to 4344)
  AUTHORS   Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B.
  TITLE     SINK is a p65-interacting negative regulator of NF-kappaB-dependent
            transcription
  JOURNAL   J Biol Chem 278 (29), 27072-27079 (2003)
   PUBMED   12736262
REFERENCE   9  (bases 1 to 4344)
  AUTHORS   Du,K., Herzig,S., Kulkarni,R.N. and Montminy,M.
  TITLE     TRB3: a tribbles homolog that inhibits Akt/PKB activation by
            insulin in liver
  JOURNAL   Science 300 (5625), 1574-1577 (2003)
   PUBMED   12791994
REFERENCE   10 (bases 1 to 4344)
  AUTHORS   Wilkin,F., Suarez-Huerta,N., Robaye,B., Peetermans,J., Libert,F.,
            Dumont,J.E. and Maenhaut,C.
  TITLE     Characterization of a phosphoprotein whose mRNA is regulated by the
            mitogenic pathways in dog thyroid cells
  JOURNAL   Eur J Biochem 248 (3), 660-668 (1997)
   PUBMED   9342215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009486.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 14, 2020 this sequence version replaced NM_021643.3.
            
            Summary: This gene encodes one of three members of the Tribbles
            family. The Tribbles members share a Trb domain, which is
            homologous to protein serine-threonine kinases, but lacks the
            active site lysine and probably lacks a catalytic function. The
            Tribbles proteins interact and modulate the activity of signal
            transduction pathways in a number of physiological and pathological
            processes. This Tribbles member induces apoptosis of cells mainly
            of the hematopoietic origin. It has been identified as a protein
            up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and
            also as an oncogene that inactivates the transcription factor
            C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute
            myelogenous leukemia. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87119.1, AY245544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000155926.9/ ENSP00000155926.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1642              AC009486.4         74024-75665
            1643-1935           AC009486.4         80348-80640
            1936-4344           AC009486.4         97414-99822
FEATURES             Location/Qualifiers
     source          1..4344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.3"
     gene            1..4344
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /note="tribbles pseudokinase 2"
                     /db_xref="GeneID:28951"
                     /db_xref="HGNC:HGNC:30809"
                     /db_xref="MIM:609462"
     exon            1..1642
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1373..2404
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /codon_start=1
                     /product="tribbles homolog 2"
                     /protein_id="NP_067675.1"
                     /db_xref="CCDS:CCDS1683.1"
                     /db_xref="GeneID:28951"
                     /db_xref="HGNC:HGNC:30809"
                     /db_xref="MIM:609462"
                     /translation="MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLG
                     SPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLA
                     PCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIA
                     SAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAY
                     VSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPET
                     LSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNM
                     EENLDPFFN"
     exon            1643..1935
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..4344
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /note="hexamer: AATAAA"
     polyA_site      4344
                     /gene="TRIB2"
                     /gene_synonym="C5FW; GS3955; TRB2"
                     /note="major polyA site"
ORIGIN      
        1 gagaccgagc gcgagcgagg cgcgcgcgcg cacacgcgca ctcacggccc cgctcgctcc
       61 gagatccccg gccacgtaag taactattaa taccgcctcg ccgggggatg cgggcgtgct
      121 gagcgcgggg attggcctcg ggcaccgtcg gccgtcccct ttaattttta aatacacggt
      181 cccctctttt ctctgggggg ggcaagcaag aaatcaaaga aggaggagac aagccgtcaa
      241 ttttctccaa aacaaacccc accgggcaat ttggtctcgg ggtaggggga gacggggtga
      301 ttgcaaatta ttccaggacg agatccagtt ctccagcggg aaaggggcaa aggaacgccg
      361 cgcgttggaa gggccaggga cgcagctccc cttgcagcgc ccgcaggacc cccgcaagct
      421 cgtgccggcg aaatcggaga ccgccgatct gtcctcgttc tctcctgcac gtctggctgc
      481 attcggagga agacctgggg cgcgagcgag cggcgacagc atgagcctgt gctgacctcc
      541 gcgcggcggg ccgagcccag ggctttgtcg cggtacctgc gcccagcccg cgccgcaact
      601 ctgtgcccag cttttgcaat cttttgttgg cagcgctgac cgcaccaagt taaatgctcc
      661 cttgcaattt ttcttttttt tgtttgtttg tttaattttt ggagagctcg cgatcttgga
      721 aaagcctcag acgccatcta cagttaaaac gtaggtaact gccctctccc gcaccccccc
      781 cttacacgcc ccccaccctt tccaccaaaa aaagggggtg cagcgcggat tctggctgcc
      841 gtgcgtcgcc agccggtaga cccgtgcttg tttcctttct ctttttgttt ggcttctaac
      901 gcgttgggac tgagtcgccg ccgtgagctc cccgaagact gcacaaacta ccgcgggctc
      961 ctccgccccg tctgcgattc ggaagccggc ctgggggtcg cgtcgggagc cctggcgctg
     1021 cagctccgca ccttagcagc ccgggtactc atccagatcc acgccgggga cacacacaca
     1081 gagtaactaa aagtgcggcg attctgcaca tcgccgactg ctttggggta acaaaaagac
     1141 ccgagttgcc tgccgaccga ggacccccgg gagccgggct cggagcagac gaggtatccg
     1201 gcggcgccca tttgggggct tctaactctt tctccacgca gcccctcttc tgtcccctcc
     1261 cctctcgctc ccttttaaaa tcagtggcac cgaggcgcct gcagccgcac tcgccagcga
     1321 ctcatctctc cagcgggttt ttttttgttt gtcgtgtgcg atcctcacac tcatgaacat
     1381 acacaggtct acccccatca caatagcgag atatgggaga tcgcggaaca aaacccagga
     1441 tttcgaagag ttgtcgtcta taaggtccgc ggagcccagc cagagtttca gcccgaacct
     1501 cggctccccg agcccgcccg agactccgaa cttgtcgcat tgcgtttctt gtatcgggaa
     1561 atacttattg ttggaacctc tggagggaga ccacgttttt cgtgccgtgc atctgcacag
     1621 cggagaggag ctggtgtgca aggtgtttga tatcagctgc taccaggaat ccctggcacc
     1681 gtgcttttgc ctgtctgctc atagtaacat caaccaaatc actgaaatta tcctgggtga
     1741 gaccaaagcc tatgtgttct ttgagcgaag ctatggggac atgcattcct tcgtccgcac
     1801 ctgcaagaag ctgagagagg aggaggcagc cagactgttc taccagattg cctcggcagt
     1861 ggcccactgc catgacgggg ggctggtgct gcgggacctc aagctgcgga aattcatctt
     1921 taaggacgaa gagaggactc gggtcaagct ggaaagcctg gaagacgcct acattctgcg
     1981 gggagatgat gattccctct ccgacaagca tggctgcccg gcttacgtaa gcccagagat
     2041 cttgaacacc agtggcagct actcgggcaa agcagccgac gtgtggagcc tgggggtgat
     2101 gctgtacacc atgttggtgg ggcggtaccc tttccatgac attgaaccca gctccctctt
     2161 cagcaagatc cggcgtggcc agttcaacat tccagagact ctgtcgccca aggccaagtg
     2221 cctcatccga agcattctgc gtcgggagcc ctcagagcgg ctgacctcgc aggaaattct
     2281 ggaccatcct tggttttcta cagattttag cgtctcgaat tcagcatatg gtgctaagga
     2341 agtgtctgac cagctggtgc cggacgtcaa catggaagag aacttggacc ctttctttaa
     2401 ctgagctcat gccccacgga gacttagcag gttccaggag tgagcgaggg cagcggaaag
     2461 gagttcttcc gggggacacg aattgcctgg ctgagtagca agaaagacac actcttaagt
     2521 ttcttggttc agagcaggaa aaccttcaag gagctgactg accacgtagc atgggggcaa
     2581 gaggcgtggg atggggattg gggtgagatg gatgggagcc cgctggagct tgtcttccct
     2641 aacatagcct gggagaccac cccttgccac ttgggccact tccgcctacc ccacttttca
     2701 ttttgttcca aaatagttgc agatcctgac agaatcaaaa ctctctgcct caaacacaca
     2761 tcctggcatc gcactgttag catttaactt cttgttagga ttcagggaag gaacagttgg
     2821 ccaagaattt tttttctttt aaacaagcca accacctagc tggtaattaa tgaggttcac
     2881 ttaaaaaaaa aattcggtgc acacagactg acatgaaacc tgggtgctac agtaaaagaa
     2941 aacaaaagtc cagtttgtgt ctcttaatcg ctcacttcaa ctcatttctt ctaaataaac
     3001 tatttaatat cctggtcagg aaatgacatg ttaatgcttt gctccctgaa gggggaaaaa
     3061 atctgtcctt taacaagcta ttctgttttg tgtcaattgg ttcgtggcag gaagctatta
     3121 gaagtcaaac gtccagatgc attactgcta tcttagttta aagggggaaa gaaaagggaa
     3181 gaagaaagga aaagagaaat ccaactcctt tttcatgttt tgcttttgaa caatgagggt
     3241 ttgtgtgaca ggcattcctc tttgctgaga tgatagcaat ggcctgagat tttagcaagc
     3301 tcctggagtc tgatgctttt gcagtactct gatcgcaact aaacatttgt ctttgtttta
     3361 ttagaaacta gtgaaacaaa gcaggttgtc ccacatgtat aaaatacagg gcagctattt
     3421 agttttcttt acagagaatg atccttttaa ggcttgtaag gccctctggt ttggacaaaa
     3481 accctcagta gagacaagcg ggaaggataa ttagctgaaa gctatgatga tataaataaa
     3541 aacagctctc tatcccaata cgcacctttg tattttcaag aactcttcta tttattaagg
     3601 aaaatgtcac attgtgatgt attaagccag tacttcaatt acgggttgac ttgggatgac
     3661 atattacatg ctgtagttaa catttataat tctttttcct tgtttgagta tttctgtctc
     3721 tgaaataacc ttttacttgg cttttctaga tagctttatt tgatttcgag tggcaaaatg
     3781 ttttttatta cggcttttct attgctgtat gatacagaac tcttttggca taaatatttg
     3841 tgttcccagt acctcacttg ttcggatttg actgcctgta tatgttttgt gaaatggtcc
     3901 tgtttttggg taggtgacac gtggactcta gtatgtaaat gttacttgaa tctgtgcttc
     3961 ataatagtgt gtggcatgta tgtgcagact cttggatgct ttatgcctgc gcagcaggag
     4021 ccctgtcctc acgttcccag gagggcggct tcacccttcg taaccaggag acaaggcggc
     4081 catggatttg cccttgattc tattttgcta atggaagata gaaaggagag aaggtttttt
     4141 ttttttttaa cattctgaag atggtgctgt gtcaagaagg accttttttt tcccctctcc
     4201 cctatttttt aagtaccttg gaggaggaga ggttggtgac atgcatggtg gggatctatg
     4261 gcctctggtg ctttgtcctg tatttggttt aatgtttttg tcctaatctc ttcaatcaat
     4321 aaaattgtgc gtatttaact aaaa
//
