LOCUS       NM_025195               3596 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens tribbles pseudokinase 1 (TRIB1), transcript variant 1,
            mRNA.
ACCESSION   NM_025195
VERSION     NM_025195.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3596)
  AUTHORS   Malinowski,D., Safranow,K. and Pawlik,A.
  TITLE     PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina
  JOURNAL   Genes (Basel) 15 (7), 871 (2024)
   PUBMED   39062650
  REMARK    GeneRIF: PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3596)
  AUTHORS   Hammond,F.R., Lewis,A., Pollara,G., Tomlinson,G.S., Noursadeghi,M.,
            Kiss-Toth,E. and Elks,P.M.
  TITLE     Tribbles1 is host protective during in vivo mycobacterial infection
  JOURNAL   Elife 13, e95980 (2024)
   PUBMED   38896446
  REMARK    GeneRIF: Tribbles1 is host protective during in vivo mycobacterial
            infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3596)
  AUTHORS   Jiang,J., Chen,X., Li,C., Du,X. and Zhou,H.
  TITLE     Polymorphisms of TRIB1 genes for coronary artery disease and stroke
            risk: A systematic review and meta-analysis
  JOURNAL   Gene 880, 147613 (2023)
   PUBMED   37414350
  REMARK    GeneRIF: Polymorphisms of TRIB1 genes for coronary artery disease
            and stroke risk: A systematic review and meta-analysis.
            Review article
REFERENCE   4  (bases 1 to 3596)
  AUTHORS   Soubeyrand,S., Lau,P. and McPherson,R.
  TITLE     Regulation of TRIB1 abundance in hepatocyte models in response to
            proteasome inhibition
  JOURNAL   Sci Rep 13 (1), 9320 (2023)
   PUBMED   37291259
  REMARK    GeneRIF: Regulation of TRIB1 abundance in hepatocyte models in
            response to proteasome inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3596)
  AUTHORS   Popovic,R., Yu,Y., Leal,N.S., Fedele,G., Loh,S.H.Y. and
            Martins,L.M.
  TITLE     Upregulation of Tribbles decreases body weight and increases sleep
            duration
  JOURNAL   Dis Model Mech 16 (4) (2023)
   PUBMED   37083954
  REMARK    GeneRIF: Upregulation of Tribbles decreases body weight and
            increases sleep duration.
REFERENCE   6  (bases 1 to 3596)
  AUTHORS   Xu,C., Zhang,J., Huang,X., Sun,J., Xu,Y., Tang,Y., Wu,J., Shi,Y.,
            Huang,Q. and Zhang,Q.
  TITLE     Solution structure of human peptidyl prolyl isomerase-like protein
            1 and insights into its interaction with SKIP
  JOURNAL   J Biol Chem 281 (23), 15900-15908 (2006)
   PUBMED   16595688
  REMARK    GeneRIF: used chemical shift perturbation experiments to show the
            possible SKIP binding interface on PPIL1
REFERENCE   7  (bases 1 to 3596)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
  REMARK    GeneRIF: Tribbles controls both the extent and the specificity of
            MAPK kinase activation of MAPK
REFERENCE   8  (bases 1 to 3596)
  AUTHORS   Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B.
  TITLE     SINK is a p65-interacting negative regulator of NF-kappaB-dependent
            transcription
  JOURNAL   J Biol Chem 278 (29), 27072-27079 (2003)
   PUBMED   12736262
REFERENCE   9  (bases 1 to 3596)
  AUTHORS   Tang,K., Finley,R.L. Jr., Nie,D. and Honn,K.V.
  TITLE     Identification of 12-lipoxygenase interaction with cellular
            proteins by yeast two-hybrid screening
  JOURNAL   Biochemistry 39 (12), 3185-3191 (2000)
   PUBMED   10727209
REFERENCE   10 (bases 1 to 3596)
  AUTHORS   Wilkin,F., Suarez-Huerta,N., Robaye,B., Peetermans,J., Libert,F.,
            Dumont,J.E. and Maenhaut,C.
  TITLE     Characterization of a phosphoprotein whose mRNA is regulated by the
            mitogenic pathways in dog thyroid cells
  JOURNAL   Eur J Biochem 248 (3), 660-668 (1997)
   PUBMED   9342215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091114.11, AL832388.1 and BC012441.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025195.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript nd encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832388.1, BC063292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311922.4/ ENSP00000312150.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AC091114.11        38886-39216
            332-1795            AL832388.1         1-1464
            1796-3596           BC012441.1         184-1984
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..3596
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="tribbles pseudokinase 1"
                     /db_xref="GeneID:10221"
                     /db_xref="HGNC:HGNC:16891"
                     /db_xref="MIM:609461"
     exon            1..905
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..1664
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G-protein-coupled receptor induced protein; phosphoprotein
                     regulated by mitogenic pathways; tribbles-like protein 1;
                     G-protein-coupled receptor-induced protein 2;
                     G-protein-coupled receptor-induced gene 2 protein;
                     tribbles homolog 1"
                     /codon_start=1
                     /product="tribbles homolog 1 isoform 1"
                     /protein_id="NP_079471.1"
                     /db_xref="CCDS:CCDS6357.1"
                     /db_xref="GeneID:10221"
                     /db_xref="HGNC:HGNC:16891"
                     /db_xref="MIM:609461"
                     /translation="MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVA
                     AKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAER
                     EHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFF
                     EKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER
                     TQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT
                     LLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILL
                     HPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC"
     exon            906..1198
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..3596
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3577..3582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="hexamer: AATAAA"
     polyA_site      3596
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="major polyA site"
ORIGIN      
        1 acactcactc acagtcactc tctctgagcg cgtctcgctc gctctcatac acgcccggag
       61 cccaggagcg ctcaggatcc cgagcgccgc gaaaaagttc ccccggcttt tgctggagac
      121 tcatcgcttt gggaagtgca tttgcttcgt ggctccgccg agcctgctga atcctgtcct
      181 cgcggctcgg gaccccggga tcgctgaccg ctgccgccgc cgcctctgcc tcccggacta
      241 tcggcagcct cggcaacaat agtggcggcc gcccccagcg aggctccggg agcccttgcc
      301 tgcgggggtc cggggactcg agccggcctc cgcctcccgg acgcacagcc agcgtggtcc
      361 ccgcgtgcaa cgcgagcgcc ggggagtggc tcctgctttg cccctcgtgg gggccgagcc
      421 aagaccagtc tgcaaactcc atcccgccgg ctggaagaag tcgcggagcc ggcaccaaac
      481 ccgcagcgtc ttcccgcgcg gatcccggga cttaaaaagc cggggccacc ccggcccagg
      541 acgggatgcg ggtcggtccg gtgcgctctg ccatgagcgg cgcctcgcag ccccgcggcc
      601 cggccctgct cttcccagcc acccgaggcg tcccggccaa acgcctgctg gacgccgacg
      661 acgcggcggc tgtggcggcc aagtgcccgc gcctctccga gtgctccagc cccccggact
      721 acctcagccc ccccggctcg ccctgcagcc cgcagccccc gcctgccgct ccgggggccg
      781 gcggaggctc cgggagcgcg ccggggccca gccgcatcgc cgactacctg ctgctgcccc
      841 tagccgagcg cgagcatgtg tcccgggcgc tgtgcatcca cactggacgc gagctgcgct
      901 gcaaggtgtt tcccattaaa cactaccagg acaaaatcag gccttacatc cagctgccat
      961 cgcacagcaa cattactggc attgtggaag tgatccttgg ggaaaccaag gcctatgtct
     1021 tctttgagaa ggactttggg gacatgcact cctatgtgcg aagccggaag aggctgcggg
     1081 aagaggaagc cgcccggctc ttcaagcaga ttgtctccgc cgtcgcccac tgccaccagt
     1141 cagccatcgt gctgggggac ctgaagctta ggaagttcgt cttctccacg gaggagagaa
     1201 cccagcttag actagaaagt ctagaagaca cacacataat gaagggggaa gatgatgctt
     1261 tgtcagacaa acatggctgc ccagcctacg tgagccctga gatcctcaac accactggga
     1321 cctactccgg aaaggctgcg gacgtttgga gcctgggggt gatgctctac acccttctgg
     1381 ttggacgata ccccttccat gactcagacc ccagtgccct tttctccaaa attcggcgtg
     1441 gacagttctg cattcctgag cacatttccc ccaaagccag gtgcctcatt cgcagcctct
     1501 tgagacggga gccctccgag agactcactg cccccgagat cctactgcac ccctggtttg
     1561 agtccgtctt ggaacccggg tacatcgact cagaaatagg aacttcagac cagattgttc
     1621 cagagtacca ggaggacagt gacattagtt ccttcttctg ctaatcccca aaacctcaga
     1681 aacctcataa ttcttaacac ctggcatttc catttctaaa gatggacagg ccctttggcg
     1741 tggtaccaac cagataatga ctgcatcagg atgaaagctg ctgaactcgg catggcgcct
     1801 cctcttctct gttgggatga gtgactttat tgatttgagc agcatatgct gtgattggct
     1861 gccctgcaaa tttgtttccc ttaaggaacc ctcaccaact atctctgctg gatttgggag
     1921 ttccgcatct tttgtggagg gcagagtatg gacatcttac acccggtggt caagtgtgta
     1981 ataaacttga gcattcgaat gggagaaaaa gcaaatcgca caatgacata ttttgagtaa
     2041 taaccgtatt tttcacaggg tgacaaattg ggccaataaa tctgccatct ttgaactcat
     2101 ctttggtggc tagactgcta cggcagcttc tctgatggga aagttccttt tttggcttaa
     2161 cactcaccct ttcttcacac tcacatttac caatgactct gctccgtttt tggagcagac
     2221 tgttttaagt tgctcaggag cctgatggaa ccatgaaccg agactcttct ctgtttcctg
     2281 ccaagacctc atctgcacta atgccttctc cctgaccttg acacttcccc ctttagctat
     2341 aaaagcactt accagccgaa cgtggaacag tatcacaaaa gattccatct cccaacgatt
     2401 tcagaactct gagctcagag agactccaga ttttaaaaaa taatttgagt gcttggaaac
     2461 tattagcttt ttaagttcct tccaaatatg ttagtaccta ccctttactt tttccccaag
     2521 accatctcag ggtggagcat tctgtctaag agaagaaaga taaggaggct cccacccacc
     2581 tctcccaaga gcagacatta aacatctttg tgctttgaag agagtgaatt ttggatagtc
     2641 ttgtgattct cagactaact tccagaatta tactttaacc cctcccagat atggtccgcc
     2701 tttggcattg tgtgtacatc tgcagttttg catggtgggt tgttaatatt tcaaatgtgt
     2761 ggtttatgaa tacgtctgta taatcggctt ctggagtgaa acagcaaacc ccaaatcttc
     2821 aaagttggaa ggaactttaa aaatcatccg gtccaatctc tttcctcttt ctgccacctc
     2881 ccaaggcaga aatcccctct tcagcttctt ttgtaggtgg gaatccagcc tctgttagat
     2941 atgtccagag atggaaactc actcccctac aaaagatgga gcttaatgga gaaattgcaa
     3001 ctttcattaa aaaacaaatt cagatgaaat atcagtaact gtcttggaca gtgctgaaat
     3061 caggtggtta aacgggtaaa caaaatatac tgtattttga gaaatggcac aaaaacaggc
     3121 agtcatcttt aagggctatg cctaggcaaa ctactaacat gcattgtgag aatgccgtgt
     3181 atacctcacg tactgtgtac tttgtacata tattttacct tttataccta tgttcgattt
     3241 tgttttgttt tgttttgttc tggctttgag gcttgttttg ttgtctgtgt ctgtctgaat
     3301 aacctgcgtg tctaaaacca cgtgaaatgt gaatgattat tggcaatatt accttgacag
     3361 aatcatggga ctttgagaag agggaggaca gaggcctctg tcgcactaac gctctcgtgg
     3421 ttgctcgact gttgtatctg tgatacatta tccgactaag gactctgggc tggcagggcc
     3481 ttctgccggg aaagctagaa acactaggtt cttcctgtac atacgtgtat atatgtgaac
     3541 agtgagatgg ccgtttctga cttgtagaga aattttaata aacctggttt cgtaaa
//
