LOCUS       NP_079471                372 aa            linear   PRI 27-APR-2025
DEFINITION  tribbles homolog 1 isoform 1 [Homo sapiens].
ACCESSION   NP_079471
VERSION     NP_079471.1
DBSOURCE    REFSEQ: accession NM_025195.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Malinowski,D., Safranow,K. and Pawlik,A.
  TITLE     PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina
  JOURNAL   Genes (Basel) 15 (7), 871 (2024)
   PUBMED   39062650
  REMARK    GeneRIF: PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Hammond,F.R., Lewis,A., Pollara,G., Tomlinson,G.S., Noursadeghi,M.,
            Kiss-Toth,E. and Elks,P.M.
  TITLE     Tribbles1 is host protective during in vivo mycobacterial infection
  JOURNAL   Elife 13, e95980 (2024)
   PUBMED   38896446
  REMARK    GeneRIF: Tribbles1 is host protective during in vivo mycobacterial
            infection.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Jiang,J., Chen,X., Li,C., Du,X. and Zhou,H.
  TITLE     Polymorphisms of TRIB1 genes for coronary artery disease and stroke
            risk: A systematic review and meta-analysis
  JOURNAL   Gene 880, 147613 (2023)
   PUBMED   37414350
  REMARK    GeneRIF: Polymorphisms of TRIB1 genes for coronary artery disease
            and stroke risk: A systematic review and meta-analysis.
            Review article
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Soubeyrand,S., Lau,P. and McPherson,R.
  TITLE     Regulation of TRIB1 abundance in hepatocyte models in response to
            proteasome inhibition
  JOURNAL   Sci Rep 13 (1), 9320 (2023)
   PUBMED   37291259
  REMARK    GeneRIF: Regulation of TRIB1 abundance in hepatocyte models in
            response to proteasome inhibition.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Popovic,R., Yu,Y., Leal,N.S., Fedele,G., Loh,S.H.Y. and
            Martins,L.M.
  TITLE     Upregulation of Tribbles decreases body weight and increases sleep
            duration
  JOURNAL   Dis Model Mech 16 (4) (2023)
   PUBMED   37083954
  REMARK    GeneRIF: Upregulation of Tribbles decreases body weight and
            increases sleep duration.
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Xu,C., Zhang,J., Huang,X., Sun,J., Xu,Y., Tang,Y., Wu,J., Shi,Y.,
            Huang,Q. and Zhang,Q.
  TITLE     Solution structure of human peptidyl prolyl isomerase-like protein
            1 and insights into its interaction with SKIP
  JOURNAL   J Biol Chem 281 (23), 15900-15908 (2006)
   PUBMED   16595688
  REMARK    GeneRIF: used chemical shift perturbation experiments to show the
            possible SKIP binding interface on PPIL1
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
  REMARK    GeneRIF: Tribbles controls both the extent and the specificity of
            MAPK kinase activation of MAPK
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B.
  TITLE     SINK is a p65-interacting negative regulator of NF-kappaB-dependent
            transcription
  JOURNAL   J Biol Chem 278 (29), 27072-27079 (2003)
   PUBMED   12736262
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Tang,K., Finley,R.L. Jr., Nie,D. and Honn,K.V.
  TITLE     Identification of 12-lipoxygenase interaction with cellular
            proteins by yeast two-hybrid screening
  JOURNAL   Biochemistry 39 (12), 3185-3191 (2000)
   PUBMED   10727209
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Wilkin,F., Suarez-Huerta,N., Robaye,B., Peetermans,J., Libert,F.,
            Dumont,J.E. and Maenhaut,C.
  TITLE     Characterization of a phosphoprotein whose mRNA is regulated by the
            mitogenic pathways in dog thyroid cells
  JOURNAL   Eur J Biochem 248 (3), 660-668 (1997)
   PUBMED   9342215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091114.11, AL832388.1 and BC012441.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript nd encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832388.1, BC063292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311922.4/ ENSP00000312150.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     Protein         1..372
                     /product="tribbles homolog 1 isoform 1"
                     /note="G-protein-coupled receptor induced protein;
                     phosphoprotein regulated by mitogenic pathways;
                     tribbles-like protein 1; G-protein-coupled
                     receptor-induced protein 2; G-protein-coupled
                     receptor-induced gene 2 protein; tribbles homolog 1"
                     /calculated_mol_wt=40878
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RU8.2)"
     Region          52..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RU8.2)"
     Region          97..338
                     /region_name="PK_TRB1"
                     /note="Pseudokinase domain of Tribbles Homolog 1; cd14023"
                     /db_xref="CDD:270925"
     Region          355..360
                     /region_name="COP1-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8K4K4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RU8.2)"
     CDS             1..372
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /coded_by="NM_025195.4:546..1664"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS6357.1"
                     /db_xref="GeneID:10221"
                     /db_xref="HGNC:HGNC:16891"
                     /db_xref="MIM:609461"
ORIGIN      
        1 mrvgpvrsam sgasqprgpa llfpatrgvp akrlldadda aavaakcprl secssppdyl
       61 sppgspcspq pppaapgagg gsgsapgpsr iadylllpla erehvsralc ihtgrelrck
      121 vfpikhyqdk irpyiqlpsh snitgivevi lgetkayvff ekdfgdmhsy vrsrkrlree
      181 eaarlfkqiv savahchqsa ivlgdlklrk fvfsteertq lrlesledth imkgeddals
      241 dkhgcpayvs peilnttgty sgkaadvwsl gvmlytllvg rypfhdsdps alfskirrgq
      301 fcipehispk arclirsllr repserltap eillhpwfes vlepgyidse igtsdqivpe
      361 yqedsdissf fc
//
