LOCUS       NM_001282985            2807 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens tribbles pseudokinase 1 (TRIB1), transcript variant 2,
            mRNA.
ACCESSION   NM_001282985 XM_005250752
VERSION     NM_001282985.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Malinowski,D., Safranow,K. and Pawlik,A.
  TITLE     PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina
  JOURNAL   Genes (Basel) 15 (7), 871 (2024)
   PUBMED   39062650
  REMARK    GeneRIF: PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Hammond,F.R., Lewis,A., Pollara,G., Tomlinson,G.S., Noursadeghi,M.,
            Kiss-Toth,E. and Elks,P.M.
  TITLE     Tribbles1 is host protective during in vivo mycobacterial infection
  JOURNAL   Elife 13, e95980 (2024)
   PUBMED   38896446
  REMARK    GeneRIF: Tribbles1 is host protective during in vivo mycobacterial
            infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Jiang,J., Chen,X., Li,C., Du,X. and Zhou,H.
  TITLE     Polymorphisms of TRIB1 genes for coronary artery disease and stroke
            risk: A systematic review and meta-analysis
  JOURNAL   Gene 880, 147613 (2023)
   PUBMED   37414350
  REMARK    GeneRIF: Polymorphisms of TRIB1 genes for coronary artery disease
            and stroke risk: A systematic review and meta-analysis.
            Review article
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Soubeyrand,S., Lau,P. and McPherson,R.
  TITLE     Regulation of TRIB1 abundance in hepatocyte models in response to
            proteasome inhibition
  JOURNAL   Sci Rep 13 (1), 9320 (2023)
   PUBMED   37291259
  REMARK    GeneRIF: Regulation of TRIB1 abundance in hepatocyte models in
            response to proteasome inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Popovic,R., Yu,Y., Leal,N.S., Fedele,G., Loh,S.H.Y. and
            Martins,L.M.
  TITLE     Upregulation of Tribbles decreases body weight and increases sleep
            duration
  JOURNAL   Dis Model Mech 16 (4) (2023)
   PUBMED   37083954
  REMARK    GeneRIF: Upregulation of Tribbles decreases body weight and
            increases sleep duration.
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Xu,C., Zhang,J., Huang,X., Sun,J., Xu,Y., Tang,Y., Wu,J., Shi,Y.,
            Huang,Q. and Zhang,Q.
  TITLE     Solution structure of human peptidyl prolyl isomerase-like protein
            1 and insights into its interaction with SKIP
  JOURNAL   J Biol Chem 281 (23), 15900-15908 (2006)
   PUBMED   16595688
  REMARK    GeneRIF: used chemical shift perturbation experiments to show the
            possible SKIP binding interface on PPIL1
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
  REMARK    GeneRIF: Tribbles controls both the extent and the specificity of
            MAPK kinase activation of MAPK
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B.
  TITLE     SINK is a p65-interacting negative regulator of NF-kappaB-dependent
            transcription
  JOURNAL   J Biol Chem 278 (29), 27072-27079 (2003)
   PUBMED   12736262
REFERENCE   9  (bases 1 to 2807)
  AUTHORS   Tang,K., Finley,R.L. Jr., Nie,D. and Honn,K.V.
  TITLE     Identification of 12-lipoxygenase interaction with cellular
            proteins by yeast two-hybrid screening
  JOURNAL   Biochemistry 39 (12), 3185-3191 (2000)
   PUBMED   10727209
REFERENCE   10 (bases 1 to 2807)
  AUTHORS   Wilkin,F., Suarez-Huerta,N., Robaye,B., Peetermans,J., Libert,F.,
            Dumont,J.E. and Maenhaut,C.
  TITLE     Characterization of a phosphoprotein whose mRNA is regulated by the
            mitogenic pathways in dog thyroid cells
  JOURNAL   Eur J Biochem 248 (3), 660-668 (1997)
   PUBMED   9342215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA686993.1, AC091114.11 and BC012441.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001282985.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region and initiates translation at a downstream start codon
            compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297539.1, DA686993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               DA686993.1         1-546
            547-823             AC091114.11        44671-44947
            824-2807            BC012441.1         1-1984
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..2807
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="tribbles pseudokinase 1"
                     /db_xref="GeneID:10221"
                     /db_xref="HGNC:HGNC:16891"
                     /db_xref="MIM:609461"
     exon            1..116
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..409
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..875
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     G-protein-coupled receptor induced protein; phosphoprotein
                     regulated by mitogenic pathways; tribbles-like protein 1;
                     G-protein-coupled receptor-induced protein 2;
                     G-protein-coupled receptor-induced gene 2 protein;
                     tribbles homolog 1"
                     /codon_start=1
                     /product="tribbles homolog 1 isoform 2"
                     /protein_id="NP_001269914.1"
                     /db_xref="CCDS:CCDS64971.1"
                     /db_xref="GeneID:10221"
                     /db_xref="HGNC:HGNC:16891"
                     /db_xref="MIM:609461"
                     /translation="MHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRK
                     FVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVW
                     SLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSER
                     LTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC"
     exon            410..2807
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="hexamer: AATAAA"
     polyA_site      2807
                     /gene="TRIB1"
                     /gene_synonym="C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1"
                     /note="major polyA site"
ORIGIN      
        1 ctactgccca acccgaatga aatttcagac gcatgatcaa gcccagttta atagggagga
       61 aaaaaaaacc ttttcttctc catgactggg gctaagagct gttctgggac aagcatgtgt
      121 ttcccattaa acactaccag gacaaaatca ggccttacat ccagctgcca tcgcacagca
      181 acattactgg cattgtggaa gtgatccttg gggaaaccaa ggcctatgtc ttctttgaga
      241 aggactttgg ggacatgcac tcctatgtgc gaagccggaa gaggctgcgg gaagaggaag
      301 ccgcccggct cttcaagcag attgtctccg ccgtcgccca ctgccaccag tcagccatcg
      361 tgctggggga cctgaagctt aggaagttcg tcttctccac ggaggagaga acccagctta
      421 gactagaaag tctagaagac acacacataa tgaaggggga agatgatgct ttgtcagaca
      481 aacatggctg cccagcctac gtgagccctg agatcctcaa caccactggg acctactccg
      541 gaaaggctgc ggacgtttgg agcctggggg tgatgctcta cacccttctg gttggacgat
      601 accccttcca tgactcagac cccagtgccc ttttctccaa aattcggcgt ggacagttct
      661 gcattcctga gcacatttcc cccaaagcca ggtgcctcat tcgcagcctc ttgagacggg
      721 agccctccga gagactcact gcccccgaga tcctactgca cccctggttt gagtccgtct
      781 tggaacccgg gtacatcgac tcagaaatag gaacttcaga ccagattgtt ccagagtacc
      841 aggaggacag tgacattagt tccttcttct gctaatcccc aaaacctcag aaacctcata
      901 attcttaaca cctggcattt ccatttctaa agatggacag gccctttggc gtggtaccaa
      961 ccagataatg actgcatcag gatgaaagct gctgaactcg gcatggcgcc tcctcttctc
     1021 tgttgggatg agtgacttta ttgatttgag cagcatatgc tgtgattggc tgccctgcaa
     1081 atttgtttcc cttaaggaac cctcaccaac tatctctgct ggatttggga gttccgcatc
     1141 ttttgtggag ggcagagtat ggacatctta cacccggtgg tcaagtgtgt aataaacttg
     1201 agcattcgaa tgggagaaaa agcaaatcgc acaatgacat attttgagta ataaccgtat
     1261 ttttcacagg gtgacaaatt gggccaataa atctgccatc tttgaactca tctttggtgg
     1321 ctagactgct acggcagctt ctctgatggg aaagttcctt ttttggctta acactcaccc
     1381 tttcttcaca ctcacattta ccaatgactc tgctccgttt ttggagcaga ctgttttaag
     1441 ttgctcagga gcctgatgga accatgaacc gagactcttc tctgtttcct gccaagacct
     1501 catctgcact aatgccttct ccctgacctt gacacttccc cctttagcta taaaagcact
     1561 taccagccga acgtggaaca gtatcacaaa agattccatc tcccaacgat ttcagaactc
     1621 tgagctcaga gagactccag attttaaaaa ataatttgag tgcttggaaa ctattagctt
     1681 tttaagttcc ttccaaatat gttagtacct accctttact ttttccccaa gaccatctca
     1741 gggtggagca ttctgtctaa gagaagaaag ataaggaggc tcccacccac ctctcccaag
     1801 agcagacatt aaacatcttt gtgctttgaa gagagtgaat tttggatagt cttgtgattc
     1861 tcagactaac ttccagaatt atactttaac ccctcccaga tatggtccgc ctttggcatt
     1921 gtgtgtacat ctgcagtttt gcatggtggg ttgttaatat ttcaaatgtg tggtttatga
     1981 atacgtctgt ataatcggct tctggagtga aacagcaaac cccaaatctt caaagttgga
     2041 aggaacttta aaaatcatcc ggtccaatct ctttcctctt tctgccacct cccaaggcag
     2101 aaatcccctc ttcagcttct tttgtaggtg ggaatccagc ctctgttaga tatgtccaga
     2161 gatggaaact cactccccta caaaagatgg agcttaatgg agaaattgca actttcatta
     2221 aaaaacaaat tcagatgaaa tatcagtaac tgtcttggac agtgctgaaa tcaggtggtt
     2281 aaacgggtaa acaaaatata ctgtattttg agaaatggca caaaaacagg cagtcatctt
     2341 taagggctat gcctaggcaa actactaaca tgcattgtga gaatgccgtg tatacctcac
     2401 gtactgtgta ctttgtacat atattttacc ttttatacct atgttcgatt ttgttttgtt
     2461 ttgttttgtt ctggctttga ggcttgtttt gttgtctgtg tctgtctgaa taacctgcgt
     2521 gtctaaaacc acgtgaaatg tgaatgatta ttggcaatat taccttgaca gaatcatggg
     2581 actttgagaa gagggaggac agaggcctct gtcgcactaa cgctctcgtg gttgctcgac
     2641 tgttgtatct gtgatacatt atccgactaa ggactctggg ctggcagggc cttctgccgg
     2701 gaaagctaga aacactaggt tcttcctgta catacgtgta tatatgtgaa cagtgagatg
     2761 gccgtttctg acttgtagag aaattttaat aaacctggtt tcgtaaa
//
