LOCUS       NM_016399               1151 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1),
            mRNA.
ACCESSION   NM_016399
VERSION     NM_016399.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1151)
  AUTHORS   Liu,G., Shi,H., Zheng,H., Kong,W., Cheng,X. and Deng,L.
  TITLE     Circular RNA NFIX Functions as an Oncogene in Non-Small Cell Lung
            Cancer by Modulating the miR-214-3p/TRIAP1 Axis
  JOURNAL   Clin Respir J 18 (8), e13801 (2024)
   PUBMED   39135128
  REMARK    GeneRIF: Circular RNA NFIX Functions as an Oncogene in Non-Small
            Cell Lung Cancer by Modulating the miR-214-3p/TRIAP1 Axis.
REFERENCE   2  (bases 1 to 1151)
  AUTHORS   Pavani,M., Chiroli,E., Cancrini,C., Gross,F., Bonaiuti,P.,
            Villa,S., Giavazzi,F., Matafora,V., Bachi,A., Fava,L.L.,
            Lischetti,T. and Ciliberto,A.
  TITLE     Triap1 upregulation promotes escape from mitotic-slippage-induced
            G1 arrest
  JOURNAL   Cell Rep 42 (3), 112215 (2023)
   PUBMED   36917609
  REMARK    GeneRIF: Triap1 upregulation promotes escape from
            mitotic-slippage-induced G1 arrest.
REFERENCE   3  (bases 1 to 1151)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1151)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1151)
  AUTHORS   Li,D., Huang,Y. and Wang,G.
  TITLE     Circular RNA circPVT1 Contributes to Doxorubicin (DXR) Resistance
            of Osteosarcoma Cells by Regulating TRIAP1 via miR-137
  JOURNAL   Biomed Res Int 2021, 7463867 (2021)
   PUBMED   33981772
  REMARK    GeneRIF: Circular RNA circPVT1 Contributes to Doxorubicin (DXR)
            Resistance of Osteosarcoma Cells by Regulating TRIAP1 via miR-137.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1151)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1151)
  AUTHORS   Felix,R.S., Colleoni,G.W., Caballero,O.L., Yamamoto,M.,
            Almeida,M.S., Andrade,V.C., Chauffaille Mde,L., Silva,W.A. Jr.,
            Begnami,M.D., Soares,F.A., Simpson,A.J., Zago,M.A. and Vettore,A.L.
  TITLE     SAGE analysis highlights the importance of p53csv, ddx5, mapkapk2
            and ranbp2 to multiple myeloma tumorigenesis
  JOURNAL   Cancer Lett 278 (1), 41-48 (2009)
   PUBMED   19171422
  REMARK    GeneRIF: Upregulated in at least 50% of multiple myeloma cases
            tested.
REFERENCE   8  (bases 1 to 1151)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1151)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   10 (bases 1 to 1151)
  AUTHORS   Park,W.R. and Nakamura,Y.
  TITLE     p53CSV, a novel p53-inducible gene involved in the p53-dependent
            cell-survival pathway
  JOURNAL   Cancer Res 65 (4), 1197-1206 (2005)
   PUBMED   15735003
  REMARK    GeneRIF: Under specific conditions of stress, p53 regulates
            transcription of p53CSV and that p53CSV is one of the important
            players in the p53-mediated cell survival.
            GeneRIF: HSPC132 is p53CSV, a novel p53-inducible gene involved in
            the p53-dependent cell-survival pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB141335.1 and U75688.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016399.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002638.2, SRR5189664.88452.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546954.2/ ENSP00000449795.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CB141335.1         29-49
            22-1151             U75688.1           1-1130
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1151
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /note="TP53 regulated inhibitor of apoptosis 1"
                     /db_xref="GeneID:51499"
                     /db_xref="HGNC:HGNC:26937"
                     /db_xref="MIM:614943"
     exon            1..159
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..243
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /note="p53-inducible cell-survival factor; protein 15E1.1;
                     mitochondrial distribution and morphology 35 homolog"
                     /codon_start=1
                     /product="TP53-regulated inhibitor of apoptosis 1"
                     /protein_id="NP_057483.1"
                     /db_xref="CCDS:CCDS9198.1"
                     /db_xref="GeneID:51499"
                     /db_xref="HGNC:HGNC:26937"
                     /db_xref="MIM:614943"
                     /translation="MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRY
                     QQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS"
     exon            160..1151
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1124..1129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1151
                     /gene="TRIAP1"
                     /gene_synonym="HSPC132; MDM35; P53CSV; WF-1"
                     /note="major polyA site"
ORIGIN      
        1 accactgtcg ccatgaacag tgtgggggag gcatgcacgg acatgaagcg cgagtacgac
       61 cagtgcttca atcgctggtt cgccgagaaa tttctcaagg gggacagctc cggggacccg
      121 tgcaccgacc tcttcaagcg ctaccagcag tgtgttcaga aagcaataaa ggagaaagag
      181 attcctattg aaggactgga gttcatgggc catggcaaag aaaagcctga aaattcttct
      241 tgaccttgac agtcaccttg aaggatttcg caagtccaga aattgaggac tctggatttt
      301 tgtcaactaa ctctgtgaac atagccatca gatttgatga ggaacttagg agagaggagt
      361 tttatttcct ccttcgatgt tttcctctca gttgtaaaag atgaactctt tgagatgatt
      421 tctcacctgc tgtggtatct tgcaggaact gtgtgctaaa attgaacaat ttttttgaga
      481 ttatggttgc aatacttggc gtggaatcag ctttacataa atataccttg tatgcaaacg
      541 atgataaact agtcaggatg agcagagctg cctgacctct tgatttctgc tgcaaaagac
      601 atatacactg tactggggtc actatttatg aaagcaattg gttaggacct ctttttttcc
      661 tctcagggaa ctaatgctct gaaaagggat ctgggcacaa cagtttcagt gagtgctttt
      721 gagcacactt ttatttttat atagtaacta atggttaaga ttgatggtgg cctggattag
      781 caaagaggaa gacagctttt aacacagttc cctgccttca caagaggtgt cagattaaga
      841 tgtgaaagct gcaagaatgt tgcagtgaac accatttcag agctctcagt gtgcagttca
      901 ggaattaaga tacttggaat agctgtggag gaagaaccta aattgcaaag atctgctatt
      961 gccagctctc aacccaagtc agtgaattgt caacctgcat atcctaaaaa tgtcaaaatg
     1021 ctgcatctgg ttaaatgtcg gggtaggggg gaagctgaag gtgctcgctt catttgcctt
     1081 gtttactcat cctgccctgt aatgtctgta atcctgaaga tggaataaat tgtaacattt
     1141 agtttctatc a
//
