LOCUS       NM_003301               3694 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens thyrotropin releasing hormone receptor (TRHR), mRNA.
ACCESSION   NM_003301
VERSION     NM_003301.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Matre,V., Hovring,P.I., Orstavik,S., Frengen,E., Rian,E.,
            Velickovic,Z., Murray-McIntosh,R.P. and Gautvik,K.M.
  TITLE     Structural and functional organization of the gene encoding the
            human thyrotropin-releasing hormone receptor
  JOURNAL   J Neurochem 72 (1), 40-50 (1999)
   PUBMED   9886052
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Iwasaki,T., Yamada,M., Satoh,T., Konaka,S., Ren,Y., Hashimoto,K.,
            Kohga,H., Kato,Y. and Mori,M.
  TITLE     Genomic organization and promoter function of the human
            thyrotropin-releasing hormone receptor gene
  JOURNAL   J Biol Chem 271 (36), 22183-22188 (1996)
   PUBMED   8703031
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Yamada,M., Iwasaki,T., Satoh,T., Monden,T., Konaka,S., Murakami,M.,
            Iriuchijima,T. and Mori,M.
  TITLE     Activation of the thyrotropin-releasing hormone (TRH) receptor by a
            direct precursor of TRH, TRH-Gly
  JOURNAL   Neurosci Lett 196 (1-2), 109-112 (1995)
   PUBMED   7501234
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Hinuma,S., Hosoya,M., Ogi,K., Tanaka,H., Nagai,Y. and Onda,H.
  TITLE     Molecular cloning and functional expression of a human
            thyrotropin-releasing hormone (TRH) receptor gene
  JOURNAL   Biochim Biophys Acta 1219 (2), 251-259 (1994)
   PUBMED   7918619
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Morrison,N., Duthie,S.M., Boyd,E., Eidne,K.A. and Connor,J.M.
  TITLE     Assignment of the gene encoding the human thyrotropin-releasing
            hormone receptor to 8q23 by fluorescence in situ hybridization
  JOURNAL   Hum Genet 93 (6), 716-718 (1994)
   PUBMED   8005602
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Yamada,M., Monden,T., Satoh,T., Satoh,N., Murakami,M.,
            Iriuchijima,T., Kakegawa,T. and Mori,M.
  TITLE     Pituitary adenomas of patients with acromegaly express
            thyrotropin-releasing hormone receptor messenger RNA: cloning and
            functional expression of the human thyrotropin-releasing hormone
            receptor gene
  JOURNAL   Biochem Biophys Res Commun 195 (2), 737-745 (1993)
   PUBMED   8396925
REFERENCE   9  (bases 1 to 3694)
  AUTHORS   Duthie,S.M., Taylor,P.L., Anderson,L., Cook,J. and Eidne,K.A.
  TITLE     Cloning and functional characterisation of the human TRH receptor
  JOURNAL   Mol Cell Endocrinol 95 (1-2), R11-R15 (1993)
   PUBMED   8243797
REFERENCE   10 (bases 1 to 3694)
  AUTHORS   Matre,V., Karlsen,H.E., Wright,M.S., Lundell,I., Fjeldheim,A.K.,
            Gabrielsen,O.S., Larhammar,D. and Gautvik,K.M.
  TITLE     Molecular cloning of a functional human thyrotropin-releasing
            hormone receptor
  JOURNAL   Biochem Biophys Res Commun 195 (1), 179-185 (1993)
   PUBMED   8395824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104945.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2019 this sequence version replaced NM_003301.6.
            
            Summary: This gene encodes a G protein-coupled receptor for
            thyrotropin-releasing hormone (TRH). Upon binding to TRH, this
            receptor activates the inositol phospholipid-calcium-protein kinase
            C transduction pathway. Mutations in this gene have been associated
            with generalized thyrotropin-releasing hormone resistance.
            [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: D16845.1, AY493373.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2159931, SAMEA2467143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518632.2/ ENSP00000430711.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AC104945.4         135273-135571       c
            300-1176            AC104945.4         133855-134731       c
            1177-3694           AC104945.4         100591-103108       c
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..3694
                     /gene="TRHR"
                     /gene_synonym="CHNG7; TRH-R"
                     /note="thyrotropin releasing hormone receptor"
                     /db_xref="GeneID:7201"
                     /db_xref="HGNC:HGNC:12299"
                     /db_xref="MIM:188545"
     exon            1..299
                     /gene="TRHR"
                     /gene_synonym="CHNG7; TRH-R"
                     /inference="alignment:Splign:2.1.0"
     exon            300..1176
                     /gene="TRHR"
                     /gene_synonym="CHNG7; TRH-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1584
                     /gene="TRHR"
                     /gene_synonym="CHNG7; TRH-R"
                     /note="thyroliberin receptor"
                     /codon_start=1
                     /product="thyrotropin-releasing hormone receptor"
                     /protein_id="NP_003292.1"
                     /db_xref="CCDS:CCDS6311.1"
                     /db_xref="GeneID:7201"
                     /db_xref="HGNC:HGNC:12299"
                     /db_xref="MIM:188545"
                     /translation="MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNI
                     MVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCIT
                     YLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLW
                     FFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARIL
                     FLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFA
                     LLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKL
                     CNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASE
                     VSFSQS"
     exon            1177..3694
                     /gene="TRHR"
                     /gene_synonym="CHNG7; TRH-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtctctg tgtgtgagag agcgagcgag cgtgtatgtt ctcattaggg gacgatctat
       61 gatttgacag cctcactgct gctgctcctg ctgctgcttc tgcttctgcc gcggctgtat
      121 ggtttgtcat tagttggaaa gggctgtgag ggtttggaga aactgcagtt ttaaagactg
      181 agcactgcta agtggtctcc ctctcaaata gagtagacaa gattttctgc aagattagaa
      241 acttggaact attaccactt catctaccca gaaaatcagg cagcgctaca gaggataagg
      301 gggatggaac tgctgcaata aaggtgggcg ctggaaagaa gatgttttga gaagtcagtg
      361 tttccgagaa actttaagct tctaaagatg gaaaacgaga cagtcagtga actgaaccaa
      421 acacagcttc agccacgagc agtggtggcc ttagaatacc aggtggtcac catcttactt
      481 gtactcatta tttgtggcct gggcattgta ggcaacatca tggtagtcct ggttgtcatg
      541 agaaccaagc acatgaggac ccccacaaac tgctacctgg tgagcctggc agtagctgat
      601 ctcatggtct tggtggccgc aggcctcccc aacataacag acagtatcta cggttcctgg
      661 gtctatggct atgttggatg cctctgcatt acttacctcc agtatttggg aattaatgca
      721 tcctcttgtt caataacagc ctttaccatt gagaggtaca tagcaatctg tcaccccatc
      781 aaagcccagt ttctctgcac attttccaga gccaaaaaga ttatcatctt tgtctgggct
      841 ttcacatctc tttactgtat gctctggttc ttcttgctgg atctcaatat tagcacctac
      901 aaagatgcta ttgtgatatc ctgtggctac aagatctcca ggaattacta ctcacctatt
      961 tacctaatgg actttggtgt cttttatgtt gtgccaatga tcctggctac cgtcctctat
     1021 ggattcatag ctagaatcct tttcttaaat cccattcctt cagatcctaa agaaaactct
     1081 aagacatgga aaaatgattc aacccatcag aacacaaatc tgaatgtaaa tacctctaat
     1141 agatgtttca acagcacagt atcttcaagg aagcaggtca ccaagatgct ggcagtggtt
     1201 gtaattctgt ttgccctttt atggatgccc tacaggactc tagtggttgt caactcattt
     1261 ctctccagtc ctttccaaga aaattggttt ttgctctttt gcagaatttg catttatctc
     1321 aacagtgcca tcaacccggt gatttacaat ctcatgtccc agaaattccg tgcagccttc
     1381 agaaagctct gcaactgcaa gcagaagcca acagagaaac ctgctaacta cagtgtggcc
     1441 ctaaattaca gcgtcatcaa ggagtcagac catttcagca cagagcttga tgatatcact
     1501 gtcactgaca cttacctgtc tgccacaaaa gtgtcttttg atgacacctg cttggcttct
     1561 gaggtatcct ttagccaaag ttgattcatg aattagaaga aaatggatga caaagaaaat
     1621 gagaatctgt gcagtcatca acaaaaggga gaacatggcc aatagtcata tgtgaagaca
     1681 gagcagatca gtctttgtca atgctctaac aaattctggc cctagatact ttaacccatg
     1741 aggatgattc agactttcct tcttacaaac taatatcact aaaaatggag cagatctgtg
     1801 aaatagctaa atgatggaaa cttaaagttt agcccttttc atttaactta agaaattcac
     1861 tatattttct ggacttatag agtttcaata aaatctagac atcaatttac attattcata
     1921 gtaaccttat caaatgtcac ttttcaactt ccctaattta tttatacatt cgataatttg
     1981 acaacatgca gatttttaaa tgtttgcatt tagtattcat tttaacatag tacagggcta
     2041 gttcatgaat atctgaaatt aaagggaaaa atattacaga aacattttat ttattgagta
     2101 aaaataagat tttagacata catgttaact gtattttaaa agttgccata atgtttataa
     2161 aattctgaga tgatttttat atcttagaag gtagataatc atcactcaac tttaatgtaa
     2221 aataaacctc aaaatatctg aaattattaa ttaaggagaa atgtagattt taagataaat
     2281 ccaactctta tcaactcttc cagcctccca catgatgggt ggaaaaaggc aaaagcccag
     2341 attaagtaac tgtgaagata caaactaaca tacaattaaa tttgaaaagt atagtcaaga
     2401 caaagcaagt atttataatt agattttgct tcttctctga cgcttttaag caataaaatc
     2461 tttttgaaca ttcttgttta taaactactc agccatgtca agcaaatcat tcaagcaaaa
     2521 tctagctgaa aagtctgaaa cattcttaaa agctttgttg ttattctaag tcagccaaaa
     2581 tcctggtatc cctcttccag ataaagagct cccactgaga attgtagtct atggatttta
     2641 ccttgactgc aattgtcttt ccttcctatc tgcttgttgt ttgtaggttc tttttttgtt
     2701 tttctcaaat gctagtgata ttttgtttac agattctaaa agcaatgcaa aattctgttg
     2761 gctttatttt cagcagagtt aaaactgatt tcatcatatt atcagtatgt catctttata
     2821 tttatgactg acatctgcta ttccagtgtt tattggagac ttgtgaatga atctgtccag
     2881 gacacttgtc agttcctacc tgaatctctt acctattgag atttggccaa ccagaatctc
     2941 cgagggcaaa aattgccctt ggtgatggtt cagtagtcat tgatttttaa tgagtagatc
     3001 aaaaaagtac ccataccttt acatgcccgt aggctgtcat tttccctctc cagcctatat
     3061 ccctatttta tggacttttc tagaacctaa tcgctaatga taattatgcc tccccatctt
     3121 cttaatgaag aatataccat tcttctgaaa cttgttttta cgtgctgttt catggagact
     3181 atgctatcca gaacctcatt ctagagtgcg cttttttttt tttgaaaatt ggccttatct
     3241 actccagcaa gacattttta tcctgttact ataacagtaa atgaatgcaa gcaaatattt
     3301 gcaggaaata ccctaaaacc ctacctgcat gacagtaagc aatctatgtt aactgacttt
     3361 tcattctggt ataaatatta atcttggcat catataaata gagcaccaga gtgacccaac
     3421 cccaaatcac acaagcacat gtgtgtttat aaacacatac ccacatgttc ataaattggt
     3481 gaaaaagggg attggaatat acgagatttt ttcattacag aaaggaccta atatcattga
     3541 gcatcgacta tgtctcaggt atgctggtag gtagtcaatc aacattatct tcatcacaat
     3601 ttcactacag ctgtaatttc tctgatgatt agaccagtat tcctgtgacc taattcctaa
     3661 ttaataaaaa gttatggatt ttgcagaatg atta
//
