LOCUS       XM_017019244           10138 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens thyrotropin releasing hormone degrading
            enzyme (TRHDE), transcript variant X3, mRNA.
ACCESSION   XM_017019244
VERSION     XM_017019244.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017019244.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..10138
                     /gene="TRHDE"
                     /gene_synonym="PAP-II; PGPEP2; TRH-DE"
                     /note="thyrotropin releasing hormone degrading enzyme;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 26 ESTs, 224 long SRA reads, and
                     98% coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:29953"
                     /db_xref="HGNC:HGNC:30748"
                     /db_xref="MIM:606950"
     CDS             410..2575
                     /gene="TRHDE"
                     /gene_synonym="PAP-II; PGPEP2; TRH-DE"
                     /codon_start=1
                     /product="thyrotropin-releasing hormone-degrading
                     ectoenzyme isoform X3"
                     /protein_id="XP_016874733.1"
                     /db_xref="GeneID:29953"
                     /db_xref="HGNC:HGNC:30748"
                     /db_xref="MIM:606950"
                     /translation="MPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTK
                     SGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAA
                     MENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKE
                     GFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRV
                     FDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG
                     KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSY
                     LWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDL
                     RNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLP
                     WHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHE
                     ELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVW
                     EFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVA
                     RNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNY
                     DGVAAASFSRAVETVEANVRWKMLYQDELFQWLGKALRH"
ORIGIN      
        1 agaagagaag gcattcctga cccaaagagc atcagaagaa aagtccatat aaacttgctt
       61 accttatcac attagagcct gtttgtttgc tgcaggagaa agcaaagggc aagataaaac
      121 ctgaagacac agaagaaaga tgggatcaat aatagaacat ggcttggtga agagaagaga
      181 aactgaggca caagtgttat gtggtcaaga tcatacagct aataggtggc agtctgactc
      241 caagtctgtg cttttcactg ctgtgctatg ccactaaaga ttccttggtg ttactcagtt
      301 ttcgcctaca catgccagaa aggcatttcc ttgttttgat gagccaatct acaaggctac
      361 tttcaaaatc agcatcaagc atcaagcaac ctatttatct ttatctaata tgccagtgga
      421 aacttccgtg tttgaggaag atggatgggt tacggatcac ttttcacaga cccctctcat
      481 gtccacatat tatttagcct gggcaatttg caacttcaca tacagagaaa ctaccaccaa
      541 gagtggggtt gtagtacgat tatatgcaag acctgatgct atcagaagag gatccgggga
      601 ctatgctctc catataacaa agagattaat agaattttat gaagactact ttaaagtgcc
      661 ctattccttg ccaaaactag atcttttagc tgtgcctaag catccgtatg ctgctatgga
      721 gaactgggga ctaagtattt ttgtggaaca aagaatactg ctggatccca gtgtttcatc
      781 tatttcttat ttgctggatg tcaccatggt cattgttcat gagatatgtc accagtggtt
      841 tggtgacctt gtgacgcctg tgtggtggga agacgtgtgg ctgaaggaag ggtttgctca
      901 ctactttgaa tttgttggta cagactacct ctatcctggc tggaacatgg aaaagcagag
      961 gtttctgacc gatgttctgc atgaagtgat gctgctggac ggtttggcca gttcccatcc
     1021 agtatcacag gaagtgctgc aggcaacaga tattgacagg gtgtttgact ggatcgcata
     1081 taaaaagggt gctgctttaa taagaatgct ggctaatttt atgggccatt cagttttcca
     1141 gaggggtttg caagattatt taaccattca taagtatggt aatgcagcca gaaatgatct
     1201 ctggaataca ttatcggagg ctttaaaaag aaatgggaaa tatgtaaata tacaagaagt
     1261 aatggatcag tggacactcc agatgggtta tcctgttatc accatcttgg gaaacacaac
     1321 agcagaaaat agaataataa ttacccaaca gcattttatc tatgatatca gtgctaaaac
     1381 taaagcactt aaacttcaga ataacagtta cctgtggcag attccattaa ctattgtggt
     1441 aggaaataga agccatgtgt cttcagaagc aattatttgg gtgtctaaca aatcagagca
     1501 ccacagaata acttatttgg acaaaggaag ctggctgctg gggaacatca atcaaactgg
     1561 ctattttaga gtcaactatg acctaaggaa ctggagatta ttaattgatc aattaatccg
     1621 gaatcatgag gttctttctg tcagtaaccg agcgggcttg atcgatgatg ccttcagcct
     1681 agccagggct ggctatttgc ctcagaatat tcctctggag attatcagat acctgtctga
     1741 ggagaaggat tttcttcctt ggcatgctgc cagccgagct ctttatcctc tagataaatt
     1801 actggaccgc atggaaaact acaacatttt caatgaatat attttaaagc aagttgcaac
     1861 aacatatatc aagcttgggt ggccgaaaaa taattttaat ggatctcttg ttcaagcatc
     1921 ctaccaacat gaagaactac gtagagaagt tataatgctg gcctgcagtt ttggcaacaa
     1981 gcactgtcac caacaggcat caacacttat ttcagattgg atttccagca acaggaacag
     2041 aataccacta aatgttagag acatcgtata ctgtacagga gtgtcactac tggatgagga
     2101 tgtctgggaa ttcatatgga tgaaattcca ttccaccaca gcagtttctg agaagaaaat
     2161 attattggaa gccttaactt gcagtgatga caggaattta ttaaacaggc ttctaaatct
     2221 gtcactgaat tctgaggtgg tgctggatca agatgcaatt gatgtcataa tccatgtagc
     2281 tcgaaatcca catggtcgag accttgcctg gaagtttttc agggataaat ggaagatatt
     2341 aaataccagg tatggagaag cattgtttat gaattccaaa ctcatcagtg gtgtcacaga
     2401 atttcttaat actgaaggtg aactcaaaga gctcaagaac ttcatgaaaa actatgatgg
     2461 ggtagctgct gcttctttct cacgagctgt ggaaactgtc gaagccaatg tgcgctggaa
     2521 aatgctttac caagacgagc ttttccaatg gttaggaaaa gctctaagac actaatatat
     2581 gtatcttata aacaaacaat tcaactcaga agtttatgag aagacacgct ttttgtggaa
     2641 tgaggaaaat gtactaccta gaaaatggcc agattttcag tgttaacgtg tgggaggaat
     2701 ttttttttta gtttttattt tttggttttg ggggatattt tttatttgtt tcattcattc
     2761 tgttctgttt ctctactggg tgttcctctc taaagaaact cttgcaagtg aaactagcca
     2821 tgattgcttc agctgtacat tccttgctgt acaggaccaa atatgatagt gatgcatgtt
     2881 gatgttacag tcaatttgga aaaacatatt cagaatatct gtgcatggat atattgtcct
     2941 gcctgtgttc cagcatgctt atttcaaacg tccagtgttg tgtgtgaata tgtgttacac
     3001 ctaggatggg cattatgcaa aagcacaaag attatatatg acaatcagta ttgcaatgaa
     3061 agaaaaacta aaaacagaaa tgatattctc aattttgggc aatgtgagag gtaaaatagc
     3121 ccttgacatg atgaacatca cttatttcag cacttggatt gtctggcaat gattactgtg
     3181 ttgctaactc attttctttg agttaaagct gtgtatacat tttaaaaggc atatagatag
     3241 tgtatgcata tgtatatgta catagggaag ccccatatgt atatagtatg ttgtacactg
     3301 cacatgtaca aagaatgtct tcagatcaaa gaaaatttat ctctttttat aaacttaagg
     3361 acagttgcaa aaggcttcaa ggaatttatc tcaacattat tctttctatg tcctaactaa
     3421 atttctcaac tgttatgaat ttttcatcta cttcttgaac agtggtctat tctgctacat
     3481 gaagatgaat acaaacaaaa tttttgtata aactactatt ccagttctcc tgtgtcagtc
     3541 ttgcctatag attttgccat cgttttctgt caaagttcct tttgcatgaa acaattatgc
     3601 aaacttataa ttattagtgc tgaaaaagag tttattttcc atcttgtttg ttttcctacc
     3661 ttatgctgag tagtccagag agttaaaaaa attctctgca tgttggtctt ttaagtctgt
     3721 tttgctctaa tcctccatta agcgagcata cctcaagtgg gtctattagc atttaatgac
     3781 cttttgtgcc agttgtgcca tcccttaaga tgaaaagttc cttttcttgt gttaatgtac
     3841 aaagcttttc ttttggcact gacaactgtg ttctacctgg gaattttgaa tagccatttt
     3901 catggctgtg tgttgtgtaa cacaaatgtt tttaaatggt attctcaccc agtaggccag
     3961 ctctccaaac gttgcttaga tgcttcaaaa ttagcatatt ttaagtttac cagtataaaa
     4021 taccaatgca actactctac atagccaaat gtttgtaaat cacgtcttat tttcctgagg
     4081 tttttcactc caccaaatct tacaaatcat tgaaagaaat atattctaac agtacgcact
     4141 gaatagtgaa aataattaga cattttaaga accagagcca tagaattatt ttaaattagt
     4201 agaaaagagg agctatttcc gaatctatag aataaagtac cacctaaaac tgaattttat
     4261 catataagca agtaatacct attagtcata cctaaatttt tcagcacttc attcaattaa
     4321 aatacatgaa ttttaaatat tttacatgat gtgaataggc atgataatac ttttagtata
     4381 aaatctaaac tttttccatt tatcagaaat gataaaatcc agttaccaca tatcacgttt
     4441 ataaaatcct taattaaatg agtaacttct aaaatataac aatactaaat atcacactgc
     4501 gatggaggtc ccaaatatgt ggtctatcac cactgaattc atgtaataga taagaaaaaa
     4561 attagaggtg gatgtcttgt tttgtgtcat gaattactaa aatctcttag tagttgtggt
     4621 atatttttga gtaaaattac catttccaga tttgagtttg aagggctttt atagttgtat
     4681 tttcctcctc actgttaata atcataatcc tttttcagta ttttagtggc cttgaacaac
     4741 tggtttatct acaatctcaa atcctaagtg tataattatg tgcaatgttc aatacctcat
     4801 ataatacttg ctcaacagta tagtggtacc aatggcatta agatggtgtt tttgttctac
     4861 atatttttca ataatttatt ctttctaatg ttgaaattat atcaggcttt accggttttt
     4921 ttagttgttt aaataagtaa tattttcaaa agaataaaat aaccaatgat atctcttgga
     4981 ataatctgta aaacgtagtt ataaaattct attttctact tagagttttt atcttttctt
     5041 ttttgtcggc tttacaaatt atatgtatgc atgaaataac taactgttga aagtgtccaa
     5101 cctccagcca tagcaatttg ctgtgccaat atgtgtacaa aaaagtagtt tcaattagaa
     5161 aggacaacat tatttatcac attgagtatt aaacatttcc aggtaactcg taaataaaaa
     5221 gatttcccca tttttacaca ttttttctta aaatttttct ataatctttg aagtttctaa
     5281 aatacacaat ctcaacctct aagactaaca tctacaatac taggtctatt cttgagtttc
     5341 aataacatgt attttagttg ggtcataaac ttgcattatt ttatattatc tccaggacaa
     5401 ttatatcata ggactaagat ttttgtgata gtattattta caaatattat aagtataata
     5461 tcttgtgagg ctattattaa ggttatgcca tgtattgata aaatgcattg ctttctcaaa
     5521 gaactgttac acattttgtt ttatttgact catcacaaaa acataataaa tgttgtgagc
     5581 cctaatattc tgatgagaaa actggggctc aggtagcaac atgagctatt taaaactaca
     5641 aaatagggct gggcacagtg gctcatgcct gtaatcccag cactttggga ggctgagggt
     5701 gggaggatca cttgagccca ggggtttgag accagtctgg gaaacatatt gaggccccat
     5761 ttctataaaa ataaaaatga aaactagcca ggcatggtgg tgtgcacctg ttgtcccagc
     5821 tactggggag gctgaggtgg gagaattatt taagtccaaa agttcagtgc tctagtgagc
     5881 tatgatcact gtactccagc ctgggtgaca gagtgagatc ctgtctctaa aaaaataaaa
     5941 taaaatcaca atgtttgttg ttattttggg aaccaatata acaacctaag tctatcacaa
     6001 catcattccc caactaaaat ataaatatat gttgaaaata tctctatcga ttgcattaat
     6061 tggagatttt ccaaatacta gaccagcatc aaaatacaca gttaaatata tttgcaataa
     6121 ttccattgtt tgttaacttt tgcatttcta atttgcagga tgttaaacaa ctggatgaaa
     6181 tgttatgatt taatttggtc agtataaata atcaaatatt gggacaaata atttaattca
     6241 tttagtttat taattatatt tcctgtctgt atcttttatt gaacattgtt taaacataac
     6301 cttaaagtac tgataatttg cttaattttc aacacaaatt tatctgacaa attctgtcta
     6361 tagtaacaga tggtcagaat gcagataaat tgtgtgcatc tcaatcagta aaaataatat
     6421 tcagtaaaat gtctataaat ctatgcagat taagttgtga aaaacaatgc aattttagta
     6481 ctactggatt agatgcagta aaggaatccc taaggaagtt tacaataata tatttaatta
     6541 aaatctactg gcaattagaa ttttaaggaa ttcttttcta agaagttgga gaacctaaaa
     6601 tagcttgctt attcgcctgg gtactctcat gaagtaacca tgtacaccta ataaagaaat
     6661 agtaaaagca catataatga aaaataatta agatttctta cacctgattt tttcattatc
     6721 agagataatt atcagagata atttttcatt atcagagatc atagctgaat tatcatttga
     6781 caatacataa gaatatatat tgtatagata caatatataa ctatacttaa agaaatattt
     6841 attgagcatc ttttatttca caaggcactt agtgagggaa aggaatacag agatgaatat
     6901 ggcctgaagg aatgaactca tattacaata aatgaaaaag aaaaagaaat aatgaaccaa
     6961 gggaatgagg gcaacaggaa aaataattcc ttgctacaga cgggaagtca atcattttta
     7021 ggtatacata atattataca actatttttg tacactagtt ctcaaaacat ttatgatacc
     7081 tagtataatt tttattgttt gatttcctag tgcttacttg tgttttacag aaatatgtta
     7141 cattttgaaa ttataataaa ataatagagt ttaaactcta ataattggaa tataaattgg
     7201 gatggaattt atccttaaga aaagctgttt aaacaattta gtagtattag taagttgcag
     7261 gaatacttta atctacttac gaaaaagtag ttcaagtttt ctaaaatggt ttcagcatac
     7321 tatcggtatc tcacaatgtg ttaattttaa gttaattata tattctttaa agcagattaa
     7381 ataatacttg tcctaagcat aatttatttg ttgaaattag tatatgtgaa cttatgaaaa
     7441 aatgttcttg taaattattc tagaatccca aattttaatt atataagaac aaccttttgt
     7501 tcaattgctt tgaactaatg atgaagtttt ttaaaatatt aagtatttta tttaatgtga
     7561 tatagattca ggaaaagtct aacaaaaatg tacttcagta gttttatttt tattttgtga
     7621 aattttattt taaagtttag gtaaggaaag tttttaaact gtcttaaata tttaataaaa
     7681 gcagttgtta aaaatatatg ttctaatgtt aactatatga catatatgcc attgcatgca
     7741 ttttgttttt taaataggtt tttcaccact ggccccacta gtagatgatt ttaccccaga
     7801 ttttgaaaac ataccacttt aatggccttt atttcaaata cttcgtactt tagggatagt
     7861 attttgaaga tgtttatctt ttgtacattc ctagttcatt tattaatgta ctaagaaaaa
     7921 gaaaacaaaa tgactgattc ttttgttttg aattaaatgt ttgtgctgta ttaatgttaa
     7981 gtgagttaag ataaagggaa gctacaaaaa tttgaatgcc tactaaatgc taggcacttt
     8041 ataggtgtct tctaatatat gtctattggt atcacatcaa ttaataaccc tgtgaaatgt
     8101 cattagctct aattcaccaa agagtagatg gaggcagagt tgttatcagt ttacataatt
     8161 aattagtggt attcacttgg attcaaaact ctgcaaactg aagccttata tagctcaaac
     8221 tagtcattaa tctgccctca gcatgtatga aaacataatg tttatccgta cagaccattc
     8281 tctatagcag atttgaatag gtacttagca cactttatca ttgtcactgg ctctttcgaa
     8341 agaagtatta atttgtgcat tctggtttac cattcatttc ttaacaaagt tgctttatac
     8401 gttccataaa aagttttcat gaaaacattt tacattagca tgttgtgtag tgggttttaa
     8461 gttataacag gtaattaaca gatatttcgg ccaacgagac acacacacac atgaaaaaaa
     8521 taagtgaaaa gacagaataa attgcaaagg ttttacgagt ggaccacaaa gttaaggtta
     8581 aacttctgtc tttgcatgtg gaggagacat attagtctag ccagaacttt ccttttgctt
     8641 agcagtgagg tcagagaagt atctctgtca ttctgcttag aagtatacat ggactgcaat
     8701 tgcttaattt acttaaactt aacattttca atgggtttgc tgtgtgaaga tacagtctaa
     8761 gataagtgct ttgacttgcc tctgcagagg tcaacttatt tctcatcaca cacatttttc
     8821 ttatgtcata taagtaaagg aaagagtgaa acgttttata gaaaatatta cagtggagtt
     8881 aagaacatct gcctcaaatg tacagtgcat ttacttttta agttaatcat ttagtagcta
     8941 cccttttaac ctctactatg ttcacagtat tgcatttgct cttgtaaaca attttgttcc
     9001 cacctttaca tagcgtatga cctactcagt gagaacattc attattaagt ttttgctatt
     9061 aattttcatt taaaataggt ttattaacta gcaaatctca aatgcaaaac atttttgagt
     9121 gaatttttcc tcaaatgttg tattctacct ttcaaaatat tgtgtaacag caattccaca
     9181 ttatcctttt gaatgctacc tatatattgc cacatataaa gatatttttc atttttcatt
     9241 tttcattgct atcttttaat ccctttgcat tttgataata tcgaaaacag attagggctg
     9301 aaaaactaaa aaagattagg gcttgtatta tgcattgtct agttacttga acaataagag
     9361 aaattctatc tttgagcttt cataattggc tttctggaca ccactgagtt tattagataa
     9421 tctttaaaaa tattatgaac tattttgagt ggacctaaat ttattcagta ataaagttta
     9481 ctttcctaaa tccattcccc aagtgaacag gcttatttaa aatatgtcat ataaaagcac
     9541 ttttcctttc taacatttta tgatttagga attaaaaagt agctgttctt tcagtaaata
     9601 agtgttaata aagcagtgac caaataaata accttttgtt agtttagcag ataaatgttt
     9661 tcaatgtatg cctttaaaat tattcagtaa aaattgaatt agtacgtatt caacatgaaa
     9721 tttttagtct tttctgacca agcactaata aaattgattt ccctaaatga gaaaatttgt
     9781 cttctgtatt ttaagcagaa aaaatatgaa ttctgcctct gataatcaaa ttttgtacag
     9841 caatgtgtaa tgtgtcacaa tttaaaaagt tttaattttc tgacatgcag ataaggccaa
     9901 aataaataat accatctgtt tttttcactt gaaaatacat ttttaaaatt ttgagtatat
     9961 atattataga ggtccatgca aatggaaaaa aattattctc ttctgacatg gactttttca
    10021 tgactataca catgctgagg ctagaataaa aacatatatt tgtgctatat tgtaaaaata
    10081 aaaacaattt gttctccttt ctaattatat gcctttagaa taaatgaaat gatctgca
//
