LOCUS       NM_007117               1560 bp    mRNA    linear   PRI 06-NOV-2022
DEFINITION  Homo sapiens thyrotropin releasing hormone (TRH), mRNA.
ACCESSION   NM_007117
VERSION     NM_007117.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Gao Y, Zhou JF, Mao JY, Jiang L and Li XP.
  TITLE     Identification of the Thyrotropin-Releasing Hormone (TRH) as a
            Novel Biomarker in the Prognosis for Acute Myeloid Leukemia
  JOURNAL   Biomolecules 12 (10), 1359 (2022)
   PUBMED   36291567
  REMARK    GeneRIF: Identification of the Thyrotropin-Releasing Hormone (TRH)
            as a Novel Biomarker in the Prognosis for Acute Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Kent NL, Young SL, Akison LK and Cuffe JSM.
  TITLE     Is the link between elevated TSH and gestational diabetes mellitus
            dependant on diagnostic criteria and thyroid antibody status: a
            systematic review and meta-analysis
  JOURNAL   Endocrine 74 (1), 38-49 (2021)
   PUBMED   33991314
  REMARK    GeneRIF: Is the link between elevated TSH and gestational diabetes
            mellitus dependant on diagnostic criteria and thyroid antibody
            status: a systematic review and meta-analysis.
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Puttipanyalears C, Arayataweegool A, Chalertpet K, Rattanachayoto
            P, Mahattanasakul P, Tangjaturonsasme N, Kerekhanjanarong V,
            Mutirangura A and Kitkumthorn N.
  TITLE     TRH site-specific methylation in oral and oropharyngeal squamous
            cell carcinoma
  JOURNAL   BMC Cancer 18 (1), 786 (2018)
   PUBMED   30081853
  REMARK    GeneRIF: cg01009664 of TRH as a potential biomarker for oral
            squamous cell carcinoma and oropharyngeal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Brejchova J, Sykora J, Ostasov P, Merta L, Roubalova L, Janacek J,
            Hof M and Svoboda P.
  TITLE     TRH-receptor mobility and function in intact and
            cholesterol-depleted plasma membrane of HEK293 cells stably
            expressing TRH-R-eGFP
  JOURNAL   Biochim Biophys Acta 1848 (3), 781-796 (2015)
   PUBMED   25485475
  REMARK    GeneRIF: Data indicate that decrease of cholesterol level impaired
            the functional coupling between the thyrotropin-releasing hormone
            receptor and the cognate G proteins.
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Nillni EA.
  TITLE     Regulation of the hypothalamic thyrotropin releasing hormone (TRH)
            neuron by neuronal and peripheral inputs
  JOURNAL   Front Neuroendocrinol 31 (2), 134-156 (2010)
   PUBMED   20074584
  REMARK    Review article
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Yamada M, Iwasaki T, Satoh T, Monden T, Konaka S, Murakami M,
            Iriuchijima T and Mori M.
  TITLE     Activation of the thyrotropin-releasing hormone (TRH) receptor by a
            direct precursor of TRH, TRH-Gly
  JOURNAL   Neurosci Lett 196 (1-2), 109-112 (1995)
   PUBMED   7501234
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Pekary AE, Gwirtsman H, Tourtellotte WW, Smith VP and Hershman JM.
  TITLE     High levels of thyrotropin-releasing hormone precursor peptide
            immunoreactivity and binding substance occur in human cerebrospinal
            fluid
  JOURNAL   Neuroendocrinology 53 (3), 246-252 (1991)
   PUBMED   1904138
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Yamada M, Wondisford FE, Radovick S, Nakayama Y, Weintraub BD and
            Wilber JF.
  TITLE     Assignment of human preprothyrotropin-releasing hormone (TRH) gene
            to chromosome 3
  JOURNAL   Somat Cell Mol Genet 17 (1), 97-100 (1991)
   PUBMED   1900134
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Yamada M, Radovick S, Wondisford FE, Nakayama Y, Weintraub BD and
            Wilber JF.
  TITLE     Cloning and structure of human genomic DNA and hypothalamic cDNA
            encoding human prepro thyrotropin-releasing hormone
  JOURNAL   Mol Endocrinol 4 (4), 551-556 (1990)
   PUBMED   2126343
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313473.1 and AC083906.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007117.4.
            
            Summary: This gene encodes a member of the thyrotropin-releasing
            hormone family. Cleavage of the encoded proprotein releases mature
            thyrotropin-releasing hormone, which is a tripeptide hypothalamic
            regulatory hormone. The human proprotein contains six
            thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing
            hormone is involved in the regulation and release of
            thyroid-stimulating hormone, as well as prolactin. Deficiency of
            this hormone has been associated with hypothalamic hypothyroidism.
            [provided by RefSeq, May 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110515.2, AK313473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302649.4/ ENSP00000303452.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AK313473.1         54-788
            736-1560            AC083906.23        130564-131388       c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..1560
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /note="thyrotropin releasing hormone"
                     /db_xref="GeneID:7200"
                     /db_xref="HGNC:HGNC:12298"
                     /db_xref="MIM:613879"
     exon            1..104
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /inference="alignment:Splign:2.1.0"
     exon            105..323
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..841
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /note="prothyroliberin; protirelin; TSH-releasing factor;
                     thyrotropin-releasing factor; pro-thyrotropin-releasing
                     hormone"
                     /codon_start=1
                     /product="thyrotropin releasing hormone preproprotein"
                     /protein_id="NP_009048.1"
                     /db_xref="CCDS:CCDS3066.1"
                     /db_xref="GeneID:7200"
                     /db_xref="HGNC:HGNC:12298"
                     /db_xref="MIM:613879"
                     /translation="MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDD
                     FLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEEEE
                     EEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLAD
                     PKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQGAYGQAGLLLGLLDDLSR
                     SQGAEEKRQHPGRRAAWVREPLEE"
     exon            324..1560
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="TRH"
                     /gene_synonym="Pro-TRH; TRF"
                     /note="major polyA site"
ORIGIN      
        1 cggcaggcgc ccggggtcct cagcgctgca gactcctgac ctgccgactg cggatcccga
       61 gtccccggat cccggaccca tcctgtggag cccactcctg gcagacgccg cgatgcccgg
      121 cccttggttg ctgctcgctc tggctttgac cctgaacctg accggtgtcc ccggcggccg
      181 tgctcagcca gaggcggccc agcaggaggc agtgacggcc gcggagcatc cgggcctgga
      241 tgacttcctg cgccaggtgg agcgcctcct cttcctccgg gaaaacatcc agcggctgca
      301 aggggaccag ggtgagcact ccgcgtccca gatctttcaa tctgactggc tctccaaacg
      361 tcagcatcca ggcaaaagag aggaggagga ggaagaggga gttgaagaag aggaagagga
      421 agaagggggg gctgtgggac cccacaaacg gcagcaccct ggccgacgag aagatgaggc
      481 ttcatggtca gtcgatgtaa cccagcacaa gcggcagcat cctggccggc gctccccctg
      541 gcttgcatat gctgtcccga agcggcagca cccaggcaga aggctggcag atcccaaggc
      601 tcaaaggagc tgggaagaag aggaggagga ggaagagaga gaggaagacc tgatgcctga
      661 aaaacgccag catccgggca agagggccct gggaggcccc tgtgggcccc agggagccta
      721 tggtcaagcg ggccttctgc tggggctcct ggatgacctg agtaggagcc agggagctga
      781 ggaaaagcgg cagcaccctg gtcggcgggc agcctgggtc agagagcccc tggaggagtg
      841 aacccagttt tccctgaagt cgagtttgtg gtctaaggat gtcttgagcc ctgtgtgccc
      901 caccattcat gacctctgta ttctctagtt agatccctga ccataagcct gagcccctcc
      961 ctcccagccc catattcaca cacatcccag cccctggcct tgccctcttc ctttaggcat
     1021 gtgagaaaat cagcctagca gtttaaaccc cactttcctc cacttagcac cataggcaag
     1081 ggggcagatc ccagagcccc tctcaccccc cccaccacag gcctgctcct tccttagcct
     1141 tggctaagat ggtccttctg tgtcttgcaa agactcccca agtgggacag ggagcccctg
     1201 ggagggcagc cagtgagggt ggggtgggac tgaagcgttg tgtgcaaatc cagcttccat
     1261 cccctcccca acctggcagg attctccatg tgtaaacttc acccccagga cccaggatct
     1321 tctcctttct gggcatccct ttgtgggtgg gcagagccct gacccacagc tgtgttactg
     1381 cttggagaag catatgtagg ggcataccct gtggtgttgt gctgtgtctg gctgtgggat
     1441 aaatgtgtgt gggaatattg aaacatcgcc taggaattgt ggtttgtata taaccctcta
     1501 agcccctatc ccttgtcgat gacagtcatc ctaatgataa taaaacctgc atccagataa
//
