LOCUS       NM_080701               1071 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens three prime repair exonuclease 2 (TREX2), mRNA.
ACCESSION   NM_080701 NM_007205
VERSION     NM_080701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1071)
  AUTHORS   Kurshakova,M.M., Georgieva,S.G. and Kopytova,D.V.
  TITLE     The Human TREX-2 Complex Interacts with Subunits of the ORC Complex
  JOURNAL   Dokl Biochem Biophys 513 (1), 346-349 (2023)
   PUBMED   38066323
  REMARK    GeneRIF: The Human TREX-2 Complex Interacts with Subunits of the
            ORC Complex.
REFERENCE   2  (bases 1 to 1071)
  AUTHORS   Ko,J.H., Son,M.Y., Zhou,Q., Molnarova,L., Song,L., Mlcouskova,J.,
            Jekabsons,A., Montagna,C., Krejci,L. and Hasty,P.
  TITLE     TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced
            Replication Fork Defects in Cells Expressing RAD51K133A
  JOURNAL   Cell Rep 33 (12), 108543 (2020)
   PUBMED   33357432
  REMARK    GeneRIF: TREX2 Exonuclease Causes Spontaneous Mutations and
            Stress-Induced Replication Fork Defects in Cells Expressing
            RAD51(K133A).
REFERENCE   3  (bases 1 to 1071)
  AUTHORS   Aksenova,V., Smith,A., Lee,H., Bhat,P., Esnault,C., Chen,S.,
            Iben,J., Kaufhold,R., Yau,K.C., Echeverria,C., Fontoura,B.,
            Arnaoutov,A. and Dasso,M.
  TITLE     Nucleoporin TPR is an integral component of the TREX-2 mRNA export
            pathway
  JOURNAL   Nat Commun 11 (1), 4577 (2020)
   PUBMED   32917881
  REMARK    GeneRIF: Nucleoporin TPR is an integral component of the TREX-2
            mRNA export pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1071)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1071)
  AUTHORS   Chen,M.J., Ma,S.M., Dumitrache,L.C. and Hasty,P.
  TITLE     Biochemical and cellular characteristics of the 3' -> 5'
            exonuclease TREX2
  JOURNAL   Nucleic Acids Res 35 (8), 2682-2694 (2007)
   PUBMED   17426129
  REMARK    GeneRIF: Results suggest that TREX2 plays an important function
            during DNA metabolism and cellular proliferation.
REFERENCE   6  (bases 1 to 1071)
  AUTHORS   Perrino,F.W., Krol,A., Harvey,S., Zheng,S.L., Horita,D.A.,
            Hollis,T., Meyers,D.A., Isaacs,W.B. and Xu,J.
  TITLE     Sequence variants in the 3'-->5' deoxyribonuclease TREX2:
            identification in a genetic screen and effects on catalysis by the
            recombinant proteins
  JOURNAL   Adv Enzyme Regul 44, 37-49 (2004)
   PUBMED   15581481
  REMARK    GeneRIF: Polymorphisms exist in prostatic cancer patients.
REFERENCE   7  (bases 1 to 1071)
  AUTHORS   Shevelev,I.V., Ramadan,K. and Hubscher,U.
  TITLE     The TREX2 3'-->5' exonuclease physically interacts with DNA
            polymerase delta and increases its accuracy
  JOURNAL   ScientificWorldJournal 2, 275-281 (2002)
   PUBMED   12806015
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1071)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases.
            Characterization of the recombinant proteins
  JOURNAL   J Biol Chem 276 (20), 17022-17029 (2001)
   PUBMED   11279105
REFERENCE   9  (bases 1 to 1071)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Structure and expression of the TREX1 and TREX2 3' --> 5'
            exonuclease genes
  JOURNAL   J Biol Chem 276 (18), 14718-14727 (2001)
   PUBMED   11278605
REFERENCE   10 (bases 1 to 1071)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Identification and expression of the TREX1 and TREX2 cDNA sequences
            encoding mammalian 3'-->5' exonucleases
  JOURNAL   J Biol Chem 274 (28), 19655-19660 (1999)
   PUBMED   10391904
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U82695.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 2, 2020 this sequence version replaced NM_080701.3.
            
            Summary: This gene encodes a nuclear protein with 3' to 5'
            exonuclease activity. The encoded protein participates in
            double-stranded DNA break repair, and may interact with DNA
            polymerase delta. [provided by RefSeq, Nov 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370231.3/ ENSP00000359251.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                U82695.3           50746-50793         c
            49-1071             U82695.3           49210-50232         c
FEATURES             Location/Qualifiers
     source          1..1071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1071
                     /gene="TREX2"
                     /note="three prime repair exonuclease 2"
                     /db_xref="GeneID:11219"
                     /db_xref="HGNC:HGNC:12270"
                     /db_xref="MIM:300370"
     exon            1..48
                     /gene="TREX2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..1071
                     /gene="TREX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..824
                     /gene="TREX2"
                     /EC_number="3.1.11.2"
                     /note="3'-5' exonuclease TREX2 long form"
                     /codon_start=1
                     /product="three prime repair exonuclease 2"
                     /protein_id="NP_542432.2"
                     /db_xref="CCDS:CCDS35437.1"
                     /db_xref="GeneID:11219"
                     /db_xref="HGNC:HGNC:12270"
                     /db_xref="MIM:300370"
                     /translation="MSEAPRAETFVFLDLEATGLPSVEPEIAELSLFAVHRSSLENPE
                     HDESGALVLPRVLDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGFDGAVVRTLQ
                     AFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGARLPRDTVCLDTLPALRGLDRAHSH
                     GTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTLLLIFLHRAAELLAWADEQARG
                     WAHIEPMYLPPDDPSLEA"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREX2"
                     /note="hexamer: AATAAA"
     polyA_site      1071
                     /gene="TREX2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgacaggt gcccagaagc ccaggaagcc ggtcagtgcc cgccccagtc ctcagggttt
       61 gtgcctctcg ctcggacagt ttgaggactt gctatccccg tgggaacatc accatgtccg
      121 aggcaccccg ggccgagacc tttgtcttcc tggacctgga agccactggg ctccccagtg
      181 tggagcccga gattgccgag ctgtccctct ttgctgtcca ccgctcctcc ctggagaacc
      241 cggagcacga cgagtctggt gccctagtat tgccccgggt cctggacaag ctcacgctgt
      301 gcatgtgccc ggagcgcccc ttcactgcca aggccagcga gatcaccggc ctgagcagtg
      361 agggcctggc gcgatgccgg aaggctggct ttgatggcgc cgtggtgcgg acgctgcagg
      421 ccttcctgag ccgccaggca gggcccatct gccttgtggc ccacaatggc tttgattatg
      481 atttccccct gctgtgtgcc gagctgcggc gcctgggtgc ccgcctgccc cgggacactg
      541 tctgcctgga cacgctgccg gccctgcggg gcctggaccg cgcccacagc cacggcaccc
      601 gggcccgggg ccgccagggt tacagcctcg gcagcctctt ccaccgctac ttccgggcag
      661 agccaagcgc agcccactca gccgagggcg acgtgcacac cctgctcctg atcttcctgc
      721 accgcgccgc agagctgctc gcctgggccg atgagcaggc ccgtgggtgg gcccacatcg
      781 agcccatgta cttgccgcct gatgacccca gcctggaggc ctgagcacca gggccacctc
      841 ctgtgccatg gacagtgcca gcctccaccg ttcagctggc ctctaccacc cccggctcct
      901 cctatctggg cagcctcagg tccgtgcacc tgccaggcct tccctggctg cctgaccagc
      961 catacggccc tggattcctc tccaggcccc gcttccaggg ccgtgctctc ccggctggcc
     1021 tgggtgccca gcagagtttg ctgtttccca ataaacattg ccaactactc a
//
