LOCUS       NM_001395490            7844 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens transcriptional regulating factor 1 (TRERF1),
            transcript variant 5, mRNA.
ACCESSION   NM_001395490
VERSION     NM_001395490.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7844)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 7844)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 7844)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7844)
  AUTHORS   Cao,B., Zeng,Y., Wu,F., Liu,J., Shuang,Z., Xu,X. and Guo,J.
  TITLE     Novel TRERF1 mutations in Chinese patients with ovarian
            endometriosis
  JOURNAL   Mol Med Rep 17 (4), 5435-5439 (2018)
   PUBMED   29393434
  REMARK    GeneRIF: the present study was the first to identify 2 novel,
            potentially 'diseasecausing' TRERF1 somatic mutations in the
            endometriotic lesions in 2 out of 92 patients with ovarian
            endometriosis; therefore, TRERF1 mutations may be involved in the
            pathogenesis of ovarian endometriosis.
REFERENCE   5  (bases 1 to 7844)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 7844)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 7844)
  AUTHORS   Gizard,F., El-Alfy,M., Duguay,Y., Lavallee,B., DeWitte,F.,
            Staels,B., Beatty,B.G. and Hum,D.W.
  TITLE     Function of the transcriptional regulating protein of 132 kDa
            (TReP-132) on human P450scc gene expression
  JOURNAL   Endocr Res 28 (4), 559-574 (2002)
   PUBMED   12530663
  REMARK    GeneRIF: TReP-132 interacts with steroidogenic factor-1 (SF-1)
            through specific domains; and along with the interaction with
            CBP/p300 these factors are postulated to form a complex to regulate
            expression of the P450scc gene.
REFERENCE   8  (bases 1 to 7844)
  AUTHORS   Gizard,F., Lavallee,B., DeWitte,F., Teissier,E., Staels,B. and
            Hum,D.W.
  TITLE     The transcriptional regulating protein of 132 kDa (TReP-132)
            enhances P450scc gene transcription through interaction with
            steroidogenic factor-1 in human adrenal cells
  JOURNAL   J Biol Chem 277 (42), 39144-39155 (2002)
   PUBMED   12101186
  REMARK    GeneRIF: TReP-132 plays a role in regulating p450scc expression
            with steroidogenic factor-1 and CBP/p300
REFERENCE   9  (bases 1 to 7844)
  AUTHORS   Gizard,F., Lavallee,B., DeWitte,F. and Hum,D.W.
  TITLE     A novel zinc finger protein TReP-132 interacts with CBP/p300 to
            regulate human CYP11A1 gene expression
  JOURNAL   J Biol Chem 276 (36), 33881-33892 (2001)
   PUBMED   11349124
REFERENCE   10 (bases 1 to 7844)
  AUTHORS   Dorssers,L.C. and Veldscholte,J.
  TITLE     Identification of a novel breast-cancer-anti-estrogen-resistance
            (BCAR2) locus by cell-fusion-mediated gene transfer in human
            breast-cancer cells
  JOURNAL   Int J Cancer 72 (4), 700-705 (1997)
   PUBMED   9259413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450325.5, AL138735.7 and
            AL096814.26.
            
            Summary: This gene encodes a zinc-finger transcriptional regulating
            protein which interacts with CBP/p300 to regulate the human gene
            CYP11A1. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.449511.1,
                                           SRR14038196.2007708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695948.1/ ENSP00000512293.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AL450325.5         68103-68355         c
            254-338             AL450325.5         67606-67690         c
            339-421             AL138735.7         62883-62965         c
            422-533             AL138735.7         524-635             c
            534-2228            AL096814.26        30367-32061
            2229-2275           AL096814.26        34418-34464
            2276-2426           AL096814.26        35361-35511
            2427-2675           AL096814.26        36647-36895
            2676-3060           AL096814.26        40492-40876
            3061-3127           AL096814.26        42014-42080
            3128-3267           AL096814.26        43113-43252
            3268-3371           AL096814.26        43384-43487
            3372-3447           AL096814.26        45289-45364
            3448-3536           AL096814.26        53671-53759
            3537-3650           AL096814.26        56854-56967
            3651-3857           AL096814.26        63804-64010
            3858-4105           AL096814.26        67287-67534
            4106-7844           AL096814.26        71546-75284
FEATURES             Location/Qualifiers
     source          1..7844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..7844
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="transcriptional regulating factor 1"
                     /db_xref="GeneID:55809"
                     /db_xref="HGNC:HGNC:18273"
                     /db_xref="MIM:610322"
     exon            1..253
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            254..338
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            339..421
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            422..533
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            534..2228
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     CDS             792..4430
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="isoform 4 is encoded by transcript variant 5;
                     rapa-2; rapa-1; transcriptional regulating protein 132;
                     breast cancer anti-estrogen resistance 2; zinc finger
                     protein rapa; zinc finger transcription factor TReP-132"
                     /codon_start=1
                     /product="transcriptional-regulating factor 1 isoform 4"
                     /protein_id="NP_001382419.1"
                     /db_xref="CCDS:CCDS93925.1"
                     /db_xref="GeneID:55809"
                     /db_xref="HGNC:HGNC:18273"
                     /db_xref="MIM:610322"
                     /translation="MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGG
                     MDAPQASPISPHFPQDTRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLA
                     NSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVN
                     NMAQVLHTQSAVMDGAPDSALRQLLSQKPMEPPAPAIPSRYQQVPQQPHPGFTGGLSK
                     PALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQYYPPQQQQ
                     QAGQQRISMQEIQTQPQQIRPSQPQPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQ
                     HLQEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQ
                     QSHLSQHQQREDSQLKTYSSDRQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPH
                     RPLLSPSGIHLNNMGPQHQQLSPSAMWPQMHLPDGRAQPGSPESSGQPKGAFGEQFDA
                     KNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPLPPPPPP
                     PPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDE
                     MPVLEIPRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPPSYNPNPAASYSGATL
                     YQSQLRSPRVLGDHLLLDPTHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGAHPQL
                     PLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDIS
                     ALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAK
                     GDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQK
                     MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEED
                     RKSTKEEESEVPKSPEPPPVPVLAPTEGPPLQALGQPSGSFICEMPNCGADCRCHVTP
                     FLPQVFSSRQALNGHARIHGGTNQVTKARGAIPSGKQKPGGTQSGYCSVKSSPSHSTT
                     SGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIER
                     TTGPVGAPGLLPLDQLSLIKPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQDSV
                     LLQGDAEL"
     exon            2229..2275
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2426
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2675
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..3060
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3127
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3267
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3371
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3447
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3536
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3650
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3857
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4105
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..7844
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4629..4634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="hexamer: AATAAA"
     polyA_site      4649
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="major polyA site"
     regulatory      7055..7060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="hexamer: AATAAA"
     polyA_site      7078
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="major polyA site"
     regulatory      7507..7512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="hexamer: AATAAA"
     polyA_site      7538
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="major polyA site"
     regulatory      7820..7825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
                     /note="hexamer: AATAAA"
     polyA_site      7844
                     /gene="TRERF1"
                     /gene_synonym="BCAR2; dJ139D8.5; HSA277276; RAPA;
                     TReP-132; TREP132"
ORIGIN      
        1 cttccctcta agcgatggct gagaggcggt gcatgcagat ggggagtaag tttcctgaag
       61 gggagggtgg atgcacgcgc gcagcccggc gctgcaaatt tccactgggg agggagaacg
      121 gctggatgcg gagagtttgg agttgcttgc ggcggagggc aggaagggga gcagggctgg
      181 gaaagggggc tggcgggcgc tatatctggg agtaagtttc cagcatcagg agagcctgca
      241 cgcttgctca ctactctgct cgccccccat ctcacccccc aagcggatac tggtcttctc
      301 gtcggattgc ccatgcactt gttgcagaaa cagccaaggc cctggctgtg gagaatgctg
      361 aaggaagaag acgcagaagc aggacgaccc tgaaagattc agcctcttca tcctcaaaca
      421 ggaccaggcc tcctcttccc acctgtccag cagcatgaaa gcagcatgat tggccgaccg
      481 caggagaagc ccccagaacc aggcccccaa ctcagccatc tgcggaggtc aaggtgtgag
      541 cgacgtctcc tcaccacagt gctgtgtggt ctatacctca gccagggaga ggatgtgaaa
      601 ccccccgccc tgcacatgag tggtacaggc caacaggaac acctggctcc agccacgttc
      661 acagacatgt cagccgtgga gtagtgctga cacttttctc tcagcttctc agggtttcag
      721 tccttttggg tttgttttat ttaccttttt tatggttttg tggctggacg ttcacaacca
      781 aggcagacag catgggtgac cagcaactgt acaagaccaa ccatgtggcc catggtagtg
      841 agaacctttt ctaccaacag ccaccacttg gcgtccacag cgggctgaac cacaactatg
      901 ggaatgcagt tacagggggc ggaatggatg cccctcaggc ctcgccaatc tccccccact
      961 tccctcaaga tacacgggat ggtctgggct tgcctgttgg ctccaaaaac cttggccaaa
     1021 tggatacctc gaggcaggga gggtggggaa gtcatgcagg gcctggaaac catgtccagc
     1081 tacgtggaaa cctggccaac tcaaacatga tgtggggggc accagcccag gctgagccca
     1141 ctgatggcta ccaatacacc tactcccagg ccagcgagat ccggacccag aagcttacca
     1201 gcggtgtctt acacaagctg gactctttca cccaggtgtt tgccaaccaa aacctgcgaa
     1261 ttcaggtcaa caatatggcc caggtgctgc acactcagtc agcagtgatg gatggagccc
     1321 ctgacagtgc tctccgccag ctgctgtctc agaagcccat ggagccccca gcaccggcta
     1381 tcccttcccg ctaccagcag gtgccccagc agcctcaccc tggtttcact ggtgggctgt
     1441 ccaaaccagc tcttcaggtc gggcagcacc ctacccaagg gcacctgtat tatgactacc
     1501 agcagcctct ggctcaggtg ccagtgcagg gaggacagcc actgcaggcc ccacagatgc
     1561 tgtcacagca catgcaacag atgcagcagc accagtatta cccaccgcag caacagcagc
     1621 aagccgggca acagcgtatc tccatgcaag aaatacagac gcagccgcaa caaattcgcc
     1681 catcacagcc acagccgccg ccacagcagc agcagccgca gcagctacag ctgcagcagc
     1741 ggcagggttc aatgcagata cctcagtatt atcagcccca acccatgatg cagcacttgc
     1801 aagagcagca gcagcaacag atgcacctgc agcctccttc ttatcacagg gaccctcacc
     1861 agtatacccc agagcaggca cacactgtcc agctgattcc cctgggctcc atgtcccagt
     1921 actactacca ggagccccag cagccctaca gccaccccct ctaccagcag agccacctgt
     1981 cccagcacca gcagcgtgag gacagtcagc tgaagaccta ctctagtgac agacaggccc
     2041 aggccatgct gagctcccat ggggacctgg ggcctcctga cacaggaatg ggagacccag
     2101 cgagctcaga tctgacccgg gtcagcagca ccctccccca tcgccccctc ctatccccca
     2161 gtgggatcca cctcaacaac atggggcctc agcatcagca gctgtctccc agtgccatgt
     2221 ggccccagat gcacctacct gatgggagag cccagccagg gtcccctgag tcaagtggcc
     2281 aacccaaagg agcgtttggg gagcagtttg atgccaagaa caagctgaca tgctccatct
     2341 gcctgaagga gttcaagaac ctgcctgccc tgaatggcca catgcggtcc cacgggggaa
     2401 tgagggcctc ccccaacctc aaacaggagg aaggagagaa ggtcctgccg cctcagcccc
     2461 agccaccact gccgcctccg cctccgcctc cgccgccacc acagctccct cccgaggcag
     2521 aaagcctcac gcctatggtc atgcccgtgt ctgtccctgt caagcttctc ccgcccaagc
     2581 ccagctctca ggggttcacc aacagcaccg ttgccgcccc ctccgccaga gacaagccag
     2641 ccagctcgat gtcggacgac gagatgcctg tgctcgaaat ccccaggaag catcagccga
     2701 gtgtgcccaa agccgaggag cccctcaaga ccgtgcagga gaagaaaaag ttccggcacc
     2761 ggccggaacc tctcttcatc ccgccgccgc cctcctacaa cccgaacccc gctgcctcct
     2821 actcgggcgc caccctgtac cagagccagc tgcgctcccc gcgcgtcctc ggggaccacc
     2881 tgctcctgga ccccacccac gagctgcccc cttacacgcc cccacccatg ctgagcccgg
     2941 tgcgccaggg ctcggggctc ttcagcaatg tcctcatctc cggccacggc cctggcgccc
     3001 acccgcagct gcccctgacg cccctgacgc ccacaccacg ggtgctgctg tgtcgctcca
     3061 acagcatcga tggcagcaac gtgacggtca ccccagggcc tggagagcag actgtagatg
     3121 ttgaaccacg catcaacatt ggcttgagat tccaagcaga aatccctgaa ctccaagata
     3181 tctctgccct ggcccaggac acacacaagg ccacactggt atggaagccc tggccagaac
     3241 tagaaaacca tgacctccag caaagagtgg agaatcttct gaatttgtgc tgttccagtg
     3301 cattgccagg tggagggacc aattctgaat ttgctttgca ctctctgttt gaggccaaag
     3361 gtgatgtgat ggttgctctg gaaatgctgc tactgcggaa gcctgtcagg ttaaaatgtc
     3421 atcctttagc aaattaccac tatgccggtt cggacaagtg gacctcccta gaaagaaaac
     3481 tgtttaacaa agcactagcc acttacagca aagactttat ttttgtacag aagatggtga
     3541 agtccaagac ggtggctcag tgcgtggagt actactacac gtggaaaaag atcatgcggc
     3601 tggggcggaa acaccggaca cgcctggcag aaatcatcga cgattgtgtg acaagtgaag
     3661 aagaagaaga gttagaggag gaggaggagg aggacccgga agaagatagg aaatccacaa
     3721 aagaagaaga gagtgaggtg ccgaagtccc cggagccacc acccgtcccc gtcctggctc
     3781 ccacggaggg gccgcccctg caggccctgg gccagccctc aggctccttc atctgtgaaa
     3841 tgcccaactg tggggctgac tgtagatgtc atgtcactcc ctttcttccc caggtgttca
     3901 gctcccgaca ggcactgaat ggccatgccc gcatccacgg gggcaccaac caggtgacca
     3961 aggcccgagg tgccatcccc tctgggaagc agaagcctgg tggcacccag agtgggtact
     4021 gttcggtaaa gagctcaccc tctcacagca ccaccagcgg cgagacagac cccaccacca
     4081 tcttcccctg caaggagtgt ggcaaagtct tcttcaagat caaaagccga aatgcacaca
     4141 tgaaaactca caggcagcag gaggaacaac agaggcaaaa ggctcagaag gcggcttttg
     4201 cagctgagat ggcagccacg attgagagga ctacggggcc cgtgggggcg ccggggctgc
     4261 tgcccctgga ccagctgagt ctgatcaaac ccatcaagga tgtggacatc ctcgacgacg
     4321 acgtcgtcca gcagttggga ggtgtcatgg aagaggctga agttgtggac accgatcttc
     4381 tcttggatga tcaagattca gtcttgcttc agggtgacgc agaactataa agccctgtgt
     4441 gtcacttaga gacagtgaaa acccacggcc tccatcttca ttaatcagga aacctggact
     4501 gcctgcttgt tttgtaaccc ttttaaacta cctgttttaa aagtggtcat tttattcagg
     4561 tttagaaaaa aaaatcctat ttcttttcct tttatttaaa aaaatttgtt tttgtggggg
     4621 gttgggggaa taaataattg gcacaactat ctttaagagg tgtttcatct gggctacctt
     4681 ctcatgaaat cattcccagt agggactgaa gctgaccttc atgttccatt gcattcagat
     4741 gtcaaccatc ccggttgcct tttatcccaa agcttgctgt gagtgtgtgt gtgtgagacg
     4801 caggcgaccc tcttagtact ggggtcttgg ggccaacttt tcccatcaag cgttactttg
     4861 attctgttct gacctcattc catagtttgc agtgagcatg gcatctttgc ctggagatac
     4921 tatgctaggg gcagctttcc aggggcaaag caagccctcg tgttacacgg ctctcctcca
     4981 gctcacacga catgtgagga gatgaccaaa tgtgaaaaca ggtttcccct gtgttgcccg
     5041 tcatcctttg gcccgttcac aggaatggag tactgtataa ttttaggctt tcattcccag
     5101 cagtgtttac tgaggacctg gttttctaga acaggtgtgt cctgtcctct tccatgttcc
     5161 ctgggggctg gtcagctcca agttgtgggt ggcagagctg tgtttcagca tgaactgact
     5221 agagacccat ctggaggcaa atattaagtt gccaggactg ctttcacttc agggtgattg
     5281 aaggacacat attgaagtac ctagaatgcc agaaagtgtt ctattgccca aaaaacaaat
     5341 cagaaaagcc tattcttttt tgcaacgctg ttaatgatta gtggagttct gaaattactt
     5401 tgtgccactt ggaagtactg tgaaaccgca ttcactggga ttttgctgta attcacatcc
     5461 gctggactga agtttacctt gatgttagct ataagaaata gttttctaac acatacgata
     5521 gcaaatacaa gacaaatagc attgaaggcc aacaaaaatg gcttcagata caccttagct
     5581 ataatgtttg cattcaaaca atgaatgtat tcatcacaag tcacttacca aagcacttct
     5641 agacttctcc aacctccatg actttgctct gcttcctcct gtccctgtca gcagggttgc
     5701 tgtttgtact tgaaggtaat aaacctgtaa tccttcaaaa atgccattta gccccaggct
     5761 tctgagctga gtcagactga cccatcccac cgttagggca aaagtcaggc tgggacacag
     5821 cgccagtaca gagaggatcc tgcttcatgc aactcccctt ttggagttaa tgcagcgtga
     5881 tttcctgggc cggtgttttc aggcatcgcc caccccaggt atgctggttc ccagctccac
     5941 gtaggtgtgc ctatcacgct gggccacttt gctgacaaca ttcatagctt gacatgagag
     6001 agaatatcag cagaagcatg agagtaggac ctgacgtctt tgactctgca aaagcattta
     6061 gcacacactc atggggggga actggctgtg agccacagca gccccacaca gacagtggtc
     6121 tctgaacttc aggaaagcca tggacagaaa aaaaaataaa attcttttcc atcattctat
     6181 tttcaaagag gtcttggcgt tttcctacat cttttgttta gagggggaaa aaagtttcat
     6241 ttgctgccat ttcagaaagg ttatgctatc ctgttttatc caagcagttg tgagtcagga
     6301 actgcctggg cagtgtgcat caactttgtg gccgaaccat tacagctgtc atatccttgg
     6361 ctgatcgtct ctcccaggga ctactgccct ccacttagtg tctgagggta agcctagaag
     6421 ggtgctgcta ttgggtctat ggaagcttat ctatcaaagg agcaaacatc cagaaaagtg
     6481 tttataaagc aaatgtattg cctctgttta gagatttgcc cagctgttcc agttttaaac
     6541 attaaaaaat aaactcagtt gccatggcaa aaatagaatg cacagcttac ttataatttt
     6601 ccatgcagta tagcataagg atttttgact tgaaacaacc aaagaactcc tccttaacga
     6661 gacagttcaa attcctgaat tagtatttct tgactatcaa cttaaagaat ggacttccta
     6721 gtacaatgtt gcacttattt ttttttctga aataattctg cctgcatgta tgtgttgtgt
     6781 tttagcttct ccccttaccc caccccaaag atcttttctt cctaatggtt aatgtctcaa
     6841 ctcggttact gtttactatc agatggtttt tcattagtga atttagacct ctttgagaaa
     6901 gcttgtatat aaaaagttaa cagatatatt ttatggaaaa acccatctta ttttcaaata
     6961 tatttaactg ctgttatatt ttattagagg aaggttgtaa atattttcta ggagttctat
     7021 tgtaaagaaa agtatttttg aaaaaaatta atgtaataaa aaggaaaaca tttttaaata
     7081 gtggttgtga ttgcttcctg ttctggcttc gttatgttct attctcagca gatgaattgc
     7141 atgccttcca tatcaggatg taatttattc aggtttgcac tattataagt tgacatcata
     7201 atatctagtg tgcttaactg tattttcccg gaatgcaagt cccttggtcc atattaaagc
     7261 actatgtata gcatattcat aatttttctt ttgtaacgtg tgtattttta ataaggattt
     7321 tatgtaacat tttggcaaca agaggaccgt attttctagt gaattttata ataacatttt
     7381 gctaaaaatg tttcttccta ggtcagtttt tgttaaggtg aaccaaaagt cttattttac
     7441 caggggttta aaaaaagttt gaagcttgaa agcaaagtta tatttaaaca tcatatgtaa
     7501 caaataaata aagatgtttt atagacttgt cctaaaaagg tgcattcctt aaaaaaaaaa
     7561 aaaagaaaaa aaaaggaaac tggggcattc taggttgttt cccctccaag tgataagctt
     7621 tttttttttc ttaattatca caatgcttct tcaaaaaggg aaccagggaa attttattta
     7681 acacattcta atcattagcc tctcagaaag ttattacagt tcctatagat gggcattcat
     7741 caaatggaga tgtaaccaaa cagacactgt catatttatt tgtgaaaacc tgattcaata
     7801 ttgcatcagc tgctctgaaa ataaaatatt aatcttttgc gttt
//
