LOCUS       NM_198153               2545 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens triggering receptor expressed on myeloid cells like 4
            (TREML4), mRNA.
ACCESSION   NM_198153
VERSION     NM_198153.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Duarte,V.H.R., Cruz,M.S., Bertolami,A., Hirata,M.H., Hirata,R.D.C.,
            Luchessi,A.D. and Silbiger,V.N.
  TITLE     TREML4 polymorphisms increase the mRNA in blood leukocytes in the
            progression of atherosclerosis
  JOURNAL   Sci Rep 12 (1), 18612 (2022)
   PUBMED   36329152
  REMARK    GeneRIF: TREML4 polymorphisms increase the mRNA in blood leukocytes
            in the progression of atherosclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Gonzalez-Cotto,M., Guo,L., Karwan,M., Sen,S.K., Barb,J.,
            Collado,C.J., Elloumi,F., Palmieri,E.M., Boelte,K., Kolodgie,F.D.,
            Finn,A.V., Biesecker,L.G. and McVicar,D.W.
  TITLE     TREML4 Promotes Inflammatory Programs in Human and Murine
            Macrophages and Alters Atherosclerosis Lesion Composition in the
            Apolipoprotein E Deficient Mouse
  JOURNAL   Front Immunol 11, 397 (2020)
   PUBMED   32292401
  REMARK    GeneRIF: TREML4 Promotes Inflammatory Programs in Human and Murine
            Macrophages and Alters Atherosclerosis Lesion Composition in the
            Apolipoprotein E Deficient Mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Duarte,V.H.R., Miranda,C.T.O.F., Cruz,M.S., de Araujo,J.N.G.,
            Duarte,M.K.R.N., Santos,A.M.Q.S.D., Santos,I.C.C.D., Santos,J.C.D.,
            da Silva,A.M.G., de Oliveira,J.M., Paiva,M.S.M.O., de Oliveira
            Galvao,M.F., Rezende,A.A., Hirata,M.H., Hirata,R.D.C.,
            Luchessi,A.D. and Silbiger,V.N.
  TITLE     TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are
            Associated with Atherosclerotic Lesion Extension in Coronary Artery
            Disease
  JOURNAL   Sci Rep 9 (1), 7229 (2019)
   PUBMED   31076644
  REMARK    GeneRIF: TREML4 mRNA Expression and Polymorphisms in Blood
            Leukocytes are Associated with Atherosclerotic Lesion Extension in
            Coronary Artery Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Ramirez-Ortiz,Z.G., Prasad,A., Griffith,J.W., Pendergraft,W.F. 3rd,
            Cowley,G.S., Root,D.E., Tai,M., Luster,A.D., El Khoury,J.,
            Hacohen,N. and Means,T.K.
  TITLE     The receptor TREML4 amplifies TLR7-mediated signaling during
            antiviral responses and autoimmunity
  JOURNAL   Nat Immunol 16 (5), 495-504 (2015)
   PUBMED   25848864
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Sen,S.K., Boelte,K.C., Barb,J.J., Joehanes,R., Zhao,X., Cheng,Q.,
            Adams,L., Teer,J.K., Accame,D.S., Chowdhury,S., Singh,L.N.,
            Kavousi,M., Peyser,P.A., Quigley,L., Priel,D.L., Lau,K.,
            Kuhns,D.B., Yoshimura,T., Johnson,A.D., Hwang,S.J., Chen,M.Y.,
            Arai,A.E., Green,E.D., Mullikin,J.C., Kolodgie,F.D.,
            O'Donnell,C.J., Virmani,R., Munson,P.J., McVicar,D.W. and
            Biesecker,L.G.
  CONSRTM   NISC Comparative Sequencing Program; CHARGE Consortium
  TITLE     Integrative DNA, RNA, and protein evidence connects TREML4 to
            coronary artery calcification
  JOURNAL   Am J Hum Genet 95 (1), 66-76 (2014)
   PUBMED   24975946
  REMARK    GeneRIF: determined by von Kossa staining that TREML4 colocalizes
            with areas of microcalcification within coronary plaques. Overall,
            we present integrative RNA, DNA, and protein evidence implicating
            TREML4 in coronary artery calcification
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Allcock,R.J., Barrow,A.D., Forbes,S., Beck,S. and Trowsdale,J.
  TITLE     The human TREM gene cluster at 6p21.1 encodes both activating and
            inhibitory single IgV domain receptors and includes NKp44
  JOURNAL   Eur J Immunol 33 (2), 567-577 (2003)
   PUBMED   12645956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391903.15 and AY358271.1.
            
            On May 17, 2019 this sequence version replaced NM_198153.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358271.1, BC105101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341495.7/ ENSP00000342570.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL391903.15        30153-30222
            71-1103             AY358271.1         99-1131
            1104-2009           AL391903.15        39245-40150
            2010-2045           AY358271.1         2038-2073
            2046-2545           AL391903.15        40187-40686
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2545
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /note="triggering receptor expressed on myeloid cells like
                     4"
                     /db_xref="GeneID:285852"
                     /db_xref="HGNC:HGNC:30807"
                     /db_xref="MIM:614664"
     exon            1..142
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..682
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /note="TREM like transcript 4; trem-like transcript 4
                     protein; triggering receptor expressed on myeloid
                     cells-like protein 4"
                     /codon_start=1
                     /product="trem-like transcript 4 protein precursor"
                     /protein_id="NP_937796.1"
                     /db_xref="CCDS:CCDS34446.1"
                     /db_xref="GeneID:285852"
                     /db_xref="HGNC:HGNC:30807"
                     /db_xref="MIM:614664"
                     /translation="MAWGGVHTCCFHLCCCCSWPQGAVPEELHKHPGQTLLLQCQYSP
                     KRGPYQPKSWCQQTSPSRCTLLVTSSKPWTAVQKSHYTIWDKPNAGFFNITMIQLTQN
                     DSGFYWCGIYNASENIITVLRNISLVVSPAPTTSPMWTLPWLPTSTVLITSPEGTSGH
                     PSINGSETRKSRAPACLGSGGPRFLVLVLCGLLLAKGLML"
     exon            143..473
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..524
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..585
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            586..717
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            718..2545
                     /gene="TREML4"
                     /gene_synonym="TLT-4; TLT4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccagcg tctgactcct cctgagaggg ctcccttttt tctcctctcc tccgctgtca
       61 gaaacagatc tgggctggaa tggcctgggg tggggtccac acctgctgct tccacctgtg
      121 ctgctgctgc tcctggcctc agggtgctgt gcctgaagaa cttcacaaac acccaggaca
      181 gaccctcctc ctgcaatgcc agtactcacc caagagaggg ccctatcagc ccaaatcctg
      241 gtgtcagcag acatctccaa gtcggtgtac cttacttgtc accagctcca agccctggac
      301 agcagttcag aagtctcatt acacaatctg ggacaagccc aatgctggct tcttcaacat
      361 caccatgatt cagctgacac agaatgactc gggattctac tggtgtggaa tctacaacgc
      421 ttccgaaaac atcatcactg ttcttagaaa tatcagcctg gtggtgtctc cagccccaac
      481 cacgtctcct atgtggactc ttccctggct cccaacaagc acagttctga tcacttctcc
      541 agaggggacc tctggccatc cctccatcaa tggctctgag accaggaaat caagagcccc
      601 tgcctgcctt ggctcaggtg gccccagatt cctggtcttg gtgctatgtg gactcctcct
      661 ggccaagggc ctgatgttgt gagtcctgtt agtgctcctg atctgcaggt gccacaggac
      721 agcagtgacg aggtttctga ttgtcccagc acagccttgt cccaggaccc ttgggtgcat
      781 gagccacaac atggatcctg gatgaatccc agttcttccc ctgcccagct attgggagct
      841 ggcctaagta ttgctcccca cctccttgtg aggaaaggct agcgctaagc ctattggaga
      901 gaactttcag cccctgaact ccccggtggt gacccctcac ccctgcactg agccccctta
      961 gatctactgc ccctgccctg actttcgcca ttgggaagac ctggggtggg ggtttctgca
     1021 tccgggtcaa tgcccagctc agcatcttca gctgtgccca ggctcctctc cagcactctg
     1081 tcgttctctg agccccacct cagcaggtct ccaggatccc tcacatttcc cctgtttgtt
     1141 gcctgtggtc tgccctagag tcctatgaat ttcctcttgt gcttaattaa attcaacctc
     1201 tgaactgaaa tgtgtcaggg gcagctgagc aagacagcag ttgtatcccc tcaccttcct
     1261 cccgtcccac cccagatatc ctaaatgaga gagaaatgac ttaaaaataa atgataaaat
     1321 tgaaactaag aaaggctgta atcagcagac tggaagctga ggaagatcta gaagtaaaag
     1381 aaaaaattag atgcgttaaa atgacatgag caggcgactc agtggcccaa aacaggaccc
     1441 agaacattca tccgtaaatg gaatctgata atctggggcc caaattctgt ttacttaaca
     1501 tgtgagaaga ttcacagcct aaaagagaaa atcaagttga actaacaata aatgatggtg
     1561 ggtgaaagat aaatgtttta gggaacagaa gaggagcaca tatttatgaa gcaagaatag
     1621 gtacagtcat tttccaacta acatctagtg agactgggat tcaccactca gaatgggggt
     1681 ccaccatgag caacagattt gaggtaccag tgcatagcag ctgaatgcca gccctgtaaa
     1741 agaccaccat aaagagagct ccatgttctt ttgctctttt ggggatggga catcaaacaa
     1801 aagtctcttc gtgtatatct cagctcctgc cacatgatca tcacctatct gtgagaggca
     1861 tcgcttttgc tttgtttatt tattttttta atcctcattc cctatgtcca cttgccttcc
     1921 tctccgaggc aactactcta atgcatttgg tatgtaactt taaatttgaa tgtattcttg
     1981 taaaacatcc agtatttttt tttctgtgac tatgttttca cttacataaa agaaattgtg
     2041 atagaccttt ttcatatgct tgtcttactc cttgctgggc acatatacac agcccacttc
     2101 ttttcagtgc ttattccatt gcgtacatat cccacagtgc atcattccga acccagggtg
     2161 catgtgcttt tttgccttca cttttctata tcataaatga tgctgtgatg aataccctcc
     2221 ttcacgttct cttgtggaat catgtgagac ttcctttagg acttatacac aggtggcatc
     2281 agctgggttg tgggatctca gacatctaat taatactgcc agcttgtgtt gcctgaacca
     2341 agaatctaga cactagcgat tatgtgtttt ctctgagtct atgtgaagta cacagcacaa
     2401 cctatggaat ggtattgcca attaaaaaaa aaatggaagg caagaataaa cgtagctgag
     2461 tgatgctaca tggggctaga tatatgatta tctctacttt tgtgtatgct tggaaatttt
     2521 cataattaaa atggtaccta aaatt
//
