LOCUS       NM_024807               3785 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens triggering receptor expressed on myeloid cells like 2
            (TREML2), mRNA.
ACCESSION   NM_024807
VERSION     NM_024807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Li,J.Q., Zhong,X.L., Song,J.H., Chi,S., Xie,A.M., Tan,L. and
            Yu,J.T.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Associations Between TREML2 Gene Variants and Alzheimer's Disease:
            Biomarkers, Neuroimage, and Cognition
  JOURNAL   J Alzheimers Dis 96 (4), 1555-1563 (2023)
   PUBMED   37980675
  REMARK    GeneRIF: Associations Between TREML2 Gene Variants and Alzheimer's
            Disease: Biomarkers, Neuroimage, and Cognition.
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Kuhn,A.L., Frenzel,S., Teumer,A., Wittfeld,K., Garvert,L.,
            Weihs,A., Homuth,G., Prokisch,H., Bulow,R., Nauck,M., Volker,U.,
            Volzke,H., Grabe,H.J. and Van der Auwera,S.
  TITLE     TREML2 Gene Expression and Its Missense Variant rs3747742 Associate
            with White Matter Hyperintensity Volume and Alzheimer's
            Disease-Related Brain Atrophy in the General Population
  JOURNAL   Int J Mol Sci 23 (22), 13764 (2022)
   PUBMED   36430248
  REMARK    GeneRIF: TREML2 Gene Expression and Its Missense Variant rs3747742
            Associate with White Matter Hyperintensity Volume and Alzheimer's
            Disease-Related Brain Atrophy in the General Population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Li,J., Cao,C., Xiang,Y., Hong,Z., He,D., Zhong,H., Liu,Y., Wu,Y.,
            Zheng,X., Yin,H., Zhou,J., Xie,H. and Huang,X.
  TITLE     TLT2 Suppresses Th1 Response by Promoting IL-6 Production in
            Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis
  JOURNAL   Front Immunol 11, 2031 (2020)
   PUBMED   33042115
  REMARK    GeneRIF: TLT2 Suppresses Th1 Response by Promoting IL-6 Production
            in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Wang,S.Y., Xue,X., Duan,R., Gong,P.Y., E,Y., Jiang,T. and
            Zhang,Y.D.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     A TREML2 missense variant influences specific hippocampal subfield
            volumes in cognitively normal elderly subjects
  JOURNAL   Brain Behav 10 (4), e01573 (2020)
   PUBMED   32073739
  REMARK    GeneRIF: A TREML2 missense variant influences specific hippocampal
            subfield volumes in cognitively normal elderly subjects.
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Yu,X., Wei,B., Su,R., Yao,J., Feng,X., Jiang,G., Xie,H., Wu,J.,
            Xu,X., Zhang,M., Zheng,S. and Zhou,L.
  TITLE     A risk assessment model of acute liver allograft rejection by
            genetic polymorphism of CD276
  JOURNAL   Mol Genet Genomic Med 7 (6), e689 (2019)
   PUBMED   31044564
  REMARK    GeneRIF: rs6915083 and rs7754593 of TREML2 were associated with
            acute liver allograft rejection.
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   King,R.G., Herrin,B.R. and Justement,L.B.
  TITLE     Trem-like transcript 2 is expressed on cells of the
            myeloid/granuloid and B lymphoid lineage and is up-regulated in
            response to inflammation
  JOURNAL   J Immunol 176 (10), 6012-6021 (2006)
   PUBMED   16670310
  REMARK    GeneRIF: TLT2 may be involved in the innate immune response based
            on its expression profile and the fact that it is up-regulated in
            response to inflammation.
REFERENCE   8  (bases 1 to 3785)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 3785)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3785)
  AUTHORS   Allcock,R.J., Barrow,A.D., Forbes,S., Beck,S. and Trowsdale,J.
  TITLE     The human TREM gene cluster at 6p21.1 encodes both activating and
            inhibitory single IgV domain receptors and includes NKp44
  JOURNAL   Eur J Immunol 33 (2), 567-577 (2003)
   PUBMED   12645956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358171.1, AL133404.9 and AJ420509.1.
            
            On Nov 25, 2018 this sequence version replaced NM_024807.3.
            
            Summary: TREML2 is located in a gene cluster on chromosome 6 with
            the single Ig variable (IgV) domain activating receptors TREM1 (MIM
            605085) and TREM2 (MIM 605086), but it has distinct structural and
            functional properties (Allcock et al., 2003 [PubMed
            12645956]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023755.1, BC125078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000483722.2/ ENSP00000418767.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1256              AY358171.1         40-1295
            1257-3685           AL133404.9         7920-10348
            3686-3785           AJ420509.1         1539-1638
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3785
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="triggering receptor expressed on myeloid cells like
                     2"
                     /db_xref="GeneID:79865"
                     /db_xref="HGNC:HGNC:21092"
                     /db_xref="MIM:609715"
     exon            1..196
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1107
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="trem-like transcript 2 protein; triggering receptor
                     expressed on myeloid cells-like protein 2"
                     /codon_start=1
                     /product="trem-like transcript 2 protein precursor"
                     /protein_id="NP_079083.2"
                     /db_xref="CCDS:CCDS4853.2"
                     /db_xref="GeneID:79865"
                     /db_xref="HGNC:HGNC:21092"
                     /db_xref="MIM:609715"
                     /translation="MAPAFLLLLLLWPQGCVSGPSADSVYTKVRLLEGETLSVQCSYK
                     GYKNRVEGKVWCKIRKKKCEPGFARVWVKGPRYLLQDDAQAKVVNITMVALKLQDSGR
                     YWCMRNTSGILYPLMGFQLDVSPAPQTERNIPFTHLDNILKSGTVTTGQAPTSGPDAP
                     FTTGVMVFTPGLITLPRLLASTRPASKTGYSFTATSTTSQGPRRTMGSQTVTASPSNA
                     RDSSAGPESISTKSGDLSTRSPTTGLCLTSRSLLNRLPSMPSIRHQDVYSTVLGVVLT
                     LLVLMLIMVYGFWKKRHMASYSMCSDPSTRDPPGRPEPYVEVYLI"
     exon            197..517
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..926
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1027
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..3785
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="hexamer: GATAAA"
     polyA_site      3045
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="major polyA site"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="hexamer: ATTAAA"
     polyA_site      3785
                     /gene="TREML2"
                     /gene_synonym="C6orf76; dJ238O23.1; TLT-2; TLT2"
                     /note="major polyA site"
ORIGIN      
        1 acactgcctc acttccctaa atgggcagct tcacttttag aaccccgggt ccttccctgg
       61 caggcccagg tggcacatcc tgtgtcgggt gggccctcac cttggatctc caggcctgac
      121 actgcccagc tggatggaac catggcccca gccttcctgc tgctgctgct gctgtggcca
      181 cagggttgcg tctcaggccc ctctgctgac agtgtataca caaaagtgag gctccttgaa
      241 ggggagactc tgtctgtgca gtgctcctat aagggctaca aaaaccgcgt ggagggcaag
      301 gtttggtgca aaatcaggaa gaagaagtgt gagcctggct ttgcccgagt ctgggtgaaa
      361 gggccccgct acttgctgca ggacgatgcc caggccaagg tggtcaacat caccatggtg
      421 gccctcaagc tccaggactc aggccgatac tggtgcatgc gcaacacctc tgggatcctg
      481 taccccttga tgggcttcca gctggatgtg tctccagctc cccaaactga gaggaacatt
      541 cctttcacac atctggacaa catcctcaag agtggaactg tcacaactgg ccaagcccct
      601 acctcaggcc ctgatgcccc ttttaccact ggtgtgatgg tgttcacccc aggactcatc
      661 accttgccta ggctcttagc ctccaccaga cctgcctcca agacaggcta cagcttcact
      721 gctaccagca ccaccagcca gggacccagg aggaccatgg ggtcccagac agtgaccgcg
      781 tctcccagca atgccaggga ctcctctgct ggcccagaat ccatctccac taagtctggg
      841 gacctcagca ccagatcgcc caccacaggg ctctgcctca ccagcagatc tctcctcaac
      901 agactaccct ccatgccctc catcaggcac caggatgttt actccactgt gcttggggtg
      961 gtgctgaccc tcctggtgct gatgctgatc atggtctatg ggttttggaa gaagagacac
     1021 atggcaagct acagcatgtg cagcgatcct tctacacgtg acccacctgg aagaccagag
     1081 ccctatgtgg aagtctactt gatctgaggc cacttaagca tggggtgggg agcttctccc
     1141 agagtggccc cagggggtta gaggaggggt gaagattggg gccagtatcg atcttatgaa
     1201 gctggaggac ttgtgcagtg ctggactcac ccaggacttc ccaaacccag aggctgccat
     1261 cctaagcagc cccacagccc agtgttctcc ttgggggcag gaacctgggg aggggcccag
     1321 agcaaagggc atcagggaga aagtcccgag gaaatgtgac cagtggtttc tgctcggagc
     1381 tgcagacccc agggctcttg gtggaggcag gggaaccctg agagtgctgt ttacagagaa
     1441 cctcagctcc cgtctgcctc agaaacccta ttgggctgag ctgccctccc caccagggcc
     1501 actgtgtcct ctgcttccct ccgttctgct tcagcttccc ctaaggttag ggaagaaaga
     1561 atcgggctca cgaatgccag aggcagtgat gtcccatcct ggaggagagg aaacagtgac
     1621 taaaagctgg ggacccacag aggggttggc agcttctctt gtcgggacag gtgtcctttg
     1681 ctgggcctct ggatggccct gccctgactg gggctgctcc tccctcctgt cctgggaccg
     1741 cgcagagccc acgctctcac tgctgcctcc tgctggccgc tgcctcctta gaaagctgtg
     1801 accaggcagc taagagcctc tgggctgcag ggtcagcctc tcccaagact gaagtgcaga
     1861 ggctggactt ggggctctct cccccagctt ctacacctgg gctccaagtc tgagttccca
     1921 caggggaccc agcagcctcc aggaagtcca taccctgggg tggctgagac cttggctctg
     1981 tatggaggct gctcacccca cagacactgg tggggagacc atggctcaga ggaagggtgg
     2041 agcaaccctc ctcctacccc tcaggataga gagagaagac acacttggga cacagtgaag
     2101 acagtaactt ggaactgacc acggcctgga ggactggccc aggcaggggg acagggaaaa
     2161 tggagcccaa gtagcctctg gccagggacc caatgtcccg aggaatctgc ctcccaccca
     2221 ctgactcagg gctcagactc agcctctatt gtccagagca ctggcttggc gtccagcaat
     2281 gaaggctgga gaatgcagcc tggattcccc tacacacaca cacacacaca cacacacaca
     2341 cacacacaca cacacacaca cacaggtgtc tactgacctg gagtgactgg aatagcacct
     2401 ggggataaat gtgacaactg tgcattgaac cctgggtcag ggacgttcca atggccaaga
     2461 gagtgacaca gccaggaccc tggtggacag ccagaggggc cacttcagga tggatgtggg
     2521 gagagtggaa gaggcaggga gtaatcctgg gggacagcag ggaggaggca cttcttccct
     2581 atgtccagga gagggcaata gagggaagac tgaggctgaa gaattgacgg ctctggaccc
     2641 aggacagaca gacagacaga cagacagaca gacagacaga cacgcacaca cacccatctc
     2701 tgtctagcaa gcagcctcct aagatagctg ttctccctat catgacggtg tagccaccat
     2761 cctgttgtat actaggagag aacttaaccc acctggggga aaatagctcc ccaagagctg
     2821 gcaccagtac cactgatggc cctgcttcct ctgagtgaga tgcccaggag gaggagccct
     2881 agggaagaag tcagggacag ggaccaggat accactctgt cactgtgtga ccctcagcaa
     2941 gtcactaacc cttggcctca tttttcctgt cttgtgaaag aggacaataa ttcctacttc
     3001 tcaagattgt tttcaagata aaataacatt agcattgtac aatgatgcaa atgcctcatt
     3061 accattattc cttaagttgt tttccagctc taatgttgtt tccaacatta catttaagac
     3121 cttaggattc tgtttcttgc ttttgtcata tctcttccca agtgtcatca ctatatggat
     3181 gttgagggcc cccgatgaca gtccctttgg taaggtcctc ttttgaggag gggagggtac
     3241 agggtggact catctcagtg tgaacttggc aagtcactgt ccctctctga tcttgtttcc
     3301 tcatctggag aaggagtgag agaggagaaa ggaagaaacc agtcaggcag gcagttaggg
     3361 tgggttctcg gtagaattct tttaaacaaa agaacagcct gaaaaatcaa gctgcaggca
     3421 cagatatggg aacttgcaca ggggggcttg cctaagacat gcccacagcc tcatagataa
     3481 gacagactac acaggtgact tgcccaaaca tgcctgcaat ggaaaatttc atcccctgac
     3541 atgtgcagta aggggaacaa agcaatatgg agtaagtaac tcaagccaag ggcccacatg
     3601 tacattagaa ggacagcagg gagctaccag aaattcatgc cttatgcaga tgagctgccc
     3661 agtcctcatc ggtttcttat aaaagccttt acattcaact gtaaaaatgg caaccctctt
     3721 tcaggcctcc tctccacagc agagagcttt cttctctcac tcattaaact ttcactccaa
     3781 cctca
//
