LOCUS       NM_178174               1262 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens triggering receptor expressed on myeloid cells like 1
            (TREML1), transcript variant 1, mRNA.
ACCESSION   NM_178174
VERSION     NM_178174.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Pena-Garcia,P.E., Morales-Ortiz,J., Marrero-Polanco,J.,
            Virgillio,A., Finette,B.A., Washington,A.V. and Bonney,E.A.
  TITLE     Decreased level of TREM like Transcript 1 (TLT-1) is associated
            with prematurity and promotes the in-utero inflammatory response to
            maternal lipopolysaccharide (LPS) exposure
  JOURNAL   Am J Reprod Immunol 90 (4), e13772 (2023)
   PUBMED   37766406
  REMARK    GeneRIF: Decreased level of TREM like Transcript 1 (TLT-1) is
            associated with prematurity and promotes the in-utero inflammatory
            response to maternal lipopolysaccharide (LPS) exposure.
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   He,L., Zhang,Y., Hou,C., Zhu,Z., He,Q., Huang,Q. and Ji,S.
  TITLE     Triggering receptor expressed on myeloid cells (TREM) like
            transcript-1 (TLT-1) reveals platelet activation in preeclampsia
  JOURNAL   Platelets 33 (8), 1132-1138 (2022)
   PUBMED   35348422
  REMARK    GeneRIF: Triggering receptor expressed on myeloid cells (TREM) like
            transcript-1 (TLT-1) reveals platelet activation in preeclampsia.
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Wang,M., Li,X., Wang,Q., Zhang,M., He,J., Ming,S., Wang,Z., Cao,C.,
            Zhang,S., Geng,L., Gong,S., Huang,X., Chen,K. and Wu,Y.
  TITLE     TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce
            IL-10-Producing B Cells in Tuberculosis
  JOURNAL   J Immunol 208 (7), 1642-1651 (2022)
   PUBMED   35277419
  REMARK    GeneRIF: TLT-1 Promotes Platelet-Monocyte Aggregate Formation to
            Induce IL-10-Producing B Cells in Tuberculosis.
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Lin,J.C., Xu,Z.R., Chen,Z.H. and Chen,X.D.
  TITLE     Low-soluble TREM-like transcript-1 levels early after severe burn
            reflect increased coagulation disorders and predict 30-day
            mortality
  JOURNAL   Burns 47 (6), 1322-1332 (2021)
   PUBMED   33958244
  REMARK    GeneRIF: Low-soluble TREM-like transcript-1 levels early after
            severe burn reflect increased coagulation disorders and predict
            30-day mortality.
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Shen,L., Yang,T., Xia,K., Yan,Z., Tan,J., Li,L., Qin,Y. and Shi,W.
  TITLE     P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are
            associated with coronary artery disease: a case control study
  JOURNAL   BMC Cardiovasc Disord 20 (1), 387 (2020)
   PUBMED   32831023
  REMARK    GeneRIF: P-selectin (CD62P) and soluble TREM-like transcript-1
            (sTLT-1) are associated with coronary artery disease: a case
            control study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Gattis,J.L., Washington,A.V., Chisholm,M.M., Quigley,L., Szyk,A.,
            McVicar,D.W. and Lubkowski,J.
  TITLE     The structure of the extracellular domain of triggering receptor
            expressed on myeloid cells like transcript-1 and evidence for a
            naturally occurring soluble fragment
  JOURNAL   J Biol Chem 281 (19), 13396-13403 (2006)
   PUBMED   16505478
  REMARK    GeneRIF: A soluble fragment of the TLT-1 extracellular domain is
            found in serum of humans and mice and that an isoform of similar
            mass is released from platelets following activation with thrombin.
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Washington,A.V., Schubert,R.L., Quigley,L., Disipio,T., Feltz,R.,
            Cho,E.H. and McVicar,D.W.
  TITLE     A TREM family member, TLT-1, is found exclusively in the
            alpha-granules of megakaryocytes and platelets
  JOURNAL   Blood 104 (4), 1042-1047 (2004)
   PUBMED   15100151
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Barrow,A.D., Astoul,E., Floto,A., Brooke,G., Relou,I.A.,
            Jennings,N.S., Smith,K.G., Ouwehand,W., Farndale,R.W.,
            Alexander,D.R. and Trowsdale,J.
  TITLE     Cutting edge: TREM-like transcript-1, a platelet immunoreceptor
            tyrosine-based inhibition motif encoding costimulatory
            immunoreceptor that enhances, rather than inhibits, calcium
            signaling via SHP-2
  JOURNAL   J Immunol 172 (10), 5838-5842 (2004)
   PUBMED   15128762
  REMARK    GeneRIF: In contrast to previously characterized immunoreceptor
            tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances
            rather than inhibits calcium signaling in rat RBL-2H3 cells, a
            property dependent on the SHP-2 recruiting classical Tyr281 ITIM.
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Allcock,R.J., Barrow,A.D., Forbes,S., Beck,S. and Trowsdale,J.
  TITLE     The human TREM gene cluster at 6p21.1 encodes both activating and
            inhibitory single IgV domain receptors and includes NKp44
  JOURNAL   Eur J Immunol 33 (2), 567-577 (2003)
   PUBMED   12645956
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Washington,A.V., Quigley,L. and McVicar,D.W.
  TITLE     Initial characterization of TREM-like transcript (TLT)-1: a
            putative inhibitory receptor within the TREM cluster
  JOURNAL   Blood 100 (10), 3822-3824 (2002)
   PUBMED   12393607
  REMARK    GeneRIF: initial characterization of TREM-like transcript (TLT)-1
            results indicate it is likely that TLT-1 regulates the signaling of
            the TREM family receptors(TLT-1)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133404.9.
            
            On Jan 26, 2021 this sequence version replaced NM_178174.3.
            
            Summary: This gene encodes a member of the triggering receptor
            expressed on myeloid cells-like (TREM) family. The encoded protein
            is a type 1 single Ig domain orphan receptor localized to the
            alpha-granule membranes of platelets. The encoded protein is
            involved in platelet aggregation, inflammation, and cellular
            activation and has been linked to Gray platelet syndrome.
            Alternative splicing results in multiple transcript variants
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100944.1, AF534822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426005.7/ ENSP00000402855.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL133404.9         45850-45951
            103-435             AL133404.9         46107-46439
            436-538             AL133404.9         48813-48915
            539-627             AL133404.9         49290-49378
            628-680             AL133404.9         49884-49936
            681-1262            AL133404.9         50279-50860
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1262
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /note="triggering receptor expressed on myeloid cells like
                     1"
                     /db_xref="GeneID:340205"
                     /db_xref="HGNC:HGNC:20434"
                     /db_xref="MIM:609714"
     exon            1..102
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..995
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; trem-like transcript 1 protein; triggering
                     receptor expressed on myeloid cells-like protein 1"
                     /codon_start=1
                     /product="trem-like transcript 1 protein isoform a
                     precursor"
                     /protein_id="NP_835468.1"
                     /db_xref="CCDS:CCDS4851.1"
                     /db_xref="GeneID:340205"
                     /db_xref="HGNC:HGNC:20434"
                     /db_xref="MIM:609714"
                     /translation="MGLTLLLLLLLGLEGQGIVGSLPEVLQAPVGSSILVQCHYRLQD
                     VKAQKVWCRFLPEGCQPLVSSAVDRRAPAGRRTFLTDLGGGLLQVEMVTLQEEDAGEY
                     GCMVDGARGPQILHRVSLNILPPEEEEETHKIGSLAENAFSDPAGSANPLEPSQDEKS
                     IPLIWGAVLLVGLLVAAVVLFAVMAKRKQGNRLGVCGRFLSSRVSGMNPSSVVHHVSD
                     SGPAAELPLDVPHIRLDSPPSFDNTTYTSLPLDSPSGKPSLPAPSSLPPLPPKVLVCS
                     KPVTYATVIFPGGNKGGGTSCGPAQNPPNNQTPSS"
     exon            103..435
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..538
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..627
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..680
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1262
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /note="hexamer: AATAAA"
     polyA_site      1257
                     /gene="TREML1"
                     /gene_synonym="dJ238O23.3; GLTL1825; PRO3438; TLT-1; TLT1"
                     /note="major polyA site"
ORIGIN      
        1 aggcgaatgc tgcatcagtg cccaggcaag cccaggagtt gacatttctc tgcccagcca
       61 tgggcctcac cctgctcttg ctgctgctcc tgggactaga aggtcagggc atagttggca
      121 gcctccctga ggtgctgcag gcacccgtgg gaagctccat tctggtgcag tgccactaca
      181 ggctccagga tgtcaaagct cagaaggtgt ggtgccggtt cttgccggag gggtgccagc
      241 ccctggtgtc ctcagctgtg gatcgcagag ctccagcggg caggcgtacg tttctcacag
      301 acctgggtgg gggcctgctg caggtggaaa tggttaccct gcaggaagag gatgctggcg
      361 agtatggctg catggtggat ggggccaggg ggccccagat tttgcacaga gtctctctga
      421 acatactgcc cccagaggaa gaagaagaga cccataagat tggcagtctg gctgagaacg
      481 cattctcaga ccctgcaggc agtgccaacc ctttggaacc cagccaggat gagaagagca
      541 tccccttgat ctggggtgct gtgctcctgg taggtctgct ggtggcagcg gtggtgctgt
      601 ttgctgtgat ggccaagagg aaacaaggga acaggcttgg tgtctgtggc cgattcctga
      661 gcagcagagt ttcaggcatg aatccctcct cagtggtcca ccacgtcagt gactctggac
      721 cggctgctga attgcctttg gatgtaccac acattaggct tgactcacca ccttcatttg
      781 acaataccac ctacaccagc ctacctcttg attccccatc aggaaaacct tcactcccag
      841 ctccatcctc attgccccct ctacctccta aggtcctggt ctgctccaag cctgtgacat
      901 atgccacagt aatcttcccg ggagggaaca agggtggagg gacctcgtgt gggccagccc
      961 agaatccacc taacaatcag actccatcca gctaagctgc tcatcacact ttaaactcat
     1021 gaggaccatc cctaggggtt ctgtgcatcc atccagccag ctcatgccct aggatcctta
     1081 ggatatctga gcaaccaggg actttaagat ctaatccaat gtcctaactt tactagggaa
     1141 agtgacgctc agacatgact gagatgtctt ggggaagacc tccctgcacc caactccccc
     1201 actggttctt ctaccattac acactgggct aaataaaccc taataatgat gtgcaaactc
     1261 tt
//
