LOCUS       NM_018643               3252 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens triggering receptor expressed on myeloid cells 1
            (TREM1), transcript variant 1, mRNA.
ACCESSION   NM_018643
VERSION     NM_018643.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Ren,L., Qiao,G.L., Zhang,S.X., Zhang,Z.M. and Lv,S.X.
  TITLE     Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell
            Metastasis by Inactivating TLR/PI3K/AKT Signaling
  JOURNAL   Cell Biochem Biophys 82 (3), 2673-2685 (2024)
   PUBMED   38954352
  REMARK    GeneRIF: Pharmacological Inhibition or Silencing of TREM1 Restrains
            HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling.
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Li,C., Cai,C., Xu,D., Chen,X. and Song,J.
  TITLE     TREM1: Activation, signaling, cancer and therapy
  JOURNAL   Pharmacol Res 204, 107212 (2024)
   PUBMED   38749377
  REMARK    GeneRIF: TREM1: Activation, signaling, cancer and therapy.
            Review article
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Dong,M., Zhang,X., Peng,P., Chen,Z., Zhang,Y., Wan,L., Xiang,W.,
            Liu,G., Guo,Y., Xiao,Q., Wang,B., Guo,D., Zhu,M., Yu,X. and Wan,F.
  TITLE     Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma
            stem cells via alternatively activating tumor-associated
            macrophages
  JOURNAL   Cancer Lett 590, 216801 (2024)
   PUBMED   38479552
  REMARK    GeneRIF: Hypoxia-induced TREM1 promotes mesenchymal-like states of
            glioma stem cells via alternatively activating tumor-associated
            macrophages.
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Yu,S.M., Li,H., Deng,G.H., Wang,X.B., Zheng,X., Chen,J.J.,
            Meng,Z.J., Zheng,Y.B., Gao,Y.H., Qian,Z.P., Liu,F., Lu,X.B.,
            Shi,Y., Shang,J., Chen,R.C. and Huang,Y.
  TITLE     sTREM-1 as promising prognostic biomarker for acute-on-chronic
            liver failure and mortality in patients with acute decompensation
            of cirrhosis
  JOURNAL   World J Gastroenterol 30 (9), 1177-1188 (2024)
   PUBMED   38577193
  REMARK    GeneRIF: sTREM-1 as promising prognostic biomarker for
            acute-on-chronic liver failure and mortality in patients with acute
            decompensation of cirrhosis.
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Zhang,L., Qu,X. and Xu,Y.
  TITLE     Molecular and immunological features of TREM1 and its emergence as
            a prognostic indicator in glioma
  JOURNAL   Front Immunol 15, 1324010 (2024)
   PUBMED   38370418
  REMARK    GeneRIF: Molecular and immunological features of TREM1 and its
            emergence as a prognostic indicator in glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Allcock,R.J., Barrow,A.D., Forbes,S., Beck,S. and Trowsdale,J.
  TITLE     The human TREM gene cluster at 6p21.1 encodes both activating and
            inhibitory single IgV domain receptors and includes NKp44
  JOURNAL   Eur J Immunol 33 (2), 567-577 (2003)
   PUBMED   12645956
  REMARK    GeneRIF: The human TREM gene cluster at 6p21.1 encodes both
            activating and inhibitory single IgV domain receptors and includes
            TREM1.
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Gingras,M.C., Lapillonne,H. and Margolin,J.F.
  TITLE     TREM-1, MDL-1, and DAP12 expression is associated with a mature
            stage of myeloid development
  JOURNAL   Mol Immunol 38 (11), 817-824 (2002)
   PUBMED   11922939
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Bouchon,A., Hernandez-Munain,C., Cella,M. and Colonna,M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Bouchon,A., Facchetti,F., Weigand,M.A. and Colonna,M.
  TITLE     TREM-1 amplifies inflammation and is a crucial mediator of septic
            shock
  JOURNAL   Nature 410 (6832), 1103-1107 (2001)
   PUBMED   11323674
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Bouchon,A., Dietrich,J. and Colonna,M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF287008.1, DA362458.1,
            DA938757.1, AL391903.15 and CA417244.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018643.4.
            
            Summary: This gene encodes a receptor belonging to the Ig
            superfamily that is expressed on myeloid cells. This protein
            amplifies neutrophil and monocyte-mediated inflammatory responses
            triggered by bacterial and fungal infections by stimulating release
            of pro-inflammatory chemokines and cytokines, as well as increased
            surface expression of cell activation markers. Alternatively
            spliced transcript variants encoding different isoforms have been
            noted for this gene.[provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292162.1, SRR5189664.100615.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244709.9/ ENSP00000244709.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AF287008.1         38-891
            855-1043            DA362458.1         365-553
            1044-1596           DA938757.1         4-556
            1597-2595           AL391903.15        76066-77064         c
            2596-3252           CA417244.1         19-675              c
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3252
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="triggering receptor expressed on myeloid cells 1"
                     /db_xref="GeneID:54210"
                     /db_xref="HGNC:HGNC:17760"
                     /db_xref="MIM:605085"
     exon            1..76
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..732
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; triggering receptor expressed on monocytes 1"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 1
                     isoform 1 precursor"
                     /protein_id="NP_061113.1"
                     /db_xref="CCDS:CCDS4854.1"
                     /db_xref="GeneID:54210"
                     /db_xref="HGNC:HGNC:17760"
                     /db_xref="MIM:605085"
                     /translation="MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYT
                     LEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVN
                     LQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTK
                     ALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKS
                     LVFSVLFAVTLRSFVP"
     exon            77..433
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..626
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3252
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="hexamer: ATTAAA"
     polyA_site      867
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="major polyA site"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="hexamer: AATAGA"
     polyA_site      1569
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3252
                     /gene="TREM1"
                     /gene_synonym="CD354; TREM-1"
                     /note="major polyA site"
ORIGIN      
        1 agcagttgga gctggtgcac aggaaggatg aggaagacca ggctctgggg gctgctgtgg
       61 atgctctttg tctcagaact ccgagctgca actaaattaa ctgaggaaaa gtatgaactg
      121 aaagaggggc agaccctgga tgtgaaatgt gactacacgc tagagaagtt tgccagcagc
      181 cagaaagctt ggcagataat aagggacgga gagatgccca agaccctggc atgcacagag
      241 aggccttcaa agaattccca tccagtccaa gtggggagga tcatactaga agactaccat
      301 gatcatggtt tactgcgcgt ccgaatggtc aaccttcaag tggaagattc tggactgtat
      361 cagtgtgtga tctaccagcc tcccaaggag cctcacatgc tgttcgatcg catccgcttg
      421 gtggtgacca agggtttttc agggacccct ggctccaatg agaattctac ccagaatgtg
      481 tataagattc ctcctaccac cactaaggcc ttgtgcccac tctataccag ccccagaact
      541 gtgacccaag ctccacccaa gtcaactgcc gatgtctcca ctcctgactc tgaaatcaac
      601 cttacaaatg tgacagatat catcagggtt ccggtgttca acattgtcat tctcctggct
      661 ggtggattcc tgagtaagag cctggtcttc tctgtcctgt ttgctgtcac gctgaggtca
      721 tttgtaccct aggcccacga acccacgaga atgtcctctg acttccagcc acatccatct
      781 ggcagttgtg ccaagggagg agggaggagg taaaaggcag ggagttaata acatgaatta
      841 aatctgtaat caccggctat ttctaaagtc agcgtctcac cttcctgccc actgccctcg
      901 ttcctctaat aatcttgggt gggcatttgt gcctcagaaa agaagttaca gccccaaaca
      961 tgcttggtcc ttcattccac cagccacttg gggttggcat gaaatacaga cagctcaatg
     1021 cttttcaccg taattctctt gtgggggctg tgacatgcag aaggcacacc tgatacttct
     1081 cctgctcagt tttgccctgg accatacaat tttggcctga cctggacaga gctcccacta
     1141 cagaagcatc ctgctcgccc catgctggga cttcctcttt ctagcatcag acacttgggt
     1201 ttcatgctta tgtgtggttc tttccaacac tcccagaaaa gggtgttgaa gattgtggaa
     1261 cctggagaaa taagacatcg tggtgagaaa gtgcatcctt ctcagagaaa agagttaaac
     1321 tgagtatctt cttctgggga aatactggca ggccgagatg ggatccatag gagagcaaca
     1381 acagaccatg tcagacatcc tgtgtgcatt tatcgctgga tcctgaaaat agccccgtga
     1441 aggcagaaat gtatgtgact agaacgaggc cacatgaata agccactgcc cactggcagg
     1501 agtgaaaact gaagcgctcc ttacctgaag gaccccaaaa ccatatagaa tagaataacc
     1561 aggagttccg cctgtgtcta aatgcctctt ttcctgtatc acacaagggt cagggatggt
     1621 ggagtaaaag ctctccccct gggaggcttc tggaggctgt ccccatgtgc ttgcctagtt
     1681 ccccactctg ccctcctcct cttctctcag tctgctcctg gaacacctgc ctcagtttcc
     1741 atgctctctc cagtgccctc cccggtgaag caggtaggtg ttcaggccac cacagagaca
     1801 atctctgtgg gagattgtct tgcaatctcc cacagatttc aatcaggatt ttgttatttc
     1861 ctactttgag ctttaaaggg aaatgggcct catgggtggg gaaaggatgg tgggtccttc
     1921 cagcccaatt tagtgatgcc cagggcagat attatcctca gttcccaaga gcaatcatac
     1981 ttttccacac ataccgtgtg tctcatgtta ggtaaatgta tttttacaat gagcaccact
     2041 tctgtggaaa aagttccctg cacggggagg tccagcttcc agactgctcc atcgcataag
     2101 gacttcccca ttcccctaaa tgctgctctg tcagaacctg cccaggtaat ggtaatgacc
     2161 ctagagagat gatttctgaa ccgcaatttt gagcccatta gaaggtgtgt ggtgggcatt
     2221 tatttcatcc tgatgctctg gtgagaatct ttgcagacgc actagatcca gaagctgtta
     2281 atcttggtgc atttattttc ctacctaaaa gaaccaagca gctcagaggc agtgactgta
     2341 caggatgcag tgtttataat aatgctgagc ttgctggtct ggaaccccac actttagcaa
     2401 tcccagcatt gttcctgttt atgaagttga caaagtgacc agggcaaggg ggtattatca
     2461 ttaaatacac tctaggagag gcagaacaca tgagggcaat gtttttcaga ggtctttagg
     2521 ccaccgcatc agattctcct ggagcataaa gcaaatgctt tatgagtcca gggcccctgc
     2581 agacctactg tatactagta tacagctccc tcttagtgga tctcaagctt gtttccaaaa
     2641 agtcattaca ctccttacca aagcccatga cacattcata cagattcatc cagacataac
     2701 ccactgcatg gtccagtgca tgcttgtgtg cttaacttat tatagatcaa gtgttattta
     2761 agtccaacat attaaacgtg actgaaatat tatatgcact aaatcggaag acaaatggcc
     2821 gtgctggata ctctcccatt tgcacttaca ggccacgcca tgctccatcc tccccatcct
     2881 gcctgggaac ctgaccaatg tggctaaacc agcaggctcc ctggctgcca gcttctggct
     2941 ggttgagcca atgggaagca tgagaggaga gccgagggtg gggagacagt cagatcaggg
     3001 tttctgtcct cagggctccc tccctggcag gtggtggcag gagtggctgc attcccctct
     3061 gaaggctcct tcaagcctct cagcaaacag ctcccatctc caagtccagc cacctgttcc
     3121 atcctctcct ctgtaggccc agcagtggga atgacccacc actattgcca gcctcagcat
     3181 actgaagcac cccttactgg attccctaaa ttctatgcac atgtttatta aatgctcctc
     3241 aattacccag tt
//
